The role of environmental access to exercise opportunities in cardiovascular mortality: evidence from a nationwide study by Xiaowen Wang, Yongshi Gu, Ying Wang, Yuqing Qiu, Tianling Chen, Philip K. Hopke, Kai Zhang, Shao Lin, Yanji Qu, Ziqiang Lin, Xinlei Deng, Jie Sun, Shuming Zhu, Xueqing Deng, Sizhe Li, Xian Lin, Zhicheng Du, Yuantao Hao, Wangjian Zhang

“…We explored the associations between county-level access to exercise opportunities and cardiovascular disease (CVD) mortality across US counties. Methods We conducted an ecological analysis using aggregated data from two primary sources: the County Health Rankings and Roadmaps data and CDC WONDER mortality data. …”
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Association Between Long Term Exposure to PM_2.5 and Its Components on Severe Obesity in Chinese Children and Adolescents: A National Study in China by Tongjun Guo, Tianjiao Chen, Li Chen, Jieyu Liu, Xinli Song, Yi Zhang, Ruolin Wang, Jianuo Jiang, Yang Qin, Ziqi Dong, Dengcheng Zhang, Zhiying Song, Wen Yuan, Yanhui Dong, Yi Song, Jun Ma

“…Background: The aim of this study was to explore the association between long-term exposure to particulate matter with an aerodynamic diameter <2.5 μm (PM_2.5) and its components and severe obesity in children and adolescents. Methods: Data for children and adolescents aged 9–18 in this cross-sectional study were obtained from the 2019 Chinese National Survey on Students’ Constitution and Health (CNSSCH). …”
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Positive rate and influencing factors of adolescent idiopathic scoliosis among school children aged 9 to 18 years in Xiamen, China by Zhongrui Peng, Yuanchao Li, Hong Yang, Yanfang Jiang, Yuqing Li, Mengyang Gao, Yangjingling Hua, Guimei Liu, Manqi Zhou, Tianmu Chen, Huarong Hong, Lei Li

“…Abstract Objective The present study aimed to investigate the positive rate of adolescent idiopathic scoliosis (AIS) among school children in Xiamen, Fujian province, China, and evaluate its possible risk factors. Methods The study was a school-based, cross-sectional scoliosis screening program in Xiamen city. …”
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Lipoprotein(a) as an early marker of cardiovascular events in high-risk subjects: insights from the Moli-sani cohort study by Francesco Gianfagna, Simone Poli, Simona Costanzo, Simona Costanzo, Augusto Di Castelnuovo, Teresa Panzera, Amalia De Curtis, Sara Magnacca, Mariarosaria Persichillo, Lorenzo De Santi, Claudia Cristofani, Daniele Loffredo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, Licia Iacoviello, the Moli-sani Study Investigators, Licia Iacoviello, Giovanni de Gaetano, Maria Benedetta Donati, Chiara Cerletti, Marialaura Bonaccio, Americo Bonanni, Simona Costanzo, Amalia De Curtis, Augusto Di Castelnuovo, Alessandro Gialluisi, Francesco Gianfagna, Mariarosaria Persichillo, Jos Vermylen, Renzo Pegoraro, Antonio G. Spagnolo, Deodato Assanelli, Livia Rago, Simona Costanzo, Sabatino Orlandi, Teresa Panzera, Augusto Di Castelnuovo, Marialaura Bonaccio, Francesca Bracone, Simona Costanzo, Giuseppe Di Costanzo, Simona Esposito, Alessandro Gialluisi, Anwal Ghulam, Francesco Gianfagna, Martina Morelli, Maria Loreto Muñoz Venegas, Antonietta Pepe, Emilia Ruggiero, Amalia De Curtis, Concetta Civitillo, Alisia Cretella, Sara Magnacca, Mariarosaria Persichillo, Francesca Bracone, Giuseppe Di Costanzo, Martina Morelli, Americo Bonanni

“…We analyzed the association between Lp(a) and the risk of a major cardiovascular event in subjects with previous CVD.MethodsThe analysis was conducted on the Moli-sani study population (24,325 individuals aged ≥35 years, recruitment from 2005 to 2010), focusing on subjects with prior CVD. …”
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Clinicopathological characteristics and outcomes of rare histologic subtypes of gallbladder cancer over two decades: A population-based study. by Sandeep Samuel, Sarbajit Mukherjee, Nischala Ammannagari, Venkata K Pokuri, Boris Kuvshinoff, Adrienne Groman, Charles M LeVea, Renuka Iyer

“…<h4>Background</h4>There is limited literature about the clinicopathological characteristics and outcomes of rare histologic variants of gallbladder cancer (GBC).<h4>Methods</h4>Using SEER database, surgically managed GBC patients with microscopically confirmed adenocarcinoma, adenosquamous/squamous cell carcinoma and papillary carcinoma were identified from 1988 to 2009. …”
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The Interactive Effects of Fruit Intake Frequency and Serum miR-484 Levels as Biomarkers for Incident Type 2 Diabetes in a Prospective Cohort of the Spanish Adult Population: The D... by Ana Lago-Sampedro, Wasima Oualla-Bachiri, Cristina Maldonado-Araque, Sergio Valdés, Inmaculada González-Molero, Viyey Doulatram-Gamgaram, Elias Delgado, Felipe J. Chaves, Luis Castaño, Alfonso Calle-Pascual, Josep Franch-Nadal, Gemma Rojo-Martínez, Sara García-Serrano, Eva García-Escobar

“…The aim of this study was to evaluate the possible association between serum miR-484 levels and fruit intake frequency with the risk of T2DM in the Spanish adult population. <b>Methods</b>: 2234 subjects from the Di@bet.es cohort study without T2DM at baseline were studied. …”
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The relationship between exercise and the occurrence of abdominal wall complications in patients on peritoneal dialysis by Xinqiu Li, Tiantian Ma, Jiayu Hao, Di Song, Hongyan Wang, Tianjiao Liu, Xiao Xu, Jie Dong

“…This study aims to investigate the association between exercise and abdominal wall complications in the PD population. Methods A retrospective data analysis of a prospective cohort. …”
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Peak systolic blood pressure during preparticipation exercise testing in 12,083 athletes: age, sex, and workload-indexed values and predictors by Petra Pesova, Petra Pesova, Bogna Jiravska Godula, Bogna Jiravska Godula, Otakar Jiravsky, Otakar Jiravsky, Libor Jelinek, Marketa Sovova, Katarina Moravcova, Jaromir Ozana, Ivan Ranic, Ivan Ranic, Radek Neuwirth, Radek Neuwirth, Radek Neuwirth, Roman Miklik, Matej Pekar, Matej Pekar, Libor Sknouril, Libor Sknouril, Vladimir Tuka, Eliska Sovova

“…This study examines the response of systolic blood pressure (SBP) to exercise in a large cohort of athletes and establishes normative values by sex and age.MethodsCompetitive athletes free of cardiovascular disease underwent pre-participation exercise testing on a bicycle ergometer. …”
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Effect of levothyroxine on major adverse cardiovascular events in patients with hypothyroidism and cardiovascular disease by Lijia Liu, Lijia Liu, Haiqing Zhang, Haiqing Zhang, Haiqing Zhang, Xiaowei Chen, Xiaowei Chen, Zuoxiang Liu, Zuoxiang Liu, Houyu Zhao, Shizhan Ma, Shizhan Ma, Shizhan Ma, Meng Zhao, Meng Zhao, Meng Zhao, Peng Shen, Yexiang Sun, Hongbo Lin, Siyan Zhan, Siyan Zhan, Siyan Zhan, Jiajun Zhao, Jiajun Zhao, Jiajun Zhao, Feng Sun, Feng Sun

“…ObjectiveThis study aimed to evaluate the effectiveness of levothyroxine, compared to non-levothyroxine treatment, in preventing adverse cardiovascular events and mortality in patients with hypothyroidism and cardiovascular disease (CVD).MethodsThis is a retrospective study utilizing medical record data from the Yinzhou Regional Health Care Database. …”
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British Columbia CARMA-CHIWOS Collaboration (BCC3): protocol for a community-collaborative cohort study examining healthy ageing with and for women living with HIV by Joel Singer, Melanie Lee, Angela Kaida, Neora Pick, Valerie Nicholson, Rebecca Gormley, Shayda A Swann, Jason Brophy, Amber R Campbell, Allison Carter, Chelsea Elwood, Tsion Gebremedhen, Elizabeth M King, Vonnie Lee, Evelyn J Maan, Patience Magagula, Sheila Nyman, Davi Pang, Tetiana Povshedna, Jerilynn C Prior, Shelly Tognazzini, Melanie C M Murray, Helene C F Cote

“…This interdisciplinary cohort study aims to understand how biological, clinical and sociostructural determinants of health interact to modulate healthy ageing in WLWH.Methods and analysis The British Columbia Children and Women: AntiRetroviral therapy and Markers of Aging-Canadian HIV Women’s Sexual and Reproductive Health Cohort Study (CARMA-CHIWOS) Collaboration (BCC3) study will enrol WLWH (n=350) and sociodemographically matched HIV-negative women (n=350) living in British Columbia. …”
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Multimorbidity patterns and premature mortality in a prospective cohort: effect modifications by socioeconomic status and healthy lifestyles by Qingping Xue, Shanshan Zhang, Xue Yang, Yan-Bo Zhang, Yidan Dong, Fan Li, Shuo Li, Nianwei Wu, Tong Yan, Ying Wen, Chun-Xia Yang, Jason HY Wu, An Pan, Yunhaonan Yang, Xiong-Fei Pan

“…This study aimed to assess the associations between multimorbidity patterns and long-term mortality and whether the associations were modified by socioeconomic status (SES) and healthy lifestyles. Methods Data were from the National Health and Nutrition Examination Survey (NHANES) 1999–2018 in the US. …”
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Changes in the estimated glucose disposal rate and incident cardiovascular disease: two large prospective cohorts in Europe and Asia by Xiaowei Zheng, Wenyang Han, Yiqun Li, Minglan Jiang, Xiao Ren, Pinni Yang, Yiming Jia, Lulu Sun, Ruirui Wang, Mengyao Shi, Zhengbao Zhu, Yonghong Zhang

“…The aim of this study was to investigate the association of change in eGDR with CVD risk. Methods This study used data of two prospective cohorts: UK Biobank and China Health and Retirement Longitudinal Study (CHARLS) with two measurements of eGDR. …”
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Ten years preceding a diagnosis of neurodegenerative disease in Europe and Australia: medication use, health conditions, and biomarkers associated with Alzheimer's disease, Parkins... by Dang Wei, Anna Freydenzon, Octave Guinebretiere, Karim Zaidi, Fen Yang, Weimin Ye, Niklas Hammar, Karin Modig, Naomi R. Wray, Maria Feychting, Nadine Hamieh, Bruno Ventelou, Beranger Lekens, Laurene Gantzer, Stanley Durrleman, Allan McRae, Baptiste Couvy-Duchesne, Fang Fang, Thomas Nedelec, Stanley Durrleman, Bruno Ventelou, Thomas Nedelec, Octave Guinebretiere, Karim Zaidi, Fang Fang, Dang Wei, Fen Yang, Allan McRae, Naomi Wray, Baptiste Couvy-Duchesne, Anna Freydenzon, Lydie Tran, Evans Cheruiyot

“…Conditional logistic regression models and meta-analysis were applied to assess the associations between these factors and the risk of receiving a diagnosis of AD, PD, or ALS. …”
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Relevance of superoxide dismutase type 1 to lipoid pneumonia: the first retrospective case-control study by Yinan Hu, Yanhong Ren, Yinzhen Han, Zhen Li, Weiqing Meng, Yuhui Qiang, Mengyuan Liu, Huaping Dai

“…SOD1 had the highest importance score in ML-based LP predictive models. Additionally, advanced age may be associated with higher mortality in LP. …”
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Replication differences of SARS-CoV-2 lineages may arise from unique RNA replication characteristics and nucleocapsid protein expression by Isadora Alonso Corrêa, Marcos Romário Matos de Souza, Gustavo Peixoto Duarte da Silva, Anna Beatriz Sampaio Vianna Macedo Pimentel, Pedro Telles Calil, Marcela Sabino Cunha, Diana Mariani, Rodrigo de Moraes Brindeiro, Sara Mesquita Costa, Maria Clara da Costa Simas, Victor Akira Ota, Elisa Cavalcante Pereira, Marilda Mendonça Siqueira, Paola Cristina Resende, Rafael Mello Galliez, Rafael Mello Galliez, Debora Souza Faffe, Debora Souza Faffe, Rosane Silva, Terezinha Marta Pereira Pinto Castiñeiras, Terezinha Marta Pereira Pinto Castiñeiras, Amilcar Tanuri, Amilcar Tanuri, Luciana Jesus da Costa, Luciana Jesus da Costa

“….*), and Omicron (BA.1).MethodsWe employed three different cellular models susceptible to viral infection to demonstrated the differences in virus binding, entry and total RNA production through RT-qPCR assay and viral infectious progeny by plaque assay. …”
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Association of surrogate adiposity markers with prevalence, all-cause mortality and long-term survival of heart failure: a retrospective study from NHANES database by Fan-Shun Guo, Fan-Shun Guo, Chen Guo, Chen Guo, Jia-Hao Dou, Jia-Hao Dou, Jun-Xiang Wang, Rui-Yun Wu, Rui-Yun Wu, Shou-Fang Song, Shou-Fang Song, Xue-Lu Sun, Xue-Lu Sun, Yi-Wei Hu, Yi-Wei Hu, Jin Wei, Jin Wei

“…Cox proportional hazards models and restricted cubic spline (RCS) analysis were employed to assess the association between surrogate adiposity markers and all-cause mortality in HF patients. …”
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Effects of Carnosine Supplementation on Cognitive Outcomes in Prediabetes and Well-Controlled Type 2 Diabetes: A Randomised Placebo-Controlled Clinical Trial by Rohit Hariharan, Aya Mousa, Kirthi Menon, Jack Feehan, Barbara Ukropcová, Jozef Ukropec, Martin Schön, Arshad Majid, Giancarlo Aldini, Maximilian de Courten, James Cameron, Simon M. Bell, Barbora de Courten

“…The aim of this study is to assess the effects of carnosine on cognitive function in individuals with prediabetes or well-controlled T2DM. <b>Methods:</b> This is a secondary analysis of a double-blind randomised controlled trial (RCT), whereby 49 adults with prediabetes or early-stage well-controlled T2DM were randomised to receive 2 g of carnosine or identical placebo daily for 14 weeks. …”
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Global Burden of Oral Diseases in Adolescents and Young Adults Aged 10–24 Years by Wei Lu, Bing Wang, Mi Du, Shaohua Ge

“…Objectives: This study aims to analyse global trends in the burden of oral diseases, including dental caries and noncarious oral diseases (NCODs), in individuals aged 10 to 24 from 1990 to 2021 and project future trends up to 2050. Methods: Using data from the Global Burden of Disease Study (GBD) 2021, this trend analysis examines the number, age-standardised rates (ASRs), and average annual percentage changes (AAPCs) in prevalence, incidence, and disability-adjusted life years for oral diseases across different age groups, sexes, social-development index (SDI) levels, regions, and nations. …”
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C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation by Veronica Veschi, Francesco Verona, Sebastiano Di Bella, Alice Turdo, Miriam Gaggianesi, Simone Di Franco, Laura Rosa Mangiapane, Chiara Modica, Melania Lo Iacono, Paola Bianca, Ornella Roberta Brancato, Caterina D’Accardo, Gaetana Porcelli, Vincenzo Luca Lentini, Isabella Sperduti, Elisabetta Sciacca, Peter Fitzgerald, David Lopez-Perez, Pierre Martine, Kate Brown, Giuseppe Giannini, Ettore Appella, Giorgio Stassi, Matilde Todaro

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Meta-analyses of IL1A polymorphisms and the risk of several autoimmune diseases published in databases. by Hang Su, Na Rei, Lei Zhang, Jiaxiang Cheng

“…<h4>Background</h4>Based on published data, we aimed to quantitatively elucidate the possible genetic influence of rs17561 G/T and rs1800587 C/T polymorphisms of the IL1A (interleukin 1 alpha) gene in the susceptibility to several autoimmune diseases.<h4>Methods</h4>A series of meta-analyses were carried out. …”
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