Frequency of Tumor Necrosis Factor-α, Interleukin-6, and Interleukin-10 Gene Polymorphisms in Mexican Patients with Diabetic Retinopathy and Diabetic Kidney Disease by Patricia Elvira Sánchez-Valencia, Juan Daniel Díaz-García, Margarita Leyva-Leyva, Fabiola Sánchez-Aguillón, Nelly Raquel González-Arenas, Jesús Guillermo Mendoza-García, Erika Karina Tenorio-Aguirre, Mercedes Piedad de León-Bautista, Aurora Ibarra-Arce, Pablo Maravilla, Angélica Olivo-Díaz

“…The aim of the present study was to determine the frequency of polymorphisms of Tumor Necrosis Factor-α, interleukin-6, and interleukin-10 (<i>TNF-α</i>, <i>IL-10,</i> and <i>IL-6</i>), as well as to describe the clinical and laboratory characteristics of T2D association with these microvascular complications. Methods: This study included 203 patients with T2D, of which 102 had microvascular complications: 95 with DR, 50 with DKD, and 15 with diabetic neuropathy (the latter were not included in the statistical analysis); those with T2D without confirmed microvascular complications were considered as controls. …”
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Clinical Features and Outcomes of Neuropsychiatric Systemic Lupus Erythematosus in China by Shangzhu Zhang, Meng Li, Li Zhang, Ziqian Wang, Qiang Wang, Hui You, Yanhong Wang, Mengtao Li, Xiaofeng Zeng

“…To identify the clinical characteristics, magnetic resonance imaging (MRI) results, and prognostic factors of neuropsychiatric (NP) systemic lupus erythematosus (SLE; NPSLE) in a relatively large patient series in China. Methods. Data of patients with NPSLE at Peking Union Medical College Hospital (PUMCH) were collected retrospectively from June 2012 to June 2016. …”
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Prevalence of major adverse cardiovascular events among Saudi patients with systemic lupus erythematosus compared with the general population: updates from the national SLE and PUR... by Jiandong Su, Khalid F Alhabib, Ibrahim Almaghlouth, Najma Khalil, Kawther Ghassan Bohuliga, Boshra Alanazi, Bushra Khaled Alhawsa, Abdulaziz Mohammed Alabdulkareem, Wael Alqarawi, Kazi Nur Asfina, Hebatallah Hamed Ali, Mohammed Bedaiwi, Aos Aboabat, Tariq Asef Alam, Fehaid Ghali Alanazi, Mohammed A Omair, Abdurhman S Alarfaj, Haya M Almalag, Mostafa Al Shamiri

“…MACE was defined as myocardial infarction (MI), stroke or angina. The analysis was adjusted for demographics, traditional cardiovascular risk factors and SLE diagnosis through logistic regression models.Results The PURE and national SLE cohorts comprised 488 and 746 patients, respectively. …”
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Ashwagandha (Withania somnifera (L.) Dunal) for promoting recovery in long covid: protocol for a randomised placebo-controlled clinical trial (APRIL Trial) by Kamlesh Khunti, Shailen Sutaria, Poppy Alice Carson Mallinson, Sanjay Kinra, Rohini Mathur, Anoop SV Shah, Tim Clayton, Judith Lieber, Alexander Perkins, Shereen Allaham, Nick Birk, Lily Hopkins, Manisha Joshi, Mahesh Mathpathi, Arandeep Dhillon, Sidra S Beg, Archie Khan, Vanessa TW Kam, Galib R, S Rajagopala, Amarjeet Bhamra, Geetha Krishnan G Pillai, Tanuja Nesari

“…Therefore, this study aims to assess whether Ashwagandha is effective and safe for improving functional status and reducing symptom burden in adults living with long covid.Methods A randomised double-blind placebo-controlled trial will be performed at participating general practice (GP) surgeries and long covid clinics across the UK. …”
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Characterizing spatial immune architecture in metastatic melanoma using high-dimensional multiplex imaging by Joel Eliason, Santhoshi Krishnan, Yasunari Fukuda, Matias A. Bustos, Dan Winkowski, Sungnam Cho, Akshay Basi, Akshay Basi, Regan Baird, Elizabeth A. Grimm, Michael A. Davies, Dave S. B. Hoon, Arvind Rao, Arvind Rao, Arvind Rao, Arvind Rao, Jared K. Burks, Jared K. Burks, Suhendan Ekmekcioglu

“…Understanding how the spatial architecture of immune and inflammatory components changes across disease stages may reveal novel prognostic biomarkers and therapeutic targets.MethodsWe performed high-dimensional spatial profiling of two melanoma tissue microarrays (TMAs), representing Stage III (n = 157) and Stage IV (n = 248) metastatic tumors. …”
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Role of insulin signaling dysregulation in pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension by Gufeng Gao, Gufeng Gao, Gufeng Gao, Gufeng Gao, Gufeng Gao, Ai Chen, Ai Chen, Ai Chen, Ai Chen, Ai Chen, Yan Yan, Yan Yan, Yan Yan, Yan Yan, Yan Yan, Mohammad Ismail Hajary Sagor, Mohammad Ismail Hajary Sagor, Mohammad Ismail Hajary Sagor, Mohammad Ismail Hajary Sagor, Mohammad Ismail Hajary Sagor, Weijun Lin, Weijun Lin, Weijun Lin, Weijun Lin, Weijun Lin, Huakan Lin, Huakan Lin, Huakan Lin, Huakan Lin, Huakan Lin, Guili Lian, Guili Lian, Guili Lian, Guili Lian, Guili Lian, Liangdi Xie, Liangdi Xie, Liangdi Xie, Liangdi Xie, Liangdi Xie, Li Luo, Li Luo, Li Luo, Li Luo, Li Luo

“…The objective of this research was to explore the role of the protein kinase C (PKC)/IRS-1/ERK signaling pathway in the progression of PAH and its influence on the proliferation and migration of PASMCs.MethodsTo establish the PAH model, low-dose Monocrotaline (MCT) was intraperitoneally administered to male SD rats twice a week. …”
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Sleep Phenotypes, Genetic Susceptibility, and Risk of Obesity in Patients With Type 2 Diabetes: A National Prospective Cohort Study by Lei Xi, Li Li, Songbo Fu, Yuancheng Dai, Juan Shi, Yanmei Yu, Ying Peng, Hongmei Qiu, Jinsong Kuang, Hongyun Lu, Huige Shao, Chunlei Yuan, Xiaohu Wang, Ping Zhang, Sheli Li, Yanhui Pan, Ling Hu, Zhigang Zhao, Yunxia Chen, Jian Kuang, Yi Shu, Jinhua Qian, Qibin Mao, Jieji Zhang, Yan Liu, Hong Yang, Zhaoli Yan, Weici Xie, Qian Zhang, Ping Zhang, Hongji Wu, Ling Gao, Yongjun Jin, Ning Xu, Chaoyang Xu, Xiaohui Sun, Zhimin Feng, Qing Zhang, Lin Li, Guang Ning, Yifei Zhang, Yanan Cao, Weiqing Wang

“…ABSTRACT Background To determine the associations between sleep phenotypes and the risks of specific obesity types and weight gain in patients with type 2 diabetes (T2D), especially in different genetic risk groups. Materials and Methods We conducted a prospective study involving 58 890 participants. …”
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Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV)Research in context by Podjanee Jittamala, Simon Boyd, William H.K. Schilling, James A. Watson, Thundon Ngamprasertchai, Tanaya Siripoon, Viravarn Luvira, Elizabeth M. Batty, Phrutsamon Wongnak, Lisia M. Esper, Pedro J. Almeida, Cintia Cruz, Fernando R. Ascencao, Renato S. Aguiar, Najia K. Ghanchi, James J. Callery, Shivani Singh, Varaporn Kruabkontho, Thatsanun Ngernseng, Jaruwan Tubprasert, Wanassanan Madmanee, Kanokon Suwannasin, Amornrat Promsongsil, Borimas Hanboonkunupakarn, Kittiyod Poovorawan, Manus Potaporn, Attasit Srisubat, Bootsakorn Loharjun, Walter R.J. Taylor, Farah Qamar, Abdul Momin Kazi, M. Asim Beg, Danoy Chommanam, Sisouphanh Vidhamaly, Kesinee Chotivanich, Mallika Imwong, Sasithon Pukrittayakamee, Arjen M. Dondorp, Nicholas P.J. Day, Mauro M. Teixeira, Watcharapong Piyaphanee, Weerapong Phumratanaprapin, Nicholas J. White

“…However, these SSRIs have not been recommended in therapeutic guidelines and their antiviral activity in vivo has not been characterised. Methods: PLATCOV is an open-label, multicentre, phase 2, randomised, controlled, adaptive pharmacometric platform trial running in Thailand, Brazil, Pakistan, and Laos. …”
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Exposure to volatile organic compounds and chronic respiratory disease mortality, a case-cohort study by Mahdi Nalini, Hossein Poustchi, Deepak Bhandari, Benjamin C. Blount, Brandon M. Kenwood, Cindy M. Chang, Amy Gross, Christopher Ellison, Masoud Khoshnia, Akram Pourshams, Mitchell H. Gail, Barry I. Graubard, Sanford M Dawsey, Farin Kamangar, Paolo Boffetta, Paul Brennan, Christian C. Abnet, Reza Malekzadeh, Neal D. Freedman, Arash Etemadi

“…Data of the associations between specific volatile organic compounds (VOCs), a major component of air pollution and tobacco smoke, and subsequent CRD mortality in the general population are scarce. Methods In a case-cohort analysis within the population-based Golestan cohort study (n = 50045, aged 40–75 years, 58% women, enrollment: 2004–2008, northeastern Iran), we included all participants who died from CRD during follow-up through 2018 (n = 242) as cases and stratified them into 16 strata defined by age, sex, residence, and tobacco smoking. …”
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A Novel Formulation Based on Resveratrol and Water Extracts from <i>Equisetum arvense</i>, <i>Crataegus curvisepala</i>, <i>Vitex agnus-castus</i>, and <i>Glycine max</i> Inhibits... by Simonetta Cristina Di Simone, Alessandra Acquaviva, Maria Loreta Libero, Nilofar Nilofar, Fatma Tunali, Mariachiara Gabriele, Angelica Pia Centulio, Gianluca Genovesi, Davide Ciaramellano, Lucia Recinella, Sheila Leone, Luigi Brunetti, Gokhan Zengin, Giustino Orlando, Luigi Menghini, Annalisa Chiavaroli, Claudio Ferrante

“…The phenolic composition and radical scavenger properties were evaluated using chromatographic and colorimetric (ABTS) methods, whilst the limits of biocompatibility were assessed through allelopathy, the <i>Artemia salina</i> (brine shrimp) lethality test, and <i>Daphnia magna</i> cardiotoxicity assay. …”
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Tumor-derived lactate inhibit the efficacy of lenvatinib through regulating PD-L1 expression on neutrophil in hepatocellular carcinoma by Ming Zhao, Qifeng Chen, Wenhua Lu, Ning Lyu, Zhenfeng Zhang, Qiankun Xie, Haijing Deng, Anna Kan, Meng He, Shuang Qiao, Shaolong Li, Huiming Chen, Jinfa Lai, Xiongying Jiang, Shousheng Liu

“…In this study, we elucidate the stimulators of PD-L1+ neutrophils in tumor microenvironment (TME) and explore the optimal combination to enhance the effect of lenvatinib by inhibiting PD-L1+ neutrophils in hepatocellular carcinoma.Methods Neutrophil infiltration after lenvatinib treatment was examined with RNA sequencing and multicolor flow cytometry analysis in patient samples, subcutaneous and orthotopic mouse models. …”
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Risk and protective factors for coronavirus disease 2019 (COVID-19) in allergic rhinitis patients: a national survey in China by Xiaozhe Yang, Xiaozhe Yang, Xiaozhe Yang, Yutong Sima, Yutong Sima, Yutong Sima, Jinming Zhao, Jinming Zhao, Jinming Zhao, Jing Zhang, Jing Zhang, Jing Zhang, Xiangdong Wang, Xiangdong Wang, Xiangdong Wang, Luo Zhang, Luo Zhang, Luo Zhang, Luo Zhang

“…Binary logistic regression and analysis of covariance (different adjusted models) were conducted.ResultsIn all, 830 AR patients were included; 627 patients (75.54%) were infected with SARS-CoV-2. …”
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Impact of multidimensional assessment on anti-fracture treatment decisions in patients with fragility hip fractures within a Fracture Liaison Service by Chiara Ceolin, Stefania Sella, Cristina Simonato, Ester Bukli, Giulia Bano, Valentina Camozzi, Anna Bertocco, Marco Onofrio Torres, Alberta Cecchinato, Martin Diogo, Mor Peleg Falb, Francesca Guidolin, Maria Grazia Rodà, Michele Cannito, Antonio Berizzi, Andrea Venturin, Vito Cianci, Elisa Pala, Mariachiara Cerchiaro, Deris Gianni Boemo, Maria Vittoria Nesoti, Gaetano Paride Arcidiacono, Paolo Simioni, Pietro Ruggieri, Giuseppe Sergi, Sandro Giannini, Marina De Rui, on behalf of the Hip-POS working group

“…This study aimed to identify the primary factors influencing anti-fracture therapy decisions in older patients with fragility fractures, using a multidimensional geriatric assessment approach integrated into our FLS program. Methods A retrospective analysis was conducted on patients aged 65 and above with hip fractures admitted to Azienda Ospedale-Università Padova. …”
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Early-life tobacco smoke elevating later-life osteoporosis risk: Mediated by telomere length and interplayed with genetic predisposition by Dongsheng Di, Haolong Zhou, Zhangbo Cui, Jianli Zhang, Qian Liu, Tingting Yuan, Tingting Zhou, Xiao Luo, Danyang Ling, Qi Wang

“…Linear, Cox, and Laplace regression models were mainly used for data analysis. Results: Individuals with IUTSE showed a higher OP risk [hazard ratio (HR): 1.06, 95 % confidence interval (CI): 1.01, 1.11] and experienced earlier OP onset by 0.30 years [50th percentile difference = -0.30, 95 % CI: −0.51, −0.09] compared to those without. …”
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Comparison of the long‐term outcomes of patients with hepatocellular carcinoma within the Milan criteria treated by ablation, resection, or transplantation by Ning‐Ning Zhang, Jian Zheng, Ying Wu, Jia‐Yu Lv, Shu‐Wen Zhang, Ya‐Min Zhang, Wen‐Tao Jiang, Tian‐Qiang Song, Victoria Kim, Samer Tohme, Tian Liu, Wei Zhang, Jie Gu, Ze‐Yu Wang, Yu‐Hong Suo, Shuai Wang, Wang Li, Li Zhang, Yan Xie, Yong‐He Zhou, Jian‐Yong Liu, Yi‐Bo Qiu, Zhong‐Yang Shen, Ji‐Hui Hao, David Geller, Wei Lu

“…We aimed to develop a prognostic calculator to compare the long‐term outcomes following each of these therapies. Methods A total of 976 patients with HCC within the Milan criteria who underwent LT, LR, and LA between 2009 and 2019 from four institutions were evaluated. …”
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Applying machine learning to assist in the morphometric assessment of brain arteriolosclerosis through automation by Jerry J. Lou, Peter Chang, Kiana D. Nava, Chanon Chantaduly, Hsin-Pei Wang, William H. Yong, Viharkumar Patel, Ajinkya J. Chaudhari, La Rissa Vasquez, Edwin Monuki, Elizabeth Head, Harry V. Vinters, Shino Magaki, Danielle J. Harvey, Chen-Nee Chuah, Charles S. DeCarli, Christopher K. Williams, Michael Keiser, Brittany N. Dugger

“… Objective quantification of brain arteriolosclerosis remains an area of ongoing refinement in neuropathology, with current methods primarily utilizing semi-quantitative scales completed through manual histological examination. …”
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Effect of sodium-glucose cotransporter 2 inhibitors on ventricular function in systemic right ventricular failure by Lorna Swan, Gruschen R Veldtman, Hubert W Vliegen, Philippine Kiès, Filip Zemrak, Amanda Hunter, Anastasia D Egorova, Monique RM Jongbloed, J Wouter Jukema, Simon T MacDonald, Niki L Walker, Ali N Zaidi, Madelien V Regeer, Bart JA Mertens, Ralph ML Neijenhuis, Ari M Cedars

“…This study investigated the changes in ventricular function in sRV failure patients in the first year after starting SGLT2i.Methods Adult sRV patients from the international, real-world ACHIEVE-SGLT2i registry were included if they had a clinical diagnosis of sRV failure, a transthoracic echocardiogram before starting SGLT2i, and at least one in the first year after starting available for analysis. …”
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Phenome-wide diagnostic comparison among suicide deaths and living individuals with chronic pain diagnoses by Emily DiBlasi, Erin A. Kaufman, Sam Webster, Emily E. Hagn, Andrey A. Shabalin, Danli Chen, Seonggyun Han, Rana Jawish, Eric T. Monson, Michael J. Staley, Brooks R. Keeshin, Anna R. Docherty, Amanda V. Bakian, Akiko Okifuji, Hilary Coon

“…Better characterization of clinical risk profiles and comorbidities across the medical spectrum among people with chronic pain who die by suicide is urgently needed to aid treatment and prevention strategies. Methods This case–control study leverages population-based data from the Utah Suicide Mortality Risk Study. …”
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Postprandial triglyceride-rich lipoproteins as predictors of carotid atherosclerosis in individuals with normal fasting lipid profiles: a prospective follow-up study by Yilin Hou, Yilin Hou, Peipei Tian, Peipei Tian, Guangyao Song, Guangyao Song, Guangyao Song, An Song, Dandan Liu, Dandan Liu, Zhimin Wang, Zhimin Wang, Yihe Shi, Yihe Shi, Yale Tang, Yale Tang, Xiaoyu Wang, Xiaoyu Wang, Luxuan Li, Luxuan Li, Luping Ren, Luping Ren, Luping Ren

“…This study explores the oral fat tolerance test (OFTT) for its predictive value in CAS, using postprandial TRL levels as a diagnostic biomarker.MethodsA total of 107 volunteers with normal fasting lipid profiles and no CAS at baseline were included. …”
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ISG15 as a Potent Immune Adjuvant in MVA-Based Vaccines Against Zika Virus and SARS-CoV-2 by Juan García-Arriaza, Michela Falqui, Patricia Pérez, Rocío Coloma, Beatriz Perdiguero, Enrique Álvarez, Laura Marcos-Villar, David Astorgano, Irene Campaña-Gómez, Carlos Óscar S. Sorzano, Mariano Esteban, Carmen Elena Gómez, Susana Guerra

“…One such molecule is interferon-stimulated gene 15 (ISG15), a key modulator of antiviral immunity that acts both through ISGylation-dependent mechanisms and as a cytokine-like molecule. <b>Methods:</b> In this study, we assessed the immunostimulatory potential of ISG15 as an adjuvant in <i>Modified Vaccinia virus Ankara</i> (MVA)-based vaccine candidates targeting <i>Zika virus</i> (ZIKV) and <i>Severe Acute Respiratory Syndrome Coronavirus 2</i> (SARS-CoV-2). …”
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