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69761
Differential Effects of Gynecological and Chronological Age on Low Birth Weight and Small for Gestational Age
Published 2025-07-01“…<b>Objective:</b> To evaluate the relationship between chronological age and gynecological age with low birth weight and small for gestational age among adolescent mothers in Mexico City. <b>Methods:</b> A retrospective cohort design of adolescent mother–child dyads was conducted. …”
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69762
Racial/ethnic disparities in the association of maternal diabetes and obesity with risk of preterm birth among 17 million mother-infant pairs in the United States: a population-bas...
Published 2025-03-01“…We further categorized preterm birth into three subtypes: extremely (< 28 weeks), very (28–31 weeks), and moderately (32–36 weeks) preterm birth. Logistic regression models were used for association analyses in this study. …”
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69763
Impact of Apolipoprotein A-I Infusions on Cardiovascular Events Post-MI by Neutrophil-Lymphocyte Ratio and LDL-Cholesterol Levels
Published 2025-05-01“…Cox proportional hazards models evaluated risk by dichotomized baseline NLR (>median vs ≤median). …”
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69764
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69765
Metabolomic profiles differentiate between porto-sinusoidal vascular disorder, cirrhosis, and healthy individuals
Published 2024-12-01“…This study aimed to identify distinct metabolomic signatures in patients with PSVD or cirrhosis to facilitate non-invasive diagnosis and elucidate perturbed metabolic pathways. Methods: Serum samples from 20 healthy volunteers (HVs), 20 patients with histologically confirmed PSVD or 20 patients with cirrhosis were analyzed. …”
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69766
Meet-in-the-middle meets multi-omics identifying molecular signatures of environmental drivers of childhood overweight
Published 2025-08-01“…Exposome and multi-omics features were integrated into latent factors by Multi-omics Factor Analysis, based on which structural equation modelling was used to assess whether multi-omics mediated associations between exposome and child body mass index (BMI). …”
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69767
CDK4/6 inhibitor PD-0332991 suppresses hepatocarcinogenesis by inducing senescence of hepatic tumor-initiating cells
Published 2025-07-01“…Objectives: This study was designed to investigate whether senescence induction of hTICs in the precancerous stage inhibit HCC initiation. Methods and Results: HCC models developed from chronic liver injury (CLI) were established by using Fah-/- mice and N-Ras + AKT mice. …”
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69768
Diagnostic Criteria for Cancer‐Associated Cachexia: Insights from a Multicentre Cohort Study
Published 2025-02-01“…We also examined which diagnostic criteria are more feasible and appropriate for cancer‐associated cachexia in clinical practice. Methods A multicentre cohort study was conducted, which involved 5769 participants with cancer. …”
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69769
Targeting Stat3 with conditional knockout or PROTAC technology alleviates renal injury by Limiting pyroptosisResearch in context
Published 2025-06-01“…The role of the Signal Transducer and Activator of Transcription 3 (Stat3) in AKI remains controversial, and its complex regulatory mechanisms must be further explored. Methods: We generated renal tubular epithelial cells Stat3 conditional knockout (cKO) mice and used them in cecal ligation and puncture (CLP) and ischaemia-reperfusion (I/R) induced AKI models. …”
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69770
CArdiovasculaR Outcomes Based Upon EjectIon Systolic TimE in Patients With ST Elevation Myocardial Infarction (ARISE-STEMI) Study
Published 2025-04-01“…This study aims to investigate the utility of the ejection systolic time (EST) and ejection systolic period (ESP) in identifying high-risk STEMI patients. Methods: In this retrospective study, consecutive patients with STEMI undergoing PPCI at a tertiary cardiac center between January 2020 and October 2021 were included. …”
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69771
EPOCHS. XI. The Structure and Morphology of Galaxies in the Epoch of Reionization to z ∼ 12.5
Published 2025-01-01“…We further find a galaxy size–mass correlation up to z ∼ 12, with galaxies of a given mass also becoming smaller. Using nonparametric methods, we find that galaxy merger fractions, classified through asymmetry parameters, at these redshifts remain consistent with those in the literature, maintaining a value of f _m ∼ 0.12 ± 0.07 showing little dependence with redshift when combined with the literature at z > 4. …”
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69772
Longitudinal Body Composition Identifies Hepatocellular Carcinoma With Cachexia Following Combined Immunotherapy and Target Therapy (CHANCE2213)
Published 2024-12-01“…Multiple Cox proportional hazards models were used to calculate adjusted hazard ratios (HRs) for survival. …”
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69773
Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum diso...
Published 2025-04-01“…Time to disability milestones was estimated through Kaplan-Meier analysis and Cox proportional hazard regression models adjusted for sex, year of onset, immunotherapy exposure and antibody status. …”
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69774
Myo-inositol affects the health, metabolome, and lactation performance of peripartum dairy cows
Published 2025-06-01“…Therefore, this study explored the effects of myo-inositol on the health, metabolome, and lactation performance of peripartum dairy cows using both in vitro and in vivo models.MethodsThe ANKOM RFS gas production system was used for the in vitro experiment; Twenty four healthy Holstein cows were assigned to CON group (n = 4; no supplementation of YC or myo-inositol), YC group (n = 10; 2 g/kg YC), and IN65 group (n = 10; 2 g/kg YC + 16 mg/kg myo-inositol) for in vivo experiment.ResultsThe concentrations of five volatile fatty acids (acetic acid, butyric acid, isobutyric acid, valeric acid, and isovaleric acid), and total volatile fatty acids were significantly higher in the IN65 group compared to the CON group at 6 h in vitro (P < 0.01). …”
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69775
Metabolic obesity phenotypes and the risk of cancer: a prospective study of the Kailuan cohort
Published 2024-10-01“…This study aimed to investigate the relationship between metabolic health status combined with obesity phenotypes and the risk of cancer.MethodsData from 91,834 participants in the Kailuan cohort were analyzed, excluding individuals with a body mass index (BMI) < 18.5 kg/m² and those with a history of cancer. …”
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69776
EPOCHS. I. The Discovery and Star-forming Properties of Galaxies in the Epoch of Reionization at 6.5 < z < 18 with PEARLS and Public JWST Data
Published 2025-01-01“…We describe our rigorous methods for identifying these galaxies, involving the use of Lyman-break strength, detection significance criteria, visual inspection, and integrated photometric redshift probability distributions predominately at high redshift. …”
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69777
ECM1 expression in chronic liver disease: Regulation by EGF/STAT1 and IFNγ/NRF2 signalling
Published 2025-08-01“…We investigated the mechanism of ECM1 regulation in hepatocytes under pathophysiological conditions. Methods: We used promoter analysis to predict Ecm1 transcriptional regulators and assessed the expression of Ecm1-related genes by single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq. …”
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69778
LRH‐1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype
Published 2024-12-01“…Methods Peripheral blood mononuclear cells (PBMCs) were isolated from individuals with and without T1D and derived into various immune cells, including macrophages and dendritic cells. …”
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69779
The effect of exposure to radiofrequency fields on cancer risk in the general and working population: A systematic review of human observational studies – Part II: Less researched...
Published 2025-02-01“…Here, we report on less researched neoplasms, which include lymphohematopoietic system tumours, thyroid cancer and oral cavity/pharynx cancer, in relation to wireless phone use, or occupational RF exposure. Methods: Eligibility criteria: We included cohort and case-control studies of neoplasia risks in relation to three types of exposure to RF-EMF: 1. exposure from wireless phone use; 2. environmental exposure from fixed-site transmitters; 3. occupational exposures. …”
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69780
Recurrence of autoimmune hepatitis cholestatic variant syndromes after liver transplantation affects graft and patient survival
Published 2025-05-01“…The aim of this international, multicentric, retrospective study is to evaluate the risk factors associated with recurrence and the impact of the disease recurrence after LT on graft and patient survival. Methods: We evaluated 166 patients undergoing LT for VS in 33 centers in North America, South America, Europe, and Asia. …”
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