CPT1A/HIF-1α positive feedback loop induced fatty acid oxidation metabolic pathway contributes to the L-ascorbic acid-driven angiogenesis in breast cancer by Xiao Ma, Baojian Zhang, Xuezhe Yin, ShiPeng Yang, Zhenhua Lin, Yang Yang, Xianchun Zhou

“…This research seeks to explore whether and how CPT1A, a crucial rate-limiting enzyme in fatty acid oxidation (FAO), supports angiogenesis through metabolic pathways in BC. Methods First, cell functional assays and animal models were employed to elucidate the pro-carcinogenic effects of CPT1A on BC and its role in metabolic alterations. …”
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Determinants of poor access to health care among women of reproductive age in Sierra Leone: a cross-sectional study by Augustus Osborne, Peter Bai James, Camilla Bangura

“…A mixed-effect multilevel binary logistic regression analysis was conducted, determining the factors associated with poor access to healthcare using a four-modeled approach. …”
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Biocompatibility and osteointegrative characteristics of zirconium ceramic implants for diaphyseal defect filling by Elena A. Volokitina, Maksim V. Saushkin, Irina P. Antropova, Sergey M. Kutepov, Svetlana A. Brilliant

“…Diaphyseal defects with intramedullary implantation of a rod made of a new ceramic porous (PC), non-porous (NPC) material and titanium alloy (TA) were modelled. The animals were divided into 3 groups based on the rod used: PC, NPC and TA (n = 6 in each). …”

Multidrug-resistant tuberculosis treatment outcomes and associated factors at Yirgalem General Hospital, Sidama Region, South Ethiopia: a retrospective cohort study by Assefa Hamato Kebede, Hassen Mamo

“…Bivariate and multivariable logistic regression models were used to identify factors associated with treatment outcomes for MDR-TB. …”
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SORBS3-β suppresses lymph node metastasis in cervical cancer by promoting the ubiquitination of β-catenin by Huating Sun, Yinghui Zhang, Fang Wang, Zizhao Wang, Yuhong Zhang, Youguo Chen, Li Wang, Jinhua Zhou

“…This study aimed to identify the functional isoform of SORBS3 driving LNM suppression and elucidate its mechanisms. Methods Proteomic analysis of clinical CC tissues and metastatic lymph nodes revealed progressive downregulation of SORBS3. …”
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Which Parameter Related to Low-Density Lipoprotein Cholesterol is Superior for Predicting the Recurrence of Myocardial Infarction in Young Patients with Previous Coronary Heart Dis... by Feng Xu, Hao-Ran Xing, Hong-Xia Yang, Jin-Wen Wang, Xian-Tao Song, Hui-Juan Zuo

“…The primary outcome was MI events, analyzed using survival analysis and logistic regression models to determine associations with LDL-C parameters. …”
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Decoding Survival in Elderly Acute Myocardial Infarction: The Prognostic Interplay of B-Type Natriuretic Peptide, Ejection Fraction, and Renal Function – An Observational Study by Rajpal Prajapati, Abhishek Kapoor, Salini Mukhopadhyay, Arjun Tandon, Soumik Ghosh, Om Shankar

“…Further large-scale, multi-center studies are warranted to refine risk assessment models and optimize management strategies in this high-risk population.…”
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Direct and Indirect Effects of Risk Perception and Risk Information on PTSD in Frontline Healthcare Workers by Wu L, Geng S, Zhou Y, Jiao R, Ouyang H, Cheng S, Shang Z, Yan W, Wang J, Jia Y, Li X, Liu W

“…The PTSD checklist for DSM-5 (PCL-5), risk information questionnaire, and risk perception questionnaire are utilized to collect data.Methods: Bivariate correlation analysis and structural equation modelling are performed to analyze the mediating role of risk perception in the relationship between risk information and PTSD.Results: The estimated prevalence of PTSD among frontline healthcare workers is 28.2%. …”
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Efficacy and safety of radiotherapy combined with immunotherapy and targeted therapy versus immunotherapy plus targeted therapy alone in unresectable hepatocellular carcinoma: a re... by Yanling Yuan, Yongsheng Chen, Chumin Huang, Mindong Liu, Lihua Tong, Wubing Tang, Wen Yang

“…Outcomes were assessed using the modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria. Survival analysis was performed using Kaplan–Meier and Cox regression models.ResultsCompared with the IO+T group, the RT+IO+T group demonstrated superior short-term efficacy, as indicated by the objective response (69.0% vs. 35.7%, p=0.006) and disease control (89.7% vs. 57.1%, p=0.003) rates. …”
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Hypertension mediates the association between weight-adjusted waist index and new onset stroke risk in middle-aged and older Chinese adults: evidence from the CHARLS study by Fei Xu, Hongwei Liu, Meng Li, Minheng Zhang, Xuan Chen, Miaomiao Hou

“…However, the association between WWI and stroke risk across varying blood pressure statuses remains poorly understood.MethodsThis study included 12,580 individuals aged 45 and above with no prior stroke incidents, drawn from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2020. …”
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Factors influencing the kinetics of MSU crystal depletion measured with dual-energy CT in patients with gout by Tristan Pascart, Victor Laurent, Charlotte Jauffret, Aurore Pacaud, Vincent Ducoulombier, Julie Legrand, Stéphane Verdun, Laurène Norberciak, Jean-François Budzik

“…Objective To examine factors influencing the kinetics of monosodium urate (MSU) crystal dissolution measured with dual-energy computed tomography (DECT) during follow-up of patients with gout.Methods Patients with a diagnosis of gout with baseline knees and feet DECT scans exhibiting MSU crystal volumes ≥0.1 cm3 and at least one follow-up DECT were included. …”
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Candida albicans-Derived β-Glucan as a Novel Modulator of Tumor Microenvironment: Targeting Macrophage Polarization and Inducing Ferroptosis in Lung Cancer by He X, Ran Q, Li X, Xiong A, Zhang L, Jiang M, Bai L, Peng D, Wang J, Sun B, Li G

“…This study investigates the inhibitory effects of β-glucan extracted from Candida albicans on lung cancer progression, focusing on its impact on TAM polarization and the induction of ferroptosis, a form of regulated cell death.Methods: Utilizing both in vivo animal models and in vitro cellular assays, we assessed the impact of β-glucan on tumor growth, cellular proliferation, and migration. …”
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Development of the composition and technology of a combined gel for the treatment of osteoarthritis with a pharmacological rationale for the content of components by U. V. Nogaeva, Ju. M. Kotsur, E. V. Flisyuk, D. Yu. Ivkin, E. D. Semivelichenko, I. A. Titovich, I. A. Narkevich, V. G. Antonov

“…The concentrations of active substances were selected based on the results of preclinical studies. OA was modeled by the combined administration of 0.1 ml of a mixture of Freund's complete adjuvant with a 10 % talc suspension in isotonic sodium chloride solution in a ratio of 1 : 10 into the hock (tarsus) joint cavity. …”
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Risk of Moderate to Severe Ocular Surface Disease Associated with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy: A Multicenter Cohort Study by Yu-Ting Tsao, Eugene Yu-Chuan Kang, Chiao-En Wu, Ning Hung, Hung-Chi Chen, Ching-Hsi Hsiao

“…In this study, we investigated the key risk factors for moderate to severe OSD in patients with lung cancer receiving EGFR-TKI therapy. Methods This multicenter retrospective (November 2004–December 2019) cohort study included 31,491 patients with lung cancer. …”
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Genetic variation in patent foramen ovale: a case-control genome-wide association study by Bosi Dong, Yajiao Li, Fandi Ai, Jia Geng, Ting Tang, Wan Peng, Yusha Tang, Hui Wang, Zixuan Tian, Fengxiao Bu, Lei Chen

“…Expression quantitative trait loci (eQTL) analysis was conducted using the GTEx database. Single-cell sequencing analyses with pseudotime trajectory modeling were employed to evaluate their expression in human fetal hearts.ResultsThe case-control GWAS of discovery cohort ultimately included 517 cases and 517 demographically matched controls. …”
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Evaluating the intended and unintended consequences of opioid-prescribing interventions on primary care in British Columbia, Canada: protocol for a retrospective population-based c... by Tara Gomes, Perry Kendall, M Ruth Lavergne, Dimitra Panagiotoglou, Rita McCracken, Erin C Strumpf, Benedikt Fischer, Austyn Brackett, Cheyenne Johnson

“…Specifically, we aim to understand the effects of these measures on physician prescribing behaviours, identify physician characteristics associated with uptake of the new measures, and measure the effects of the policy changes on patients’ access to quality primary care.Methods and analysis This is a population-level, retrospective cohort study of all BC primary care physicians who prescribed any opioid medication for opioid-use disorder or chronic non-cancer pain during the study period, and their patients. …”
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Academic motivation in association with mental health and quality of life among medical and health science students: a survey in Vietnam by Ngoc Le Mai Duong, Viet Ha Nguyen, Minh Tri Ngo, Dai Minh Le, Tien Dat Nguyen, Thi Thu Trang Nguyen, Huu Tu Nguyen, Bao Giang Kim, Thanh Tung Pham

“…This study aimed to describe students’ academic motivation and investigate the association between it and depression, anxiety, and quality of life at Hanoi Medical University. Methods A cross-sectional study was conducted on first and final year students of doctor and bachelor programs from October to November 2018 via a computer-based questionnaire. …”
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ACE Loss Drives Renal Cell Carcinoma Growth and Invasion by Modulating AKT-FOXO1 by Yin L, Mao L, Yin R, Lv C, Shi X, Yue C, Chen Y, Lu C, Wu Z, Xu K, Cao W

“…The clinical significance of ACE was evaluated through Cox regression analysis. To assess the impact of ACE expression on ccRCC cell growth, metastasis, and glucose activity, CCK-8 assays, transwell assays, Seahorse detection, and xenograft models were utilized. …”
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Association of preclinical blood glucose with hospitalization rate and in‐hospital mortality: A single‐center retrospective cohort study by Simon Kloock, Danilo Skudelny, Peter Kranke, Gülmisal Güder, Dirk Weismann, Martin Fassnacht, Christian G. Ziegler, Ulrich Dischinger

“…Multivariable logistic regression models were used to correct for age, prediagnosed diabetes, and sex. …”
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Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma by Jing Wang, Meng Song, Jinming Tang, Haoran Yue, Xiaoyang Guo, Zhan Chen, Xiaolan Shen, Mingbo Cao, Mingbo Cao

“…Furthermore, univariate and multivariate Cox analysis were used to assess the prognostic effects of ARPs. …”
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