Age-related determinants of the metabolic syndrome in women of reproductive age of the main ethnic groups of the Baikal Region by L. V. Belenkaia, L. V. Suturina, M. A. Darenskaya, A. V. Atalyan, L. M. Lazareva, Ia. G. Nadelyaeva, N. I. Babaeva, L. F. Sholokhov, L. I. Kolesnikova

“…To determine the age limit of the initial manifestations of the metabolic syndrome in women of reproductive age of the Caucasian and Asian ethnic groups. Materials and methods. The study included women of reproductive age of the Russian and Buryat ethnic groups (n = 1231). …”
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Individual and joint association of serum 25-hydroxyvitamin D and folate levels with the risk of sarcopenia: a cross-sectional study from the NHANES 2011–2018 by Yaping Wei, Qiangqiang He, Qiangqiang He, Qiannan Di, Jing Li, Jingyi Zhang, Lixin Na

“…This study aims to investigate both the individual and joint associations of serum 25-hydroxyvitamin D [25(OH)D] and folate concentrations with the risk of sarcopenia.MethodsThis study conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES), covering the years 2011–2018. …”
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Anlotinib inhibits c-MET and ITGA2 in the treatment of anaplastic thyroid carcinoma by Shunshun Zhao, Mingyao Meng, Ruochuan Cheng, Min Zhang, Chuanyuan Liu, Qiuyu Meng, Tingting Yang, Haohan Huang, Bin Liu, Xiaodan Wang, Yanjun Su

“…Abstract Objective This study explored the therapeutic effects of anlotinib in anaplastic thyroid carcinoma (ATC) models and the underlying molecular mechanisms. Methods Human C643 and CAL-62 anaplastic thyroid carcinoma cell lines were cultured in vitro and treated with anlotinib. …”
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Detection, linkage to care, treatment and monitoring of hypertension in coastal communities in Accra, Ghana: protocol for a quasi-experimental study (The Ghana Heart Initiative Hyp... by Charles Agyemang, Vincent Boima, Charles Hayfron-Benjamin, Alfred Doku, Afua A A Twumasi, Doris Ottie-Boakye, Juliette Edzeame Selom

“…This study aims to identify patients with hypertension in the coastal communities of the Greater Accra region, link patients newly diagnosed with hypertension to appropriate medical care and monitor treatment outcomes using task-shifting strategies.Methods and analysis In this quasi-experimental study, participants with a mean blood pressure of ≥140/90 mm Hg will be recruited from seven coastal communities of Ghana’s Greater Accra region. …”
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Pharmacokinetic and pharmacodynamic assessment of oral nicotinamide in the NEAT clinical trial for early Alzheimer’s disease by Gabriel L Ketron, Felix Grun, Joshua D Grill, Howard H Feldman, Robert A Rissman, Gregory J Brewer

“…Abstract Background Nicotinamide, a form of B3 vitamin, is an NAD+ precursor that reduces pTau231 levels via histone deacetylase inhibition in murine models of Alzheimer’s disease (AD). A recent phase 2a randomized placebo-controlled trial tested high-dose oral nicotinamide for the treatment of early AD. …”
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Causes and Predictors of 30‐Day Readmission in Patients With Syncope/Collapse: A Nationwide Cohort Study by Amer N. Kadri, Hasan Abuamsha, Leen Nusairat, Nazih Kadri, Hussam Abuissa, Ahmad Masri, Adrian V. Hernandez

“…Future prospective studies are needed to derive risk‐stratification models to reduce the high burden of readmissions.…”
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Association between community violence exposure and teen parental firearm ownership: data from a nationally representative study by Karissa R. Pelletier, Jesenia M. Pizarro, Regina Royan, Rebeccah Sokol, Rebecca M. Cunningham, Marc A. Zimmerman, Patrick M. Carter

“…Methods Data from the Firearm Safety Among Children and Teens Consortium’s National Survey (6/24/2020-7/24/2020) was examined. …”
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Effects of an e-Learning Program (Physiotherapy Exercise and Physical Activity for Knee Osteoarthritis [PEAK]) on Chinese Physical Therapists’ Confidence and Knowledge: Randomized... by Zi-Ru Wang, Yunqi Wang, Shuning Duan, Xier Chen, Guoxin Ni

“…Quantitative data were analyzed using regression models, 2-sided t tests, and descriptive statistics, while thematic analysis was performed on the interview data of 10 participants. …”
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Low apolipoprotein B and LDL-cholesterol are associated with the risk of cardiovascular and all-cause mortality: a prospective cohort by Xiaolin Yu, Yujuan Yuan, Xiangyu Dong, Zulipiyemu Xier, Ling Ma, Hui Peng, Guoqing Li, Yining Yang

“…However, a comprehensive analysis integrating both markers in relation to mortality risk remains unreported.Objectives This study aimed to investigate the relationship between LDL cholesterol levels and mortality across varying apoB concentrations within the general population.Methods Data from 15,380 participants in the 2005–2016 National Health and Nutrition Examination Survey (NHANES) were utilized to construct Cox regression models and apply restricted cubic splines, assessing the association between LDL cholesterol and mortality across distinct apoB stratifications.Results The study cohort had a median (IQR) age of 46.0 (32.0, 60.0) years, with 7949 (51.8%) males. …”
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Toll-like receptor activation induces airway obstruction and hyperresponsiveness in guinea pigs by Yujiao Xiang, Jielu Liu, Mu Nie, Gunnar Nilsson, Jesper Säfholm, Mikael Adner

“…To better understand microbial-induced asthma exacerbations, animal models that closely mimic human lung characteristics are essential. …”
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A cross-sectional study examining the relationship between the advanced lung cancer inflammation index and prostate cancer by Mengjun Huang, Qiliang Teng, Dong Ning, Tongyu Tong, Fei Cao, Yiting Wang, Hanqi Lei, Jun Pang

“…Multivariate logistic regression analysis revealed that compared to participants in the lowest ALI quartile (Q1: 2.89–41.94), those in higher quartiles (Q2: 41.94–59.08, Q3: 59.08–80.88, and Q4: ≥80.88) had progressively lower odds of developing PCa in both unadjusted and adjusted models. …”
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Allostatic load and its determinants in a German sample-Results from the Carla cohort. by Eric Priedemann, Alexander Kluttig, Frank Bernhard Kraus, Daniel Sedding, Rafael Mikolajczyk, Amand Führer

“…This study aimed to investigate associated factors and patterns of AL in the population over a 20-year period using data from the CARLA cohort.<h4>Methods</h4>The analysis included 473 participants from the CARLA study (Cardiovascular Disease, Living and Ageing in Halle), aged 45-80 years at baseline. …”
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Mediators affecting the higher risk of stillbirth among foreign‐born women in Sweden: A nationwide cohort study by Minna Lundén, Ingela Hulthén Varli, Helena Kopp Kallner, Hanna Åmark

“…In this nationwide cohort of more than 2 million births, we assessed the risk factors for stillbirth among foreign‐born women with the aim of understanding which mediators have the largest impact on the elevated risk of stillbirth. Material and Methods This was a nationwide cohort study in Sweden including 2 300 391 births between 2000 and 2021. …”
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The relationship between maternal oral health parameters, inflammatory blood markers, and the evaluation of their effects on preterm low birth weight by Isa Temur, Katibe Tugce Temur, Safak Necati Dönertas, Aycan Dal Dönertas, Mustafa Kacmaz

“…Logistic regression modeling was conducted on variables exhibiting statistical significance (p < 0.05) following group comparisons. …”
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Different Approaches to requesting Consent for Routine data linkage in Neonatal follow-up (ACORN): protocol for a 2×2 factorial randomised trial by Jane E Harding, Barry Milne, Jenny Rogers, Greg Gamble, Jane Marie Alsweiler, Christopher McKinlay, Gavin Brown, Aakash Bajirao Rajay, Caroline Anne Crowther, Nike Franke, Trecia Wouldes

“…Reported rates of consent to data linkage for children ranged from 21% to 96%, but no studies have investigated different approaches to seeking consent for data linkage for school-age children.Methods and analysis The Approaches to Consent for Routine Data Linkage in Neonatal Follow-up (ACORN) trial is a 2×2 factorial randomised trial to assess whether, for children who participated in neonatal randomised trials (pre-hypoglycaemia Prevention with Oral Dextrose Gel (hPOD), hPOD and The Impact of Protein Intravenous Nutrition on Development in Extremely Low Birth Weight Babies (ProVIDe)) and are approached to participate in an in-person assessment at 6–7 years of age, parental consent to data linkage is higher if consent is sought (1) after the in-person assessment (delayed) or concurrently and (2) for health and education data combined or separately. …”
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Genetic context modulates aging and degeneration in the murine retina by Olivia J. Marola, Michael MacLean, Travis L. Cossette, Cory A. Diemler, Amanda A. Hewes, Alaina M. Reagan, Jonathan Nyandu Kanyinda, Daniel A. Skelly, Gareth R. Howell

“…Our investigations identified and validated WSB and NZO mice as improved preclinical models relevant to common retinal neurodegenerative diseases.…”
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Poppers use, adherence to antiretroviral therapy and risky sexual behaviors among HIV-positive men who have sex with men in Chongqing, China by Huailiang Chen, Jin Chen, Qingge Zhao, Min Zhou

“…Multivariate logistic regression models were constructed to identify factors associated with poppers use, as well as its relationship with adherence to ART and risky sexual behaviors. …”
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Robust molecular subgrouping and reference-free aneuploidy detection in medulloblastoma using low-depth whole genome bisulfite sequencing by Dean Thompson, Jemma Castle, Martin Sill, Stefan M. Pfister, Simon Bailey, Debbie Hicks, Steven C. Clifford, Edward C. Schwalbe

“…We developed and optimised pipelines for processing, QC, and analysis of low-pass WGBS data, suitable for routine molecular subgrouping and reference-free aneuploidy assessment. …”
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C5a/C5aR pathway blocking promoted CuS-mediated cancer therapy effect by inhibiting cuproptosis resistance by Jing Zhao, Xiao Han, Hong Yang, Zihan Sun, Jian Chen, Lulu Wang, Yuzhang Wu, Boshao Deng, Yunpei Zhao, Siyi Wang, Guokang Liu

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CCNY-mediated phosphorylation and TET2-BACH1-driven DNA demethylation activate PRC1 to augment NSCLC progression by Dayu Huang, Xianglin Chu, Chunxiao Wu, Xuan Wang, Mengkun Shi, Xiaofeng Chen, Yubao Lyu, Dapeng Li, Xuyu Gu

“…This study aims to examine the function of PRC1 in non-small cell lung cancer (NSCLC) cells and investigates its regulatory mechanisms. Methods PRC1 expression in NSCLC cells was assessed using qPCR and western blot analyses. …”
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