RNF31 induces paclitaxel resistance by sustaining ALYREF cytoplasmic–nuclear shuttling in human triple‐negative breast cancer by Shumei Huang, Dongni Shi, Shuqin Dai, Xingyu Jiang, Rui Wang, Muwen Yang, Boyu Chen, Xuwei Chen, Lingzhi Kong, Lixin He, Pinwei Deng, Xiangfu Chen, Chuyong Lin, Yue Li, Jun Li, Libing Song, Yawei Shi, Weidong Wei

“…The present study aimed to determine whether paclitaxel treatment impairs Aly/REF export factor (ALYREF) cytoplasmic–nuclear shuttling, its mechanism, and the role of ubiquitinated ALYREF in paclitaxel resistance. Methods The subcellular proportion of ALYREF was detected in samples from patients with TNBC using immunohistochemistry to analyze the relationship between ALYREF distribution and paclitaxel response. …”
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Early bevacizumab dose and time modifications may affect efficacy of atezolizumab plus bevacizumab for advanced hepatocellular carcinoma treatment by F. Rossari, D. Lavacchi, E. Alimenti, C. Soldà, F. Salani, L. Esposito, S. Foti, S. Camera, M. Persano, F. Lo Prinzi, F. Vitiello, E. Pellegrini, M. Bruccoleri, M.D. Rizzato, M. Caccese, I.G. Rapposelli, A. Guidolin, A. De Rosa, L. Antonuzzo, G. Masi, M.A. Iavarone, S. Lonardi, M. Rimini, A. Casadei-Gardini

“…Additionally, early bevacizumab dose/time modifications (eBEVmod) may negatively impact outcome. Materials and methods: Data from AtezBev-treated aHCC patients (n = 100) in five Italian institutions were retrospectively analyzed. …”
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The relationship between prenatal perfluorine and polyfluoroalkyl substances (PFAS) exposure and infant neurodevelopment: Modifying effects of DHA revised by Ting-ting Jiang, Lian-man Lei, Xia-yu Zhang, Ya-ling Li, Lu-ming Yan, Zi-shun Lu, Zi-yi Liu, Bo-lin Liu, Lian-jie Dou, An-hui Zhang, Min Yu, Min Zhu, Fei Li, Ji-an Xie, Chao Zhang, Jia-hu Hao

“…Objective: This study aimed to investigate the relationship between prenatal PFAS exposure and infant neurodevelopmental delay and evaluate the effects of postnatal DHA supplementation on infant neurodevelopment. Methods: From October 2020 to December 2022, 2415 mother–newborn pairs were enrolled in the study from China WuHu Birth Cohort Study (WH-BC). …”
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Are vision transformers replacing convolutional neural networks in scene interpretation?: A review by N. Arockia Rosy, K. Balasubadra, K. Deepa

“…This review presents a comprehensive and methodical analysis of recent developments in CNN and ViT-based models for scene recognition. …”
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Reperfusion failure after successful thrombectomy of large vessel occlusion stroke: clinical and imaging evidence by M. Barbagallo, M. Barbagallo, M. Zahn, M. Zahn, J. Zimmermann, J. Zimmermann, R. Klövekorn, R. Klövekorn, J. Held, J. Held, B. Nemeth, B. Nemeth, B. Reolon, B. Reolon, J. Bellomo, J. Bellomo, A. Schwarz, J. M. Veerbeek, C. H. B. Van Niftrik, C. H. B. Van Niftrik, M. Sebök, M. Sebök, M. Piccirelli, M. Piccirelli, L. Michels, L. Michels, A. R. Luft, A. R. Luft, A. R. Luft, Z. Kulcsar, Z. Kulcsar, L. Regli, L. Regli, G. Esposito, G. Esposito, J. Fierstra, J. Fierstra, P. Thurner, P. Thurner, T. Schubert, T. Schubert, S. Wegener, S. Wegener

“…Our current understanding of the underlying pathomechanisms is limited and mostly based on rodent models. The goal of this study was to further characterize RF by applying advanced multimodal hemodynamic imaging in stroke patients.MethodsPatients from the IMPreST study with LVO stroke and successful recanalization [corresponding to thrombolysis in cerebral ischemia grade (TICI) 2b-3] were included. …”
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Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT by Graham Devereux, Seonaidh Cotton, Mintu Nath, Nicola McMeekin, Karen Campbell, Rekha Chaudhuri, Gourab Choudhury, Anthony De Soyza, Shona Fielding, Simon Gompertz, John Haughney, Amanda Lee, Graeme MacLennan, Alyn Morice, John Norrie, David Price, Philip Short, Jorgen Vestbo, Paul Walker, Jadwiga Wedzicha, Andrew Wilson, Olivia Wu, Brian Lipworth

“…In total, there were 357 participants defined as adherent and are included in the protocol analysis (174 bisoprolol, 183 placebo). The results of per-protocol analysis were not substantially different from the results from the ITT analysis. …”
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Screening for breast cancer: a systematic review update to inform the Canadian Task Force on Preventive Health Care guideline by Alexandria Bennett, Nicole Shaver, Niyati Vyas, Faris Almoli, Robert Pap, Andrea Douglas, Taddele Kibret, Becky Skidmore, Martin Yaffe, Anna Wilkinson, Jean M. Seely, Julian Little, David Moher

“…Abstract Objective This systematic review update synthesized recent evidence on the benefits and harms of breast cancer screening in women aged ≥ 40 years and aims to inform the Canadian Task Force on Preventive Health Care’s (CTFPHC) guideline update. Methods We searched Ovid MEDLINE® ALL, Embase Classic + Embase and Cochrane Central Register of Controlled Trials to update our searches to July 8, 2023. …”
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Use of drones in offshore wind farm inspections by Hanna Dzido

“…The article presents the potential of drones in the process of inspecting wind farms, including offshore wind farms, presents examples of UAV models used for inspections, indicates methods of conducting inspections with the use of drones and highlights a significant reduction in the costs of the operation of offshore wind farms as a result of limiting the use of manned aviation (helicopters and flight crews) and the elimination of the risk associated with the involvement of personnel to perform inspections of wind farms at sea. …”
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Global Methane Budget 2000–2020 by M. Saunois, A. Martinez, B. Poulter, Z. Zhang, Z. Zhang, P. A. Raymond, P. Regnier, J. G. Canadell, R. B. Jackson, P. K. Patra, P. K. Patra, P. Bousquet, P. Ciais, E. J. Dlugokencky, X. Lan, X. Lan, G. H. Allen, D. Bastviken, D. J. Beerling, D. A. Belikov, D. R. Blake, S. Castaldi, M. Crippa, B. R. Deemer, F. Dennison, G. Etiope, G. Etiope, N. Gedney, L. Höglund-Isaksson, M. A. Holgerson, P. O. Hopcroft, G. Hugelius, A. Ito, A. K. Jain, R. Janardanan, M. S. Johnson, T. Kleinen, P. B. Krummel, R. Lauerwald, T. Li, X. Liu, K. C. McDonald, J. R. Melton, J. Mühle, J. Müller, F. Murguia-Flores, Y. Niwa, Y. Niwa, S. Noce, S. Pan, R. J. Parker, C. Peng, C. Peng, M. Ramonet, W. J. Riley, G. Rocher-Ros, J. A. Rosentreter, M. Sasakawa, A. Segers, S. J. Smith, S. J. Smith, E. H. Stanley, J. Thanwerdas, J. Thanwerdas, H. Tian, A. Tsuruta, F. N. Tubiello, T. S. Weber, G. R. van der Werf, D. E. J. Worthy, Y. Xi, Y. Yoshida, W. Zhang, W. Zhang, B. Zheng, B. Zheng, Q. Zhu, Q. Zhu, Q. Zhuang

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Efficiency Factors and Motivations Driving Innovative Activity of Russian Industrial Enterprises by Tatiana Kuznetsova, Vitaliy Roud

“…Relevant methodological and methodical approaches are thoroughly studied and adapted by Russian experts. …”
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Efficacy, safety and cost-effectiveness of methotrexate, adalimumab or their combination in non-infectious non-anterior uveitis: a protocol for a multicentre, randomised, parallel... by José Antonio Pinto, Alex Fonollosa, Ester Carreño, Maria Isabel Rodriguez, David Diaz-Valle, Diana Peiteado, Luis Rodriguez-Rodriguez, Miguel Cordero-Coma, Marta Tejera Santana, Lidia Cocho, Ana Belen Rivas, Amanda Lopez-Picado, Valentina Calamia, Felix M Francisco Hernandez, Angel Garcia-Aparicio, Javier Garcia-Gonzalez, Jose Juan Mondejar, Leticia Lojo-Oliveira, Llucí Martínez-Costa, Santiago Munoz, Beatriz Rodriguez-Lozano, Esperanza Pato, Elena Molina, Luis Alberto Tebar, Mara Albert Fort, Mayte Ariño Gutierrez, Pedro Arriola Villalobos, Joseba Artaraz Beobide, Antonio Atanes Sandoval, Jose Manuel Sanchez, Francisco Blázquez, Pablo Borges Deniz, Lara Borrego Sanz, Gabriela Bustamante Sanchez-Arnedo, Bruno Casco Silva, Ricardo Cuiña Sardiña, Almudena De Pablo Cabrera, Maria Del Mar Esteban Ortega, Patricia Fernandez Puente, Dalifer Dayanira Nuñez, Javier Garcia Bella, Sara Garcia Carazo, Luis Garcia Onrubia, Jose Maria Morales, Jose Antonio Fernandez, Vanesa Hernandez Hernandez, Inés Hernanz Rodriguez, Jose Maria Cantalapiedra, Ventura Hidalgo Barrero, Maria De Jovani Casano, Sara López Sierra, Virginia Lozano Lopez, Alfredo Madrid Garcia, Rosalia Mendez Fernandez, Pilar Nozal Aranda, Eugenio Perez Blazquez, Chamaida Plasencia Rodriguez, Sheila Recuero Diaz, Ignacio Robles Barrena, Esther Rodriguez Almaraz, Fayna Maria Gonzalez, Guadalupe Rodriguez Martinez, Fredeswinda Isabel Bueno, Ioana Ruiz Arruza, Beatriz Sanchez Marugan, Olga Sanchez Pernaute, Armelle Schlinker Giraud, Alvaro Seijas Lopez, Patricia Simon Alonso, Elia Valls Pascual

“…However, a direct comparison between these two treatment strategies has not been carried out yet.Methods and analysis The Combination THerapy with mEthotrexate and adalImumAb for uveitis (CoTHEIA) study is a phase III, multicentre, prospective, randomised, single-blinded with masked outcome assessment, parallel three arms with 1:1:1 allocation, active-controlled, superiority study design, comparing the efficacy, safety and cost-effectiveness of methotrexate, adalimumab or their combination in non-infectious non-anterior uveitis. …”
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Adherence to Life’s Essential 8 enhances gut microbiota diversity and cognitive performance by Yannick N. Wadop, Jazmyn Muhammad, Rebecca Bernal, Claudia L. Satizabal, Claudia L. Satizabal, Claudia L. Satizabal, Claudia L. Satizabal, Alexa Beiser, Alexa Beiser, Alexa Beiser, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramnik Xavier, Ramnik Xavier, Ramnik Xavier, Tiffany Kautz, Tiffany Kautz, Sudha Seshadri, Sudha Seshadri, Sudha Seshadri, Sudha Seshadri, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Bernard Fongang, Bernard Fongang, Bernard Fongang

“…Multivariable linear regression models and mediation analysis were used to investigate this relationship.ResultsParticipants with greater adherence to LE8 demonstrated significantly increased gut microbial diversity (α-diversity: Chao1, p = 0.0014; Shannon, p = 0.0071) and distinct microbial compositions (β-diversity: PERMANOVA p = 1e-4). …”
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CO Isotopologue-derived Molecular Gas Conditions and CO-to-H2 Conversion Factors in M51 by Jakob den Brok, María J. Jiménez-Donaire, Adam Leroy, Eva Schinnerer, Frank Bigiel, Jérôme Pety, Glen Petitpas, Antonio Usero, Yu-Hsuan Teng, Pedro Humire, Eric W. Koch, Erik Rosolowsky, Karin Sandstrom, Daizhong Liu, Qizhou Zhang, Sophia Stuber, Mélanie Chevance, Daniel A. Dale, Cosima Eibensteiner, Ina Galić, Simon C. O. Glover, Hsi-An Pan, Miguel Querejeta, Rowan J. Smith, Thomas G. Williams, David J. Wilner, Valencia Zhang

“…The average non-LTE α _CO is 2.4 ± 0.5 M _⊙ pc ^−2 (K km s ^−1 ) ^−1 . While both methods show dispersion due to underlying assumptions, the scatter is larger for LTE-derived values. …”
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Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…Logarithmic transformation was applied to these data and the models refitted. None then showed any statistically significant difference except the model for length of stay. …”
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Cost-effectiveness of sodium zirconium cyclosilicate for the treatment of hyperkalemia in patients with chronic kidney disease or heart failure in Spain by Roberto Alcázar-Arroyo, María G Crespo-Leiro, Jordi Bover, Juan Oliva, Miren Sequera-Mutiozabal, Simona Gradari, Anisia Martínez-López, Blanca López-Chicheri, Neus Vidal-Vilar, Susana Aceituno, Marta Cobo

“…Materials and methods: Two microsimulation models reflecting the natural history of CKD and HF were used. …”
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Decentralized Grant-Free mMTC Traffic Multiplexing With eMBB Data Through Deep Reinforcement Learning by Giovanni Di Gennaro, Amedeo Buonanno, Gianmarco Romano, Stefano Buzzi, Francesco A. N. Palmieri

“…Within this DRL framework, a methodical comparison between two possible deep neural networks is conducted, using different generative models employed to ascertain their intrinsic capabilities in various application scenarios. …”
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Health program for prEvention of cardiovascuLar disEases based on a risk screeNing strategy with Ankle-brachial index: HELENA study protocol by Gina Domínguez-Armengol, Gina Domínguez-Armengol, Francesc Ribas-Aulinas, Francesc Ribas-Aulinas, Elisabet Balló, Maite Alzamora-Sas, Maite Alzamora-Sas, Mar Serrat-Costa, Anna Ruiz-Comellas, Anna Ruiz-Comellas, Anna Ruiz-Comellas, Maria Jose Forcadell-Peris, Maria Jose Forcadell-Peris, Pere Toran, Ruth Martí-Lluch, Ruth Martí-Lluch, Ruth Martí-Lluch, Anna Ponjoan, Anna Ponjoan, Anna Ponjoan, Jordi Blanch, Lia Alves-Cabratosa, Lluís Zacarías-Pons, Lluís Zacarías-Pons, Eric Tornabell-Noguera, Eric Tornabell-Noguera, Álvaro Sánchez-Pérez, Álvaro Sánchez-Pérez, Anna Berenguera-Ossó, Anna Berenguera-Ossó, Rafel Ramos, Rafel Ramos, Rafel Ramos, Rafel Ramos, Rafel Ramos, The HELENA Study Group

“…Secondary outcomes include CHD (a composite of angina and hard CHD), cerebrovascular disease, and adverse effects from lipid-lowering medication. Survival analysis will estimate the effectiveness of adding the ABI screening strategy, with Cox models (intention-to-treat) and marginal structural models controlling for confounding variables.Results and discussionDirect health improvements in the intervened population are expected, including a reduction in CHD incidence and its risk factors. …”
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Technology of automated video observation of a drogue-sensor basket in the problem of autonomous aerial refueling by A. V. Gaidenkov, M. I. Kanevskiy, A. S. Ostrovskiy, O. I. Ganyak, N. Yu. Chizhov

“…An analysis of the design of experimental foreign systems for autonomous aerial refueling is carried out. …”
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A Novel Definition and Grading Diagnostic Criteria for Tumour‐Type‐Specific Comprehensive Cachexia Risk by Chunlei Hu, Minghua Cong, Chunhua Song, Hongxia Xu, Zengqing Guo, Fuxiang Zhou, Lan Zhou, Min Weng, Benqiang Rao, Li Deng, Kaiying Yu, Yongbing Chen, Ziwen Wang, Guotian Ruan, Ming Yang, Chenan Liu, Jiuwei Cui, Wei Li, Kunhua Wang, Zengning Li, Ming Liu, Tao Li, Junqiang Chen, Stephan vonHaehling, Rocco Barazzoni, Hanping Shi

“…Risk factors for cachexia, including tumour characteristics and nutritional parameters, were examined to develop diagnostic scales using Cox proportional hazards models and Kaplan–Meier analysis. Results Ten nutrition items (body mass index, weight loss, intake reduction, physical activity function, fatigue, handgrip strength, anorexia, albumin level, albumin/globulin ratio and neutrophil/lymphocyte ratio) with different weighted scores were identified to construct a nutrition‐weighted scoring scale (NWSS) for nutrition risk. …”
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تقييم تأثير وسائل الاعلام والدعاية على إدراک المستخدمين للعمارة والعمران "دراسة حالة مشروعات الاسکان في مصر"... by محمود سليمان, ولاء زقدان

“….- Evaluating the role played by mass media, in terms of positivity and negativity, through running an analysis of the messages conveyed by media and advertising, whichare often influenced by the vision of the investing developers, in quest for marketing their housing products.- Detecting the criteria upon which the mass media rely in order to market an architectural product, to see if such mass media adopt honesty in presenting the characteristicsof the product, and to see whether such presentation provides the user with the informed knowledge of what he/she is going to possess or not.- Outline controls system to regulate the methods of promotion and marketing, in connection with the information to be provided by the mass media about the architecturalproducts available at the housing market, to enable residence seekers to select the most suitable product, among the available residential models, in accordance wi th theirdiverse and versatile characteristics and needs.…”
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