Legal Challenges of Marine Insurance Laws in the Use of Unmanned Ships by Mahsa Bahadoran- Baghbaderani, Masoud Shirani, Reza Soltani

“…The results of this research, which was written with the descriptive-analytical research method, indicate that although the existing rules in current insurance laws do not pose a barrier to insuring unmanned ships, there is a need to establish a suitable legal framework due to the emergence of new concepts in such ships. …”
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Social determinants of recovery from ongoing symptoms following COVID-19 in two UK longitudinal studies: a prospective cohort study by Tim Spector, Adrian Hopper, Sebastien Ourselin, Emma L Duncan, Julia Brown, Carole H Sudre, Jie Deng, Christina Hu, Ruth C E Bowyer, Ellen J Thompson, Jonathan Wolf, Claire J Steves, Marc Modat, Benjamin Murray, Andy Guise, Nicholas Harvey, Deborah Hart, Alexander Hammers, Carole Sudre, Michela Antonelli, Liane S Canas, Erika Molteni, Eric Kerfoot, Claire Steves, Vicky Bowyer, Emma Duncan, Nathan Cheetham, Ayrun Nessa, Samuel Wadge, Nathan J Cheetham, María Paz García, J D Carpentieri, Rose S Penfold, Nicholas R Harvey, Khaled Rjoob, Liane Canas, Joan Capdevila Pujol, Lynn Cherkas, Katie Doores, Michael Malim

“…Whether combinations of pre-existing social factors, particularly those that confer cumulative advantage and disadvantage, affect recovery from ongoing symptoms following COVID-19 and long COVID is less well understood.Methods We analysed data on self-perceived recovery following self-reported COVID-19 illness in two UK community-based cohorts, COVID Symptom Study Biobank (CSSB) (N=2548) and TwinsUK (N=1334). …”
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Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19Research in context by Hui Ying, Xueyan Wu, Xiaojing Jia, Qianqian Yang, Haoyu Liu, Huiling Zhao, Zhihe Chen, Min Xu, Tiange Wang, Mian Li, Zhiyun Zhao, Ruizhi Zheng, Shuangyuan Wang, Hong Lin, Yu Xu, Jieli Lu, Weiqing Wang, Guang Ning, Jie Zheng, Yufang Bi

“…Limited effective immune-mediated antiviral drugs have been launched. Methods: We conducted a Mendelian randomization (MR) and colocalization analysis using 26,597 single-cell expression quantitative trait loci (sc-eQTL) to proxy effects of expressions of 16,597 genes in 14 peripheral blood immune cells and tested them against four COVID-19 outcomes from COVID-19 Genetic Housing Initiative GWAS meta-analysis Round 7. …”
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Exposure to a mixture of arsenic species and growth indicators in 6–12-year-old children from the cycles 2007–2020 NHANES by Miguel García-Villarino, Rocío Fernández-Iglesias, Ana Victoria García, Elsa Villa-Fernández, Lucía Fernández-Arce, Isolina Riaño-Galán, Carmen Lambert, Vicente Martín, Margaret R. Karagas, Elías Delgado-Álvarez, Ana Fernández-Somoano, Antonio J. Signes-Pastor

“…Hence, this study aims to analyze how the combined effects of As and its metabolites can impact growth indicators in 1,792 US children aged 6–12 years, from the NHANES. Methods: Levels of arsenic species in urine were measured using HPLC coupled with ICP-DRC-MS during the 2007–2020 NHANES cycles. …”
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Retrospective study of definitive therapy for head and neck mucosal melanoma: The RESUME study by Motoo Nomura, Naomi Kiyota, Yasushi Shimizu, Atsushi Motegi, Tetsuo Akimoto, Takashi Mukaigawa, Takashi Fujii, Nayuta Tsushima, Kiyoto Shiga, Taiji Koyama, Daisuke Kawakita, Akira Ohkoshi, Mitsuhiko Nakahira, Nobuhiro Hanai, Shigeyuki Murono, Tsutomu Ueda, Hiroki Mitani, Mutsukazu Kitano, Junichiro Ohori, Yuki Saito, Nobuhiko Oridate, Naoki Nishio, Hisayuki Kato, Kenji Okami, Takenori Ogawa, Yasushi Fujimoto, Mioko Matsuo, Kiyoaki Tsukahara, Morimasa Kitamura, Satoshi To, Shujiro Minami, Yosuke Ariizumi, Soichi Fumita, Akihiro Homma

“…In addition, the role of immune checkpoint inhibitors (ICIs) in improving survival in patients with locally advanced HNMM has not been fully evaluated. Patients and methods: This multi-institutional retrospective cohort study analyzed patients with locally advanced HNMM who were treated within the period October 2014 to March 2022. …”
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Advancements and gaps in natural language processing and machine learning applications in healthcare: a comprehensive review of electronic medical records and medical imaging by Priyanka Khalate, Shilpa Gite, Shilpa Gite, Biswajeet Pradhan, Chang-Wook Lee

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Endovascular treatment for cerebral venous thrombosis: a multicenter study in China by He-Tao Bian, Xia Wang, Gui-You Liu, Chen Zhou, Ran Meng, Lan Liu, Jian-Gang Duan, Feng Yan, Chuan-Hui Li, Min Li, Wen Hui, Xu-Xiang Zhang, Dong Zhao, Ya-Peng Li, Qi Fang, De-Zhi Kang, Hong-Liang Zeng, Zhi-Jian Liang, Zheng-Hao Shi, Wei Yue, Qin-Jian Sun, Gui-Sheng Chen, Jian-Long Song, Zhong-Rui Yan, Qiu-Hong Ji, Kai-Jie Wang, Lu-Sha Tong, Xiao Hu, Wen-Feng Cao, Wei Yan, Rui-Jiang Gao, Qi Li, Jian-Yi Wang, Yi Liu, Bao-Jun Wang, Xiao-Hua Wang, Sheng-Tao Yao, Ye Lang, Hai-Peng Li, Craig S. Anderson, Xun-Ming Ji, on behalf of the RETAIN-CH Investigators and Coordinators

“…Abstract Background Endovascular treatment (EVT) is gaining popularity for the management of severe forms of cerebral venous thrombosis (CVT), but the evidence supporting its efficacy and safety is limited. Methods This multicenter study included patients with CVT admitted to 104 hospitals in 31 provinces/cities in China between January 2018 and June 2022. …”
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PDGF-BB overexpressing dental pulp stem cells improve angiogenesis in dental pulp regeneration by Wentao Jiang, Wentao Jiang, Wentao Jiang, Wentao Jiang, Shuhan Duan, Shuhan Duan, Shuhan Duan, Shuhan Duan, Weiping Li, Huijiao Yan, Huijiao Yan, Huijiao Yan, Huijiao Yan, Chenli Si, Chenli Si, Chenli Si, Ningwei Xu, Ningwei Xu, Ningwei Xu, Ningwei Xu, Yishuai Li, Yishuai Li, Yishuai Li, Yishuai Li, Wenjie Zhang, Wenjie Zhang, Wenjie Zhang, Wenjie Zhang, Shensheng Gu, Shensheng Gu, Shensheng Gu, Shensheng Gu

“…Through Single-cell RNA sequencing (scRNA-seq) analysis of human dental pulp, we discovered a PDGF (+) mesenchymal subset exhibiting enhanced angiogenic signatures, suggesting targeted cell selection could overcome this bottleneck.MethodsScRNA-seq identified PDGF (+) subpopulation in human pulp samples, validated through multiplex immunohistochemical of the localization of PDGF/CD73/CD31. …”
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Canagliflozin alleviates progestin resistance by suppressing RARβ/CRABP2 signaling in THRB knockout endometrial cancer cells by Ye Yang, Ye Yang, Jieyun Zhou, Qiaoying Lv, Qicheng Ni, Qicheng Ni, Baichun Hu, Yulong Wang, Shuning Qu, Guoting Li, Wenjie Yang, Ruihua Zhong, Xiaojun Chen, Yan Zhu

“…Previous studies have suggested that silencing thyroid hormone receptor B (THRB) is associated with progestin resistance in EC cells.MethodsTHRB-knockout RL95-2 (THRB(−/−)/RL95-2) cells were constructed to investigate progestin resistance mechanisms. …”
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Exploring the impact of chronic urticaria profile as a key predictor of alexithymia: A cross‐sectional study by Ivan Cherrez‐Ojeda, Simon Francis Thomsen, Ana M. Gimenez‐Arnau, Jennifer Astrup Sørensen, Hermenio Lima, Kiran Godse, Carole Guillet, Luis Escalante, Astrid Maldonado, Gonzalo Federico Chorzepa, Blanca Morfin‐Maciel, Jose Ignacio Larco Sousa, Erika deArruda‐Chaves, Abhishek De, Daria Fomina, Anant Patil, Roberta Jardim Criado, Luis Felipe Ensina, Solange O. R. Valle, Rosana Câmara Agondi, Herberto Chong Neto, Nelson Rosario, German Dario Ramon, Marco Faytong‐Haro, Isabel Ogueta, Ivan Tinoco Moran, Jennifer Donnelly, Emek Kocatürk, Anna Zalewska‐Janowska, Karla Robles‐Velasco

“…This study aimed to identify predictors of alexithymia in CU patients by focusing on the impact of coexisting mental illnesses and antihistamine use. Methods An online survey was distributed to specialized allergy and dermatology centers from 2021 to 2022. …”
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Integration of genomic and pharmacokinetic data to predict clinical outcomes in HIV-associated cryptococcal meningitis by Dr Katharine Stott, Mr Jason Mohabir, Miss Kate Bowers, Assistant Professor Jennifer Tenor, Associate Professor Dena Tofaletti, Dr Jennifer Unsworth, Ms Ana Jimenez-Valverde, Mr Ajisa Ahmadu, Dr Melanie Moyo, Mrs Ebbie Gondwe, Mrs Wezi Chimang'anga, Mr Madalitso Chasweka, Dr David Lawrence, Professor Joseph Jarvis, Professor Tom Harrison, Professor William Hope, Professor David Lalloo, Professor Henry Mwandumba, Professor John Perfect, Professor Christina Cuomo

“…We integrated pathogen genomic and phenotypic data with pharmacokinetic data to assess the relative contribution of each to clinical outcomes from cryptococcal meningitis. Methods: Based in Malawi, we conducted a sub-study of the phase 3 Ambition-CM trial (ISRCTN72509687), collecting plasma and cerebrospinal fluid at serial time points during the first 14 days of antifungal therapy. …”
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Metabolic Acidosis Is Associated With an Accelerated Decline of Allograft Function in Pediatric Kidney Transplantation by Agnieszka Prytula, Rukshana Shroff, Ineke van Gremberghe, Kai Krupka, Justine Bacchetta, Elisa Benetti, Ryszard Grenda, Isabella Guzzo, Nele Kanzelmeyer, Bahar Büyükkaragöz, Birgitta Kranz, Hülya Nalçacıoğlu, Jun Oh, Lars Pape, Mohan Shenoy, Anne-Laure Sellier-Leclerc, Burkhard Tönshoff, Gema Ariceta, Atif Awan, Sevcan Bakkaloğlu, Marjolein Bonthuis, Charlotte Bootsma Robroeks, Antonia Bouts, Martin Christian, Marlies Cornelissen, Ali Duzova, Nasrin Esfandiar, Luciana Ghio, Ryszard Grenda, Isabella Guzzo, Maria Herrero Goni, Julien Hogan, Nattaphorn Hongsawong, Nele Kanzelmeyer, Aysun Karabay Bayazit, Gülşah Kaya Aksoy, Noel Knops, Linda Koster Kamphuis, Daniella Levy Erez, Victor Lopez-Baez, Alvaro Madrid, Stephen Marks, Anette Melk, Luisa Murer, Lars Pape, Licia Peruzzi, Edita Petrosyan, Evgenia Preka, Nikoleta Printza, Andreea Liana Rachisan, Ann Raes, Mohan Shenoy, Oguz Soylemezoglu, Luca Dello Strologo, Ana Teixeira, Rezan Topaloglu, Markus Weitz, Jakub Zieg, Galia Zlatanova, Christian Patry, Jerome Harambat, Ayşe Ağbaş, Varvara Askiti, Marina Avramescu, Justine Bacchetta, Sevcan Bakkaloglu, Marjolein Bontuis, Caroline Booth, Laurene Dehoux, Giacomo Dizazzo, Dorota Drozdz, Ismail Dursun, Michaela Gessner, Jaap Groothoff, Giuliana Guido, Isabella Guzzo, Aysun Karabay Bayazit, Guenter Klaus, Linda Koster-Kamphuis, Alexander Lalayiannis, Maren Leifheit-Nestler, Sinha Manish, Chiara Matteucci, Jun Oh, Ozan Ozkaya, Edita Petrosyan, Christine Pietrement, Agnieszka Prytula, George Reusz, Franz Schaefer, Claus Peter Schmitt, Anne Schön, Fatma Lale Sever, Stella Stabouli, Serra Sürmeli Döven, Camilla Tondel, Enrico Verrina, Enrico Vidal, Dean Wallace, Zainab Arslan, M. Bald, H. Fehrenbach, D. Haffner, M. Hansen, C. Hempel, U. John, G. Klaus, J. König, B. Lange-Sperandio, D. Müller, J. Oh, L. Pape, M. Pohl, K. Sauerstein, G. Schalk, H. Staude, P. Strotmann, L.T. Weber, M. Weitz, L. Berta, K. Heindl-Rusai

“…Introduction: We investigated the relationship between metabolic acidosis over time and allograft outcome in pediatric kidney transplantation (KTx). Methods: This registry study collected data up to 10 years posttransplant. …”
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Triglyceride glucose-weight-adjusted waist index as a cardiovascular mortality predictor: incremental value beyond the establishment of TyG-related indices by Jiajun Qiu, Jin’e Li, Shan Xu, Jingqi Yang, Haixia Zeng, Yuying Zhang, Shiqi Yang, Lixuan Fang, Jiadian Huang, Hongtao Zhou, Jiaying Feng, Yujie Zan, Jia Zhan, Jianping Liu

“…Weighted Cox proportional hazards models were used to assess the associations between TyG-related indices and cardiovascular mortality. …”
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FirstCPR: A pragmatic community organisation-based cluster randomised trial to increase community training and preparedness to respond to out-of-hospital cardiac arrest by Sonali Munot, Julie Redfern, Janet E Bray, Blake Angell, Andrew Coggins, Alan Robert Denniss, Garry Jennings, Sarah Khanlari, Pramesh Kovoor, Saurabh Kumar, Kevin Lai, Simone Marschner, Paul M. Middleton, Ian Oppermann, Zoe Rock, Christopher Semsarian, Matthew Vukasovic, Adrian Bauman, Clara K. Chow

“…Outcomes were assessed via surveys at 12 months and pre-specified analysis involved hierarchical mixed-models. Results: Of 165 randomised clusters (82 intervention), 58% were sports and 42% were social/faith-based. …”
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GPATCH3, a splicing regulator that facilitates tumor immune evasion via the modulation of ATPase activity of DHX15 by Tingrong Ren, Gaigai Wei, Gaigai Wei, Jingjing Yi, Jingjing Yi, Yuqi Zhang, Haiping Zhao, Nana Wu, Huiling Zhang, Zhihan Guo, Yihan Wang, Jiating Kuang, Zhaoying Sheng, Duanwu Zhang

“…Here, we identify GPATCH3, a previously uncharacterized G-patch domain–containing protein, as a critical modulator of alternative splicing and immune regulation in cancer.MethodsWe employed biochemical studies, splicing reporter assays, and transcriptomic analyses to elucidate the function of GPATCH3. …”
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Fumarprotocetraric acid and geraniin were identified as novel inhibitors of human respiratory syncytial virus infection in vitro by Chao Wang, Chao Wang, Yi-Man Huang, Yi-Man Huang, Jun Zhao, Jun Zhao, Yi-Ming Bai, Yi-Ming Bai, Cai-Qin Yan, Cai-Qin Yan, Guan-Hua Du, Guan-Hua Du, Li-Shu Zheng, Li-Shu Zheng, Ai-Lin Liu, Ai-Lin Liu

“…In this study, natural products were screened to identify novel anti-RSV inhibitors.MethodsThe antiviral effect of 320 compounds on RSV in HEp-2 cells was tested using a Cytopathic effect (CPE) inhibition assay. …”
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Systematic Review of the Effects of Iron on Cardiovascular, Kidney, and Safety Outcomes in Patients With CKD by Bernard Chan, Amanda Varghese, Sunil V. Badve, Roberto Pecoits-Filho, Murilo Guedes, Clare Arnott, Rebecca Kozor, Emma O’Lone, Min Jun, Sradha Kotwal, Geoffrey A. Block, Glenn M. Chertow, Scott D. Solomon, Muthiah Vaduganathan, Vlado Perkovic, Brendon L. Neuen

“…We evaluated the effects of iron versus usual care or placebo on the clinical outcomes in patients with CKD. Methods: We conducted a systematic review and meta-analysis of randomized trials on i.v. or oral iron in patients with CKD (PROSPERO CRD42023453468). …”
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Multicenter validation of an RNA-based assay to predict anti-PD-1 disease control in patients with recurrent or metastatic head and neck squamous cell carcinoma: the PREDAPT study by Howard L McLeod, A Dimitrios Colevas, Georges Azzi, Kevin C Flanagan, Douglas Adkins, Jessica Ley, Ezra E W Cohen, James Wade, Jon Earls, Jeffrey Hiken, Rachel L Wellinghoff, Michelle M Ponder, William H Westra, Vera Vavinskaya, Leisa Sutton, Ida Deichaite, Orlan K Macdonald, Karim Welaya, Andrew W Pippas, Jennifer Slim, Bruce Bank, Xingwei Sui, Steven E Kossman, Todd D Shenkenberg, Warren L Alexander, Katharine A Price, David N Messina, Jarret I Glasscock, Eric J Duncavage

“…There is a critical clinical need to identify patients who benefit from these antiprogrammed cell death protein 1 (anti-PD-1) immune checkpoint inhibitors.Methods Here, we report findings from a multicenter observational study, PREDicting immunotherapy efficacy from Analysis of Pre-treatment Tumor biopsies (PREDAPT), conducted across 17 US healthcare systems. …”
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Sexual dimorphism in the association of umbilical cord blood lipidome with abdominal fat in early childhood by Kothandaraman Narasimhan, Mya Thway Tint, Li Chen, Sartaj Ahmad Mir, Suresh Anand Sadananthan, Navin Michael, Adaikalavan Ramasamy, Karen Mei-Ling Tan, Priti Mishra, Anne K. Bendt, Kok Hian Tan, David Cameron-Smith, Yap Seng Chong, Peter D. Gluckman, Peter J. Meikle, Melvin Khee Shing Leow, Fabian Yap, Yung Seng Lee, Chan Shiao Yng, Johan G. Eriksson, S Sendhil Velan, Neerja Karnani, Markus R. Wenk

“…Understanding these relationships could provide insights into early sex-specific differences in lipid metabolism. Methods We conducted lipidomics of umbilical cord blood plasma samples (350 (46.6%) girls and 401 (53.4%) boys) from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort. …”
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Clonal divergence and genomic meltdown in prostatic pleomorphic giant cell adenocarcinoma by Xiaoshi Ma, Xiaoshi Ma, Kun Chen, Kun Chen, Jing Zhang, Liming Liu, Liming Liu, Jiping Luo, Kaipeng Huang, Hongying Zhang, Danni Liu, Jizhou Gou, Changyin Feng, Xia Zhao, Wanying Li, Lipeng Chen, Li Yin, Li Yin, Li Yin, Xianlin Meng, Zhiqiang Cheng, Zhiqiang Cheng

“…This study presents the first integrative clinicogenomic profiling of PGCA, revealing a novel prognostic gene signature with direct implications for diagnosis and treatment.MethodsWe conducted comprehensive clinicopathological and genomic analyses of a treatment-refractory PGCA case using histology, immunohistochemistry (IHC), whole-exome sequencing (WES), clonal evolution modeling, and multicohort validation. …”
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