Sustainable milk-based postbiotics beverages fermented by Lactobacillus plantarum: allies in celiac disease inflammation by Claudia Bellomo, Claudia Bellomo, Francesca Mauriello, Federica Nigro, Francesca Passannanti, Francesca Passannanti, Rosa Colucci Cante, Rosa Colucci Cante, Roberto Nigro, Maria Vittoria Barone, Maria Vittoria Barone, Merlin Nanayakkara, Merlin Nanayakkara

“…Intestinal organoids from CeD biopsies are good models for studying CeD inflammation. Postbiotics have been shown to modulate the effects of p31-43 in Caco-2 cells and inflammation in CeD organoids. …”
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Sex-Specific Physical Activity and Weight Status in German Schoolchildren: Interim Results from the Hand on Heart Study by Meike Schrader, Jennifer Wieprecht, Federico Morassutti Vitale, Simone Katrin Manai, Samar Shamas, Marcel Müller, Maren Baethmann, Anja Tengler, Roxana Riley, Guido Mandilaras, Nikolaus Alexander Haas, Delphina Gomes

“…Sex-specific differences in sport participation, sport types, and weight status were analyzed using descriptive statistics and logistic regression models. Results: based on the eligibility criteria for analysis (ages 8–18 years), 883 pupils were included (mean age 13.1 ± 2.4 years), 406 (46%) were females. …”
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Trends in knee cartilage repair procedures in the United States, 2010 to 2020 by Akshar P. Thakkar, Ting Zhang, Michael Bodine, Aaron A. Bare, Michael B. Ellman, Sanjeev Bhatia, Andreas H. Gomoll, Brian J. Chilelli

“…Student t and χ2 tests were used for statistical comparisons and analysis of data trends. Regression models and compound annual growth rates further assessed the trends of each procedure. …”
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Post-treatment changes in bowel and urinary function in prostate cancer patients treated with moderate or ultra-hypofractionation: A prospective cohort study by W.D. Heemsbergen, F. Sinzabakira, K.C. de Vries, M. Franckena, M.E.M.C. Christianen, F.E. Froklage, H. Westerveld, L. Incrocci

“…Prognostic factors were assessed using regression models. Results: Proportion of the total cohort with MCID deterioration for bowel and urinary function was 20 % and 17 %, respectively. …”
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In vitro impact of Streptococcus mitis on the inhibition of oral cancer cell proliferation via mitotic modulation by Inori Inui, Inori Inui, Shinichi Mochizuki, Fumika Hirabayashi-Nishimuta, Yoshie Yoshioka, Osamu Takahashi, Masaaki Sasaguri, Manabu Habu, Wataru Ariyoshi, Ryota Yamasaki, Ryota Yamasaki

“…In this study, we aimed to elucidate the effects of Streptococcus spp. on oral squamous cell carcinoma (OSCC) cells in vitro.MethodsHSC-3 (tongue carcinoma) and Ca9-22 (gingival carcinoma) cells were used as models of OSCC cells, and their responses were examined after adding major oral Streptococcus species—S. mitis, S. sanguinis, S. anginosus, S. salivarius, and S. mutans—to the culture medium. …”
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Nano-coolants for thermal enhancement in heat exchangers: A review of prospects, challenges and applications by E.T. Bello, A. Nasir, A.S. Abdulkareem, M.M. Muhammadu, N.A. Musa, J.O. Tijani, Samson Oluwaseyi Bada

“…This review provides a comprehensive analysis of the prospects, challenges and applications of nano-coolants in various heat exchanger systems. …”
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Primary liver cancer burden and its association with health development in the Western Pacific, 1990–2021 by Teng-Chao Zhou, Teng-Chao Zhou, Dan Qin, Peng Yan, Peng Yan, Bin Lan, Bin Lan, Qing Wang, Qing Wang, Jie Tan, Jie Tan

“…This study aimed to assess the burden of primary LC and its association with health system development indicators across the WPR from 1990 to 2021.MethodsWe conducted a secondary analysis using data from the Global Burden of Disease (GBD) Study 2021, covering 31 countries and territories in the WPR. …”
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Ouabain alleviates Mycobacterium abscessus-triggered inflammatory responses through dual regulation of NLRP3 inflammasome activity and M1 macrophage polarization by Nan Li, Nan Li, Nan Li, Songqiang Huang, Songqiang Huang, Xing Shi, Kuo Lu, Kuo Lu, Xiu Yu, Chen Qiu, Rongchang Chen

“…The cardiac glycoside ouabain exhibits broad anti-inflammatory effects in various disease models, but its therapeutic potential against M. abscessus-induced pneumonia remains unexplored.MethodsWe investigated the role of ouabain in M. abscessus-induced inflammation using in vivo and in vitro models. …”
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The influence of the ratio of liver cells and bone marrow in the implantable cell-engineering structures of the liver on the recovery efficiency of functional and morphological par... by M. Yu. Shagidulin, N. A. Onishchenko, M. E. Krasheninnikov, A. O. Nikolskaya, E. A. Volkova, I. M. Iljinsky, N. P. Mogeiko, V. I. Sevastianov, S. V. Gautier

“…CECs with different ratios of liver cells and MMSC BM were implanted into liver of rats in which chronic liver failure (CLF), was modeled by using CCl4. The effectiveness of the regulatory effects of CECs (with different cell ratios) on regenerative processes in livers were assessed by using biochemical, morphological and morphometric methods at different periods after their implantation.Results. …”
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Prevalence, awareness, treatment and control of arterial hypertension depending on regional characteristics in Russia: results of the ESSE-RF study 2012-2022 — evidence of COVID-19... by S. A. Maksimov, S. A. Shalnova, Yu. A. Balanova, A. E. Imaeva, V. A. Kutsenko, M. B. Kotova, G. A. Muromtseva, S. E. Evstifeeva, A. V. Kapustina, N. S. Karamnova, O. B. Shvabskaya, T. V. Repkina, T. O. Gonoshilova, A. V. Kudryavtsev, N. I. Belova, L. L. Shagrov, M. A. Samotrueva, A. L. Yasenyavskaya, O. A. Bashkina, S. V. Glukhovskaya, I. A. Levina, E. A. Shirshova, E. B. Dorzhieva, E. Z. Urbanova, N. Yu. Borovkova, V. K. Kurashin, A. S. Tokareva, Yu. I. Ragino, G. I. Simonova, A. D. Khudyakova, V. N. Nikulin, O. R. Aslyamov, G. V. Khokhlova, A. V. Solovieva, A. A. Rodionov, O. V. Kryachkova, Yu. Yu. Shamurova, E. V. Mikhailov, Yu. O. Tarabrina, M. G. Ataev, M. O. Radzhabov, Z. M. Gasanova, M. A. Umetov, I. A. Hakuasheva, L. V. Elgarova, E. I. Yamashkina, L. A. Balykova, A. A. Usanova, A. M. Nikitina, N. V. Savvina, Yu. E. Spiridonova, E. A. Naumova, V. S. Yudin, A. A. Keskinov, S. M. Yudin, A. V. Kontsevaya, O. M. Drapkina

“…To analyze the individual association of arterial hypertension (AH) prevalence, awareness, treatment, and control with regional characteristics within the national epidemiological ESSE-RF study (2012-2022), assessing the impact of the COronaVIrus Disease 2019 (COVID-19) pandemic.Material and methods. The analysis used pooled data from the ESSE-RF study across three time periods: ESSE-RF-1 (2012-2014), ESSE-RF-2 (2017-2018), ESSERF-3 (2020-2022). …”
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Plasma polymeric immunoglobulin receptor exacerbates lung injury in Klebsiella pneumoniae-induced pneumosepsis by Shuaiwei Wang, Hao Fu, Hao Fu, Xiaoqing Li, Xiaoqing Li, Hongrui Xu, Yu Bai, Wenjun Jiang, Xiaozhe Cheng, Na Chen, Na Chen, Yijie Zhang, Yijie Zhang, Wei Li

“…The role and underlying mechanisms of plasma pIgR were investigated in mouse models of sepsis and primary alveolar type 2 epithelial cells (AT2).ResultsQuantitative proteomic and ELISA analysis revealed a significant association between plasma pIgR and the prognosis of patients of pneumonia-induced sepsis. …”
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Direct high-precision radon quantification for interpreting high-frequency greenhouse gas measurements by D. Kikaj, E. Chung, A. D. Griffiths, S. D. Chambers, G. Forster, G. Forster, A. Wenger, P. Pickers, P. Pickers, C. Rennick, S. O'Doherty, J. Pitt, K. Stanley, D. Young, L. S. Fleming, L. S. Fleming, K. Adcock, E. Safi, T. Arnold, T. Arnold

“…Translating spot measurements of atmospheric GHG amount fractions into regional flux estimates (“top-down” analysis) is usually performed with atmospheric transport models (ATMs), which calculate the sensitivity of regional emissions to changes in observed GHGs at a finite number of locations. …”
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INBRX-106: a hexavalent OX40 agonist that drives superior antitumor responses via optimized receptor clustering by William L Redmond, Yoshinobu Koguchi, Melissa J Kasiewicz, Annah S Rolig, Nisha Holay, Bryan Becklund, Anya Polovina, Sae Jeong Ahn, Brendan P Eckelman, Rashi Yadav, Thi Staebler, Noah D Simons, Yaiza Diaz de Durana

“…In murine models, hexavalent OX40 agonism resulted in significant tumor regression, enhanced survival, and increased CD8+ T-cell effector function. …”
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Ovarian Cancer G protein-coupled receptor-1 signaling bias dictates anti-contractile effect of benzodiazepines on airway smooth muscle by Dominic R. Villalba, Arun K. Jannu, Elham Javed, Isha Dandekar, Ruping Wang, Deepak A. Deshpande, Steven S. An, Reynold A. Panettieri, Dale D. Tang, Raymond B. Penn, Ajay P. Nayak

“…The present study sought to determine the effects of sulazepam and lorazepam on contraction of human precision cut lung slices (hPCLS), and detail the biochemical mechanisms mediating these effects. Methods Models of histamine (His) -stimulated contraction included imaging of ex vivo human precision cut lung slices (hPCLS) and Magnetic Twisting Cytometry (MTC) analysis of human ASM cell stiffness. …”
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Supplemental oxygen for pulmonary embolism (SO-PE): study protocol for a mechanistic, randomised, blinded, cross-over study by Nour Al Jalbout, Hamid Shokoohi, Christopher Kabrhel, David M Dudzinski, Mads Dam Lyhne, Andrew S Liteplo, Oana Alina Zeleznik, Asger Andersen, Onyinyechi Franca Eke, Christina C Morone, Calvin K Huang, Thomas F Heyne, Mannudeep K Kalra

“…The overall objective of the supplemental oxygen in pulmonary embolism (SO-PE) study is to investigate the mechanisms of supplemental oxygen in patients with acute PE.Methods and analysis This randomised, double-blind, cross-over trial at Massachusetts General Hospital will include adult patients with acute PE and evidence of RV dysfunction but without hypoxaemia (SaO2 ≥90% on room air). …”
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Investigating the associations between personality functioning, cognitive biases, and (non-)perceptive clinical high-risk symptoms of psychosis in the community by Giulia Rinaldi, Stefan Lerch, Frauke Schultze-Lutter, Stefanie Julia Schmidt, Marialuisa Cavelti, Michael Kaess, Chantal Michel

“…Methods A community sample (N = 444, 17–60 years, 61.8% female) was assessed via clinical telephone interview and online questionnaires. …”
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Efficacy of Erwinia amylovora and Xanthomonas campestris pv campestris phages to control fire blight and black rot in vivo by Gloria Vique, Elena Mendoza-Barberá, Maria Dolores Ramos-Barbero, Pedro Blanco-Picazo, Laura Sala-Comorera, Pablo Quirós, Sergio Atares, Ignasi Salaet, Maite Muniesa, Lorena Rodríguez-Rubio

“…In vivo experiments using pears and kohlrabi as infection models further validated the phage effectiveness. …”
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Targeting NOTCH1-KEAP1 axis retards chronic liver injury and liver cancer progression via regulating stabilization of NRF2 by Chunxiao Chang, Meng Wang, Jia Li, Sihao Qi, Xiaojuan Yu, Jun Xu, Shengbin Shi

“…The NOTCH1 signaling pathway, though not fully understood, is implicated in liver injury and may be a potential therapeutic target. Methods Clinical HCC, HBV, HCV and NASH samples and additional in vitro and in vivo performances were subjected to confirm the role of NOTCH1 and its downstream targets via a series of biochemical assays, molecular analysis approaches and targeted signaling pathway assay, etc. …”
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Association Between Low Triglyceride-Glucose Index and Mortality in Acute Decompensated Heart Failure Patients Without Diabetes by Zhang Q, Xu Y, Sun S, Ding X, Wang G, Jiang S, Zheng J, Gao P, Lin J, Wu Y

“…The restricted cubic spline analysis illustrated a decrease in the risk of all-cause and cardiovascular mortality as the TyG index increased. …”
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Integration of sentinel surveillance and climate factors to accelerate malaria elimination in a changing climate of Senegal by Ibrahima Mamby Keita, Mariama Diouf, Medoune Ndiop, Boly Diop, Khaly Gueye, Marianne Kouawo, Ousmane Ndiaye, Doudou Sene, Elhadji Mamadou Ndiaye, Marie Khemesse Ngom Ndiaye

“…This was followed by predictive modelling of MIR and its climatic factors from 2020 to 2023. …”
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