Synthesis, physical and chemical properties, antihypoxic activity of some 5-[((5-(adamantane-1-yl)-4-R-4H-1,2,4-triazole-3-yl)thio)methyl]-N-R1-1,3,4-thiadiazole-2-amines and 5-[((... by V. M. Odyntsova, Ye. G. Knysh, O. I. Panasenko

“…A series of new compounds of derivatives among 5-[((5-(adamantane-1-yl)-4-R-4H-1,2,4-triazol-3-yl)thio)methyl]-N-R1-1,3,4-thiadiazole-2-amines and 5-(5-(adamantane-1-yl)-4-R-4H-1,2,4-triazole-3-yl)thio)methyl)-4-R1-4H-1,2,4-triazole-3-thiols have been synthesized, the structure of which has been confirmed with the help of modern physical and chemical methods of analysis. The most active compounds among the studied ones were 3a and 2a, their antihypoxic activity exceeds control on 37.86 % and 36.30 % and Mexidol is on 7.35 % and 5.79 % respectively.…”
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Dietary non-enzymatic antioxidant capacity and risk of breast cancer: the Swedish National March Cohort by Daniela Mariosa, Marta Ponzano, Alessandra Grotta, Ylva Trolle Lagerros, Essi Hantikainen, Hans-Olov Adami, Mauro Serafini, Rino Bellocco, Weimin Ye

“…However, sensitivity analysis on imputed covariates did not fully confirm our findings, indicating the need for future confirmatory research.…”
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TECHNIQUES OF "COMPETITIVE PAIRS" WHILE TRAINING DENTAL DOCTORS by V. V. Ekhalov, A. V. Samoilenko, I. A. Romanyuta

“…The purpose of this work is the searching for new paradigms of educational reform and its new models and technologies, innovative approaches, learning and education. …”
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Assessing bone regeneration potential of 3D scaffold-free cell pellets from periodontal ligament and bone marrow stem cells by Xiang Liang, Yuxin Gong, Le Bai, Sina Ahmadi, Ming Yu, Zhou Zhang, Siya Fang, Fangfang Xu, Weiqi Wang, Junbo Tu, Sijia Na

“…In rat calvarial defect models, both CP types induced significant bone formation, with BMSC-CP demonstrating enhanced osteogenic capacity compared to PDLSC-CP. …”
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Lung function may recover after coal mine fire smoke exposure: a longitudinal cohort study by David Brown, Tyler Lane, Michael J Abramson, Bruce R Thompson, Caroline X Gao, Jillian Ikin, Brigitte Borg, Nicolette R Holt, Catherine L Smith, Annie Makar, Thomas McCrabb, Mikayla Thomas, Kris Nilsen

“…Background and objective The 2014 Hazelwood coal mine fire exposed residents in nearby Morwell to high concentrations of particulate matter <2.5 µm (PM2.5) for approximately 6 weeks. This analysis aimed to evaluate the long-term impact on respiratory health.Methods Adults from Morwell and the unexposed town of Sale completed validated respiratory questionnaires and performed spirometry, gas transfer and oscillometry 3.5–4 years (round 1) and 7.3–7.8 years (round 2) after the fire. …”
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Associations between self-reported sleep duration and incident cardiovascular diseases in a nationwide prospective cohort study of Chinese middle-aged and older adults by Qing Zhao, Yuan Zhu, Yu Zhang, Huanyuan Luo, Huanyuan Luo, Yantao Ma, Xiaoshan Chen, Jiaming Gu, Lizhi Wang, Lizhi Wang, Lizhi Wang, Lizhi Wang, Lizhi Wang

“…Furthermore, we aim to investigate the association between sleep duration and incident CVD in this population, while assessing potential variations across different age and gender subgroups.MethodsUtilizing data from the nationwide prospective survey of the China Health and Retirement Longitudinal Study (CHARLS) conducted in 2011, 2013, 2015, and 2018, involving 17,596 participants aged 45 years and above, we employed Cox proportional hazards regression models. …”
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Patterns of recurrence after curative D2 resection for gastric cancer: Implications for postoperative radiotherapy by Jing Xu, Li Shen, Yongjie Shui, Wei Yu, Qingqu Guo, Risheng Yu, Yulian Wu, Qichun Wei

“…Independent recurrence‐related risk factors were analyzed by logistic regression analysis. New logistic regression models were further developed to predict the probability of recurrence. …”
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Quantitative sensory testing in dogs with spontaneous osteoarthritis by James Russell Hunt, David Knazovicky, Megan Goff, John Harris, Toby G. Knowles, Masataka Enomoto, Michael Mendl, Becky Whay, B. Duncan X. Lascelles, B. Duncan X. Lascelles, B. Duncan X. Lascelles, B. Duncan X. Lascelles, Joanna C. Murrell

“…The hierarchical structure of the QST testing data was accounted for within the statistical analysis by employing general linear modelling within a multilevel modelling framework using the MLwiN statistics package.ResultsOsteoarthritis category was not a major determinant of QST outcome measures for the majority of modalities evaluated. …”
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Obstructive Sleep Apnea, Platelet Aggregation, and Cardiovascular Risk by Zanetta Kovbasyuk, Jaime Ramos‐Cejudo, Ankit Parekh, Omonigho M. Bubu, Indu A. Ayappa, Andrew W. Varga, Ming‐Huei Chen, Andrew D. Johnson, Eugenio Gutierrez‐Jimenez, David M. Rapoport, Ricardo S. Osorio

“…We applied linear regression models with adjustment for demographic and clinical covariates and explored interactions with OSA and CVD‐related factors, including age, sex, body mass index, hypertension, OSA diagnosis (apnea‐hypopnea index 4%≥5), and aspirin use. …”
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The associations between skin advanced glycation end-products and Framingham cardiovascular risk in different age groups by Yina Wang, Shangyan Liang, Ying Zhou, Xiumei Tang, Na Ye, Weilan Huang, Xixiang Tang, Boxiong Jiang, Boxiong Jiang, Yunfeng Pan

“…This association was particularly significant in individuals aged 40–59 and 60–79 (OR = 1.047, 95% CI: 1.025–1.069; OR = 1.022, 95% CI: 1.002–1.042; both P < 0.05). ROC analysis showed that skin AGEs predicted the diagnosis of medium or high ASCVD risk in the pooled group, Group Ⅱ, and Group Ⅲ.ConclusionOur study substantiates that skin AGEs play an important role as an independent risk factor for ASCVD, highlighting their significance beyond traditional risk assessment models, particularly in middle-aged and older populations.…”
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Bayesian trial of adalimumab versus secukinumab for children with juvenile idiopathic arthritis associated uveitis or chronic anterior uveitis by Athimalaipet V Ramanan, Andrew D Dick, Thomas Jaki, Gianmarco Caruso, David S Robertson, Ashley P Jones, Ben Hardwick, Sian Drake, Balini Balasubramaniam, Coziana Ciurtin, Ivan Foeldvari, Elke O Kreps, Alice Leahy, Kristina May, Pierre Quartier, Matthieu P Robert, Gabriele Simonini, Catherine Guly, Michael W Beresford

“…Inhibition of interleukin 17 ameliorates inflammation in mouse models of uveitis. Secukinumab, an antibody which neutralizes interleukin 17 A, has been shown to be partially effective in adult uveitis. …”
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Jian Pi Hua Tan Fang Reverses Trastuzumab Resistance of HER2‐Positive Gastric Cancer Through PI3K/AKT/mTOR Pathway: Integrating Network Pharmacology, Molecular Docking and Experime... by Jia Hu, Wenjing Bu, Yongfang Ding, Xin Li, Bo Zhang, Bo Shen, Cong Wu, Youqi Xu, Xiaoyang Zhang

“…Then, in vitro models of NCI‐N87/TR was developed, and JPHTF‐containing serum was utilized for intervention to confirm these crucial targets. …”
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Clinical Outcomes Following a Patient-Centered Educational Intervention on Steatotic Liver Disease: A Comparison of Patients With and Without Diabetes by Rebecca G. Kim, Shyam Patel, Amy M. Shui, Catherine Magee, Jennifer Y. Chen, Michele Tana, Mandana Khalili

“…Baseline factors associated with change in ALT, BMI, and HbA1c were assessed using linear mixed-effects modeling. Factors associated with ALT normalization were assessed using competing risk analyses. …”
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Respiratory function and respiratory complications in spinal cord injury: protocol for a prospective, multicentre cohort study in high-income countries by David J Berlowitz, Maria T E Hopman, Martin Schubert, Gabi Mueller, Martin W G Brinkhof, Xavier Jordan, Anja M Raab, Karin Postma, David Gobets, Sven Hirschfeld, Burkhart Huber, Margret Hund-Georgiadis, Renate Wildburger

“…This paper details the protocol for a large-scale, multicentre research project that aims to evaluate the ability of parameters of respiratory function to predict and understand variation in inpatient risk of pneumonia in SCI.Methods and analysis RESCOM, a prospective cohort study, began recruitment in October 2016 across 10 SCI rehabilitation centres from Australia, Austria, Germany, the Netherlands and Switzerland. …”
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Novel parent survey measures sensory behaviors incorporating sensory modality and stimulus intensity by Connor Yee, Ellie Rather, Sakib Hoque, Joon Lee, Stephanie Marton, Jill Roth, Frederick L. Oswald, Kenneth J. Nobleza, Ankona Banerjee, Holly Harris, Ariel M. Lyons-Warren

“…Stimulus intensity is an important parameter of sensory behaviors that future models should account for.…”
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Impact of suspected preterm labour in foetal cardiovascular and metabolic programming: a prospective cohort study protocol by Daniel Oros, Jon Schoorlemmer, Cristina Paules, Jesús Gonzalez, Marta Fabre, Sara Ruiz-Martínez, Lina Youssef, Natalia Abadía-Cuchí, Marcos Clavero-Adell, Ana Medel-Martinez, Ariadna Ayerza-Casas, Juan Lerma-Irureta, Pilar Maestro-Quibus, Jesús Rodriguez-Calvo, Diego Lerma

“…The aim of this prospective cohort study is to evaluate the impact of SPL on cardiac remodelling and function and on cardiovascular and metabolic profiles independently of gestational age at birth.Methods and analysis Prospective cohort study of subjects exposed and not exposed to an episode of SPL. …”
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Dietary patterns associated with benign breast nodules by subtypes: a cross-sectional study in southeast China by Pingxiu Zhu, Mei He, Jiamin Gong, Qingling Su, Ruimei Feng, Yundan Cai, Weihong Qiu, Haomin Yang, Haomin Yang, Shanshan Du, Weimin Ye, Weimin Ye

“…Dietary patterns were identified from food frequency questionnaires using principal component analysis, and the scores for these patterns were divided into quartiles. …”
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The change of MRI indexes of brain glymphatic function and sleep status before and after repeated transcranial magnetic stimulation in insomnia disorder patients by Duo Gao, Duo Gao, Zhengnan Zhang, Pingyong Feng, Lixia Zhou, Lixia Zhou, Zuojun Geng, Zuojun Geng, Caiying Li, Caiying Li, Yifei Zhu, Haiqing Yang, Haiqing Yang

“…Multivariate linear regression models indicated that N2 sleep duration and the arousal index were independently associated with DTI-ALPS in all IDs. …”
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ROS1 Expression Correlates With Inguinal Lymph Node Affection in Vulvar Cancer Patients: A Retrospective Study by Meletios P. Nigdelis, Annick Bitterlich, Mariam Parvanta, Bashar Haj Hamoud, Erich Franz Solomayer, Martin Ertz, Laura Schnöder, Annette Hasenburg, Bernd Holleczek, Mathias Wagner, Gilbert Georg Klamminger

“…This study investigated immunohistochemical ROS1 expression in VSCC to explore its potential as a future therapeutic target in this rare malignancy. Methods In this retrospective study, 48 patients with VSCC undergoing vulvectomy were included. …”
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The deficiency of chymase mast cell protease 4 exacerbates dextran sulfate sodium salt-induced colitis in mice and is associated with altered microbiota and metabolome profiles by Zhiqiang Li, Zhiqiang Li, Zhiqiang Li, Xiaoyuan Kuang, Dashuang Mo, Magnus Åbrink, Ge Shan, Jin-ping Li, Can Yang, Yuexi Wang, Tao Shen, Weiwei Yu

“…In mice, mast cell protease-4 (MCP-4) is considered as the functional homolog of human chymase, sharing similar enzymatic activity and biological roles.MethodsTo investigate the role of MCP-4 in UC, we induced colitis in Mcpt-4-deficient (Mcpt-4∆Cre) and littermate control (Mcpt-4fl/fl) mice using 2% dextran sulfate sodium salt (DSS) for 8 days followed by 2 days of water. …”
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