Association of Alzheimer's Disease Blood Biomarkers With Sarcopenia Incidence and Progression: A 12‐Year Population‐Based Study by Chiara Ceolin, Caterina Gregorio, Alice Margherita Ornago, Giulia Grande, Martina Valletta, Caterina Trevisan, Adrián Carballo Casla, Giuseppe Sergi, Amaia Calderón‐Larrañaga, Davide Liborio Vetrano

“…This study investigates the relationship between baseline blood biomarkers of Alzheimer's disease (AD) and long‐term sarcopenia trajectories in a Swedish cohort of older adults, while also examining potential sex‐based differences. Methods The study analysed 2291 participants aged ≥ 60 years (61.5% females) over a 12‐year follow‐up, classifying sarcopenia into three stages (no, probable and confirmed sarcopenia) using modified EWGSOP2 criteria. …”
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An eHealth Delivery Alternative for Cancer Genetic Testing for Hereditary Predisposition in Patients With Metastatic Cancers: Protocol for a Randomized Trial by Kimberley T Lee, Briana McLeod, Brian Egleston, Sarah Brown, Sarah Howe, Dominique Fetzer, Lauren Gutstein, Cara Cacioppo, Dana Clark, Susan M Domchek, Jessica Ebrahimzadeh, Dana Falcone, Demetrios Ofidis, Hannah Griffin, Rajia Mim, Santina Hernandez, Linda Fleisher, Kelsey Karpink, Enida Selmani, Aysha Tahsin, Lynne Wagner, Michelle Weinberg, Kuang Yi-Wen, Elisabeth Wood, Angela R Bradbury

“…ResultsAs of January 2025, we have completed enrollment of 229 participants. Data analysis is ongoing, and we expect the results to be published in 2025. …”
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Paradoxical Effect of Myosteatosis on the Immune Checkpoint Inhibitor Response in Metastatic Renal Cell Carcinoma by Jiwoong Yu, Hyeonju Ahn, Kyung Yeon Han, Wan Song, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Se Hoon Park, Woong‐Yang Park, Ji Hyun Lee, Minyong Kang

“…This study investigated the prognostic implications of pretreatment low skeletal muscle mass (LSMM) and myosteatosis in patients with mRCC undergoing first‐line ICI‐based therapies, comparing outcomes between PD‐1 inhibitor + CTLA‐4 inhibitor and PD‐1 inhibitor + TKI, incorporating single‐cell RNA sequencing. Methods A retrospective analysis was performed on 90 patients with mRCC treated with ICI‐based therapies between November 2019 and March 2023. …”
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The effect of malaria prevention and control interventions on malaria morbidity among children under 5 years and pregnant women in Kintampo North Municipality, Ghana by Christopher Tamal, Chrysantus Kubio, Delia Akosua Bandoh, Maurice Owiny, Ernest Kenu, Edwin Andrew Afari, Samuel Oko Sackey, Donne Kofi Ameme, Priscillia Nortey, Timothy Letsa, Alice Vorleto, Charles Gyamfi, Isaac Addisi

“…We analysed the malaria surveillance data to assess the trends and the association between some malaria prevention interventions and malaria incidence in Kintampo North Municipality (KNM). Methods: We extracted data on malaria indicators and interventions from the District Health Information Management System 2 database for 2012–2016. …”
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Differential expression of plasma extracellular vesicles microRNAs and exploration of their association with bone metabolism in childhood trauma participants treated in a psychosom... by Yangyang He, Yangyang He, Karin Wuertz-Kozak, Karin Wuertz-Kozak, Petra Cazzanelli, Sanne Houtenbos, Sanne Houtenbos, Francisco Garcia-Carrizo, Francisco Garcia-Carrizo, Tim J. Schulz, Tim J. Schulz, Tim J. Schulz, Pia-Maria Wippert, Pia-Maria Wippert

“…This research aimed to elucidate the association between childhood trauma, a specific form of ELS, and bone metabolism through studying miRNA in EVs within three steps: firstly, examining alterations of EV miRNAs between ELS and controls, secondly analyzing associations between altered EV miRNAs and bone markers, and thirdly exploring the target gene prediction and enrichment pathways of altered EV miRNAs.MethodsThis study included a subgroup of the DEPREHA project (total n=208) from a psychosomatic clinic. …”
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Targeted Delivery of Exosome-Derived miRNA-185-5p Inhibitor via Liposomes Alleviates Apoptosis and Cuproptosis in Dilated Cardiomyopathy by Xu S, Zeng Y, Tan X, Zhang G, Xu A, Fan H, Yu F, Qin Z, Song Y, Jiang Y, Wang X, Zhang D, Nong Y, Lian D, Tang J, Zhou Y

“…This system was used in both in vitro and in vivo models of DCM induced by doxorubicin (DOX). We evaluated the effects of this treatment on cardiac function, apoptosis, cuproptosis, oxidative stress, and fibrosis using echocardiography, histological analysis, Western blotting, and biochemical assays.Results: In vitro experiments demonstrated that the Lipo@miR-185-5p inhibitor markedly attenuated apoptosis and cuproptosis in H9C2 cells and iPSC-derived cardiomyocytes, with a 42.6% reduction in apoptotic cell rates and over 50% downregulation of cuproptosis-related markers (both P < 0.01). …”
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Relationship between time-varying achieved HbA1c and risk of coronary artery disease events among common haptoglobin phenotype groups with type 2 diabetes: the ADVANCE study by Giuseppe Mancia, Mark Woodward, John Chalmers, Neil Poulter, Eric Rimm, Elizabeth Selvin, Michel Marre, Michelle Samuel, Stephen Harrap, Katie Harris, John Sapp, Leah E Cahill, Rachel A Warren, Samantha K Lavallée, Andrew P Levy, Allie S Carew

“…Introduction This study sought to determine whether the association between attaining specific glycated hemoglobin (HbA1c) targets (<7.0% (<53 mmol/mol) and ≥8.0% (≥64 mmol/mol) compared with 7.0%–7.9%) over time and risk of incident coronary artery disease (CAD) was dependent on haptoglobin (Hp) phenotype in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) study.Research design and methods Prospectively collected HbA1c data from the ADVANCE biomarker case-cohort study, updated at 6 months and every 12 months thereafter over a median of 5.0 (IQR 4.5–5.3) years, were analyzed in relation to incident CAD in the Hp2-2 (n=1323) and non-Hp2-2 (n=2069) phenotypes separately using weighted multivariable-adjusted Cox regression models. …”
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Multimodal imaging biomarkers for progression from intermediate to advanced age-related macular degeneration (AMD): a 10-year prospective longitudinal cohort study from the Univers... by Alan Palestine, Anne M Lynch, Naresh Mandava, Ramya Gnanaraj, Andres Lisker-Cervantes, Jennifer Patnaik, Vivian Rajeswaren, Nihaal Mehta, William Gange, Marc Mathias, Niranjan Manoharan, Talisa E de Carlo Forest

“…Objective To evaluate multimodal imaging (MMI) biomarkers for predicting progression from intermediate to advanced age-related macular degeneration (AMD).Methods and analysis This prospective longitudinal cohort study included patients with intermediate AMD (iAMD) enrolled in the University of Colorado AMD registry between July 2014 and August 2023, with follow-up through February 2024. …”
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Impact of rapid temperature fluctuations on acute stroke risk: a nationwide case-crossover study from 2001 to 2020Research in context by Miku Kono, Wei-Te Wu, Chuan-Pin Lee, Yu-Yin Chang, Yao-Hsu Yang, Ching-Chun Lin, Pau-Chung Chen

“…This study aimed to explore the link between ambient temperature, sudden day-to-day temperature changes, and stroke onset in Taiwan, taking air pollutants into consideration. Methods: We conducted a time-stratified case-crossover study from 2001 to 2020 using Distributed Lag Nonlinear Models (DLNM) within conditional logistic regression to examine lagged associations between temperature parameters and stroke risk. …”
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Computer-simulated mirror osteotomy in the treatment of post-traumatic cubitus varus deformity in children by WenQiang Xu, YongFei Fan, XiuLin Ma, JianQiang Zhang, WenZhi Bi, ChaoYu Liu, Wei Wang

“…Abstract Purpose To explore the feasibility and early clinical efficacy of computer-based mirroring technology in simulating osteotomy for the treatment of post-traumatic cubitus varus deformity in children. Methods A retrospective analysis was conducted on the data of 26 patients with cubitus varus deformity who were admitted between June 2019 and June 2024. …”
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Current Landscape and Multidimensional Determinants of Spiritual Coping Mechanisms Among Tuberculosis Patients in Zhejiang, China: A Population-Based Cross-Sectional Investigation by Lu L, Zheng L, Zhu Q, Qiu Q, Zhou T, Fu J, Pan X, Zheng G, Xu Y

“…Multivariate linear regression analysis indicated that PMS (2.852, P=0.005), APGAR (3.740, P< 0.0001), BRS (3.457, P=0.001), and gender (3.343, P=0.001) significantly affected the PSC level in TB patients. …”
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Weighted Family History Density of Substance Use: Influence on Participant Substance Use Onset, Duration, and Escalation by Litteral CA, Martel MM, Mattingly DT, Moore JX

“…Substance preference concordance and sex-specific links between affected family members and participants were also assessed.Methods: A cross-sectional analysis of the National Epidemiological Survey on Alcohol and Related Conditions III (NESARC-III) included 36,309 adults. …”
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Evaluating the Effectiveness of Spousal Testing Among Syphilis-Infected Pregnant Women in the Context of Mother-to-Child Transmission Elimination: A Multicenter Study in Southeaste... by Xue X, Huang X, Liu G, Jiang X, Lin W, Chen Y, Huang C

“…This study assessed spousal testing rates among syphilis-positive pregnant women to guide public health interventions.Methods: This multicenter effectiveness study was conducted in Southeast China, utilizing data from the Chinese HIV/AIDS, Syphilis, and Hepatitis B Prevention Information System between 2018 to 2024. …”
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Multi-omics derivation of a core gene signature for predicting therapeutic response and characterizing immune dysregulation in inflammatory bowel disease by Mingming Wang, Liping Liang, Zibo Tang, Jimin Han, Lele Wu, Le Liu, Le Liu, Ye Chen, Ye Chen

“…Current precision medicine approaches lack robust molecular tools integrating transcriptomic signatures with immune dynamics for personalized treatment guidance.MethodsWe performed multi-omics analyses of GEO datasets using machine learning algorithms (LASSO/Random Forest) to derive a four-gene signature. …”
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Relationship between maternal gingival bleeding during pregnancy and neurodevelopmental delay in their one-year-old children by Xiayu ZHANG, Lianman LEI, Lianjie DOU, Min YU, Min ZHU, Chao ZHANG, Jiahu HAO

“…ObjectiveTo investigate the relationship between maternal gingival bleeding during pregnancy and neurodevelopmental delay in their one-year-old children, and to provide scientific evidence for prenatal and early childhood health care. MethodsBased on the Anhui-Wuhu Birth Cohort established by the Wuhu Maternal and Child Health Hospital in Anhui province, 528 mothers and their one-year-old children who had regular prenatal check-ups at the Wuhu Maternal and Child Health Hospital since early pregnancy (<13+6 weeks) and were followed up in December 2022 were included in this study. …”
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Development and validation of scales measuring self-efficacy and behavioral capability in managing common medical emergencies in dental clinics by Yasmine N. Alawaji, Hussam M. Alqahtani, Abdulmohsen Alfadley, Aram Alshehri, Ali Aboalela, Sahr H. Altuwaijri, Farraj Albalawi, Sara A. Kalagi, Abdulrhman Alghamdi, Abdullah Alshibani, Meshal Alharbi, Meshary Binhotan, Nesrin A. Alharthy

“…., knowing what and how to do a behavior) in handling common medical emergencies in dental clinics and to identify factors influencing these outcomes. Methods Two newly created 13-item self-efficacy and 19-item behavioral capability were validated for their construct validity and psychometric properties. …”
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Urban pertussis epidemiological patterns in a highly vaccinated megacity: Policy impacts and control strategies in Chongqing, China, 2005-2024 by Rui Shen, Jiawei Xu, Yugang Li, Jianxing Yu, Na Sun, Zilu Xu, Xueying Xu, Xiao Liu, Yang Liu, Bosong Li, Li Qi, Luzhao Feng

“…We investigated epidemiological patterns and policy impacts in a densely populated urban setting in Chongqing, China. Methods: Using population-based surveillance data (2005-2024) from Chongqing (population 32.1 million; DTP3 coverage >97%), we conducted hierarchical Bayesian spatial modeling and age-structured Susceptible-Infected-Recovered-Vaccinated transmission analysis. …”
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Development and validation of a machine learning-based early warning system for predicting venous thromboembolism risk in hospitalized lymphoma patients undergoing chemotherapy: a... by Tingting Jiang, Zailin Yang, Xinyi Tang, Xinyi Tang, Na Fan, Zuhai Hu, Jieping Li, Tingting Liu, Yu Peng, Shuang Chen, Bingling Guo, Xiaomei Zhang, Yong Chen, Jun Li, Dehong Huang, Jun Liu, Yakun Zhang, Yakun Zhang, Xuefen Liu, Xia Wei, Zhanshu Liu, Haike Lei, Yao Liu

“…This study aimed to develop a machine learning-based early warning system (VTE-EWS) tailored to these patients.MethodsData from 1,141 lymphoma patients hospitalized for chemotherapy were retrospectively collected across four academic medical centers between February 2020 and February 2024. …”
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Affective bias predicts changes in depression during deep brain stimulation therapy by Brian Cui, Madaline M. Mocchi, Brian A. Metzger, Prathik Kalva, John F. Magnotti, Jess G. Fiedorowicz, Allison Waters, Christopher K. Kovach, Yvonne Y. Reed, Raissa K. Mathura, Camille Steger, Bailey Pascuzzi, Kourtney Kanja, Ashan Veerakumar, Vineet Tiruvadi, Vineet Tiruvadi, Andrea Crowell, Lydia Denison, Christopher J. Rozell, Nader Pouratian, Wayne Goodman, Patricio Riva Posse, Helen S. Mayberg, Kelly Rowe Bijanki

“…Positive valence trials showed significant improvement post-DBS, while negative valence trials showed no notable change. A control analysis indicated that stimulation status did not significantly affect bias scores, and thus stimulation status was excluded from further modeling. …”
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Prevalence, awareness, treatment and control of arterial hypertension depending on regional characteristics in Russia: results of the ESSE-RF study 2012-2022 — evidence of COVID-19... by S. A. Maksimov, S. A. Shalnova, Yu. A. Balanova, A. E. Imaeva, V. A. Kutsenko, M. B. Kotova, G. A. Muromtseva, S. E. Evstifeeva, A. V. Kapustina, N. S. Karamnova, O. B. Shvabskaya, T. V. Repkina, T. O. Gonoshilova, A. V. Kudryavtsev, N. I. Belova, L. L. Shagrov, M. A. Samotrueva, A. L. Yasenyavskaya, O. A. Bashkina, S. V. Glukhovskaya, I. A. Levina, E. A. Shirshova, E. B. Dorzhieva, E. Z. Urbanova, N. Yu. Borovkova, V. K. Kurashin, A. S. Tokareva, Yu. I. Ragino, G. I. Simonova, A. D. Khudyakova, V. N. Nikulin, O. R. Aslyamov, G. V. Khokhlova, A. V. Solovieva, A. A. Rodionov, O. V. Kryachkova, Yu. Yu. Shamurova, E. V. Mikhailov, Yu. O. Tarabrina, M. G. Ataev, M. O. Radzhabov, Z. M. Gasanova, M. A. Umetov, I. A. Hakuasheva, L. V. Elgarova, E. I. Yamashkina, L. A. Balykova, A. A. Usanova, A. M. Nikitina, N. V. Savvina, Yu. E. Spiridonova, E. A. Naumova, V. S. Yudin, A. A. Keskinov, S. M. Yudin, A. V. Kontsevaya, O. M. Drapkina

“…To analyze the individual association of arterial hypertension (AH) prevalence, awareness, treatment, and control with regional characteristics within the national epidemiological ESSE-RF study (2012-2022), assessing the impact of the COronaVIrus Disease 2019 (COVID-19) pandemic.Material and methods. The analysis used pooled data from the ESSE-RF study across three time periods: ESSE-RF-1 (2012-2014), ESSE-RF-2 (2017-2018), ESSERF-3 (2020-2022). …”
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