Association between Clinical Frailty Scale and mortality 24 months after hospitalisation in adult patients with COVID-19 by Julia Minnema, Melvin Lafeber, Roos S.G. Sablerolles, Janneke A.L. van Kempen, Lisanne Tap, Harmke A. Polinder-Bos, Bob P.A. van de Loo, Hugo van der Kuy, Miriam C. Faes, Jacomien Aleman, Jos Tournoy, Lorenz Van der Linden, Marco Gambera, Isabella Martignoni, Ronald Van Etten, Hein van Onzenoort, Mariette Kappers, Peter van Wijngaarden, Jose Verstijnen, Vera Theeuwes, Marleen Kemper, Elise Slob, Ferdi Sombogaard, Heshu Abdullah-Koolmees, Roland van den Berg, Hugo de Wit, Betul Dilek, Freija Hogenhuis, Vahid Buyukayten, Britt te Brake, Margriet Nieuwenhuijzen, Maria Scheeren, Madelief de Wit, Arjan Bulsink, Ingrid van Haelst, Peter ter Horst, Rosalie Moorlag, Anja Vos, Annemiek Otten-Helmers, Erik van Kan, Marije Voskamp, Marieke Ebbens, Marieke Ezinga, Cees van Nieuwkoop, Loes Visser, Caroline Ghazarian, Doranne Hilarius, Gonneke Hermanides, Carlinda Bresser, Judith Derijks-Engwegen, Ebbie Boemaars, Zahira Getrouw, Barbara Maat, Peter Wierenga, Tessa Bosch, Lisanne Krens, Kajie Liang, Langeza Saleh, Milou van Heuckelum, Linda Hendriksen, Paul van der Linden, Kaylen Guda, Kristel Crommentuijn, Ilse Cornelissen-Wesseling, Jeroen Diepstraten, Jacobien Ellerbroek, Saskia Coenradie, Debbie Deben, Kim Hurkens, Dennis Wong, Marion Vromen, Marjolein de Bock, Suzan Savelkoul, Saskia Wolters, Louise Andrews, Eefje Jong, Rosanne Kranenburg, Joana Soares, Fatima Falcao, Mariana Solano, Erica Viegas, Margarida Falcao, Helena Farinha, Dina Mendes, Joao Rijo, Marta Miarons, Maria Queralt Gorgas, Cristina García Yubero, Laura Portillo Horcajada, Kim Keijzers, Silke Lim, Linden Ashfield, Helen Bell, Naomi Fitzhugh, Glenda Fleming, Nicola Goodfellow, Joanne Hanley, Michael Scott, Simon P. Mooijaart, Jacobijn Gussekloo, Petra Elders, Geeske Peeters

“…We evaluated whether the CFS is associated with mortality 24 months after hospitalisation for COVID-19. Methods: The COvid MEdicaTion (COMET) study is an international, multicentre, observational cohort study, including adult patients hospitalised for COVID-19 between March 2020–July 2020. …”
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Tauroursodeoxycholic acid regulates macrophage/monocyte distribution and improves spinal microenvironment to promote nerve regeneration through inhibiting NF-κB signaling pathway i... by Yonghui Hou, Yonghui Hou, Yage Zhang, Yage Zhang, Lin Ma, Lin Ma, Dan Luo, Dan Luo, Wanshun Wang, Wanshun Wang, Shunmei E., Chengxi Huang, Yu Hou, Yu Hou, Shudong Chen, Shudong Chen, Jiheng Zhan, Jiheng Zhan, Liangliang Xu, Liangliang Xu, Dingkun Lin, Dingkun Lin

“…This study aims to investigate the effect of TUDCA on monocyte/macrophage distribution and nerve regeneration in the subacute stage of SCI.MethodsTranswell analysis, Bromodeoxyuridine (BrdU) staining, and TUNEL staining were performed to evaluate the effect of TUDCA on regulating the inflammatory response to impact spinal neural stem cells (NSCs) proliferation and migration, spinal neuron survival, and axon degeneration in vitro. …”
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Association of serum 25-hydroxyvitamin D with sleep disorders in individuals with prediabetes and diabetes: a prospective cohort study by Guodong Liu, Guodong Liu, Huaxue Li, Huaxue Li, Yicheng Ma, Yicheng Ma, Yingzhou Shi, Yingzhou Shi, Junming Han, Junming Han, Fei Li, Fei Li, Li Fang, Li Fang, Shengyu Tian, Shengyu Tian, Yiping Cheng, Yiping Cheng

“…In fully adjusted models, sufficient serum 25(OH)D concentrations reduced sleep disorder risk by 48% in prediabetes (HR = 0.52; 95% CI: 0.41–0.65) and 52% in diabetes (HR = 0.48; 95% CI: 0.34–0.67). …”
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Growth, physical, and cognitive function in children who are born HIV-free: School-age follow-up of a cluster-randomised trial in rural Zimbabwe. by Joe D Piper, Clever Mazhanga, Marian Mwapaura, Gloria Mapako, Idah Mapurisa, Tsitsi Mashedze, Eunice Munyama, Maria Kuona, Thombizodwa Mashiri, Kundai Sibanda, Dzidzai Matemavi, Monica Tichagwa, Soneni Nyoni, Asinje Saidi, Manasa Mangwende, Dzivaidzo Chidhanguro, Eddington Mpofu, Joice Tome, Gabriel Mbewe, Batsirai Mutasa, Bernard Chasekwa, Handrea Njovo, Chandiwana Nyachowe, Mary Muchekeza, Kuda Mutasa, Virginia Sauramba, Ceri Evans, Melissa J Gladstone, Jonathan C Wells, Elizabeth Allen, Melanie Smuk, Jean H Humphrey, Lisa F Langhaug, Naume V Tavengwa, Robert Ntozini, Andrew J Prendergast

“…We characterised school-age growth, cognitive and physical function in CBHF and CHU previously enrolled in the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial in rural Zimbabwe.<h4>Methods and findings</h4>The SHINE trial enrolled pregnant women between 2012 and 2015 across 2 rural Zimbabwean districts. …”
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Association between herbicide exposure and liver enzyme levels in a middle-aged and elderly population by Weiya LI, Zhuoya ZHAO, Xu CHENG, Jun AN, Shiyang ZHANG, Chengyong JIA, Meian HE

“…The liver is an important organ for the detoxification of environmental pollutants; however, studies on the association between herbicide exposure and liver function are limited.ObjectivesTo investigate the association between baseline serum herbicide levels and changes in liver enzyme levels and liver enzyme abnormalities over a 5-year period in middle-aged and older adults.MethodsThis study was based on a nested case-control population of type 2 diabetes established in the Dongfeng-Tongji cohort, with a total of 1388 subjects included in this study and followed up for 5 years. …”
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The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study. by Adam Shardlow, Natasha J McIntyre, Simon D S Fraser, Paul Roderick, James Raftery, Richard J Fluck, Christopher W McIntyre, Maarten W Taal

“…Use of eGFRcys or eGFRcreat-cys did not improve discrimination in risk prediction models for CKD progression and all-cause mortality compared to similar models with eGFRcreat. …”
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Vitality attributes and their associations with intrinsic capacity, resilience, and happiness in community-dwelling adults: Results from Gan-Dau Healthy Longevity Plan Wave 2 by Kuan-Yu Peng, Zhi-Jun Chen, Fong-Ping Tang, Shu-Chiung Lee, Heng-Hsin Tung, Katelyn E. Chen, Liang-Kung Chen, Fei-Yuan Hsiao

“…This study examined associations between different vitality attributes and other domains of IC as well as psychosocial constructs including resilience and happiness in middle aged and older adults, as these associations were fundamental for establishing evidence-based interventions to promote healthy aging. Methods: This cross-sectional analysis included 981 participants (75.0% female and 49.2% aged between 65−74 years) from the Gan-Dau Healthy Longevity Plan wave 2 cohort. …”
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大學教師學術發表影響力之影響因素 Factors Influencing Publication Impact of Faculty by 郭玲玲 Ling-Ling Kueh, 許清芳 Ching-Fan Sheu

“…Additionally, given the hierarchical structure of educational data, this study employed generalized linear mixed-effect model tree analysis to examine data with nested and clustered properties. …”
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Targeting FASN enhances cisplatin sensitivity via SLC7A11-mediated ferroptosis in cervical cancer by Xiaojun Wang, Qiqiao Du, Qiuwen Mai, Qiaojian Zou, Shuyi Wang, Xiaoying Lin, Qianrun Chen, Mengxun Wei, Chudan Chi, Zhangqing Peng, Karima Abdugheni, Liu Du, Yili Chen, Shuzhong Yao, Junxiu Liu

“…Results: Fatty acid synthase (FASN) was identified as a key driver of cisplatin resistance in CC through transcriptome sequencing and Gene Expression Omnibus (GEO) data analysis. The clinically safe FASN inhibitor TVB-2640 was found to restore cisplatin sensitivity, resulting in synergistic tumor growth attenuation in xenograft models. …”
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Patient-reported outcomes between proton and photon therapy in nasopharyngeal carcinoma patients: A longitudinal cohort study by Ching-Nung Wu, Yu-Ming Wang, Wei-Chih Chen, Yun-Hsuan Lin, Shau-Hsuan Li, Chung-Feng Hwang, Bing-Shen Huang, Chung-Ying Lin, Sheng-Dean Luo

“…Newly diagnosed NPC patients were assessed using the modified 28-item symptom distress scale at seven time points, from baseline (T0) to one year post-radiotherapy (RT) (T6). The analysis focused on symptom changes during the acute phase (T0 to T3 [one month post-RT]) using linear mixed models. …”
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Disturbed hierarchy and mediation in reward-related circuits in depression by Ruikun Yang, Junxia Chen, Suping Yue, Yue Yu, Jiamin Fan, Yuling Luo, Hui He, Mingjun Duan, Sisi Jiang, Dezhong Yao, Cheng Luo

“…Subsequently, the mediation effects of cortical regions on the interaction within reward-related circuits were further explored by constructing mediation models. Results: In both cohorts, sFC analysis revealed two reward-related pathways from the deepest DBS targets to intermediate regions including the thalamus, insula, and anterior cingulate cortex (ACC), then to the superficial cortical cortex including medial frontal cortex, posterior default mode network (pDMN), and right dorsolateral prefrontal cortex (DLPFC). …”
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Association between higher morning preference and better health-related quality of life in asthma by Neel Patel, BSc, Andy Deprato, BScKin, Tina Qian, BSc, Ana Adan, PhD, Metin Akgün, MD, Augustus Anderson, MClinImm, Amanda Brickstock, MD, Allie Eathorne, BSc, Arundhati Garud, MPH, Prasun Haldar, PhD, Aditya Jindal, DM, Surinder Kumar Jindal, MD, Bugra Kerget, MD, Saibal Moitra, MD, Rahul Mukherjee, MD, Alex Semprini, MBBS, Alice M. Turner, MD, Nicola Murgia, MD, Paige Lacy, PhD, Subhabrata Moitra, PhD

“…Objective: We aimed to investigate the associations between individual circadian preference and HRQL in asthma. Methods: Among 691 adult asthma patients from Canada, India, New Zealand, and the United Kingdom, a digital questionnaire was administered to capture demographic information, social and psychologic attributes, comorbidities, and medication adherence. …”
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Modified Saengmaeksan, an herbal formula containing six herbs, improves hypertension through RhoA/Rho kinase-mediated vasorelaxation by Young Mi Seok, Hye-Lin Kim, Hyo In Kim, Hobin Moon, Yohan Han, Eun Sang Cho, Hyun Hee Leem, Hyo Jung Kim, Sujin Shin, Se-Jin Kim, Jin Ki Jung, Wei Huang, Kyung Oh Jung, Doo Suk Lee, Sung Giu Jin, Hyunwoo Kim, Changsop Yang, Kyungjin Lee, Jinbong Park

“…The molecular mechanisms were explored through Western blot analysis and GTP-RhoA assays. Results: mSMS significantly reduced systolic and diastolic blood pressure in both hypertensive models, with the ethanol extract demonstrating superior efficacy. mSMS inhibited the RhoA/Rho kinase pathway, leading to reduced phosphorylation of MYPT1 and CPI17, and improved vascular relaxation. …”
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Comparative adverse event profiles of triplet therapy versus docetaxel-based therapy in patients with metastatic prostate cancer: a multicenter retrospective study by Fumihiko Urabe, Hirokazu Kagawa, Takafumi Yanagisawa, Hidetsugu Takahashi, Masaki Hashimoto, Shuhei Hara, Wataru Fukuokaya, Yu Imai, Kosuke Iwatani, Taro Igarashi, Mahito Atsuta, Kojiro Tashiro, Masaya Murakami, Shunsuke Tsuzuki, Brendan A. Yanada, Toshihiro Yamamoto, Kenichi Hata, Hiroki Yamada, Jun Miki, Takahiro Kimura

“…Additionally, we sought to identify risk factors for severe AEs associated with these treatment regimens. Materials and methods: In this retrospective, multicenter study, we included 359 patients diagnosed with metastatic castration-sensitive prostate cancer (mCSPC) or metastatic castration-resistant prostate cancer (mCRPC) who were treated with docetaxel. …”
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Context-Specific Impact Of Antimicrobial Stewardship On Antibiotic Use And Antibiotic Resistance In Hospitals In A Lower-Middle Income Country - Results From Implementation Study W... by Trang Quynh Le, Dung Tien Viet Vu, Quang Minh Le, Huyen Thi Thu Nguyen, Vinh Hai Vu, Duc Minh Chau, Em Thi Hoang Dung Vo, Tu Thi Cam Nguyen, Quan Anh Truong, Khanh Hong Nguyen, Hoa Nguyen Minh Le, Thomas Kesteman, Elizabeth Dodds Ashley, Deverick J. Anderson, Hugo C. Turner, Thach Ngoc Pham, Ben S. Cooper, Choisy Marc, H Rogier Van Doorn, Huong Thi Lan Vu

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STING regulates NETs formation by activating GSDMD in influenza viral pneumonia by Rongrong Huang, Rongrong Huang, Rongrong Huang, Ranran Chen, Ranran Chen, Ranran Chen, Lijuan Xing, Lijuan Xing, Lijuan Xing, Lianhao Wu, Lianhao Wu, Lianhao Wu, Wenwen Zhu, Junsong Jing, Junsong Jing, Junsong Jing, Ting Zhou, Yueguo Wu, Sheng Zhang, Zhenqiang You, Zhenqiang You, Zhenqiang You

“…To elucidate the mechanisms of viral pneumonia progression and potential targets for its treatment.MethodsViral pneumonia models were induced by the PR8 virus strain in wild-type (WT) and STING knockout (STING-KO) mice. …”
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Association of Circulating Phenylacetylglutamine With Multi‐Vessel Coronary Disease Severity and Outcomes in ST‐Segment–Elevation Myocardial Infarction by Peng Zhao, Nana Dong, Yan Wang, Suhong Zhao, Yanan Tian, Zhifeng Qin, Xiaofang Ban, Feiyuan Han, Li Meng, Fan Yang, Yidan Wang, Yunfei Wu, Zhongzhi Yu, Qinglu Xu, Xinyue Li, Shuo Li, Huibin Liu, Shaohong Fang, Wanqing Xie, Bo Yu, Xinxin Liu, Jinwei Tian

“…Quantitative coronary angiography analysis was performed using the QAngio XA 7.3 system. …”
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Frailty, Pitavastatin, and Major Adverse Cardiovascular Events Among People With HIV by Kristine M. Erlandson, MD, MS, Ariela R. Orkaby, MD, Triin Umbleja, MSc, Heather J. Ribaudo, PhD, Todd T. Brown, MD, PhD, Markella V. Zanni, MD, Marissa R. Diggs, AB, Sarah M. Chu, MSN, Kathleen V. Fitch, MSN, Carl J. Fichtenbaum, MD, Carlos Malvestutto, MD, MPH, Judith A. Aberg, MD, Gerald S. Bloomfield, MD, MPH, Judith S. Currier, MD, Karen T. Tashima, MD, Marcus Vinícius Guimarães de Lacerda, MD, PhD, Sonya L. Heath, MD, Michael T. Lu, MD, MPH, Alan Landay, PhD, George A. Kuchel, MD, Pamela S. Douglas, MD, Steven K. Grinspoon, MD

“…Objectives: The purpose of this study was to evaluate whether frailty is associated with MACE and whether pitavastatin prevents MACE regardless of frailty. Methods: We conducted a post hoc analysis of the REPRIEVE trial, a randomized, blinded trial of pitavastatin 4 mg vs placebo. …”
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Intracellular HIV-1 Tat regulator induces epigenetic changes in the DNA methylation landscape by Andrea Rodríguez-Agustín, Andrea Rodríguez-Agustín, Rubén Ayala-Suárez, Francisco Díez-Fuertes, Francisco Díez-Fuertes, María José Maleno, Izar de Villasante, Angelika Merkel, Mayte Coiras, Mayte Coiras, Víctor Casanova, Víctor Casanova, José Alcamí, José Alcamí, José Alcamí, José Alcamí, Núria Climent, Núria Climent, Núria Climent

“…We analysed whether Tat influences DNA methylation and subsequently impacts the transcriptional signature, contributing to inflammation and accelerated ageing.MethodsWe transfected Jurkat cells with full-length Tat (Tat101), Tat’s first exon (Tat72), or an empty vector (TetOFF). …”
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Gene-expression signature predicts autoimmune toxicity in metastatic melanoma by Michael Bailey, Andrew White, Francesca Sparano, Alessandra Cesano, Mariaelena Capone, Corrado Caracò, Ester Simeone, Lucia Festino, Alfredo Budillon, Sarah Warren, Domenico Mallardo, Paolo A Ascierto, Vito Vanella, Ernesta Cavalcanti, Claudia Trojaniello, Maria Grazia Vitale, Margaret Ottaviano, Paolo Chiodini, Mario Fordellone, Bianca Arianna Facchini, Maria Ingenito, Caterina Costa, Rosaria De Filippi

“…Gene-expression signatures were identified and validated using cross-validated sparse partial least squares modeling and principal component analysis, then correlated with toxicity occurrence.Results A total of 223 and 186 irAEs were observed in the AT and FLT groups, respectively, including arthralgia, colitis, and headache. …”
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