Preterm preeclampsia screening and prevention: a comprehensive approach to implementation in a real-world setting by Stefania Ronzoni, Shamim Rashid, Aimee Santoro, Elad Mei-Dan, Jon Barrett, Nanette Okun, Tianhua Huang

“…This study assesses the feasibility of implementing preterm preeclampsia screening and prevention by leveraging information from our current aneuploidy screening program in a real-world setting with geographic separation clinical site and laboratory analysis site. Methods A prospective cohort study involved pregnant individuals undergoing nuchal translucency scans between 11 and 14 weeks. …”
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Factors associated with going outdoors frequently: a cross-sectional study among Swiss community-dwelling older adults by Christophe Büla, Laurence Seematter-Bagnoud, Brigitte Santos-Eggimann, Julia Spaltenstein, Helene Krief

“…Objective This study examines potential risk and protective factors associated with going outdoors frequently among older persons, and whether these factors vary according to physical limitations.Design Cross-sectional analysis.Setting and participants Community-dwelling participants of the Lausanne cohort Lc65+ in 2016, aged 68–82 years (n=3419).Methods Associations between going outdoors frequently and physical limitations, sociodemographic, health, psychological and social variables were examined using logistic regression models. …”
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Integrating the Interleukins in the Biomarker Panel for the Diagnosis and Prognosis of Patients with Acute Coronary Syndromes: Unraveling a Multifaceted Conundrum by Amalia-Stefana Timpau, Egidia-Gabriela Miftode, Irina-Iuliana Costache-Enache, Antoniu-Octavian Petris, Ionela-Larisa Miftode, Ivona Mitu, Radu-Stefan Miftode

“…Logistic regression models confirmed NT-proBNP and IL-10 as mortality predictors. …”
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Long-term anti-SARS-CoV-2 antibody trajectories after neutralizing monoclonal antibody treatment. by Elizabeth S Munroe, Greg A Grandits, Robert C Hyzy, Hallie C Prescott, Thomas W Barrett, Robin L Dewar, Nicole Engen, Anna L Goodman, Timothy J Hatlen, Helene Highbarger, Thomas L Holland, Gareth Hughes, Tomas O Jensen, Muhammad A Khan, Ioannis Kalomenidis, Nayon Kang, Sylvain Laverdure, Prasad Manian, Vidya Menon, Ravi Patel, Srikanth Ramachandruni, Tauseef Rehman, Kathryn Shaw-Saliba, Birgit Thorup Røge, David M Vock, Amy C Weintrob, Barnaby E Young, Anne P Frosch, STRIVE Network and Therapeutics for Inpatients with COVID-19 (TICO) study groups

“…Linear mixed effects models were fit to compare the longitudinal trajectory between treatment and placebo groups.…”
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What’s Going On With Me and How Can I Better Manage My Health? The Potential of GPT-4 to Transform Discharge Letters Into Patient-Centered Letters to Enhance Patient Safety: Prospe... by Felix Eisinger, Friederike Holderried, Moritz Mahling, Christian Stegemann–Philipps, Anne Herrmann–Werner, Eric Nazarenus, Alessandra Sonanini, Martina Guthoff, Carsten Eickhoff, Martin Holderried

“…However, these letters are often written in professional jargon, making them difficult for patients with limited medical knowledge to understand. Large language models, such as GPT, have the potential to transform these discharge summaries into patient-friendly letters, improving accessibility and understanding. …”
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Exploring the relationship between vitamin B12, methylmalonic acid levels and all-cause mortality in heart failure populations: insights from the NHANES database by Wei Yu, Yao Wang, Yao Wang, Yao Wang, Yulu Zhou, Danyu Wu, Danyu Wu, Danyu Wu

“…Despite being a specific and sensitive marker for this deficiency, the study of methylmalonic acid (MMA) in the context of HF has been infrequent.MethodsSeven hundred and forty-seven individuals with HF were incorporated in this cross-sectional study who participated in the National Health and Nutrition Examination Survey (NHANES) from two periods, 1999 to 2004, and 2011 to 2014. …”
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Neonatal outcome following metformin‐treated gestational diabetes mellitus: A population‐based cohort study by Johanna Molin, Magnus Domellöf, Christel Häggström, Eszter Vanky, Itay Zamir, Eva Östlund, Marie Bixo

“…We estimated risk as adjusted odds ratio (aOR) with 95% confidence interval (CI), using individual‐level, linkage register‐data in multivariable logistic regression models. Results In the main analysis, MT was associated with a lower risk of neonatal hypoglycemia vs NT (aOR 0.85, 95% CI: 0.74–0.96), vs MIT (0.74 [0.64–0.87]), and vs IT (0.47 [0.40–0.55]), whereas MIT was associated with a similar risk of neonatal hypoglycemia vs NT (1.14 [0.99–1.30]) and with lower risk vs IT (0.63 [0.53–0.75]). …”
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Changes in global quality of life after treatment with immune checkpoint inhibitors in patients receiving different treatment regimens for advanced stage lung cancer in the Netherl... by Manuela Quaresma, Bernard Rachet, Geertruida H De Bock, Clémence Leyrat, Willemijn J Maas, Erick Suazo-Zepeda, Ananya Malhotra, Petra C Vinke, Jeroen T J.N Hiltermann

“…We aim to study the changes in global QoL (gQoL) of patients with advanced-stage lung cancer up to 18 months after treatment with ICIs between 2015 and 2021.Methods and analysis A longitudinal cohort study was conducted using the Oncological Life Study: Living well as a cancer survivor data-biobank from the University Medical Center Groningen. …”
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School-based Hygiene Intervention to Prevent HelicObacter Pylori infection among childrEn (SHIP HOPE): protocol for a cluster-randomised controlled trial by Jing Qi, Yang Guo, Mengge Zhou, Feng Cheng, Yuhong Zeng, Yu'e Xi, Sitong Luo, Guanqi Zhao, Yamei Sun

“…Therefore, in this study, we aimed to explore whether a comprehensive hygiene intervention can prevent H. pylori infection in primary schools in China.Methods and analysis The School-based Hygiene Intervention to Prevent HelicObacter Pylori infection among childrEn study is a cluster-randomised controlled trial, which will include approximately 2400 children in grades 2–4 from 60 classes in 10 primary schools of Linqu County, Shandong Province. …”
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Excessive occupational sitting increases risk of cardiovascular events among working individuals with type 1 diabetes in the prospective Finnish Diabetic Nephropathy Study by Matias Seppälä, Heidi Lukander, Johan Wadén, Marika I. Eriksson, Valma Harjutsalo, Per-Henrik Groop, Lena M. Thorn, FinnDiane Study Group

“…Furthermore, in a stratified multivariable analysis among current smokers, excessive occupational sitting increased the risk of all-cause mortality (2.06 [1.02‒4.20]). …”
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A Personalized, Texting-Based Conversational Agent to Address Sleep Disturbance in Individuals Who Have Survived Breast Cancer: Protocol for a Pilot Waitlist Randomized Controlled... by Chi-shan Tsai, Warren Szewczyk, Michelle Drerup, Jason Liao, Alexi Vasbinder, Heather Greenlee, Jaimee L Heffner, Rachel Yung, Kerryn W Reding

“…Acceptability will be evaluated using a satisfaction survey and open-ended responses. Quantitative analysis, such as t test, Fisher exact tests, and generalized linear models, will be used to assess feasibility, baseline group differences, and the outcomes of the intervention. …”
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Identifying Current Practices and Areas for Improvement in Medication Management During Care Transition Through an Interprofessional Collaboration Framework by Solh Dost L, Maillard G, Cardoso E, Schneider MP

“…Discussions were audio-recorded, transcribed verbatim, and analysed using inductive thematic analysis. Thematic findings were categorised using the 2010 Canadian National Interprofessional Competency (CIHC) Framework, distinguishing between current practices and areas for improvement. …”
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Clinical Characteristics Associated with the PLP-PLS Index, a New Potential Metric to Phenotype Phantom Limb Pain by Jorge Ortega-Márquez, Justyna Garnier, Lucas Mena, Ana Victoria Palagi Vigano, Eleonora Boschetti Grützmacher, Gabriel Vallejos-Penaloza, Valton Costa, Daniela Martinez-Magallanes, Antonio Vaz de Macedo, Waynice Neiva de Paula-Garcia, Denise Saretta Schwartz, Felipe Fregni, Kevin Pacheco-Barrios

“…This study examines the PLP-PLS index as a novel tool to differentiate PLP from PLS and explores the association of clinical factors with the index. Methods: We conducted a cross-sectional analysis of baseline data from 112 participants in a previous factorial trial in patients with unilateral traumatic lower limb amputation. …”
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Immunopeptidomics identified antigens for mRNA-lipid nanoparticle vaccines with alpha-galactosylceramide in multiple myeloma therapy by Eline Menu, Lorenzo Franceschini, Karin Vanderkerken, Elke De Bruyne, Karine Breckpot, Kim De Veirman, Arne Van der Vreken, Fabien Thery, Chenggong Tu, Kevin Mwangi, Sofie Meulewaeter, Lien De Beck, Edith Janssens, Francis Impens, Rein Verbeke, Ine Lentacker

“…To our knowledge, immunization with messenger RNA (mRNA) and the iNKT agonist, α-galactosylceramide (αGC), has not been studied in MM, as knowledge on clinically relevant antigens in preclinical MM models is lacking.Methods Microarray data and immunopeptidomics (imPep) were used to identify candidate antigens for immunization in 5TMM models. …”
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Biomarker and clinical data–based predictor tool (MAUXI) for ultrafiltration failure and cardiovascular outcome in peritoneal dialysis patients: a retrospective and longitudinal st... by Eva María Arriero-País, María Auxiliadora Bajo-Rubio, Roberto Arrojo-García, Pilar Sandoval, Guadalupe Tirma González-Mateo, Patricia Albar-Vizcaíno, Gloria del Peso-Gilsanz, Marta Ossorio-González, Pedro Majano, Manuel López-Cabrera, Gloria del Peso-Gilsanz

“…Objectives To develop a machine learning-based software as a medical device to predict the endurance and outcomes of peritoneal dialysis (PD) patients in real time using effluent-measured biomarkers of the mesothelial-to-mesenchymal transition (MMT).Methods Retrospective, longitudinal, triple blind study in two independent hospitals (Spain), designed under information-theoretical approaches for feature selection and machine learning-based modelling techniques. …”
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Complete loss of PAX4 causes transient neonatal diabetes in humans by James Russ-Silsby, Yunkyeong Lee, Varsha Rajesh, Mahsa Amoli, Nasser Ali Mirhosseini, Tushar Godbole, Matthew B. Johnson, D. Evelyn Ibarra, Han Sun, Nicole A.J. Krentz, Matthew N. Wakeling, Sarah E. Flanagan, Andrew T. Hattersley, Anna L. Gloyn, Elisa De Franco

“…(Arg126∗) variant causes nonsense mediated decay in CRISPR-edited iPSC-derived pancreatic endoderm cells. Integrated analysis of CUT&RUN-sequencing in EndoC-βH1 cells and RNA-sequencing in PAX4-depleted islet stem cell models identified genes directly regulated by PAX4 involved in both pancreatic islet development and glucose-stimulated insulin secretion. …”
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The E3 ubiquitin ligase MARCH2 controls TNF-α mediated inflammation by autoubiquitination by Kiramage Chathuranga, Pramodya Rathnapala, Asela Weerawardhana, Tae-Hwan Kim, Yebin Seong, W. A. Gayan Chathuranga, Ashan Subasinghe, D. K. Haluwana, Nuwan Gamage, Youn Jung Choi, Jae U. Jung, Jong-Soo Lee

“…Methods We monitored disease severity and mortality in MARCH2−/− or MARCH2+/+ mice induced experimental colitis. …”
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Outcomes of Ixazomib Treatment in Relapsed and Refractory Multiple Myeloma: Insights from Croatian Cooperative Group for Hematologic Diseases (KROHEM) by Josip Batinić, Barbara Dreta, Goran Rinčić, Antonia Mrdeža, Karla Mišura Jakobac, Delfa Radić Krišto, Milan Vujčić, Mario Piršić, Željko Jonjić, Vlatka Periša, Jasminka Sinčić Petričević, Božena Coha, Hrvoje Holik, Toni Valković, Marija Stanić, Ivan Krečak, Ante Stojanović, Domagoj Sajfert, Sandra Bašić-Kinda

“…<i>Background and Objectives</i>: Ixazomib, used in combination with lenalidomide and dexamethasone (IRd), has shown efficacy in clinical trials for relapsed/refractory multiple myeloma (RRMM). <i>Materials and Methods</i>: This study evaluates the real-world effectiveness and safety of IRd in Croatian RRMM patients. …”
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Estimating the prevalence of persistent symptoms after SARS-CoV-2 infection (post-COVID-19 syndrome): a regional cross-sectional study protocol by Vivienne C Bachelet, Karena Espinoza, Lindybeth Sarmiento Varón, Hermy Alvarez, Leyla Carolina Huirimilla Casanova, Maria Paz Díaz Mora, Luis Alfredo Muñoz Cuevas, Jorge Gonzalez-Puelma, Lidia Amarales, Jonathan Lühr Henriquez, Felipe Retamal-Matus, Roberto Uribe-Paredes, Cristian Andrés Núñez-Espinosa, Claudia Estrada-Goic, Mercedes N López Nitsche, Marcelo A Navarrete

“…This study aims to estimate the prevalence of post-COVID-19 syndrome in Punta Arenas, Chile, and to explore the associated symptoms, mainly focusing on psychological, physical and molecular impacts on the affected population.Methods and analysis This cross-sectional study will use stratified random sampling to select a representative sample of 282 adults from Punta Arenas. …”
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Radiological score, asthma and NSAID‐exacerbated respiratory disease predict relapsing chronic rhinosinusitis by Markus Lilja, Anni Koskinen, Sari Hammarèn‐Malmi, Anu Laulajainen‐Hongisto, Jura Numminen, Jyri Myller, Seija Vento, Elina Penttila, Maija Hytönen, Paula Virkkula, Peter W. Hellings, Sven F. Seys, John Lee, Heini Huhtala, Johanna Sahlman, Sanna Toppila‐Salmi

“…Abstract Objectives The aim was to evaluate the predictive potential of Sinonasal Radiological (SR) and the Lund‐Mackay (LM) score of sinus computed tomography (CT) scans on postoperative relapses of chronic rhinosinusitis (CRS). Materials and Methods CRS patients (n = 483, 12–80 years) underwent routine sinus CT scans. …”
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