Cardiovascular Risk in Patients With Treated Isolated Diastolic Hypertension and Isolated Low Diastolic Blood Pressure by Wei‐Lun Chang, Ying‐Fan Chen, Yu‐Hsuan Lee, Ming‐Neng Shiu, Po‐Yin Chang, Chao‐Yu Guo, Chi‐Jung Huang, Chern‐En Chiang, Chen‐Huan Chen, Shao‐Yuan Chuang, Hao‐Min Cheng

“…MACE risk was estimated using Cox proportional‐hazards models. Among the SPRINT participants, median age was 67.0 years and 64.9% were men. …”
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BDNF expression mediates verbal learning and memory in women in a cohort enriched with risk for Alzheimer's disease by Kyle J. Edmunds, Alyssa A. Pandos, Isabella Hoang, Gabriella M. Mamlouk, Alice Motovylyak, Sarah R. Lose, Sanjay Asthana, Matthew Stremlau, Sterling C. Johnson, Henriette vanPraag, Ozioma C. Okonkwo

“…Plasma BDNF was measured using a Human BDNF Quantikine Immunoassay. Mediation analysis used bootstrapping, and stratified mediation models tested the conditional dependence of APOE ε4 carriage. …”
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PYGO1 drives gastric cancer progression via the ITGB1/CD47 axis and is therapeutically targeted by pentagalloylglucose by Yanjuan Jia, Yaling Li, Yan Li, Yonghong Li, Tao Qu, Zhuomin Fu, Yuanyuan Ma, Zhenhao Li, Wanxia Wang, Miao Yu, Xiaojie Jin, Xiaoling Gao, Yongqi Liu

“…This study aims to elucidate the role of PYGO1 in GC and uncover its regulatory mechanisms. Methods Bioinformatics analysis and immunohistochemistry were used to assess PYGO1 expression in GC tissues and its correlation with prognosis and immune cell infiltration. …”
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Gaps in health coverage for racialized im/migrant sex workers in metro Vancouver: Findings of a community-based cohort study (2014–2021) by Shira M. Goldenberg, Maggie Hamel-Smith Grassby, Alaina Ge, Melissa Braschel, Charlie Zhou, Kate Shannon

“…We developed multivariable logistic regression confounder models with generalized estimating equations (GEE) to examine associations between migration and racialization exposures of interest and health insurance coverage. …”
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Effectiveness of a standardised and interactive intervention to prevent preschooler unintentional injury in rural China: a cluster randomised controlled trial by Jie Li, Guoqing Hu, David C Schwebel, Min Zhao, Peishan Ning, Wanhui Wang, Jieyi He, Weiqiang Li

“…Adjusted ORs (aORs) with 95% CIs were calculated based on generalised linear mixed models and bootstrapped SEs with 1000 replications. …”
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The Australian and New Zealand Fontan Registry Quality of Life Study: Protocol for a population-based assessment of quality of life among people with a Fontan circulation, their pa... by Daniel S J Costa, Kim Dalziel, Yves d’Udekem, David S Winlaw, David S Celermajer, Nadine A Kasparian, Diana Zannino, Rachel Bishop, Kate H Marshall, Susan R Woolfenden, Gary F Sholler

“…The objective of this study is to describe and develop a deeper understanding of the factors that contribute to quality of life (QOL) among children, adolescents and adults living with a Fontan circulation across Australia and New Zealand, their parents and siblings.Methods and Analysis This article presents the protocol for the Australian and New Zealand Fontan Registry (ANZFR) QOL Study, a cross-sectional, population-based study designed to examine QOL among people of all ages with a Fontan circulation, their parents and siblings. …”
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Risk factors and outcomes in patients who switched from peritoneal dialysis to physician-oriented or patient-oriented kidney replacement therapy by Liu Zhang, Xu Guan, Liang Liu, Yinghui Huang, Jiachuan Xiong, Jinghong Zhao

“…Logistic regression analysis was used to explore the influencing factors related to KRT conversion in PD patients. …”
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HIF‐1α‐induced long noncoding RNA LINC02776 promotes drug resistance of ovarian cancer by increasing polyADP‐ribosylation by Yangjun Wu, Yu Zeng, Yong Wu, Xinyu Ha, Zheng Feng, Chaohua Liu, Ziqi Liu, Jiajia Wang, Xingzhu Ju, Shenglin Huang, Linhui Liang, Bin Zheng, Lulu Yang, Jun Wang, Xiaohua Wu, Shengli Li, Hao Wen

“…Abstract Background Chemoresistance remains a major hurdle in ovarian cancer (OC) treatment, as many patients eventually develop resistance to platinum‐based chemotherapy and/or PARP inhibitors (PARPi). Methods We performed transcriptome‐wide analysis by RNA sequencing (RNA‐seq) data of platinum‐resistant and ‐sensitive OC tissues. …”
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Risk factors for failure in short segment pedicle instrumentation in thoracolumbar fractures by Ana Vilela, Bibiana Couto, David Ferreira, António Cruz, Joana Azevedo, João Pereira, André Santos-Moreira, Nuno Oliveira, Paulo Gil Ribeiro, Pedro Varanda, Direito-Santos Bruno

“…Further multicenter prospective studies with larger sample sizes are necessary to validate these results and enhance risk prediction models.…”
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Relationship between breastfeeding duration, lifestyle and obesity in children aged 3–16 years: a cross-sectional study by Yu Liu, Yiyao Gu, Jie Mu, Zhi Duan, Xixiang Wang, Xiuwen Ren, Lu Liu, Jingjing Xu, Chi Zhang, Shaobo Zhou, Ning Ma, Linhong Yuan, Ying Wang

“…The study explored the association of breastfeeding duration in early life and lifestyle habits with childhood obesity.MethodsA total of 541 children aged 3–16 at Suzhou Science and Technology City Hospital were included in this analysis. …”
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Epilepsy and brain health: a large prospective cohort study by Dan-Dan Zhang, Zi-Yi Wang, Ya-Ru Zhang, Pei-Yang Gao, Wei Zhang, Yan Fu, Hao-Chen Chi, Li-Yun Ma, Yi-Jun Ge, Xiao-Yu He, Jia You, Wei Cheng, Jian-Feng Feng, Lan Tan, Jin-Tai Yu

“…Multiple linear and Cox regression models were used to explore the association between epilepsy, brain function, and other brain disorders. …”
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Association between serum and red blood cell folate concentrations and urinary phthalate metabolite concentrations in US adults: evidence from a large population-based study by Xiaojing Huang, Xiaojing Huang, Huan Zhang, Huan Zhang, Yaoyu Luo, Chenhui Yang, Jue Huang, Jue Huang, Ting Zhou, Ting Zhou, Junfeng Qi, Junlin Li, Shuzhen Zhu, Yaqin Zhang, Ling Zhang, Ling Zhang, Xiaojie Sun, Xiaojie Sun

“…Survey generalized linear regression models and restricted cubic spline and generalized additive models were used to assess the associations between blood folate biomarker and urine phthalate metabolites.ResultsAfter adjusting for covariates, each unit increase in the natural logarithm-transformed serum folate concentration was associated with significant reductions of 7.41% in MEHP and 7.10% in MEHHP. …”
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Using the R = MC2 heuristic to assess whole-of-school physical activity implementation in elementary schools: a cross-sectional study by Derek W. Craig, Kevin Lanza, Christopher D. Pfledderer, Andjelka Pavlovic, Kempson Onadeko, Natalia I. Heredia, Jizyah Injil, Laura F. DeFina, Timothy J. Walker

“…This study examines associations between constructs from the R = MC2 heuristic and schools’ implementation of a WOS approach. Methods We conducted a secondary analysis of cross-sectional data from U.S. elementary schools participating in the NFL PLAY60 FitnessGram Project during the 2022–23 school year. …”
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A latent class assessment of healthcare access factors and disparities in breast cancer care timeliness. by Matthew R Dunn, Didong Li, Marc A Emerson, Caroline A Thompson, Hazel B Nichols, Sarah C Van Alsten, Mya L Roberson, Stephanie B Wheeler, Lisa A Carey, Terry Hyslop, Jennifer Elston Lafata, Melissa A Troester

“…Associations were evaluated using adjusted linear-risk regression to estimate relative frequency differences (RFDs) with 95% confidence intervals (CIs). Delayed diagnosis models were adjusted for age; delayed and prolonged treatment models were adjusted for age and tumor size, stage, and grade at diagnosis; and OncotypeDx models were adjusted for age and tumor size and grade. …”
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Causes of death and infant mortality rates among full-term births in the United States between 2010 and 2012: An observational study. by Neha Bairoliya, Günther Fink

“…Random effects models were used to assess the relative contribution of state-level variation to FTIM. …”
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Association Between Pain and Frailty in Middle-Aged and Older Patients: The Mediating Roles of Sleep and Mood by Wang HP, Wang T, Ye HT, Dong YY, Zhao SJ, Liu QR, Hu XY, Ji MH, Yang JJ

“…For simple mediation models, we identified significant mediation effects of sleep (=0.049, 95% CI: 0.011, 0.094), anxiety (=0.054, 95% CI: 0.023, 0.094), and depression (=0.093, 95% CI: 0.049, 0.150) in the pain-frailty nexus. …”
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The predictive factors for resorption of lumbar disc herniation by A.J. Sanginov, I.D. Isakov, V.V. Belozerov, E.A. Mushkachev, A.V. Peleganchuk

“…The identification of resorption predictors was performed by building logistic regression models. Single-factor models were used to identify individual predictors associated with the target event. …”
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The mechanism of plasma exosome miR-15a-5p targeting the CF-modified protein IGF1R to regulate alveolar epithelial autophagy and influence pulmonary interstitial fibrosis by Yina Li, Nan Wang, Jinying Hu, Minlan Luo, Na Zhang, Lili Gao

“…Aims: This study investigates how plasma exosomal miRNAs regulate core fucosylation (CF)-modified targets to influence autophagy and fibrosis in idiopathic pulmonary fibrosis (IPF), aiming to identify novel therapeutic strategies targeting dysregulated alveolar epithelial cell (AEC) autophagy. Materials and methods: Plasma exosomes from IPF patients and healthy controls were isolated via ultracentrifugation, validated by TEM, nanoparticle tracking analysis (NTA), and Western blot (CD9/CD81). …”
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Preclinical Development and Phase I Study of ZSYY001, a Polymeric Micellar Paclitaxel for Advanced Solid Tumor by Ge Gao, Pei Shu, Youzhen Tan, Tongsen Zheng, Wenmao Fan, Luding Lu, Huan Zhou, Zishu Wang, Ling Liu, Zhiqiang Liu, Yongsheng Wang

“…Here, we report the results of a preclinical and phase I clinical study investigating ZSYY001, a nanoparticle formulation of polymeric micellar paclitaxel (PM‐paclitaxel). Methods In preclinical studies, A549, MDA‐MB‐231, and SKOV3 xenograft tumor models were developed. …”
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Radiation induced dermatitis by increasing triglyceride levels to induce autophagy and inhibit the PI3K/Akt/mTOR signaling pathway by Yafang Hong, Hongdan Guan, Yunhao Chen, Yao Wang, Junjian Lin, Ying Wang, Yang Zhang, Rong Zheng, Xingchen Ding, Zihan Zhou, Benhua Xu

“…A binary logistic regression analysis was used to determine risk factors. Mouse models of RD were established by administering radiating at a dose of 9 Gy over two consecutive days. …”
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