Impact of enteral nutrition initiated within 24 h of ECMO on nutritional status and inflammatory response in children by Ye Ren, Ye Ren, Ye Ren, Siwei Lu, Siwei Lu, Siwei Lu, Yingfu Chen, Yingfu Chen, Yingfu Chen, Yuelin Sun, Yuelin Sun, Yuelin Sun, Yueqiang Fu, Yueqiang Fu, Yueqiang Fu, Chengjun Liu, Chengjun Liu, Chengjun Liu, Jing Li, Jing Li, Jing Li, Hongxing Dang, Hongxing Dang, Hongxing Dang

“…This study aimed to investigate the effects of initiating enteral nutrition (EN) within 24 h on the adequacy of nutrient intake, nutritional status, anabolic metabolism, and inflammatory markers in children receiving ECMO.MethodsThis was a prospective observational cohort study, including children receiving ECMO therapy at the Children's Hospital of Chongqing Medical University of China from April 2018 to August 2024. …”
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Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway by Kyonghwan Choe, Muhammad Ali, Roy Lardenoije, Renzo J.M. Riemens, Ehsan Pishva, Horst Bickel, Siegfried Weyerer, Per Hoffmann, Michael Pentzek, Steffi Riedel-Heller, Birgitt Wiese, Martin Scherer, Michael Wagner, Diego Mastroeni, Paul D. Coleman, Alfredo Ramirez, Inez H.G.B. Ramakers, Frans R.J. Verhey, Bart P.F. Rutten, Gunter Kenis, Daniel L.A. van den Hove

“…Functional interactions between genes and identification of common phenotype-specific positive and negative elementary circuits were conducted using computational modeling, i.e. gene regulatory network (GRN) and network perturbational analysis. …”
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Decidual/placental and first trimester plasma levels of hsa-miR-199a-3p|hsa-miR-199b-3p and hsa-miR-3150b-3p are associated with insulin secretion in pregnancy by Amélie Taschereau, Frédérique White, Catherine Allard, Andrea G. Edlow, François Aguet, Kristin G. Ardlie, Jose C. Florez, Jose C. Florez, Jose C. Florez, Jose C. Florez, Pierre-Étienne Jacques, Pierre-Étienne Jacques, Pierre-Étienne Jacques, S. Ananth Karumanchi, Camille E. Powe, Camille E. Powe, Camille E. Powe, Camille E. Powe, Luigi Bouchard, Luigi Bouchard, Luigi Bouchard, Marie-France Hivert, Marie-France Hivert, Marie-France Hivert

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Long noncoding RNA LINC00339 promotes osteoporosis development via modulating of regulator CDC42 by binding PARP1 by Dong-Li Zhu, Yan Zhang, Xiao-Yu Zhang, Zi-Han Qiu, Ke Li, Xiao-Rong Zhou, Zhen-Zhen He, Xiao-Feng Chen, Shan-Shan Dong, Wen Tian, Ya-Kang Wang, Tie-Lin Yang, Bo Yang, Yan Guo

“…Functional analyses revealed that LINC00339 dysregulation exhibited an inverse correlation with osteogenic differentiation capacity across multiple osteoblast cell models. Subcellular localization analysis via FISH confirmed the predominant cytoplasmic distribution of LINC00339 in bone cells. …”
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High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetes by Hanying Wang, Liping Gu, Yuhang Ma, Xindan Xing, Yuan Qu, Xin Shi, Xinyi Liu, Hancong Wan, Qian Zhu, Yingchen Shen, Chong Chen, Li Su, Yufan Wang, Kun Liu

“…Abstract Aims To assess the association between serum uric acid (SUA) level and the prevalence of diabetic retinopathy (DR) and chronic kidney disease (CKD) in patients with long-term diabetes. Methods A cross-sectional analysis was conducted involving diabetic patients from Shanghai General hospital during October 2018 and October 2021. …”
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Associations of serum and bronchoalveolar immunoglobulins with lung microbiota diversity, B-cell memory phenotypes, and COPD morbidity and exacerbations by Vickram Tejwani, Nirupama Putcha, Han Woo, Chen Liu, David Lafon, Neil E. Alexis, Antoine Azar, R. Graham Barr, Igor Barjaktarevic, Russell P. Bowler, Alejandro Comellas, David J. Couper, Ashraf Fawzy, MeiLan K. Han, Nadia N. Hansel, Robert J. Kaner, Jerry A. Krishnan, Nathaniel Marchetti, Fernando J. Martinez, Jill Ohar, Wanda O’Neal, Victor E. Ortega, Robert Paine III, Tess D. Pottinger, Martin Stämpfli, Lisa Ruvuna, Prescott G. Woodruff, Christine M. Freeman, Yvonne J. Huang, Jeffrey L. Curtis

“…Here, we examined associations of lower respiratory tract bacterial diversity to Ig levels in serum and bronchoalveolar lavage (BAL) and to the memory phenotypes of blood and BAL B cells. Methods We analyzed data from phase I of SPIROMICS, an observational cohort study of smoking-related COPD. …”
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Effectiveness of oral step-down therapy and early oral switch for bloodstream infections caused by Enterobacterales: A post hoc emulation trial of the SIMPLIFY trial by Emanuele Rando, Mercedes Delgado-Valverde, Josune Goikoetxea Aguirre, Laura Guio Carrión, María José Blanco Vidal, José Luis Barrios Andrés, María Teresa Pérez Rodríguez, Lucía Martínez Lamas, Francisco Arnaiz de las Revillas, Carlos Armiñanzas, Carlos Ruiz de Alegría-Puig, Patricia Jiménez Aguilar, María del Carmen Martínez-Rubio, Carmen Sáez-Béjar, Carmen de las Cuevas, Andrés Martín-Aspas, Fátima Galán, José Ramón Yuste, José Leiva-León, Germán Bou, Patricia Capón González, Lucía Boix-Palop, Mariona Xercavins-Valls, Miguel Ángel Goenaga-Sánchez, Diego Vicente Anza, Juan José Castón, Manuel Recio Rufián, Esperanza Merino, Juan Carlos Rodríguez, Belén Loeches, Clara Rosso-Fernández, José María Bravo-Ferrer, Pilar Retamar-Gentil, Jesús Rodríguez-Baño, Luis Eduardo López Cortés

“…Objectives: We investigated the effectiveness of early oral switch for treating Enterobacterales bloodstream infection (BSI) by performing a post hoc emulation trial of the SIMPLIFY trial. Methods: We conducted a post hoc analysis of a randomized controlled trial. …”
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Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study. by Vijay R Varma, Youjin Wang, Yang An, Sudhir Varma, Murat Bilgel, Jimit Doshi, Cristina Legido-Quigley, João C Delgado, Anup M Oommen, Jackson A Roberts, Dean F Wong, Christos Davatzikos, Susan M Resnick, Juan C Troncoso, Olga Pletnikova, Richard O'Brien, Eelko Hak, Brenda N Baak, Ruth Pfeiffer, Priyanka Baloni, Siamak Mohmoudiandehkordi, Kwangsik Nho, Rima Kaddurah-Daouk, David A Bennett, Shahinaz M Gadalla, Madhav Thambisetty

“…We tested whether dysregulation of cholesterol catabolism, through its conversion to primary bile acids (BAs), was associated with dementia pathogenesis.<h4>Methods and findings</h4>We used a 3-step study design to examine the role of the primary BAs, cholic acid (CA), and chenodeoxycholic acid (CDCA) as well as their principal biosynthetic precursor, 7α-hydroxycholesterol (7α-OHC), in dementia. …”
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Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

“…Instead, under the PCT model, the market is saturated with a plethora of drugs to choose from. …”
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Bronchoalveolar lavage cell percentages as diagnostic markers of immune checkpoint inhibitor pneumonitis by Mahnoor Mir, Felipe Soto, Pedro Antonio Amezcua Gomez, Rodrigo Del Rio Arroyo, Adarsh Suresh, Amber Su, Qiong Gan, John Stewart, Roberto Adachi, Diwakar D. Balachandran, Lara Bashoura, Roberto F. Casal, Burton F. Dickey, George A. Eapen, Scott E. Evans, Horiana Grosu, Carlos A. Jimenez, Julie Lin, David E. Ost, Bruce F. Sabath, Vickie R. Shannon, Aung Naing, Jianjun Gao, Jia Wu, Karthik Suresh, Saadia A. Faiz, Mehmet Altan, Ajay Sheshadri

“…Bronchoalveolar lavage (BAL) lymphocytosis has been associated with ICIP, but studies have not evaluated BAL lymphocytosis as a diagnostic biomarker for ICIP.PurposeThis study aimed to measure the association of BAL immune cell percentage with ICIP and test its performance as a diagnostic biomarker.MethodsWe performed a retrospective chart review of 476 patients treated with ICIs for solid organ or hematologic malignancies who underwent BAL between 2016 and 2022. …”
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A Numerical Study on a Vertical-Axis Wind Turbine with Inclined Arms by Agostino De Marco, Domenico P. Coiro, Domenico Cucco, Fabrizio Nicolosi

“…This work presents a methodical CFD study on how inclined arms can be used on a selected wind turbine configuration to harvest additional power from the wind. …”
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Geranylgeranyl Pyrophosphate Promotes Hepatic Lipid Accumulation by Prenylation of Perilipin4Summary by Yue Zhao, Hong-Yu Nie, Shan Jiang, Meng-Fei Zhao, Peng Sun, Jing-Zi Zhang, Xiao-Chen Wang, Yi-Ping Tang, Ming-jie Zou, Xian-Wen Yuan, Xi-Tai Sun, Xiao-Dong Shan, Jian He, Jiang-Huai Liu, Yan Bi, Lei Fang, Xiao Han, Chao-Jun Li

“…This study aimed to identify the key regulator responsible for MUO. Methods: Metabolomics analysis was conducted to compare hepatic metabolite profiles between individuals with MUO and MHO and mice. …”
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Maternal asthma and newborn DNA methylation by Casper-Emil Tingskov Pedersen, Thanh T. Hoang, Jianping Jin, Anna Starnawska, Raquel Granell, Hannah R. Elliott, Anke Huels, Heather J. Zar, Dan J. Stein, Yining Zhang, Herman T. den Dekker, Liesbeth Duijts, Janine F. Felix, Júlia Sangüesa, Mariona Bustamante, Maribel Casas, Martine Vrijheid, Latha Kadalayil, Faisal I. Rezwan, Hasan Arshad, John W. Holloway, Stefan Röder, Ana C. Zenclussen, Gunda Herberth, Nicklas Heine Staunstrup, Henriette Thisted Horsdal, Jonathan Mill, Eilis Hannon, iPSYCH-MINERvA Group, Isabella Annesi-Maesano, Giancarlo Pesce, Nour Baïz, Barbara Heude, Sahra Hosseinian-Mohazzab, Carrie V. Breton, Sophia Harlid, Justin Harbs, Magnus Domellof, Christina West, Edwina Yeung, Xuehuo Zeng, Wenche Nystad, Siri E. Håberg, Maria C. Magnus, Diana Schendel, Stephanie J. London, Klaus Bønnelykke

“…Objective To investigate the relationship between parental asthma and newborn blood DNA methylation. Methods Epigenome-wide association analyses were conducted in 13 cohorts on 7433 newborns with blood methylation data from the Illumina450K or EPIC array. …”
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Antibiotic stewardship in hematological patients with Escherichia coli and Klebsiella pneumoniae bloodstream infections: evaluating short-course and carbapenem-sparing strategies by Yuqing Cui, Xiaomeng Feng, Ling Pan, Qingsong Lin, Jieru Wang, Sisi Zhen, Yuping Fan, Xin Chen, Yizhou Zheng, Yingchang Mi, Fengkui Zhang, Xiaofan Zhu, Zhijian Xiao, Erlie Jiang, Mingzhe Han, Jianxiang Wang, Sizhou Feng

“…Abstract Background To address the overuse of antibiotics, this study examined the clinical characteristics and outcomes associated with antibiotic duration and carbapenem-sparing regimens in hematological patients with Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) bloodstream infections (BSI). Methods We conducted a retrospective analysis of hematological patients with E. coli or K. pneumoniae BSI from 2017 to 2023. …”
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The competitiveness of machine-building enterprises: Current state and prospects for development by Samofalova Mariia, Karachyna Natalia, Slobodianyk Anna, Abuselidze George, Khadartsev Oleksandr, Ruban Yuriy

“…The article aims to scientifically substantiate methodological and methodical approaches to assessing the competitiveness of machine-building enterprises in Ukraine, their identification by individual categories, and rating economic entities based on an integral indicator of competitiveness with modelling of forecast indicators of their development. …”
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Trends in Global Burden and Socioeconomic Profiles of Atrial Fibrillation and Atrial Flutter: Insights from the Global Burden of Disease Study 2021 by Samuel Chin Wei Tan, MD, Mae-Ling Tang, MD, Hongyuan Chu, MD, Yun-Tao Zhao, MD, Cuilian Weng, MD

“…This study quantifies the burden and identifies key risk factors for AF/AFL across 204 countries and territories from 1990 to 2021. Methods: Using data from the Global Burden of Disease (GBD) study 2021, we employed average annual percentage change (AAPC) and Bayesian Age Period Cohort (BAPC) modelling to assess trends and future projections, with a focus on disparities across Socio-Demographic Index (SDI) levels. …”
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Improving health-promoting workplaces through interdisciplinary approaches. The example of WISEWORK-C, a cluster of five work and health projects within Horizon-Europe by Deborah De Moortel, Michelle C Turner, Ella Arensman, Alex Binh Vinh Duc Nguyen, Víctor Gonzalez

“…It applies an international co-creative and developmental evaluation of tailored compassionate workplace programs, and mixed-methods process and impact evaluation combining a timed series of quantitative cross-sectional panel surveys, qualitative interviews and fieldwork, and policy document analysis. …”
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WTAP/YTHDF1-mediated m6A modification amplifies IFN-γ-induced immunosuppressive properties of human MSCs by Quan Chen, Luoquan Ao, Qing Zhao, Lu Tang, Yanli Xiong, Yuchuan Yuan, Xiaofeng Wu, Wei Xing, Zhan Li, Wei Guo, Huaping Liang, Song Guo Zheng, Qizhou Lian, Di Lu, Weijun Wan, Xiang Xu

“…Objectives: To elucidate the regulation mechanism and biological functions of N6-methyladenosine (m6A) modification in the immunosuppressive functions by the IFN-γ-licensing MSCs. Methods: Epitranscriptomic microarray analysis and MeRIP-qPCR assay were performed to identify the regulatory effect of WTAP in the IFN-γ-licensing MSCs. …”
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Sex differences in risk factors for unsuccessful tuberculosis treatment outcomes in Eastern Europe from 2020 to 2022: a multi-country retrospective cohort studyResearch in context by Ole Skouvig Pedersen, Tetiana Butova, Valerii Miasoiedov, Yurii Feshchenko, Mykhailo Kuzhko, Stefan Niemann, Alex Rosenthal, Alina Grinev, Gabriel Rosenfeld, Michael Drew Hoppes, Julia Kilmnick, Valeriu Crudu, Nelly Ciobanu, Alexandru Codreanu, Bekzat Toxanbayeva, Lyailya Chingissova, Kateryna Yurko, Valerii Kucheriavchenko, Vitalii Vekshyn, Sergo Vashakidze, Natalia Shubladze, Zaza Avaliani, Abdullaat Kadyrov, Gulmira Kalmambetova, Merbubu Sydykova, Eugenia Ghita, Victor Ionel Grecu, Alina Marinela Miulescu, Christian Morberg Wejse, Andreas Fløe, Victor Naestholt Dahl, Dmytro Butov

“…This study examines this association and analyses sex-stratified risk factors associated with unsuccessful outcomes. Methods: This retrospective, observational cohort study analysed prospectively collected data from six Eastern European countries from 2020 to 2022. …”
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Efficacy and safety of autologous adipose tissue-derived stromal vascular fraction in patients with premature ovarian insufficiency: protocol for a single-centre randomised control... by Jie Qiao, Hui Liu, Rong Li, Tian Tian, Yang Yu, Chen Zhang, Ping Liu, Lin Zeng, Rui Yang, Jia Li, Shuo Yang, Jialin Li, Qing Guo, Hongxia Zhang, Caihong Ma, Xiaojuan Liu, Xiumei Zhen, Yaodong Zhang, Yanru Lou, Chenhong Liu, Wan Yang, Huiyu Xu, Hongsen Bi

“…Although SVF has shown therapeutic effects in animal models of POI, there is insufficient evidence demonstrating the efficacy and safety of autologous SVF in women with POI.Methods and analysis This study is a single-centre randomised controlled trial designed to explore the efficacy and safety of using autologous SVF in improving pregnancy outcomes in patients with infertility diagnosed with POI. …”
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