P4HA1 mediates YAP hydroxylation and accelerates collagen synthesis in temozolomide-resistant glioblastoma by Xueru Li, Gangfeng Yu, Xiao Zhong, Jiacheng Zhong, Xiangyu Chen, Qinglong Chen, Jinjiang Xue, Xi Yang, Xinchun Zhang, Yao Ling, Yun Xiu, Yaqi Deng, Hongda Li, Wei Mo, Yong Zhu, Ting Zhang, Liangjun Qiao, Song Chen, Fanghui Lu, Xuehong Zhang

“…This study aimed to investigate the mechanism of TMZ chemoresistance by GBM cells reprogramming collagens. Methods:. Key extracellular matrix components, including collagens, were examined in paired primary and recurrent GBM samples as well as in TMZ-treated spontaneous and grafted GBM murine models. …”
Get full text

Facies changes, sedimentary environments and sequence stratigraphy of the lower Carboniferous deposits in the Kalmard area, Central Iran, Member D of Gachal formation by Mohammadnabi Gorgij, Somayyeh Shahraki Mirzaei

“…With respect to complete Unit D in the southern part of Kalmard area and a necessary of the study of sequence stratigraphy of Tournaisian–Visean strata in this part of Central Iran, this stratigraphic section has been selected. Materials & MethodsFor identification of microfacies characters and analysis, environmental conditions, and sequence stratigraphy of unit D of Gachal formation, the Godar-e-Gachal section has been selected that has 50.4 m thickness. …”
Get full text

The absolute lactate levels versus clearance for prognostication of post‐cardiotomy patients on veno‐arterial ECMO by Mohamed Laimoud, Patricia Machado, Michelle Gretchen Lo, Mary Jane Maghirang, Emad Hakami, Rehan Qureshi

“…This work aimed to analyse the impact of changes in blood lactate levels on the survival of patients on post‐cardiotomy ECMO (PC‐ECMO) and whether lactate clearance (LC) performs better than absolute lactate levels. Methods and Results We retrospectively analysed the data of adult patients who received PC‐ECMO at our centre between 2016 and 2022. …”
Get full text

Associations of metabolic status with all-cause mortality among individuals with osteoarthritis: A prospective cohort study by Hao Yang, Muhui Zeng, Tianxiang Fan, Haowei Chen, Xiaofeng Fang, Zhong Alan Li, Xiaoshuai Wang, David J. Hunter, Changhai Ding, Zhaohua Zhu

“…Moreover, the association between metabolic status and risk of mortality among OA patients remains unclear. Methods: The analysis included baseline populations with OA from the UK Biobank (UKBB) study and the National Health and Nutrition Examination Survey (NHANES) 1999–2018. …”
Get full text

Blood plasma proteome-wide association study implicates novel proteins in the pathogenesis of multiple cardiovascular diseases by Jia-Hao Wang, Shan-Shan Dong, Wei Huang, Hao-An Wang, Shao-Shan Liu, Xiaoyi Ma, Ren-Jie Zhu, Wei Shi, Hao Wu, Ke Yu, Tian-Pei Zhang, Cong-Ru Wang, Yan Guo, Hanzhong Xue, Tie-Lin Yang

“…We also utilized these proteins to construct disease diagnostic models, and notably, models for 14 out of 18 diseases achieved an area under the curve (AUC) exceeding 0.8, indicating promising diagnostic potential. …”
Get full text

Patterns of Postablation Recurrence and Adverse Cardiovascular Outcomes in Patients With Atrial Fibrillation by Sitong Li, Jingrui Zhang, Song Zuo, Jue Wang, Yiwei Lai, Mingxiao Li, Zejun Yang, Zixu Zhao, Manlin Zhao, Lan Ren, Zhen Wang, Chao Jiang, Liu He, Xueyuan Guo, Xiaoxia Liu, Ribo Tang, Ning Zhou, Caihua Sang, Deyong Long, Xin Du, Jianzeng Dong, Changsheng Ma

“…Cardiovascular outcomes included cardiovascular death, thromboembolism, and cardiovascular hospitalization. Cox proportional models with landmark analysis were used to assess the relationship between recurrence patterns and outcomes. …”
Get full text

AGN STORM 2. X. The Origin of the Interband Continuum Delays in Mrk 817 by Hagai Netzer, Michael R. Goad, Aaron J. Barth, Edward M. Cackett, Keith Horne, Chen Hu, Erin Kara, Kirk T. Korista, Gerard A. Kriss, Collin Lewin, John Montano, Nahum Arav, Ehud Behar, Michael S. Brotherton, Doron Chelouche, Gisella De Rosa, Elena Dalla Bontà, Maryam Dehghanian, Gary J. Ferland, Carina Fian, Yasaman Homayouni, Dragana Ilić, Shai Kaspi, Andjelka B. Kovačević, Hermine Landt, Luka Č. Popović, Thaisa Storchi-Bergmann, Jian-Min Wang, Fatima Zaidouni

“…Here, we present a comprehensive analysis of the broadband continuum variations using detailed modeling of the broad line region (BLR), several types of disk winds classified by their optical depth, and new numerical simulations. …”
Get full text

SARS-CoV-2 lineage B.1.1.7 is associated with greater disease severity among hospitalised women but not men: multicentre cohort study by Judith Breuer, Catherine F Houlihan, Nick Freemantle, David Partridge, Gaia Nebbia, Jacqui Prieto, Gee Yen Shin, Andrew Copas, Oliver Stirrup, Kenneth Laing, Rachel Williams, Helen Wheeler, Paul Randell, Ana da Silva Filipe, Maria-Teresa Cutino-Moguel, Tommy Rampling, Tabassum Khan, James Price, Eleni Nastouli, Katie Johnson, Sharon Glaysher, Scott Elliott, Helen Umpleby, Emanuela Pelosi, Emma Thomson, Cristina Venturini, Anna Riddell, Alison Cox, Andrew C Hayward, Malin Bergström, David Harrington, Charlotte Williams, Tanzina Haque, Dianne Irish, Adrienn Angyal, Marios Margaritis, Moira Spyer, Florencia Boshier, José Afonso Guerra-Assunção, Adela Alcolea-Medina, Angela Beckett, Themoula Charalampous, Raghavendran Kulasegaran Shylini, Beatrix Kele, Irene Monahan, Guy Mollett, Matthew Parker, Sunando Roy, Joshua Taylor, Sophie Weller, Eleri Wilson-Davies, Phillip Wade, Joseph Hughes, Tabitha Mahungu, Cassie Pope, Samuel Robson, Kordo Saeed, Thushan de Silva, Luke Snell, Adam A Witney, James Blackstone, Leanne Hockey, Georgia Marley, Christine Peters, Flavia Flaviani, Bindi Patel, Tom G S Williams, Rahul Batra, Jonathan D Edgeworth, Pinglawathee Madona, Jennifer Hart, Juanita Pang, Helena Tutill, Nadua Bayzid, Marius Cotic, Luke Green, Benjamin Lindsey, Amy State, Alison Cope, Peijun Zhang, Max Whiteley, Marta Gallis Ramalho, Stella Christou, Stavroula Louka, Hailey Hornsby, Benjamin Foulkes, Paige Wolverson, Joe Heffer, Nikki Smith, Salman Goudarzi, Chris Fearn, Kate Cook, Katie Loveson, Adhyana Mahamana, Buddhini Samaraweera, Siona Silveira, Stephen Aplin, Sarah Jeremiah, Matthew Harvey, Thea Sass, Ngee Keong Tan, Claudia Cardoso Pereira, Dan Frampton, Matt Byott, Judith Heaney, Emilie Sanchez, Stavroula M Paraskevopoulou

“…Associations between the variant and the outcomes of all-cause mortality and intensive therapy unit (ITU) admission were evaluated using mixed effects Cox models adjusted by age, sex, comorbidities, care home residence, pregnancy and ethnicity.Findings Sequences were obtained from 2341 inpatients (HOCI cases=786) and analysis of clinical outcomes was carried out in 2147 inpatients with all data available. …”
Get full text

La gestion de l’eau à Bibracte (Saône-et-Loire), avant et après la Conquête romaine by Laetitia Borau

“…Thanks to the present study it can be assumed that in Bibracte there were specific construction methods used for the hydraulic structures corresponding to local, i.e. …”
Get full text

Survival after radical cystectomy for bladder cancer: Multicenter comparison between minimally invasive and open approaches by Weibin Xie, Junming Bi, Qiang Wei, Ping Han, Dongkui Song, Lei Shi, Dingwei Ye, Yijun Shen, Xin Gou, Weiyang He, Shaogang Wang, Zheng Liu, Jinhai Fan, Kaijie Wu, Zhiwen Chen, Xiaozhou Zhou, Chuize Kong, Yang Liu, Chunxiao Liu, Abai Xu, Baiye Jin, Guanghou Fu, Wei Xue, Haige Chen, Tiejun Pan, Zhong Tu, Tianxin Lin, Jian Huang

“…Objective: To investigate oncological outcomes in patients with bladder cancer who underwent minimally invasive radical cystectomy (MIRC) or open radical cystectomy (ORC). Methods: We identified patients with bladder cancer who underwent radical cystectomy (RC) in 13 centers of the Chinese Bladder Cancer Consortium (CBCC). …”
Get full text

X-chromosome-linked miR-542-5p as a key regulator of sex disparity in rats with adjuvant-induced arthritis by promoting Th17 differentiation by Jiu Jie Yang, Zhi Li, Lin Na Wang, Bai Xiong Huang, Jerome P. L. Ng, Xiong Fei Xu, Yu Ping Wang, David Wei Zhang, Bo Qin, Ding Qi Zhang, Chang Liu, Wei Dan Luo, Betty Yuen Kwan Law, Hui Miao Wang, Meng Han Liu, Xiao Yun Yun, Joyce Tsz Wai Chan, Wan Yu Wu, Yi Ting Li, Peter Kam Fai Cheung, Man Chon Pou, Kat Sang Ha, Wang Fai Ao Ieong, Chi Hou Leong, Kit Ieng Leong, Chan Wang Lei, Lek Hang Cheang, Vincent Kam Wai Wong

“…This study aims to investigate the possible role of X-linked miR-542-5p in RA pathogenesis and gender differences. Methods We investigated the impact of miR-542-5p on RA pathogenesis and gender differences by manipulating its expression in various rat models. …”
Get full text

Jab1 regulates HRR mRNA stability to modulate PARP inhibitor sensitivity in triple-negative breast cancer by Xin Peng, Yingying Wang, Zixiang Yu, Shengfan Huang, Shaolu Zhang, Zhenxing Zhong, Yongzhe Wang, Shanshan Liu, Kailin Wang, Christophe Nicot, Francois X. Claret, Dexin Kong

“…This study investigates the role of Jab1 in regulating the stability of homologous recombination repair (HRR)-related RNAs and evaluates its potential as a therapeutic target to enhance PARPi sensitivity in TNBC. Methods RNA-Seq analysis revealed that shRNA-mediated Jab1 knockdown profoundly affected HRR and DNA replication processes in TNBC cells. …”
Get full text

Clinicopathologic and genomic features associated with brain metastasis after resection of lung adenocarcinomaCentral MessagePerspective by Elizabeth G. Dunne, MD, Cameron N. Fick, MD, Brooke Mastrogiacomo, MS, Kay See Tan, PhD, Nicolas Toumbacaris, MSPH, Stijn Vanstraelen, MD, Gaetano Rocco, MD, Jaime E. Chaft, MD, Puneeth Iyengar, MD, Daniel Gomez, MD, Prasad S. Adusumilli, MD, Bernard J. Park, MD, James M. Isbell, MD, Matthew J. Bott, MD, Smita Sihag, MD, Daniela Molena, MD, James Huang, MD, David R. Jones, MD

“…Objective: To identify clinicopathologic and genomic features associated with brain metastasis after resection of lung adenocarcinoma (LUAD) and to evaluate survival after brain metastasis. Methods: Patients who underwent complete resection of stage I-IIIA LUAD between 2011 and 2020 were included. …”
Get full text

Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components by Marion Henderson, Anja Wittkowski, Katie Buston, Karen Crawford, Alice MacLachlan, Alex McConnachie, Emma McIntosh, Claudia-Martina Messow, Catherine Nixon, Rosaleen O’Brien, Shona Shinwell, Daniel Wight, Yiqiao Xin, Rachel Calam, Ruth Dundas, James Law, Helen Minnis, Lucy Thompson, Philip Wilson

“…Process evaluation A realist process evaluation (PE) was undertaken and utilised a range of methods, including participant observation, interviews and questionnaires to examine ‘what works for whom in what circumstances?’ …”
Get full text

Study protocol for the Bio-HEAT study: Investigating the Biological pathways from HEAT exposure to preterm birth and other adverse maternal and child health outcomes in South Afric... by Lebohang Radebe, Nicholas B. Brink, Clive Gray, Marié Landsberg, Robyn Hetem, G Justus Hofmeyr, Phelelani T. Mpangase, Sibusisiwe Makhanya, Michael Urban, Shane Norris, Amy Wise, Valerie Vannevel, Karl-Gunter Technau, Matthew F. Chersich, Renate Strehlau, Ijeoma Solarin, Kimberly Mc Alpine, Darshnika Pemi Lakhoo, Admire Chikandiwa, Howard Chang, Margaret M. Brennan

“…Understanding the pathways explaining these associations is important given rising global temperatures, and the urgent need for developing and testing adaptive interventions. Methods This transdisciplinary study in Johannesburg, South Africa, will monitor a cohort of 200 women from their second trimester until one-year postpartum, alongside their infants. …”
Get full text

Grip Strength and Age-Related Ocular Diseases: Insights from Observational, Mendelian Randomization, and Mediation Analyses by Chao Chen, Dongling Guo, Jiaqi Meng, MD, Jiao Qi, MD, Keke Zhang, MD, Wenwen He, MD, Yih Chung Tham, PhD, Xiangjia Zhu, PhD

“…Subjects: A total of 307 796 UK Biobank participants with grip strength and covariates data available. Methods: Logistic regression models were used to evaluate the associations between grip strength and age-related ocular diseases. …”
Get full text

COL4A5-p.Gly624Asp is the Predominant Variant in Europe Associated With a Mild Alport Syndrome Phenotype by Bastian M. Krüger, Annika Jens, Anna Neuhaus, Jasmina Ćomić, Riccardo Berutti, Jonathan de Fallois, Friederike Petzold, Johannes Münch, Jan Kowald, Tom H. Lindner, Klemens Budde, Klara K. Brüning, Julia Thumfart, Jacob Haas, Carolin B. Brigl, Kerstin Amann, Velibor Tasic, Nora Abazi-Emini, Valbona Nushi-Stavileci, Jovana Putnik, Nataša Stajić, Evelyn Seelow, Charlotte Hammett, Kai-Uwe Eckardt, Korbinian M. Riedhammer, Eva V. Schrezenmeier, Julia Hoefele, Jan Halbritter

“…Allelic and gene dosage effects drive phenotypic differences and should be incorporated into future risk models.…”
Get full text

Adaptación, validación e invarianza factorial de una escala para evaluar la calidad de los cursos virtuales desarrollados para estudiantes peruanos de ciencias de la salud durante... by Claudio Intimayta-Escalante, Rubí Plasencia-Dueñas, Janeth N. Nuñez-Lupaca, Kevin Flores-Lovon, Nancy Ramirez-Bernuy, Giancarlo Pares-Ballasco, Natalia Barrientos-Odias, Ronald Castillo-Blanco

“…Factor invariance was considered adequate when the ΔCFI≤0.010 and the ΔRMSEA≤0.015 between models at different levels. Reliability was assessed with the alpha and omega index. …”
Get full text

Incidence, clinical and genomic trends of hospital- and Non-hospital-onset KPC-producing Klebsiella pneumoniae infections before and during the COVID-19 era: a ten-year interrupted... by Manuel Recio-Rufián, Teresa López-Viñau, Víctor Gálvez-Soto, Ángela Cano, Rafael Ruiz-Montero, Belén Gutiérrez-Gutiérrez, Irene Gracia-Ahufinger, Germán Peñalva, Juan Antonio Marín-Sanz, Miriam Marín-Sanz, David Segorbe, Juan Jesús Pineda-Capitán, Montserrat Muñoz-Rosa, Cristina Riazzo, Federico Giovagnorio, Elisa Ruiz-Arabi, José David Torres-Peña, Juan José Castón, Isabel Machuca, Inmaculada Salcedo-Leal, Luis Martínez-Martínez, Elena Pérez-Nadales, Julián Torre-Cisneros, KLEBMAN study group

“…Interrupted time series and ARIMA models assessed ASP and IPC impacts on incidence density (ID). …”
Get full text

PDK2-enhanced glycolysis aggravates fibrosis via IL11 signaling pathway in Graves’ orbitopathy by Zhiyu Peng, Zhiyu Peng, Zhiyu Peng, Zhiyu Peng, Rui Huang, Rui Huang, Rui Huang, Lu Gan, Lu Gan, Lu Gan, Jinghan Wang, Jinghan Wang, Jinghan Wang, Xiaofeng Li, Xiaofeng Li, Xiaofeng Li, Jie Ding, Jie Ding, Jie Ding, Yinan Han, Yinan Han, Yinan Han, Jihong Wu, Jihong Wu, Jihong Wu, Kang Xue, Kang Xue, Kang Xue, Jie Guo, Jie Guo, Jie Guo, Rui Zhang, Jiang Qian, Ruiqi Ma, Ruiqi Ma, Ruiqi Ma

“…This study aimed to identify the relationship between glycolysis and TGFβ1-IL11 signaling pathway and investigate the role of IL11 in glycolysis-facilitated fibrosis in GO.MethodsOrbital connective tissues were collected from GO and control patients. …”
Get full text