Metabolism disruption induced by high ambient temperature by Ke Zhang, Gongbo Chen, Wan Liu, Jie He, Mengnan Pan, Zhongyang Chen, Jiahui Tong, Feifei Liu, Hao Xiang

“…We employed linear mixed-effect models to identify acute cardiovascular responses associated with ambient temperature, including differential biomarkers and metabolites. …”
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Tobacco policy coverage in California jurisdictions before and after enactment of proposition 56 by Dennis R. Trinidad, Candice D. Donaldson, Brian Dang, Matthew D. Stone, Thet Nwe Myo Khin, Sara B. McMenamin, Yuyan Shi, Tam D. Vuong, Xueying Zhang, Karen Messer, John P. Pierce

“…Discrete-time survival models were fitted to test the effect of Proposition 56 on the rate of population coverage for each policy of interest. …”
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Safety and efficacy of 3D navigation-guided endoscopy for intracranial hemorrhage in patients with early cerebral hernia by Jun Zhang, Sitong Zhou, Taihui Zhang, Yongsheng Chen, Haikang Zhao, Hongyu Cheng, Peng Wang, Zhuhui Li, Jiajing Chen, Wobin Huang, Bocong Liu, Dayu Li, Hanwen Zhao, Xinwei Liu, Wenqiang Gao, Lijin Huang, Yuqian Li

“…This study aimed to assess the effectiveness and feasibility of 3D navigation-guided endoscopy for ICH patients presenting early clinical manifestations of cerebral hernia. Methods: We conducted a retrospective analysis of 11 ICH patients with cerebral hernia who underwent neuroendoscopic hematoma evacuation guided by 3D navigation technology at the Department of Neurosurgery in Dalang Hospital between January 2019 and January 2022. …”
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Interplay of PAK1 and CAMKII in Pancreatic Beta Cell Insulin Secretion by Nely Gisela López-Desiderio, Genaro Patiño-López, Citlaltépetl Salinas-Lara, Carlos Sánchez-Garibay, Olga Villamar-Cruz, Alonso Vilches-Flores, José de Jesús Peralta-Romero, Leonel Armas-López, Jazmín García-Machorro, Luis Enrique Arias-Romero, Héctor Iván Saldívar-Cerón

“…To examine their expression dynamics in a physiological context, we performed immunohistochemistry (IHC) on pancreatic sections from wild-type (WT), prediabetic, and T2DM murine models. Additionally, bioinformatic analysis of publicly available RNA sequencing (RNA-Seq) data from human islets of healthy donors, prediabetic individuals, and T2DM patients provided translational validation. …”
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FMO2+ cancer-associated fibroblasts sensitize anti-PD-1 therapy in patients with hepatocellular carcinoma by Hui Li, Wenxin Xu, Qinghai Ye, Qiang Yu, Jialei Weng, Shaoqing Liu, Minghao Xu, Yinghao Shen, Hui-Chuan Sun, Yufei Zhao, Peiyi Xie, Mincheng Yu, Bugang Liang, Junbo Chen

“…Mouse orthotopic HCC models and a coculture system were constructed, and cytometry by time-of-flight analysis was performed to investigate the functions and mechanisms of specific CAFs in the immune context of HCC.Results We identified a distinct flavin-containing monooxygenase 2 (FMO2)+ CAF subset associated with a favorable response to anti-PD-1 therapy and better clinical outcomes. …”
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Mitochondrial metabolism is rapidly re-activated in mature neutrophils to support stimulation-induced response by Jorgo Lika, Jorgo Lika, James A. Votava, Rupsa Datta, Carlos A. Mellado Fritz, Carlos A. Mellado Fritz, Aleksandr M. Kralovec, Aleksandr M. Kralovec, Frances M. Smith, Anna Huttenlocher, Anna Huttenlocher, Melissa C. Skala, Melissa C. Skala, Jing Fan, Jing Fan, Jing Fan

“…This study aims to quantitatively understand neutrophil mitochondrial metabolism throughout differentiation and activation, and to elucidate the impact of mitochondrial metabolism on neutrophil functions.MethodsTo study metabolic remodeling throughout neutrophil differentiation, murine ER-Hoxb8 myeloid progenitor-derived neutrophils and human induced pluripotent stem cell-derived neutrophils were assessed as models. …”
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TSPAN18 facilitates bone metastasis of prostate cancer by protecting STIM1 from TRIM32-mediated ubiquitination by Qianghua Zhou, Xu Chen, Kai Yao, Yangjie Zhang, Haixia He, Hao Huang, Hao Chen, Shengmeng Peng, Ming Huang, Liang Cheng, Qiang Zhang, Ruihui Xie, Kaiwen Li, Tianxin Lin, Hai Huang

“…However, the regulatory mechanism and target therapy of STIM1 is poorly defined. Methods Liquid chromatography-mass spectrometry analysis was performed to identify tetraspanin 18 (TSPAN18) as a binding protein of STIM1. …”
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Protocol for a qualitative study exploring the perception of need, importance and acceptability of a digital diabetes prevention intervention for women with gestational diabetes me... by Siew Mooi Ching, Kimberley Goldsmith, Nicola Guess, Iliatha Papachristou Nadal, Helen Murphy, Barakatun Nisak Mohd Yusof, Irmi Zarina Ismail, Hanifatiyah Ali, Angus Forbes, Nur Hafizah Mahamad Sobri, Faezah Hassan, Nurul Iftida Basri, Mazatulfazura Sf Salim, Choiriyatul Azmiyaty

“…Thus, this study will explore the factors affecting the uptake of healthy behaviour changes and the use of digital technology among women and their healthcare providers (HCPs) to support healthy behaviour changes in women with GDM.Methods and analysis The study will be modelled according to the Capability, Opportunity, Motivation and Behaviour and Behaviour Change Wheel techniques, and use the DoTTI framework to identify needs, solutions and testing of a preliminary mobile app, respectively. …”
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Impact of Left Ventricular Diastolic Pressure Changes on Clinical Outcomes After Transcatheter Aortic Valve Replacement by Jiwon Seo, Ah‐Ram Kim, Iksung Cho, Chi Young Shim, Geu‐Ru Hong, Eui‐Young Choi, Se‐Joong Rim, Young‐Guk Ko, Myeong‐Ki Hong, Jae‐Kwan Song, Jong‐Won Ha

“…In multivariable Cox hazard models, Group 1 was independently associated with a favorable primary outcome (hazard ratio, 0.52 [95% CI, 0.34–0.80]; P=0.003). …”
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The Impact of Automatic Exposure Control Technology on the In Vivo Radiation Dose in Digital Mammography: A Comparison Between Different Systems and Target/Filter Combinations by Ahmad A. Alhulail, Salman M. Albeshan, Mohammed S. Alshuhri, Essam M. Alkhybari, Mansour A. Almanaa, Haitham Alahmad, Khaled Alenazi, Abdulaziz S. Alshabibi, Mohammed Alsufayan, Saleh A. Alsulaiman, Maha M. Almuqbil, Mahmoud M. Elsharkawi, Sultan Alghamdi

“…In this study, we aimed to determine the effect of various mammographic technologies on the in vivo mean glandular doses (MGDs) that are received in clinical settings. <b>Methods</b>: The MGDs and applied acquisition parameters from 194,608 mammograms, acquired employing AEC using different digital mammography systems (GE, Siemens, and two different models of Hologic), were retrospectively collected. …”
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Local adaptation and validation of a transdiagnostic risk calculator for first episode psychosis using mental health patient records by Elizabeth Ford, James Stone, James Stone, James Stone, Dominic Oliver, Dominic Oliver, Dominic Oliver, Benjamin Fell, Gloria Roque, Sam Robertson, Paolo Fusar-Poli, Paolo Fusar-Poli, Paolo Fusar-Poli, Paolo Fusar-Poli, Kathryn Greenwood, Kathryn Greenwood

“…We developed new machine-learning NLP algorithms for diagnosis, symptom and substance use concepts by fine-tuning existing open-source transformer models. Baseline and outcome coded diagnoses were supplemented with NLP-derived diagnosis data. …”
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Barriers to effective communication in UAE community pharmacies: general public perspectives on enhancing patient-pharmacist interaction and policy development by Zelal Kharaba, Ahmad Al-Azayzih, Sayer Al-Azzam, Anan Jarab, Hisham E. Hasan, Dania Rahhal, Feras Jirjees, Khalid A. Al-Kubaisi, Monia H. Aljumah, Faris El-Dahiyat, Sara Meer, Mohammad A. Y. Alqudah, Mamoon A. Aldeyab, Karem H. Alzoubi

“…This study aims to identify and evaluate the factors that obstruct general public-pharmacist interactions, providing insights to enhance pharmacy environments.Methods A total of 406 general publics were surveyed using a validated questionnaire. …”
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Predictive nomograms of repeat intrahepatic recurrence and overall survival after radiofrequency ablation of recurrent colorectal liver metastases by Ji-Chen Wang, Bin-Bin Jiang, Zhong-Yi Zhang, Yu-Hui Liu, Li-Jin Shao, Song Wang, Wei Yang, Wei Wu, Kun Yan

“…Potential prognostic factors associated with rIHR and OS, after RFA, were identified by using the competing-risks and Cox proportional hazard models, respectively, and were used to construct the nomogram. …”
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Long‐Term or Recurrent Antibiotic Use in Early Life and the Risk of Type 2 Diabetes: A Population‐Based Prospective Cohort and a Case–Control Study by Zijun Li, Qiangsheng He, Xin He, Xin Xing, Songbo Fu, Xiaoping Sun, Mina Ma, Danni Wang, Ningning Mi, Jinyu Zhao, Jinqiu Yuan, Kehu Yang

“…We performed this study to investigate this association in two population‐based studies. Methods We undertook a prospective analysis encompassing 147 010 participants from the UK Biobank. …”
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Advances and trends of non-marine shale sedimentology: A case study from Gulong Shale of Daqing Oilfield, Songliao Basin, NE China by Longde SUN, Rukai ZHU, Tianshu ZHANG, Yi CAI, Zihui FENG, Bin BAI, Hang JIANG, Bo WANG

“…Such research will focus on eight aspects: lithofacies and organic matter distribution prediction under a sequence stratigraphic framework for non-marine shale strata; lithofacies paleogeography of shale strata based on the forward modeling of sedimentation; origins of non-marine shale lamina and log-based identification of lamina combinations; source of organic matter in shale and its enrichment process; non-marine shale lithofacies classification by rigid particles + plastic components + pore-fracture system; multi-field coupling organic-inorganic interaction mechanism in shale diagenesis; new methods and intelligent core technology for shale reservoir multi-scale characterization; and quantitative evaluation and intelligent analysis system of shale reservoir heterogeneity.…”
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Effects of ambient air pollution mixtures and household fuel use on progression to advanced cardiovascular-kidney-metabolic syndrome among middle-aged and older adults by Shunchang Fan, Haoyue Hu, Yucheng Li, Ying Deng, Shiao Wang, Juxian Xian, Daoqi Zhu, Minyi Zhang

“…Results: In the longitudinal analysis, 18.2 % (604/3317) of participants developed advanced CKM syndrome. …”
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Publication of works presented in the 2016 and 2018 editions of the National Student Scientific Event on Internal Medicine -MEDINTÁVILA by Frank Hernández-García, Ibraín Enrique Corrales-Reyes, Enrique Rolando Pérez-García, Juan Antonio Sorí-Peña, Onelis Góngora-Gómez, Christian Richard Mejía

“…Bivariate analyses were performed to determine whether there were characteristics of the works associated with their publication, calculating prevalence ratios, along with their corresponding 95% confidence intervals and p-values and using generalized linear models (family=Poisson; link=log) in which each university submitting the research work was used as a cluster. …”
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Neutrophil-lymphocyte ratio (NLR); an accurate inflammatory marker to predict diabetic foot ulcer amputation: a matched case-control study by Faeze Afshar, Morteza Daraie, Fatemeh Mohammadi, Kiana Seifouri, Samira Amin Afshari, Soheil Heidari Some’eh, Amirhossein Yadegar, Parnian Naghavi, Alireza Esteghamati, Soghra Rabizadeh, Mahsa Abbaszadeh, Manouchehr Nakhjavani, Sahar Karimpour Reyhan

“…Analyses were conducted via univariate and multivariate regression models. The linearity of the relationship between each inflammatory index and the risk of amputation was further examined via restricted cubic spline (RCS) curves with four knots. …”
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Exome sequencing revealed a novel homozygous variant in TRMT61 A in a multiplex family with atypical Cornelia de Lange Syndrome from Rwanda by Esther Uwibambe, Abdoulaye Yalcouyé, Elvis Twumasi Aboagye, Lettilia Xhakaza, Kalinka Popel, Norbert Dukuze, Thashi Bharadwaj, Carmen de Kock, Isabelle Schrauwen, Suzanne M. Leal, Leon Mutesa, Ambroise Wonkam

“…(Ala222Val)] inherited from both heterozygous parents. In silico analysis suggested that the variant substitutes a highly conserved amino acid, and 2-D structure modelling revealed a significant decrease in the stability of the protein. …”
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Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain by Ang Zhang, Shenyu Wang, Yao Sun, Yikun Zhang, Long Zhao, Yang Yang, Yijian Zhang, Lei Xu, Yangyang Lei, Jie Du, Hu Chen, Lian Duan, Mingyi He, Lintao Shi, Lei Liu, Quanjun Wang, Liangding Hu, Bin Zhang

“…Our attempt to devise a novel CAR structure capable of recognizing both tumor antigens and PDL1 encountered challenges since direct targeting of PDL1 resulted in systemic adverse effects. Methods In this research, we innovatively engineered novel CARs by grafting the PD1 domain into a conventional second-generation (2G) CAR specifically targeting CD19. …”
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