Early nasal microbiota and subsequent respiratory tract infections in infants with cystic fibrosis by Ruth Steinberg, Nadja Mostacci, Elisabeth Kieninger, Bettina Frauchiger, Carmen Casaulta, Jakob Usemann, Alexander Moeller, Daniel Trachsel, Isabelle Rochat, Sylvain Blanchon, Dominik Mueller-Suter, Barbara Kern, Maura Zanolari, Urs Frey, Kathryn A. Ramsey, Markus Hilty, Philipp Latzin, Insa Korten, SCILD study group, BILD study group

“…We calculated generalized additive mixed models and permutational analysis of variance. Results Here, we show that the nasal microbiota is already altered before the first RTI or antibiotic treatment in infants with CF. …”
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Independent and interactive associations of inflammation, vascular homeostasis markers, and childhood trauma with suicide attempt history by Ainoa García-Fernández, Aiste Lengvenyte, Elia Gourguechon-Buot, Emilie Olié, Fabrice Cognasse, Pilar A. Sáiz, Philippe Courtet

“…Independent associations between PDGF-BB, childhood trauma, and suicide attempts were further assessed using interaction models. Stratified sensitivity analyses based on childhood trauma history were also conducted. …”
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Preclinical and clinical evaluation of intratumoral injection of an IL-12 expressing SKV-012 oncolytic virus for advanced solid tumors by Jing Jin, Zheng Jiang, Jun Liu, Hui Yang, Long Xu, Weiwei Zhang, Xingchen Peng, Nian Yang, Zongliang Zhang, Liangxue Zhou, Aiping Tong, Huaqing Lu, Yongdong Chen, Liyuan Jin

“…Background SKV-012 is a novel engineered oncolytic virus (containing the viral neurovirulence ICP34.5 gene transcribed by the Survivin promoter with an upstream genetic component of interleukin-12 (IL-12) driven by the cytomegalovirus promoter) that preferentially replicates in tumors and helps stimulate antitumor immune responses.Methods We evaluated SKV-012’s safety and efficacy in preclinical models. …”
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Optimising AVATAR therapy for people who hear distressing voices: study protocol for the AVATAR2 multi-centre randomised controlled trial by Philippa Garety, Clementine J. Edwards, Thomas Ward, Richard Emsley, Mark Huckvale, Paul McCrone, Mar Rus-Calafell, Miriam Fornells-Ambrojo, Andrew Gumley, Gillian Haddock, Sandra Bucci, Hamish McLeod, Amy Hardy, Emmanuelle Peters, Inez Myin-Germeys, Thomas Craig

“…The primary outcome is the PSYRATS Auditory Hallucinations Distress dimension score at 16 and 28 weeks, conducted by blinded assessors. Statistical analysis will follow the intention-to-treat principle and data will be analysed using linear mixed models. …”
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Investigator-initiated versus industry-sponsored trials – visibility and relevance of randomized controlled trials in clinical practice guidelines (IMPACT) by Manuel Hecht, Anette Blümle, Harald Binder, Martin Schumacher, Nadine Binder

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Factors explaining failure to suppress viral load in pregnant women living with HIV in Mbandaka, Equateur Province (Democratic Republic of Congo) by Jean Claude Efoloko Likulu, Jules Moti Kangite, Freddy Adu Adikaka, Tonton Manga Bosako, Patrick Bongbanga Mundembe, Guillain Boboko Bikoko, Richard Bikopo Betoko, Monizi Mawunu, Jean-Paul Koto-Te-Nyiwa Ngbolua, Félicien Kandolo Tshimungu, Jean Pierre Moyene Elongi

“…Purpose The primary aim is to identify the factors associated with virologic non-suppression in HIV-positive pregnant women and assess how these contribute to MTCT, thereby informing strategies to reduce perinatal HIV transmission. Methods A mixed-methods, longitudinal case-control design was adopted. …”
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PRACTICAL TRAINING OF OFFICERS OF THE STATE FIRE SERVICE THROUGH GAME-BASED LEARNING by V. V. Bulgakov, A. A. Lazarev, E. P. Konovalenko, T. A. Mochalova

“…The methodology is designed to develop cadets’ practical skills in the field of rescue operations and firefighting.Methodology and research methods. In the course of the research, the methods of system analysis, synthesis and modelling of professional activity were employed. …”
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Huqi formula suppresses hepatocellular carcinoma growth by modulating the PI3K/AKT/mTOR pathway and promoting T cell infiltration by Donghao Yin, Xiang Li, Xuemeng Yang, Xiaofei Shang, Zhen Li, Jiahao Geng, Yanyu Xu, Zijing Xu, Zixuan Wang, Zimeng Shang, Zhiyun Yang, Linlan Hu, Quanwei Li, Jiabo Wang, Xinhua Song, Xiuhui Li, Xiaojun Wang

“…In Akt/Nras and c-Met/sgPten-induced HCC models, HQF significantly reduced tissue damage, improved liver function, and inhibited HCC progression. …”
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Peer-Assisted Lifestyle (PAL) intervention: a protocol of a cluster-randomised controlled trial of a health-coaching intervention delivered by veteran peers to improve obesity trea... by Stephanie L Orstad, Melanie Jay, Victoria Sweat, Sandra Wittleder, Scott E Sherman, Jeannette M Beasley, Shea Smith, Binhuan Wang, Allison Squires, Laura Wong, Yixin Fang, Paula Doebrich, Damara Gutnick, Craig Tenner

“…We describe the rationale and design of a cluster-randomised controlled trial to test the efficacy of the Peer-Assisted Lifestyle (PAL) intervention compared with enhanced usual care (EUC) to improve BM loss, clinical and behavioural outcomes (aim 1); identify BM-loss predictors (aim 2); and increase PCP counselling (aim 3).Methods and analysis We are recruiting 461 veterans aged 18–69 years with obesity or overweight with an obesity-associated condition under the care of a PCP at the Brooklyn campus of the Veterans Affairs NY Harbor Healthcare System. …”
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Berberine in the treatment of radiation-induced skin injury: insights from proteomics and network pharmacology by Jie Zou, Jie Zou, Xia-Juan Xiao, Ping Zhang, Xing-Zi Huang, Jing Wang, Chun-Qin Tao, Xiao-Lan Ou, Gong Chen, Ting-Hao He, Long Yang, Biao Huang, Dao-Jiang Yu, Dao-Jiang Yu, Yu Zhao

“…Finally, the therapeutic efficacy of BBR was confirmed in irradiated cell and animal models.ResultsBBR is pivotal in modulating molecular pathways linked to inflammation, oxidative stress, and tissue repair. …”
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Utilizing multiple diffusion metrics in evaluation of corticospinal tract injury in patients with glioblastoma by Ting Chen, Peipei Wang, Eryuan Gao, Jie Bai, Guohua Zhao, Kai Zhao, Gaoyang Zhao, Yu Zhang, Yong Zhang, Mengzhu Wang, Guang Yang, Boyan Xu, Xiaoyue Ma, Jingliang Cheng, Jingliang Cheng

“…Bilateral CSTs were reconstructed, and a comparative analysis of diffusion parameters was performed based on four imaging models between affected and healthy sides. …”
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Exploration of 3D Few-Shot Learning Techniques for Classification of Knee Joint Injuries on MR Images by Vinh Hiep Dang, Minh Tri Nguyen, Ngoc Hoang Le, Thuan Phat Nguyen, Quoc-Viet Tran, Tan Ha Mai, Vu Pham Thao Vy, Truong Nguyen Khanh Hung, Ching-Yu Lee, Ching-Li Tseng, Nguyen Quoc Khanh Le, Phung-Anh Nguyen

“…Few-shot learning (FSL) addresses this by enabling models to classify new conditions from minimal annotated examples, often leveraging knowledge from related tasks. …”
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Longitudinal Lipid Trajectories and Progression of CKD in Children by Uwe Querfeld, Marietta Kirchner, Francesca Mencarelli, Karolis Azukaitis, Aysun Bayazit, Ali Duzova, Anke Doyon, Nur Canpolat, Ipek Kaplan Bulut, Lukasz Obrycki, Justine Bacchetta, Rukshana Shroff, Dusan Paripovic, Cengiz Candan, Jerome Harambat, Alev Yilmaz, Harika Alpay, Jun Oh, Hakan Erdogan, Claus P. Schmitt, Anette Melk, Franz Schaefer

“…Kidney survival was significantly different for HDL-C (P = 0.0128), but not for other lipid trajectories in the Kaplan-Meier analysis. There was no significant association of any of the lipid trajectories with CKD progression in Cox proportional hazard models. …”
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Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell lines by Alexandra Razumovskaya, Mariia Silkina, Mariia Silkina, Mariia Silkina, Andrey Poloznikov, Timur Kulagin, Maria Raigorodskaya, Nina Gorban, Anna Kudryavtseva, Maria Fedorova, Boris Alekseev, Alexander Tonevitsky, Alexander Tonevitsky, Alexander Tonevitsky, Sergey Nikulin, Sergey Nikulin, Sergey Nikulin

“…Prognostic performance was evaluated through Kaplan-Meier survival analysis and log-rank tests, while independent prognostic significance was assessed using multivariate Cox proportional hazards modeling.ResultsA small set of genes showed consistent correlation with resistance to chemotherapy across different datasets. …”
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Regenerative potential of PRP-based scaffolds in chronic wound healing: Mechanisms, advances, and therapeutic insights by Farag M.A. Altalbawy, Bilal Abdul Majeed Mukhlif, Ahemad Hussen, Jaafaru Sani Mohammed, Renuka Jyothi S, Arshdeep Singh, Shakti Bedanta Mishra, Ashish Singh Chauhan, Mohammad Ebrahim Astaneh, Narges Fereydouni

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Observational study of sudden cardiac arrest risk (OSCAR): Rationale and design of an electronic health records cohort by Kyndaron Reinier, Harpriya S. Chugh, Audrey Uy-Evanado, Elizabeth Heckard, Marco Mathias, Nichole Bosson, Vinicius F. Calsavara, Piotr J. Slomka, David A. Elashoff, Alex A.T. Bui, Sumeet S Chugh

“…We will use conventional approaches (diagnosis code algorithms) and artificial intelligence (natural language processing, deep learning) to define patient phenotypes and biostatistical and machine learning approaches for analysis. Conclusions: The OSCAR cohort will provide a large, diverse dataset and adjudicated SCA outcomes to facilitate the derivation and testing of risk prediction models for incident SCA.…”
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The association of heavy metals/metalloid and stroke—Findings in Shanxi, China and the US NHANES from 2011 to 2020 by Yuese Yuan, Li Zhang, Fuying Liu, Haobo Liu, Ying Wang, Xiujuan Yang, Liangpo Liu, Ben Li, Li Wang, Jin Yang, Hongyan Cao, Yulan Qiu, Jinping Zheng, Jian Guo, Yi Gao

“…Background: Previous studies provided contradictory evidence regarding the relationship between metal concentrations and ischemic stroke (IS). Methods: A total of 100 adults with IS were included in this study, as well as an equal number of controls. …”
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Preclinical Characterization of Efficacy and Pharmacodynamic Properties of Finotonlimab, a Humanized Anti-PD-1 Monoclonal Antibody by Yunqi Yao, Xiaoning Yang, Jing Li, Erhong Guo, Huiyu Wang, Chunyun Sun, Zhangyong Hong, Xiao Zhang, Jilei Jia, Rui Wang, Juan Ma, Yaqi Dai, Mingjing Deng, Chulin Yu, Lingling Sun, Liangzhi Xie

“…<b>Background/Objectives:</b> Finotonlimab (SCTI10A) is a humanized anti-PD-1 antibody tested in Phase III trials for several solid tumor types. <b>Methods</b>: This study characterized the in vitro and in vivo efficacy, Fc-mediated effector function, and non-clinical PK/PD properties of finotonlimab. …”
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Impact of disease location and laterality on hemodynamic response following pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension by Bryan O. Pérez Martínez, MD, Gabriella V. Rubick, MD, Avi Toiv, MD, Sidney Perkins, MD, Jorge Vinales, Victor M. Moles, MD, Vallerie V. McLaughlin, MD, Thomas M. Cascino, MD MSc, Bryan Kelly, DO, Gillian Grafton, DO, Rana Awdish, MD, Jonathan W. Haft, MD, Vikas Aggarwal, MD MPH

“…Objectives: Examine the effect of obstructive disease location and laterality on hemodynamic response following PTE. Methods: This analysis is a retrospective cohort study of 56 consecutive patients diagnosed with CTEPH who underwent PTE at the University of Michigan Hospital between August 2019 and July 2022. …”
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Association between maternal serum essential trace element concentration in early pregnancy and gestational diabetes mellitus by Jinlang Lyu, Peng Tang, Yuanyuan Wang, Na Han, Rong Zhang, Xiangming Yang, Yuelong Ji, Jue Liu, Bin Wang, Lailai Yan, Qin Li, Xu Ma, Hai-Jun Wang

“…Compared to those with the lowest tertile, the pregnant women with the highest tertile of Co concentrations had decreased risk of GDM (OR = 0.56, 95% CI: 0.34–0.93, P = 0.024) in the adjusted models. The association was further confirmed in the multiple-exposure analysis. …”
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