Prepregnancy body mass index and visceral fat exhibit divergent associations with metabolic factors in pregnant women with obesity: A Norwegian cohort study by Maja Lecic Bonnichsen, Nina Gunnes, Lill Trine Nyfløt, Guttorm Haugen, Marie Cecilie Roland

“…We hypothesized that among women with pBMI ≥35 kg/m2, visceral fat measured around gestational week 18 (visceral fat18) would show associations with greater number of metabolic variables during pregnancy, than pBMI. Material and Methods This prospective longitudinal cohort study was conducted at the Department of Gynecology and Obstetrics at Drammen Hospital from 2016 to 2019. …”
Get full text

EMCC dispatch priority for trauma patients in Norway: a retrospective cohort study by Inger Marie Waal Nilsbakken, Torben Wisborg, Stephen Sollid, Elisabeth Jeppesen

“…Two logistic regression models were used to examine the relationship between dispatch priority and factors associated with the assessment. …”
Get full text

Association Between Inflammatory Arthritis, Genetic Risk, and the Long‐Term Risk of Degenerative Aortic Stenosis: A Prospective Cohort Study by Baohua Peng, Lihuang Zha, Mukamengjiang Juaiti, Wenchao Lin, Xinyi Zhou, Ziwei Ou, Mengqiu Zhang, Zaixin Yu, Yiyang Tang

“…The primary outcome was the incidence of degenerative aortic stenosis. The primary analysis used Cox proportional hazards models to evaluate the association between inflammatory arthritis and the long‐term risk of degenerative aortic stenosis, as well as to explore potential effect modifiers. …”
Get full text

Geospatial patterns of progress towards UNAIDS ‘95-95-95’ targets and community vulnerability in Zambia: insights from population-based HIV impact assessments by Suilanji Sivile, Diego F Cuadros, Lloyd Mulenga, Sulani Nyimbili, Natalie Vlahakis, Theodora Savory, Tuhin Chowdhury, Masabho Milali, Daniel T Citron, Khozya Davie Zyambo, Anna Bershteyn

“…Multiple logistic regression models were used to examine the association between selected sociodemographic and behavioural covariates and the three main outcomes of study.Results Varied progress towards the ‘95-95-95’ targets were observed in different regions of Zambia. …”
Get full text

Efficacy and retention rate of secukinumab in psoriatic arthritis across different clinical phenotypes: insights from the Italian GISEA Registry by Giuseppe Lopalco, Maria Morrone, Fabiola Atzeni, Chiara Bazzani, Francesco Paolo Bianchi, Francesco Paolo Cantatore, Roberto Caporali, Antonio Carletto, Alberto Cauli, Maria Sole Chimenti, Sergio Colella, Fabrizio Conti, Addolorata Corrado, Ennio Giulio Favalli, Alberto Floris, Marco Fornaro, Rosario Foti, Roberta Foti, Elena Fracassi, Bruno Frediani, Stefano Gentileschi, Roberto Gorla, Elisa Gremese, Emanuela Praino, Roberta Ramonda, Cinzia Rotondo, Marco Sebastiani, Angelo Semeraro, Gianfranco Ferraccioli, Giovanni Lapadula, Florenzo Iannone

“…Adjusted hazard ratios (aHRs) for discontinuing SECU were determined using multivariate Cox regression models. Results: SECU survival at 24 months was 63.24%, significantly higher in mixed PsA compared to perPsA ( p  = 0.036). …”
Get full text

Serum reactivity to citrullinated protein/peptide antigens and left ventricular structure and function in the Multi-Ethnic Study of Atherosclerosis (MESA). by Jan M Hughes-Austin, Ronit Katz, Darcy S Majka, Michael H Criqui, William H Robinson, Gary S Firestein, W Gregory Hundley, Joachim H Ix

“…Cox proportional hazards models were used to evaluate associations between EHR antibodies and incident HF during 11 years of follow-up, adjusting for age, gender, race/ethnicity, smoking status, systolic blood pressure, use of anti-hypertensive medications, self-reported arthritis, IL-6, body surface area, and estimated glomerular filtration rate.…”
Get full text

Anti-diabetic effect of dicaffeoylquinic acids is associated with the modulation of gut microbiota and bile acid metabolism by Yujie Huang, Weiqi Xu, Wei Dong, Guijie Chen, Yi Sun, Xiaoxiong Zeng

“…Two mice models were utilized to investigate the anti-diabetic effects of DiCQAs. …”
Get full text

Investigating the Link Between Poor Sleep Patterns and Type 2 Diabetes Mellitus in Women With a History of Gestational Diabetes Mellitus: A Retrospective Population-Based Study by Yizheng Zu, Xia Xu, Xiaoyan Xiu, Yi Xie, Huangchang Yi, Lianghui Zheng, Jianying Yan

“…Background: This study aimed in this study was to investigate the association between poor sleep patterns (PSPs) and type 2 diabetes mellitus (T2DM) in women with a history of gestational diabetes mellitus (GDM). Methods: Our analysis was based on a population-based sample from National Health and Nutrition Examination Survey (NHANES) data collected between 2007 and 2018. …”
Get full text

Aging and liver health: liver chemistries and associated factors in community-dwelling older adults by Farah Safdar Husain, Siew Ling Tey, Dieu Thi Thu Huynh, Jeffery Oliver, Geraldine Baggs, Choon How How, Wai Leng Chow, Magdalin Cheong, Tar Choon Aw, Samuel Teong Huang Chew, Ngiap Chuan Tan

“…Blood samples were analyzed for ALT, aspartate transaminase (AST), albumin, total bilirubin, alkaline phosphatase (ALP), total protein, and globulin. Analysis of variance and multiple linear regression models were used to evaluate the desired associations. …”
Get full text

Enhanced prognostic value of a composite nutritional-inflammatory index (P-CONUT) for predicting mortality risk in patients initiating peritoneal dialysis. by Xing Li, Xueli Zhou, Kuo Li, Li Pu, Xueqin He, Xia Liu, Hui Zhong, Dengyan Ma

“…Net reclassification improvement (NRI) and integrated discrimination improvement (IDI) were used to assess the incremental value of P-CONUT over CONUT and PNI. Decision curve analysis (DCA) assessed the clinical utility of the models. …”
Get full text

Investigation of the effects of different denture base fabrication techniques and hard relining resin materials on the fixation of immediate provisional hybrid prosthesis to titani... by Burcu Kanat-Ertürk, Cansu Akarsu, Önjen Tak

“…Data were statistically analyzed with two-way analysis of variance (ANOVA) and Tukey post-hoc test (SPSS26, p =.05). …”
Get full text

Shift from chronic to episodic migraine frequency in a long-term phase 3 study of galcanezumab by Hans-Christoph Diener, Kathleen A. Day, Sarah Lipsius, Sheena K. Aurora, Nada A. Hindiyeh, Holland C. Detke

“…Double-blind percentage comparisons versus placebo represent modeled estimates from raw rates. Results At baseline, patients had a mean of 19.4 migraine headache days per month (SD = 4.5) and 21.4 headache days per month (SD = 4.1). …”
Get full text

Aloe Vera Gel and Rind-Derived Nanoparticles Mitigate Skin Photoaging via Activation of Nrf2/ARE Pathway by Sun Z, Zheng Y, Wang T, Zhang J, Li J, Wu Z, Zhang F, Gao T, Yu L, Xu X, Qian H, Tan Y

“…The effects were evaluated by constructing in vitro and in vivo models and using RT-qPCR, immunofluorescence, and histopathological analysis.Results: The results first revealed the exceptional anti-aging effects of ADNPs. …”
Get full text

Dysregulation of protein degradation and alteration of secretome in α-synuclein-exposed astrocytes: implications for dopaminergic neuronal dysfunction by Aishwarya Raj, Roon Banerjee, Vikram Holla, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal, Indrani Datta

“…We also investigated α-synuclein release into the secretome and its effects on healthy dopaminergic neurons. Methods Cellular models used were rat primary astrocytes alongside hiPSC-derived astrocytes, whose impact on rat primary dopaminergic neurons and the human SH-SY5Y cell line was investigated. …”
Get full text

Knowledge, attitudes, and practices toward the treatment of endodontic-periodontal lesions among oral health care providers: a multi-center cross-sectional study by Fei Sun, Mina Hu, Qiuyan Zhu, Jiaqin Wang, Peng Wang, Ying Zhou

“…Abstract Background This study aimed to evaluate the knowledge, attitudes, and practices (KAP) of oral healthcare providers concerning the treatment of endodontic-periodontal lesions (EPLs) and investigate the relationships among the KAP dimensions using correlation analysis and structural equation modeling (SEM). Methods This cross-sectional study enrolled dental healthcare professionals between February 2024 and June 2024, with questionnaire data collected in Hangzhou and Shaoxing, China. …”
Get full text

RETRACTED ARTICLE: LncRNA HAND2-AS1 exerts anti-oncogenic effects on bladder cancer via restoration of RARB as a sponge of microRNA-146 by Liping Shan, Wei Liu, Yunhong Zhan

“…Furthermore, 5637 human bladder cancer mouse models were established to investigate the interactions of lncRNA: miRNA: mRNA in vivo. …”
Get full text

Anticryptosporidial action mechanisms of Launaea spinosa extracts in Cryptosporidium parvum experimentally infected mice in relation to its UHPLC-MS metabolite profile and biochemo... by Mai M Elghonemy, Mohamed G Sharaf El-Din, Dina Aboelsoued, Mohamed F Abdelhameed, Mohamed A El-Saied, Nagwa I Toaleb, Mohamed A Farag, Abdelsamed I Elshamy, Abdelbaset M Elgamal

“…Extracts were characterized via UHPLC-ESI-LIT-Orbitrap-MS and metabolite profiles were subjected to correlation modeling with bioactivities via supervised Partial Least Square (PLS) to identify active agents. …”
Get full text

The UFMylation pathway is impaired in Alzheimer’s disease by Tingxiang Yan, Michael G. Heckman, Emily C. Craver, Chia-Chen Liu, Bailey D. Rawlinson, Xue Wang, Melissa E. Murray, Dennis W. Dickson, Nilufer Ertekin-Taner, Zhenkun Lou, Guojun Bu, Wolfdieter Springer, Fabienne C. Fiesel

“…Methods Here we used frontal and temporal cortex samples from individuals with or without AD to measure the protein levels of the UFMylation pathway in human brain. …”
Get full text

A dataset of three vine water status indicators, weather records and soil available water capacity components collected from a rain-fed Mediterranean vineyardZenodo by Yulin Zhang, Léo Pichon, Bruno Tisseyre

“…While Ψpd and δ13C are considered reference methods, they are expensive and prone to logistical constrains. …”
Get full text

C3-Liposome Delivery of MUC1 Peptide and TLR Agonists Enhances Adaptive Immunity and Results in Sex-Based Tumor Growth Differences by Shahab Soltani, Ameneh Arabi, Kristine Mann, Austin Hess, Holly A. Martinson, Max Kullberg

“…Our group previously demonstrated that C3 (OPSS)-liposomes enhance antigen uptake by antigen-presenting cells (APCs) via the complement C3 pathway and, when combined with toll-like receptor (TLR) agonists, reduce tumor growth in murine cancer models. <b>Methods</b>: In the present study, we evaluate the immunogenicity of MUC1 peptide vaccines encapsulated in C3-liposomes, with and without TLR agonists, using MUC1-tolerant transgenic mice challenged with Lewis lung carcinoma (LLC.MUC1) cells. …”
Get full text