Call volume, triage outcomes, and protocols during the first wave of the COVID‐19 pandemic in the United Kingdom: Results of a national survey by Helen Snooks, Alan John Watkins, Fiona Bell, Mike Brady, Andy Carson‐Stevens, Edward Duncan, Bridie Angela Evans, Louise England, Theresa Foster, John Gallanders, Imogen Gunson, Robert Harris‐Mayes, Mark Kingston, Ronan Lyons, Elisha Miller, Andy Newton, Alison Porter, Tom Quinn, Andy Rosser, Aloysius Niroshan Siriwardena, Robert Spaight, Victoria Williams

“…We urgently need to understand safety and effectiveness of triage models to inform care during further waves and pandemics.…”
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State of nature 2023 terrestrial and freshwater animal dataset for the United Kingdom and its constituent countriesZenodo by Fiona Burns, Simone Mordue, Nida Al-Fulaij, Philipp Boersh-Supan, Katherine L. Boughey, Philip Briggs, Mark A. Eaton, Colin Harrower, Angus C. Jackson, Steve Langton, Francesca Mancini, David Noble, Chris R. Shortall, Chloë A. Smith, Robin J. Pakeman

“…Statistical methods partially controlled for the risk of bias and the noisy nature of such occupancy data. …”
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Developing and validating utility parameters to establish patient-reported outcome-based perioperative symptom management in patients with lung cancer: a multicentre, prospective,... by Rui Zhang, Wei Dai, Qiang Li, Shaohua Xie, Qiuling Shi, Yuanqiang Zhang, Wenhong Feng, Xiaoqing Liao, Yunfei Mu, Xing Wei, Chuanmei Wu, Heling Zhou, Xuemei Cheng, Yanhua Jiang, Jintao He, Xiaojun Yang

“…We aim to develop a perioperative symptom scale (PSS) for monitoring, to determine the optimal time points for symptom assessment and to define the alert thresholds for medical intervention.Methods and analysis This study will prospectively recruit 300 patients undergoing lung cancer surgery in six hospitals. …”
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A workflow of open-source tools for drone-based photogrammetry of marine megafauna by K.C. Bierlich, Josh Hewitt, Clara N. Bird, David W. Johnston, Julian Dale, Enrico Pirotta, Robert S. Schick, Joshua D. Stewart, Leslie New, Elliott Chimienti, Jeremy A. Goldbogen, Ari S. Friedlaender, Mauricio Cantor, Leigh G. Torres

“…We also introduce Xcertainty, a novel R package for quantifying and incorporating photogrammetric uncertainty associated with different drones based on Bayesian statistical models. Stepping through this workflow, we discuss pre-flight setup and in-flight data collection, imagery post-processing (image selection, measuring, linking metadata with measurements, and incorporating uncertainty), and methods for including measurement uncertainty into analyses. …”
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Hyperspectral imaging for precision nitrogen management: A comparative exploration of two methodological approaches to estimate optimal nitrogen rate in processing tomato by Vito Aurelio Cerasola, Francesco Orsini, Giuseppina Pennisi, Gaia Moretti, Stefano Bona, Francesco Mirone, Jochem Verrelst, Katja Berger, Giorgio Gianquinto

“…Multicollinearity of spectral bands was prevented with a principal component analysis, and models were 5-fold cross-validated. Considering the pivotal role of biomass in the selected N rate estimation approaches, two distinct biomass estimation methods were explored. …”
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γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds by Johannes Trambauer, Rosa Maria Rodriguez Sarmiento, Holly J. Garringer, Katja Salbaum, Liliana D. Pedro, Dennis Crusius, Ruben Vidal, Bernardino Ghetti, Dominik Paquet, Karlheinz Baumann, Lothar Lindemann, Harald Steiner

“…Methods Mouse embryonic fibroblast and induced pluripotent stem cell-derived neuronal PS1 L166P knock-in (KI) cell models were treated with various GSMs and Aβ responses were assessed by immunoassays and/or gel-based analysis. …”
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Scope of practice of primary care nurses: a protocol for an umbrella review of international literature by Kris Aubrey-Bassler, Marie-Ève Poitras, Shabnam Asghari, Michelle Swab, Lindsay Hedden, Maria Mathews, Ruth Martin-Misener, Elizabeth J Halcomb, Julia Lukewich, Leslie Meredith, Dana Ryan, Suzanne Braithwaite, Danielle Macdonald, Kathleen Leslie, Anaelle Morin, Monica McGraw, Patrick Chiu, Émilie Dufour, Sophia Myles, Annie Rioux-Dubois, Deanne Curnew, Jen Calver, Jill Bruneau

“…We will conduct an umbrella review to synthesise and compare international knowledge syntheses focused on scope of practice enactment (ie., roles and activities) of PCNs in primary care.Methods and analysis We will conduct the umbrella review according to the Joanna Briggs Institute methodology, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol (PRISMA-P) guidelines, and using the Nursing Care Organization Framework as guidance. …”
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Time in target range for systolic blood pressure and stroke in people with and without diabetes: the Kailuan prospective cohort study by Yuxin Yang, Shouling Wu, Jingdi Zhang, Yang Liu, Mingjie Yin, Zhenyu Huo, Shuohua Chen, Guodong Wang, Yao Xiao, Yue Wang, Yuanyuan Li, Jiawen Deng, Tingting Geng, Hong Zhang

“…We aimed to investigate the associations of SBP-TTR with stroke among participants with or without diabetes using data from the Kailuan study.MethodsWe included 28,591 participants [mean age, 57.5 years; 83.8% men; 23.2% with diabetes] from the Kailuan Study. …”
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Spatiotemporal patterns of influenza in Western Australia by Kefyalew Addis Alene, Hannah C. Moore, Archie C.A. Clements, Beth Gilmour, Dylan D. Barth, Rebecca Pavlos, Ben Scalley, Christopher C. Blyth

“…Methods: Data for confirmed influenza cases were obtained from the WA Notifiable Infectious Diseases Database for the period 2017–2020. …”
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COL10A1+ fibroblasts promote colorectal cancer metastasis and M2 macrophage polarization with pan-cancer relevance by Shangshang Hu, Muzi Ding, Jinwei Lou, Jian Qin, Yuhan Chen, Zixuan Liu, Yue Li, Junjie Nie, Mu Xu, Huiling Sun, Xinliang Gu, Tao Xu, Shukui Wang, Shukui Wang, Yuqin Pan

“…Functional validation was performed using molecular assays, in vivo models, and drug screening. Results We identified a COL10A1-positive fibroblast subpopulation (COL10A1+Fib) associated with CRC progression and poor patient prognosis. …”
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The mediating role of depression in the association between health-related quality of life and suicidal ideation in adolescents: findings from a longitudinal study by Martina Preisig, Isabelle Häberling, Lukasz Smigielski, Sophie Emery, Noemi Baumgartner, Mona Albermann, Michael Strumberger, Klaus Schmeck, Lars Wöckel, Suzanne Erb, Bruno Rhiner, Brigitte Contin-Waldvogel, Susanne Walitza, Susanne Walitza, Susanne Walitza, Gregor Berger

“…A series of t-tests, Chi-squared-tests, Fisher’s exact tests and a mediation analysis including three robust linear mixed-effects models were conducted.ResultsDepressed adolescents with suicidal ideation reported lower health-related quality of life across physical, psychological, peer, and school domains compared to those without suicidal ideation, while no significant difference was observed in the family-related domain. …”
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Association between health communication on integrated healthcare and primary healthcare visits among rehabilitation outpatients: A multicenter cross-sectional study in China by Ruixue Ye, Yucong Zou, Jie Yan, Jianjun Long, Yawei Li, Guo Dan, Yongjun Jiang, Yulong Wang

“…Objective: This study examines the relationship between health communication on integrated healthcare and primary healthcare visits among rehabilitation outpatients in China. Methods: A multi-stage sampling scheme was used to select the rehabilitation outpatients as study participants. …”
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Piezo1/ITGB1 Synergizes With Ca2+/YAP Signaling to Propel Bladder Carcinoma Progression via a Stiffness‐Dependent Positive Feedback Loop by Minghai Ma, Jianpeng Li, Xing Li, Minxuan Jing, Lu Wang, Yunzhong Jiang, Zezhong Yang, Jiale He, Min Wang, Hang Liu, Yutong Chen, Kaibo Mi, Lei Wang, Jinhai Fan, Hongxia Du

“…This study systematically investigates the functional synergy of Piezo1/ITGB1 in orchestrating ECM biomechanical remodeling to fuel BLCA progression. Methods Utilizing an integrative framework combining clinical histopathology, in vivo tumor models, multiomics profiling, molecular biology experiments, matrix stiffness quantification, calcium flux analysis, and YAP signaling interrogation, we dissected the mechanochemical interplay between Piezo1/ITGB1 activation and ECM dynamics. …”
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Long-term outcomes of bilateral salpingo-oophorectomy in women with personal history of breast cancer by Diana M Eccles, Antonis C Antoniou, Marc Tischkowitz, Clare Turnbull, Eva Morris, Paul Pharoah, Craig Knott, Bethany Torr, Andrew Bacon, Lucy Loong, Catherine Huntley, Tameera Rahman, Steven Hardy, Hend Hassan, Isaac Allen, Yvonne Walburga

“…Objectives To investigate the association between bilateral salpingo-oophorectomy (BSO) and long-term health outcomes in women with a personal history of breast cancer.Methods and analysis We used data on women diagnosed with invasive breast cancer between 1995 and 2019 from the National Cancer Registration Dataset (NCRD) in England. …”
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Associations Between Atherosclerosis and Subsequent Cognitive Decline: A Prospective Cohort Study by Jie Liang, Yang Pan, Wenya Zhang, Darui Gao, Jingya Ma, Yanyu Zhang, Mengmeng Ji, Yiwen Dai, Yuling Liu, Yongqian Wang, Yidan Zhu, Bin Lu, Wuxiang Xie, Fanfan Zheng

“…Cognitive function was reassessed in wave 2 (2022–2023) using linear mixed models for analysis. A total of 932 participants (63.7% women; mean age, 60.0±6.9 years) were included. …”
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A multi-omics study of magnesium sulfate to improve prognosis in sepsis-related encephalopathy: integrating clinical data-driven network pharmacology by Yingming Kong, Yanghao Tai, Bin Chen, Meng Zhang, Haoyu Ji, Rongke Feng, Liang Shi, Hao Chen, Hao Chen

“…Propensity score matching balanced covariates. Cox models and Kaplan-Meier curves evaluated magnesium sulfate’s association with 28-day all-cause mortality (ACM). …”
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Dissecting Trichoderma antagonism: Role of strain identity, volatiles, biomass, and morphology in suppressing cacao pathogens by Insuck Baek, Jishnu Bhatt, Jae Hee Jang, Seunghyun Lim, Amelia Lovelace, Minhyeok Cha, Dilip Lakshman, Moon S. Kim, Lyndel W. Meinhardt, Sunchung Park, Ezekiel Ahn

“…Dual culture assays, detailed morphological analysis of both antagonist and pathogen, volatile organic compound (VOC) assays (comparing standard plug vs. pre-grown biomass methods), and the effect of UVC pretreatment were investigated. …”
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Family-focused intervention programme to foster adolescent mental health and well-being: protocol for a multicountry cluster randomised factorial trial (FLOURISH Phase 2) by Heather M Foran, Marija Raleva, Nina Heinrichs, Graham Moore, Yulia Shenderovich, Xiang Zhao, Judith Simon, Antonio Piolanti, Viorel Babii, Janina Mueller, Franziska Waller, Dennis Wienand, Swetha Sampathkumar, Ivo Kunovski

“…Effective and scalable interventions are urgently needed to address these challenges.Methods and analysis This protocol outlines a multicountry cluster randomised factorial trial, implemented according to the multiphase optimisation strategy (Phase 2), which evaluates the effectiveness and costs of three add-on components for the Parenting for Lifelong Health for Parents and Teens programme: adolescent mental health tools based on UNICEFs Helping Adolescents Thrive comics, adolescent peer support based on UNICEFs ‘I Support My Friends’ intervention and engagement booster designed to enhance attendance and programme completion through incentives. …”
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Prognostic value of the lactate dehydrogenase to albumin ratio in cancer patients by Dongqi Chai, Dongqi Chai, Dongqi Chai, Tao Yang, Tao Yang, Tao Yang, Lilong Zhang, Lilong Zhang, Lilong Zhang, Yuanjian Hui, Yuanjian Hui, Jiarui Feng, Jiarui Feng, Weixing Wang, Weixing Wang, Weixing Wang

“…ObjectiveThis study aimed to explore the prognostic relevance of the lactate dehydrogenase-to-albumin ratio (LAR) in cancer patients.MethodsA comprehensive literature search was conducted across PubMed, EMBASE, and the Cochrane Library for studies published before March 15, 2025. …”
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Trajectories of antenatal depression and adverse pregnancy outcomes: A prospective cohort study by Jianfei Chen, Siqi Li, Sai Yang, Yang Chen, Jackson Jr Nforbewing Ndenkeh, Intan Maharani Sulistyawati Batubara, Luyang Zhu, Jun Liu, Xinlong Pan, Zhijie Zou, Cuifang Fan, Xiaoli Chen, Zhao Ni

“…Latent class growth modeling and logistic regression were used for data analysis. …”
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