Evaluating Cardiac Impairment From Abnormal Respiratory Patterns: Insights From a Wireless Radar and Deep Learning Study by Chun-Chih Chiu, Wen-Te Liu, Jiunn-Horng Kang, Chun-Chao Chen, Yu-Hsuan Ho, Yu-Wen Huang, Zong-Lin Tsai, Rachel Chien, Ying-Ying Chen, Yen-Ling Chen, Nai-Wen Chang, Hung-Wen Lu, Kang-Yun Lee, Arnab Majumdar, Shu-Han Liao, Ju-Chi Liu, Cheng-Yu Tsai

“…Thus, this study analyzed respiratory patterns from a wireless radar framework to explore their associations with echocardiographic (2D-echo) measurements. Methods: Background details, 2D-echo parameters, and biochemical data were collected from patients in a cardiology ward in northern Taiwan. …”
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Universal Fab-Fc masked cytokine prodrug platform: αPD-L1/IL-15 prodrug activates CD44+ CD8+ T cells in tumor-draining lymph nodes to enhance antitumor immunity by Wei Li, Ying Qin, Zejian Wang, Luyao Song, Gen Qi, Wenqiang Shi, Qiongya Zeng, Zilan Song, Ao Zhang, Huili Lu

“…Antitumor efficacy of P-T was assessed in two murine cold tumor models. A comprehensive immune correlate analysis was conducted in the tumor and tumor-draining lymph node (TDLN) to identify key effector cells responsible for overcoming resistance, followed by further confirmation with egression of T cell blockade, surgical excision of TDLN, and adoptive transfer experiments. …”
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Effector T cells under hypoxia have an altered transcriptome similar to tumor-stressed T cells found in non-responsive melanoma patients by Ahmad A Tarhini, Zhihua Chen, Dongliang Du, Joshua Davis, Justin C Boucher, Katarzyna A Rejniak, Jose A Guevara-Patino, Timothy I Shaw, Alyssa Obermayer, Mate Z Nagy, Lourdes B Plaza-Rojas, Elena Kostenko, Anna L Austin, Awino Maureiq E Ojwang'

“…As T cell-based therapies often fail to work in solid tumors, this study aims to investigate the effects of hypoxia on T cell topo-distribution in the TME, gene expression association with T cell states, and clinical responses in melanoma.Methods To generate detailed information on tumor oxygenation and T cell accessibility, we used mathematical modeling of human melanoma tissue microarrays that incorporate oxygen supply from vessels, intratumoral diffusion, and cellular uptake. …”
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Long-term associations of PM1 versus PM2.5 and PM10 with asthma and asthma-related respiratory symptoms in the middle-aged and elderly population by Xue-yan Zheng, Shu-jun Guo, Jian-xiong Hu, Rui-lin Meng, Yan-jun Xu, Yun-hong Lv, Ye Wang, Ni Xiao, Chuan Li, Xiao-jun Xu, De-jian Zhao, Hong-ye Zhou, Jia-hui He, Xiao-min Tan, Jing Wei, Li-feng Lin, Wei-jie Guan

“…The objective of the present study was to compare the strength of the aforementioned associations in middle-aged and elderly adults. Methods We calculated the mean 722-day personal exposure estimates of PM1, PM2.5 and PM10 at 1 km×1 km spatial resolution between 2013 and 2019 at individual levels from China High Air Pollutants (CHAP) datasets. …”
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Differences in the pathological, transcriptomic, and prognostic implications of lymphoid structures between primary and metastatic cutaneous melanomas by Jin Xu, Andrew Knight, Jonathan Nguyen, Hong Wang, Walter J Storkus, Cindy Sander, John M Kirkwood, Jiqiang Yao, Xiaofei Song, Jane Messina, James J Mulé, Lilit Karapetyan, Carlos Moran-Segura, Aofei Li, Marion Joy, Sabrina Bruno, Hassan M Abushukair, Danielle Vargas De Stefano, Ayah N Al-Bzour, Caroline Layding

“…In this study, we examined characteristics and the prognostic utility of LA and TLS status in histological samples from patients with melanoma.Methods We assessed The Cancer Genomic Atlas-skin cutaneous melanoma digital slides and melanoma specimens from the University of Pittsburgh for the presence of LA and TLS using H&E staining, multiplex immunofluorescence (mIF) and transcriptomic analyses. …”
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Innovation Ecosystem of Iran's Tourism Industry with Emphasis on Supply Chain by Azizolah Jafari, mahdi alaei kerahrudi

“…Sustainability fosters innovation, requiring changes in traditional production and consumption methods. Successful cities have demonstrated how technology aids sustainability. …”
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Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive i... by Teresa Liu-Ambrose, Ulrik Wisløff, Maria Fiatarone Singh, Yorgi Mavros, Perminder S Sachdev, Ryan S Falck, Dorthe Stensvold, Jeff S Coombes, Trinidad Valenzuela, Nicole Kochan, Wei Wen, Jeffrey Hausdorff, Jiyang Jiang, Emily C Smith, Matthew Hollings, Tess C Hawkins, Nicholas J Ashley, Natan Feter, Guy C Wilson, Isabel Hui En Shih, Yareni Guerrero, Tom Bailey

“…The aim of the Balance, Resistance, And INterval (BRAIN) Training Trial is to determine the effects of two forms of exercise, high-intensity aerobic interval training (HIIT) and high-intensity power training (POWER) each compared with a sham exercise control group on cognition in older adults with MCI.Methods and analysis One hundred and sixty community-dwelling older (≥ 60 years) people with MCI have been randomised into the trial. …”
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Deep Penetration of Shear Deformation in Ferritic Stainless Steel via Differential Speed Rolling Considering Contact Condition by Siti Fatimah, Warda Bahanan, Jee-Hyun Kang, I Putu Widiantara, Young Gun Ko

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Plasma club cell secretory protein reflects early lung injury: comprehensive epidemiological evidence by Jiajun Wei, Jinyu Wu, Hongyue Kong, Liuquan Jiang, Yong Wang, Ying Guo, Quan Feng, Jisheng Nie, Yiwei Shi, Xinri Zhang, Xiaomei Kong, Xiao Yu, Gaisheng Liu, Fan Yang, Jun Dong, Jin Yang

“…The study aimed to explored whether club cell secretory protein (CC16) levels can reflect early lung function changes. Methods: The cumulative respiratory dust exposure (CDE) levels of 1,461 coal miners were retrospectively assessed by constructed a job-exposure matrix to replace working years. …”
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hBMSC-EVs alleviate weightlessness-induced skeletal muscle atrophy by suppressing oxidative stress and inflammation by Mengyuan Chang, Ruiqi Liu, Bingqian Chen, Jin Xu, Wei Wang, Yanan Ji, Zihui Gao, Boya Liu, Xinlei Yao, Hualin Sun, Feng Xu, Yuntian Shen

“…Extracellular vesicles derived from bone marrow mesenchymal stem cells (BMSC-EVs) possess anti-inflammatory and antioxidant properties, offering a potential strategy for combating weightless muscular atrophy. Methods In this study, human BMSCs-EVs (hBMSC-EVs) were isolated using super-centrifugation and characterized. …”
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Breaking prolonged sitting with high-intensity interval training to improve cognitive and brain health in middle-aged and older adults: a protocol for the pilot feasibility HIIT2SI... by Charles Hillman, Talha Syed, Dominika M Pindus, Tomasz S Ligeza, Jin Kuang, Scott Paluska, Joseph So, Miroslaw Wyczesany, Jesus Sarol, Flor B Quiroz, Ramiya Shanmugam, Maciej Kos, Naiman Khan, Art Kramer

“…The study will address three aims: (1) to assess feasibility, acceptability, fidelity and safety of HIIT breaks to improve neurocognitive function in middle-aged and older adults; (2) to quantify the differences between conditions in the change in the amplitude and latency of the P3b component of event-related potentials (a marker for frontoparietal function) and (3) to explore the differences between conditions in attentional control, episodic memory and FC of the FPN and DMN in middle-aged and older adults.Methods and analysis 54 healthy adults, aged 40–75 years, will be recruited from the local community and randomly assigned to a condition sequence (HIIT, LIIT vs LIIT and HIIT). …”
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Associations of reallocating sedentary leisure-time to alternative discretionary movement behaviours with incident cardiometabolic diseases in 0.5 million Chinese adultsResearch in... by Paul J. Collings, Mengyao Wang, Harrison Hin Sheung Ho, Shiu Lun Au Yeung, Parco M. Siu, Benjamin J. Cowling, Stephen J. Sharp, Søren Brage, Nicholas J. Wareham, Huaidong Du, Derrick A. Bennett, Youngwon Kim

“…This study aimed to estimate the implications of reallocating sedentary leisure-time to non-sedentary behaviours for incident cardiometabolic diseases. Methods: A prospective cohort study of 462,370 Chinese adults (mean age 51 years; 59% female) who were free from diabetes and cardiovascular diseases at baseline. …”
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Tumor mutational burden and survival on immune checkpoint inhibition in >8000 patients across 24 cancer types by Vivek Subbiah, Samuel J Klempner, Neeraj Agarwal, David P Carbone, Amit Mahipal, Shilpa Gupta, David Fabrizio, Jeffrey S Ross, Gerald Li, David R Gandara, Miles C Andrews, Jonathan W Riess, Ramez N Eskander, Ryon P Graf, Geoffrey R Oxnard, Sarah Sammons, Jeremy Snider, Lilia Bouzit, Cheryl Cho-Phan, Megan Price, Julia C F Quintanilha, Richard Sheng Poe Huang

“…Following a prespecified analysis plan, rwOS by TMB level was assessed using Cox PH models adjusted for Eastern Cooperative Oncology Group performance status, prior treatment, microsatellite instability, sex, age, opioid rx pretherapy, and socioeconomic assessment.Results 8440 patients met inclusion criteria. …”
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Hepatitis B virus mutation pattern rtL180M+A181C+M204V may contribute to entecavir resistance in clinical practice by Yan Liu, Yi Zhou, Xiaodong Li, Ming Niu, Rongjuan Chen, Jinman Shao, Lanlan Si, Dan Luo, Yayun Lin, Le Li, Kai Zhang, Xiaohe Xiao, Zhihui Xu, Min Liu, Mengji Lu, Fabien Zoulim, Dongping Xu

“…This study aimed to clarify whether rtL180M+A181C+M204V mutations may contribute to HBV ETV resistance.Methods: Serum samples were collected from 22,009 patients who underwent resistance testing in Beijing 302 Hospital from 2007 to 2016. …”
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Providing continuity of care for people living with noncommunicable diseases in humanitarian settings: A qualitative study of health actors' experiences in Lebanon by C. Akik, Z. El Dirani, R. Willis, C. Truppa, C. Zmeter, S. Aebischer Perone, J. Roswall, R. Hamadeh, K. Blanchet, B. Roberts, M.F. Fouad, P. Perel, É. Ansbro

“…Thematic analysis, combining inductive and deductive approaches, was guided by a conceptual framework for NCD models of care in humanitarian settings. …”
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A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosisResearch in context by Jeremy S. Lum, Mikayla L. Brown, Natalie E. Farrawell, Rachael Bartlett, Christen G. Chisholm, Jody Gorman, Anthony Dosseto, Florian Dux, Lachlan E. McInnes, Heath Ecroyd, Luke McAlary, Peter J. Crouch, Paul S. Donnelly, Justin J. Yerbury

“…The small molecule, CuATSM, has repeatedly shown in mouse models to be a promising therapeutic treatment for SOD1-associated ALS and is currently in Phase II/III clinical trials for the treatment of ALS. …”
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Use of Z-codes related to social determinants of health among adult inpatients in France: a nationwide study from 2014 to 2022 by Sara Fernandes, Vanessa Pauly, Sophie Klay, Veronica Orleans, Yann Brousse, Bach Tran, Masoud Rahmati, Dong Keon Yon, Lee Smith, Guillaume Fond, Coralie Lemoine, Francois Antonini, Bastien Boussat, Geoffray Agard, Laurent Boyer

“…Univariable and multivariable mixed-effects models were used to identify characteristics of hospital stays associated with SDOH codes for the year 2022. …”
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The effects of a brand-specific, hemp-derived cannabidiol product on physiological, biochemical, and psychometric outcomes in healthy adults: a double-blind, randomized clinical tr... by Gianna F. Mastrofini, Bridget A. McFadden, Alexa J. Chandler, Blaine S. Lints, Harry P. Cintineo, Nathaniel D. Rhoades, Caroline S. Vincenty, Sten O. Stray-Gundersen, Abbi D. Lane, Shawn M. Arent

“…This study aimed to investigate the physiological, biochemical, and psychometric effects of a brand-specific, hemp-derived CBD product in healthy adults over a 12-week observation period.Methods 54 healthy males and females (age = 25 ± 7y; BMI = 24.82 ± 3.25 kg/m2) recruited from a large Southeastern University completed the study. …”
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SPECIFICS OF THE GRAND MOTHER IMAGE TRANSFORMATION IN THE SHORT STORY “THE LOVELY LADY” BY D.H. LAWRENCE by Lyudmyla M. Kulakevych

“…The study has been conducted using elements of motive-based, receptive-interpretive, psychoanalytic, and comparative methods of analysis. In the short story “The Lovely Lady” D.H. …”
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Effect of low-dose primaquine treatment on Plasmodium vivax recurrence and transmission-blocking activity in southwest Ethiopia: a longitudinal cohort study by Hallelujah Getachew, Kassahun Habtamu, Ashenafi Abossie, Assalif Demissew, Arega Tsegaye, Teshome Degefa, Daibin Zhong, Xiaoming Wang, Guofa Zhou, MingChieh Lee, James W. Kazura, Christopher L. King, Delenasaw Yewhalaw, Guiyun Yan

“…Based on polymerase chain reaction (PCR) positivity, the time to the first recurrence was estimated using Kaplan–Meier survival analysis. Cox regression models were employed to assess risk factors for recurrence. …”
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