Heavy metals, epigenetic aging, and mortality: A cohort study by Hua Wang, Yunyun Liu, Shuxiang Yan, Chenbei Li, Jinxin Tang, Hongkun Hu, Mingyang Wu, Chao Tu

“…The relationships between metal exposure, EAMs and mortality risk were evaluated using multiple-linear regression, Cox regression, and weighted quantile sum (WQS) models, while the mediating role of EAMs in these associations was assessed through mediation analysis. …”
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RESILIENCE (Retrospective Linkage Study of Autoimmune Encephalitis): protocol for an Australian retrospective cohort study of outcomes in autoimmune encephalitis using data linkage... by David Brown, Wendyl D’Souza, Mark Cook, Andrew McLean-Tooke, David Gillis, Udaya Seneviratne, James Boyd, John Dunne, Nicholas Lawn, Ximena Camacho, Christine Bundell, Nerissa Jordan, Sudarshini Ramanathan, Fabienne Brilot, Kerri M Prain, Elaine Pang, Katrina Lambert, Russell Dale, Lisa Gillinder, Emma Whitham, Saxon Douglass, Amy Jean Halliday, Greg Bryson, Alan Lai, Wendyl Jude D’Souza

“…Univariate statistical methods will identify candidate coding elements for use in the operational case definition and multivariate models and evaluation methods used to identify and internally validate the optimal coding algorithms. …”
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Serum and tear autoantibodies from NOD and NOR mice as potential diagnostic indicators of local and systemic inflammation in Sjögren’s disease by Shruti Singh Kakan, Sara Abdelhamid, Sara Abdelhamid, Yaping Ju, Yaping Ju, J. Andrew MacKay, J. Andrew MacKay, J. Andrew MacKay, Maria C. Edman, Indu Raman, Chengsong Zhu, Prithvi Raj, Sarah F. Hamm-Alvarez, Sarah F. Hamm-Alvarez

“…Data were analyzed by R package Limma and Seurat.ResultsAnalysis of immunofluorescence in LG sections from both SjD models showed TLS. …”
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Optimisation and validation of Plume Chasing for robust and automated NOx and particle vehicle emission measurements by Christina Schmidt, C. David Carslaw, J. Naomi Farren, N. René Gijlswijk, Markus Knoll, E. Norbert Ligterink, Jan Pieter Lollinga, Martin Pechout, Stefan Schmitt, Michal Vojtíšek, Quinn Vroom, Denis Pöhler

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Impact evaluation of an interdisciplinary approach to patients with chronic non-cancer pain in Chilean primary care by Paula Zamorano, Teresita Varela, Isidora Salvatierra, Alvaro Tellez, Manuel Espinoza, Gustavo Torres, Victoria Rodríguez, María José Figueroa, Alejandro Rodríguez, Denisse Figueroa, Leonardo Silva, Sheila Salazar, Víctor Lucero, Francisco Suarez

“…The clinical intervention introduced patient-centered care, psychotherapy and physiotherapy from the perspective of the neuroscience of pain. The impact analysis was conducted using negative binomial regression models, generalized linear models, and ordered logistic regressions. …”
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Pyrotinib targeted EGFR/GRP78 mediated cell apoptosis in high EGFR gene copy number gastric cancer by Lingbo Bao, Xudong Wang, Xiuyong Liao, Dong Li, ChunXue Li, Nan Dai, Xiaoyan Dai, Jing Yang, Nana Hu, Xueling Tong, Zhenjie He, Yuancheng Zhao, Zheng Liu, Yue Hu, Jinlu Shan, Dong Wang, Mengxia Li, Qian Chen

“…Pyrotinib, an irreversible dual EGFR/HER2 tyrosine kinase inhibitor, has shown clinical efficacy in HER2-driven malignancies, but its potential role in EGFR-high copy number gastric cancer remains to be investigated. Methods Using EGFR-high copy number gastric cancer cell lines, primary cells and subcutaneous tumor models in nude mice, we systematically evaluated pyrotinib’s anti-tumor activity through viability assays, apoptosis analysis, and transcriptomic profiling. …”
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Therapeutic potential of placenta-derived stem cells cultivated on noggin-loaded nanochitosan/polypyrrole-alginate conductive scaffold to restore spinal cord injury by Asma Manzari-Tavakoli, Amirhesam Babajani, Nasim Vousooghi, Ali Moghimi, Roghayeh Tarasi, Fahimeh Safaeinejad, Samira Norouzi, Soheyl Bahrami, Hassan Niknejad

“…This study aims to investigate the potential of a nanochitosan/polypyrrole-alginate conductive scaffold, loaded with the Noggin growth factor, an inhibitor of BMP-4 signaling, and human amniotic epithelial cells (hAECs), in promoting the regeneration of SCI in animal models. Methods The attachment and distribution of isolated hAECs on a fabricated nanochitosan/polypyrrole-alginate conductive scaffold were assessed using SEM. …”
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Association between thyroid function and thyroid homeostasis parameters and the prevalence and all-cause and cardiovascular mortality of chronic kidney disease: a population-based... by Xue Liu, Yuhao Zhang, Yuchen Li, Xiude Fan, Haiqing Zhang

“…Weighted multivariate logistic regression models to explore the association between thyroid function and thyroid homeostasis parameters and the prevalence of CKD. …”
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“A quality of heart, of presence, and of really caring”: toward affirmative intersex health communication in Canada by Terese Knoppers, Angelica Voutsinas, Nicole Palmour, Kaleb Saulnier, Kaleb Saulnier, Morgan Holmes, Marilou Charron, Hortense Gallois, Hortense Gallois, Narges Jamali, Narges Jamali, Leslie Ordal, Yann Joly

“…Interviews were analyzed via template thematic analysis and filtered through a conceptual lens that brought together agency-based and social-ecological models of health communication.ResultsFindings produced three interlocking axes for change: HCP skills and approaches, structural access to care, and norms and discourses. …”
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Protocol for a prospective cohort study: Prevention of Transmissions by Effective Colonisation Tracking in Neonates (PROTECT-Neo) by Martin Wolkewitz, Roland Hentschel, Philipp Henneke, Daniel Jonas, Tim Götting, Sandra Reuter, Daniel Klotz, Simone Hock, Benjamin Blümel, Georg Häcker, Hajo Grundmann, Nico Mutters

“…It is the dual objective of the Prevention of Transmissions by Effective Colonisation Tracking-Neo study to determine the density of transmission events in a level III neonatal intensive care unit (NICU) and to identify risk factors that may be causally associated with transmission events.Methods and analysis A full cohort of patients treated in a 17-bed level III NICU will be prospectively followed and transmission events between two or more patients will be documented. …”
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Effect of thermocycling on flexural strength of dental CAD/CAM ceramics of variable thicknesses and structures: an in vitro study [version 3; peer review: 1 approved, 2 approved wi... by Shahad T. Alameer, Laila Al Dehailan, Sultan Akhtar, Turki Alshehri, Nourhan M. Aly, Yousif A. Al-Dulaijan, Passent Ellakany

“…Scanning electron microscopy (SEM) was employed for analysis. Two factorial ANOVA models assessed the association of different factors (ceramic type and thickness) with flexural strength and elastic modulus. …”
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Predicting Ventricular Tachyarrhythmias in Patients With Left Ventricular Ejection Fraction Improvement Following Cardiac Resynchronization Therapy by Adam Visca, Saadia Sherazi, Ilan Goldenberg, Scott McNitt, Nikhila Rao, Nilesh Rao, Ahmed Shah, Mehmet Aktas, Valentina Kutyifa, Wojciech Zareba, Krishna Rao

“…This study aimed to identify predictors of ventricular tachyarrhythmias (VTA) in patients with CRT‐D devices and LVEF improvement beyond guideline recommendations for a defibrillator. Methods Patients randomized to the CRT‐D arm of the Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy trial who improved their LVEF to > 35% at 12 months following CRT‐D implant were included in this analysis (N = 651). …”
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Crohn’s disease therapeutic dietary intervention (CD-TDI): study protocol for a randomised controlled trial by Subrata Ghosh, Levinus A Dieleman, Christopher Ma, Ian Lewis, Herman W Barkema, Humberto Jijon, Kathy D McCoy, Georgios V Gkoutos, Maitreyi Raman, Lorian M Taylor, Jeff K Vallance, Derek M McKay, David M Mutch, Deanna Gibson, Marcus Rauch

“…We aim to explore the efficacy of the CD therapeutic dietary intervention (CD-TDI), a novel dietary approach developed from best practices and current evidence, to induce clinical and biomarker remission in adult patients with active CD.Methods and analysis This study is a 13-week, multicentre, randomised controlled trial in patients with mild-to-moderate active CD at baseline. …”
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Alpha-estradiol and (R)-(−)-ibuprofen inhibit gastric cancer progression via GLI1 G-quadruplex by Qiang Li, Pan Pan, Qingqing Xian, Jingtan Li, Jingting Wang, Jiaying Cai, Jing Wang, Yanfei Jia, Haiji Sun, Lulu Zhang, Xiaoli Ma

“…These compounds were evaluated for anti-tumor effects through in vitro assays (proliferation, migration, invasion) and in vivo xenograft models. Mechanistic insights into GLI1/PRKACB signaling were obtained via chromatin immunoprecipitation and pathway analysis.ResultsStable G4 structures were confirmed in the GLI1 promoter. …”
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Effect of thermocycling on flexural strength of dental CAD/CAM ceramics of variable thicknesses and structures: an in vitro study [version 2; peer review: 1 approved, 2 approved wi... by Shahad T. Alameer, Laila Al Dehailan, Sultan Akhtar, Turki Alshehri, Nourhan M. Aly, Yousif A. Al-Dulaijan, Passent Ellakany

“…Scanning electron microscopy (SEM) was employed for analysis. Two factorial ANOVA models assessed the association of different factors (ceramic type and thickness) with flexural strength and elastic modulus. …”
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Do Short-Term Improvements in Activities of Daily Living and Instrumental Activities of Daily Living Have Association With Return to Work in Workers With Occupational Injury? From... by Fa-Chen Lin, Chia-Pin Lin, Hung-Yi Chuang, Tse-Wei Wu, Peng-Ju Huang, Chen-Cheng Yang, Chao-Hung Kuo

“…Logistic regression analysis indicated that IADL scores at 3 and 6 months postinjury were significantly linked to RTW. …”
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Impact of Hemoglobin Glycation Index on Complications Following Orthopedic Surgery: A Retrospective Comparative Propensity Score‐Matched Study by Yuhua Xiao, Bochen Sun, Guoyu Yu, Long Chen, Fenqi Luo, Jie Xu, Jun Luo, Ting Xue, Yiyang Xu

“…Propensity score matching (PSM) was performed to reduce confounding bias, and multivariate logistic regression models (with and without adjustment) for complication outcomes were applied to evaluate the odds ratios of HGI. …”
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Association between living arrangement and psychological well-being among patients with major depressive disorder: the moderating role of body mass index by Chengxi Wen, Yifeng Liu, Yanzhi Li, Ruiying Chen, Hao Zhao, Xiaojuan Zhang, Xiaoxin Zhuang, Yuhua Liao, Jiejing Hao, Yan Chen, Wanxin Wang, Huiming Zhang, Lan Guo, Roger S. McIntyre, Kayla M. Teopiz, Ciyong Lu, Xue Han

“…Univariable and multivariable logistic regression models were used to examine the association between different living arrangements and PWB at the 12-month follow-up. …”
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Perspectives on the pH-Influenced Design of Chitosan–Genipin Nanogels for Cell-Targeted Delivery by Julieta D. Glasman, Agustina Alaimo, Cecilia Samaniego López, María Edith Farías, Romina B. Currá, Diego G. Lamas, Oscar E. Pérez

“…Rheological studies and SAXS analysis assessed structural properties. Biocompatibility was evaluated via MTT assay, and internalisation was monitored by fluorescence microscopy on mammalian cell lines. …”
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Detecting fish community structure in open waters using environmental DNA: a case study from the central South China Sea by Ting Chen, Ting Chen, Shuai Zhang, Shuai Zhang, Shuai Zhang, Peiwen Jiang, Zuozhi Chen, Zuozhi Chen, Jun Zhang, Jun Zhang, Shannan Xu, Shannan Xu, Shannan Xu, Min Li, Min Li, Min Li

“…Monitoring fish diversity in open ocean environments presents substantial challenges, particularly due to the limitations of traditional sampling methods such as trawling, which are costly, labor-intensive, and ineffective for deeper water layers. …”
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