Sex Differences in Cardiovascular Outcomes of Intravascular Imaging-Guided PCI by Chidubem Ezenna, MD, BS, Sammudeen Ibrahim, MD, Prasana Ramesh, MD, Mahmoud Ismayl, MBBS, Mrinal Murali Krishna, MBBS, Meghna Joseph, MBBS, Kuan-Yu Chi, MD, S. Elissa Altin, MD, Michael G. Nanna, MD, MHS, Andrew M. Goldsweig, MD, MS

“…Risk ratios (RRs) with 95% CIs were calculated using random-effects models. Results: Eight randomized controlled trials, comprising 14,812 patients (76.1% men and 23.9% women) were included. …”
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MiR‐146a Reduces Inflammation in Experimental Pancreatitis via the TRAF6–NF‐κB Signaling Pathway in Mice by Xiaoyu Yang, Yuping Ren, Xueyang Li, Liang Xia, Jianhua Wan

“…Similar protective effects of miR‐146a were observed in AP models induced by l‐arginine and caerulein combined with LPS. …”
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Repurposing Dapagliflozin for Mitigation of the Kidney Injury Triggered by Cadmium in Rats: Role of Autophagy, Apoptosis, and the SIRT1/Nrf2/HO-1 Pathway by Hany H. Arab, Musaad M. Althobaiti, Abdulaziz S. Alharthi, Emad O. Almalki, Saif S. Alsoubie, Jawad M. Qattan, Saeed A. Almalki, Ahmed M. Ashour, Ahmed H. Eid

“…Herein, DPG was studied for its potential to attenuate kidney damage in Cd-intoxicated rats, as well as to unravel the mechanisms involving oxidative events, autophagy, and apoptosis. <b>Methods:</b> Histopathological analysis, immunohistochemical staining, and ELISA were conducted on kidney tissue samples. …”
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Prognostic factors for work disability in patients with chronic widespread pain and fibromyalgia: protocol for a cohort study by Robin Christensen, Marius Henriksen, Eva Ejlersen Wæhrens, Henning Bliddal, Lars Erik Kristensen, Karsten Thielen, Henning Locht, Kirstine Amris, Pernille H Duhn

“…Data on the primary endpoint work status at baseline and 3 years from baseline will be extracted from the Integrated Labour Market Database, Statistics Denmark and the nationwide Danish DREAM database. Prognostic factor analysis will be based on multivariable logistic regression modelling with the dichotomous work status as dependent variable.Ethics and dissemination Sensitive personal data will be anonymised according to regulations by the Danish Data Protection Agency, and informed consent are obtained from all participants. …”
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Women living in the region under an emergency command post are experiencing delays in reaching health facilities: a multi-center cross-sectional study by Besfat Berihun Erega, Abebaye Adigo Zeru, Begizew Yimenu Mekuriaw, Rahel Birhanu Arage, Yitayal Ayalew Goshu, Wassie Yazie Ferede, Mulat Ayele, Gizachew Yilak, Befkad Derese Tilahun, Habtam Desse Alemayehu, Eyob Shitie Lake

“…Variables having p-value ≤ 0.2 in the bi-variable analysis were fitted into multiple logistic regression models. …”
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Group bright light therapy compared to treatment as usual for delayed sleep–wake phase disorder among patients in psychiatric care (the SIP trials): a protocol for a pragmatic, ran... by Bjørn Bjorvatn, Ståle Pallesen, Ane Wilhelmsen-Langeland, Ingvild West Saxvig, Michael Gradisar, Veronika Alice Vågenes, Lin Sørensen, Ole-Bernt Fasmer, Julian Koenig, Berge Osnes

“…The aim of this randomised controlled trial is to investigate whether group BLT for psychiatric outpatients is superior to treatment as usual (TAU).Methods and analysis 60 patients with moderate-to-severe psychiatric illness who meet the criteria for DSWPD will be recruited from an outpatient psychiatric clinic in Norway. …”
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The Prevalence of Metabolic Syndrome and Hypertriglyceridemic Waist Based on Sociodemographic Variables and Healthy Habits in Healthcare Workers: A Retrospective Study by Pedro Javier Tárraga Marcos, Ángel Arturo López-González, Emilio Martínez-Almoyna Rifá, Hernán Paublini Oliveira, Cristina Martorell Sánchez, Pedro Juan Tárraga López, José Ignacio Ramírez-Manent

“…Descriptive analysis included categorical and quantitative variables, which were assessed through frequencies, Student’s <i>t</i>-test, chi-square, and binary logistic regression models. …”
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Behavioural and patient-individual determinants of quality of life, functioning and physical activity in older adults (MobilE-TRA 2): study protocol of an observational cohort stud... by Daniela Koller, Eva Grill, Lars Schwettmann, Benedict Katzenberger, Martin Weigl, Alexander Paulus, Sara Pedron, Sebastian Fuchs

“…Findings from behavioural economics (BE) can help to shed light on individual effects on adherence behaviour and long-term outcomes of VDB and OA.Objective Based on insights from BE concepts (ie, self-efficacy, intention, and time and risk preferences), MobilE-TRA 2 investigates the determinants of functioning and health-related quality of life (HRQoL) 3 and 12 months after discharge from total hip replacement (THR)/total knee replacement (TKR) in patients with OA and after interdisciplinary evaluation for VDB.Methods and analysis MobilE-TRA 2 is a longitudinal observational study with data collection in two specialised tertiary care centres at the university hospital in Munich, Germany between 2020 and 2023. …”
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Knowledge, attitudes, and self-reported practices regarding cholera among six MENA countries following cholera outbreaks in the region by Salma A. Bekhit, Rayane Rafei, Fatma Elnaggar, Omar Zain AL-Sakkaf, Hussein Kamal Seif, Dana Samardali, Yara Turkmani Alabead, Mohammed Osman Omer Sanosi, Marwa Shawky Abdou, Eman H. Elbanna, Doaa Mahmoud Khalil

“…Furthermore, mandatory educational workshops and programs for medical professionals are essential, as they serve as role models for the community.…”
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Divergent gene expression of PTGS1 and PTGS2 along the disease course of chronic myeloid leukaemia by Denise K. Wosniaki, Bianca N. Kusma, Anelis M. Marin, Eduardo C. Munhoz, João S. de H. Farias, Eduarda B. Mendes, Mateus N. Aoki, Dalila L. Zanette

“…Quantitative PCR (qPCR) and in vitro cell culture experiments were used to assess gene expression. Statistical analysis included the Kruskal–Wallis test and simple linear regression models. …”
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Early Outcomes With Cerebral Embolic Protection During Transcatheter Aortic Valve Replacement in Patients With Atrial Fibrillation by Shashank Shekhar, MD, Amar Krishnaswamy, MD, Grant Reed, MD, MSc, James Yun, MD, Rishi Puri, MD, PhD, Samir Kapadia, MD

“…Stroke, major stroke, in-hospital mortality, and 30-day readmission rates were compared between the CPD and no-CPD cohorts in a propensity score matched analysis. Association of CPD use with adverse events was analyzed using multivariable logistic regression models. …”
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The relationship between oxidative balance score, depression, and survival among adult cancer survivors in the United States by Qu Zhang, Qu Zhang, Yemei Wu, Qianyu Fan, Wenxi Zhou, Wenxi Zhou, Min Liu

“…This study assessed OBS, depression, and mortality in cancer survivors.MethodsUtilizing a prospective, population-based cohort design, this analysis enrolled 1,455 adult cancer survivors (age ≥20 years) through the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. …”
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APOE4 and chronic health risk factors are associated with sex-specific preclinical Alzheimer’s disease neuroimaging biomarkers by Genna M. Losinski, Mickeal N. Key, Eric D. Vidoni, Jonathan Clutton, Jill K. Morris, Jeffrey M. Burns, Amber Watts, Amber Watts

“…We identified AD risk factors including genetic (APOE genotype status) and health markers (fasting glucose, mean arterial pressure, waist-to-hip ratio, and android and gynoid body fat) associated with neuroimaging outcomes for which we observed sex differences.MethodsParticipants were sedentary, amyloid-β positive older adults (N = 112, ages 65–87 years) without evidence of cognitive impairment (CDR = 0).ResultsMultivariate analysis of covariance models adjusted for intracranial volume, age, and years of education demonstrated lower volume [F (7, 102) = 2.67, p = 0.014] and higher blood flow F (6, 102) = 4.25, p ≤ 0.001) among females compared to males in regions of interest connected to AD pathology and the estrogen receptor network. …”
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Polygenic risk score prediction accuracy convergence by Léo Henches, Jihye Kim, Zhiyu Yang, Simone Rubinacci, Gabriel Pires, Clara Albiñana, Christophe Boetto, Hanna Julienne, Arthur Frouin, Antoine Auvergne, Yuka Suzuki, Sarah Djebali, Olivier Delaneau, Andrea Ganna, Bjarni Vilhjálmsson, Florian Privé, Hugues Aschard

“…Summary: Polygenic risk scores (PRSs) models trained from genome-wide association study (GWAS) results are set to play a pivotal role in biomedical research addressing multifactorial human diseases. …”
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Core competencies for international mobility for teachers and students in higher education by Evridiki Patelarou, Alexandra Trivli, Vladimir Đorđević, Stelios E. Papadakis, Giorgos M. Papadourakis, Alkinoos- Ioannis Zourmpakis, Maria Ampartzaki, Michaela Menšíková, Nada B. Ljubišić, Michail Kalogiannakis, Athina Patelarou

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The Role of Inflammatory Sarcopenia in Increasing Fall Risk in Older Adults: Exploring the Impact on Mobility-Impaired and Immunocompromised Patients by Marc-Dan Blajovan, Simona-Alina Abu-Awwad, Mirela-Cleopatra Tomescu, Cristina Tudoran, Daniela Gurgus, Anca Dinu, Ahmed Abu-Awwad

“…Multivariate regression models were used to identify predictors of fall risk. …”
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Inflammation is associated with pain and fatigue in older adults by Sara A. Norton, Lauren M. Blaydon, Megan Niehaus, Alex P. Miller, Patrick L. Hill, Thomas F. Oltmanns, Ryan Bogdan

“…This study investigated the relationship between three inflammatory markers (IL-6, CRP, and TNFα) and pain and fatigue, both cross-sectionally and longitudinally, in a sample of older adults from the Saint Louis Personality and Aging (SPAN) study. Methods: SPAN study participants provided blood samples at two in-person sessions approximately 2 years apart for the analysis of the inflammatory biomarkers IL-6, CRP, and TNFα. …”
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Palm Tocotrienol Preserves Trabecular Osteocyte Indices and Modulates the Expression of Osteocyte Markers in Ovariectomized Rats by Sophia Ogechi Ekeuku, Shafiq Zikry Zarir, Anis Nazira Razali, Syamima Mohamad Zaidi, Noor Halinah Mohamed Ali Jinnah, Muhamed Lahtif Nor Muhamad, Sok Kuan Wong, Kok-Yong Chin

“…<b>Background/Objective:</b> Palm tocotrienol has bone-protective properties in animal models, yet its underlying mechanism remains unclear. …”
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Obesity and risk of female reproductive conditions: A Mendelian randomisation study. by Samvida S Venkatesh, Teresa Ferreira, Stefania Benonisdottir, Nilufer Rahmioglu, Christian M Becker, Ingrid Granne, Krina T Zondervan, Michael V Holmes, Cecilia M Lindgren, Laura B L Wittemans

“…Thus, we aimed to estimate observational and genetically predicted causal associations between obesity, metabolic hormones, and female reproductive disorders.<h4>Methods and findings</h4>Logistic regression, generalised additive models, and Mendelian randomisation (MR) (2-sample, non-linear, and multivariable) were applied to obesity and reproductive disease data on up to 257,193 women of European ancestry in UK Biobank and publicly available genome-wide association studies (GWASs). …”
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Trends in the Cost and Utilization of Publicly Reimbursed Cancer Medications Dispensed as Take-Home Treatments from 2017–2021 by Ria Garg, Tara Dumont, Daniel McCormack, Mina Tadrous, Tonya Campbell, Kelvin Chan, Tara Gomes

“…Therefore, in this study, we describe trends and the impact of SARS-CoV-2 on the utilization and cost of take-home cancer medications dispensed through the public payer system in Ontario, Canada. <b>Methods:</b> We conducted a repeated cross-sectional time-series analysis examining monthly and fiscal-year trends in the utilization and cost of take-home cancer medications reimbursed by the public payer between 1 April 2017 and 31 March 2021, in Ontario, Canada. …”
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