Functional Improvement Trajectories After Surgery (FIT After Surgery) study: protocol for a multicentre prospective cohort study to evaluate significant new disability after major... by E Jacobsohn, Duminda N Wijeysundera, Gerald Lebovic, M Davis, Martine T E Puts, Shabbir M H Alibhai, Karim S Ladha, C Wong, Daniel I McIsaac, C Hanley, T Barnes, G Lorello, N Siddiqui, P Serrano, Tyler R Chesney, S Choi, J Van Vlymen, D Sussman, D Macdonald, P Jüni, Emily Hladkowicz, C David Mazer, M Bosch, CD Mazer, A Jerath, J Pazmino-Canizares, E Kennedy, R Spence, V Lyon, Alice C Wei, Julian F Daza, Sahar Ehtesham, Janet M van Vlymen, DN Wijeysundera, KS Ladha, JF Daza, G Mattina, E Hladkowicz, M Tessier, S Ehtesham, S Nnorom, SMH Alibhai, M Puts, G Lebovic, TR Chesney, AC Wei, S Drozdz, M Louridas, RH Breau, M Lalu, S Abdellatif, S Gagne, E Duceppe, K Zarnke, D Dumerton, M Karizhenskaia, H El Beheiry, F Bonazza, A Zahavich, M Thorleifson, S L Russell, H Bagry, SY MacDonell, J Dale-Gandar, L Kaustov, A Fleet, E Al Azazi, M Parotto, S A McCluskey, H Poonawala, D Dillane, Di McIsaac, S Avramescu, S Shabeen

“…We propose that postoperative disability is an important patient-centred outcome to measure intermediate-to-long recovery after major surgery in older adults.Methods and analysis The Functional Improvement Trajectories After Surgery (FIT After Surgery) study is a multicentre cohort study of 2000 older adults (≥65 years) having major non-cardiac surgery. …”
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Uso de inteligencia artificial para predecir complicaciones en cirugías de columna toracolumbar degenerativa: revisión sistemática by G. Ricciardi, J.I. Cirillo Totera, R. Pons Belmonte, L. Romero Valverde, F. López Muñoz, A. Manríquez Díaz

“…Methods: A systematic literature review was conducted in Medline/Pubmed, Cochrane Library, and Lilacs/Portal de la BVS to identify machine learning models in predicting complications in patients undergoing surgery for degenerative thoracolumbar spine pathology between January 1, 2000, and May 1, 2023. …”
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[Translated article] Use of artificial intelligence to predict complications in degenerative thoracolumbar spine surgery: A systematic review by G. Ricciardi, J.I. Cirillo Totera, R. Pons Belmonte, L. Romero Valverde, F. López Muñoz, A. Manríquez Díaz

“…Methods: A systematic literature review was conducted in Medline/Pubmed, Cochrane Library, and Lilacs/Portal de la BVS to identify machine learning models in predicting complications in patients undergoing surgery for degenerative thoracolumbar spine pathology between January 1, 2000, and May 1, 2023. …”
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Targeting the LMP1‐ALIX axis in EBV+ nasopharyngeal carcinoma inhibits immunosuppressive small extracellular vesicle secretion and boosts anti‐tumor immunity by Fajian He, Yan Gong, Gan Tao, Jianguo Zhang, Qiuji Wu, Yushuang Tan, Yajie Cheng, Chunsheng Wang, Jinru Yang, Linzhi Han, Zhihao Wang, Yanping Gao, Jingyi He, Rui Bai, Peikai Sun, Xiaoyan Yu, Yajuan Zhou, Conghua Xie

“…Here, we aimed to investigate the roles and regulatory mechanisms of LMP1 and sEV PD‐L1 in NPC immune evasion. Methods We analyzed the impact of LMP1 on tumor‐infiltrating lymphocyte abundance in NPC tissues and humanized tumor‐bearing mouse models using multiplex immunofluorescence (mIF) and flow cytometry, respectively. …”
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Investigative needle core biopsies support multimodal deep-data generation in glioblastoma by Kenny K. H. Yu, Sreyashi Basu, Gerard Baquer, Ryuhjin Ahn, Jennifer Gantchev, Sonali Jindal, Michael S. Regan, Zaki Abou-Mrad, Michael C. Prabhu, Marc J. Williams, Alicia D. D’Souza, Seth W. Malinowski, Kelsey Hopland, Yuval Elhanati, Sylwia A. Stopka, Alexei Stortchevoi, Charles Couturier, Zhong He, Jingjing Sun, Yulong Chen, Alexsandra B. Espejo, Kin Hoe Chow, Smitha Yerrum, Pei-Lun Kao, Brittany Parker Kerrigan, Lisa Norberg, Douglas Nielsen, The GBM TeamLab, Vinay K. Puduvalli, Jason Huse, Rameen Beroukhim, Betty Y. S. Kim, Sangeeta Goswami, Adrienne Boire, Sarah Frisken, Michael J. Cima, Matthias Holdhoff, Calixto-Hope G. Lucas, Chetan Bettegowda, Stuart S. Levine, Tejus A. Bale, Cameron Brennan, David A. Reardon, Frederick F. Lang, E. Antonio Chiocca, Keith L. Ligon, Forest M. White, Padmanee Sharma, Viviane Tabar, Nathalie Y. R. Agar

“…Finally, we investigate the utility of stereotactic biopsies as a method for generating patient-derived xenograft (PDX) models. …”
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Epigenetic clocks as mediators of health behaviors and mortality in middle-aged and older adults by Xing-Ling Chen, Qiang-Qiang Zhao, Sheng-Rong Lin, Xing-Ling He, Xiao-Jiao Zhang, Si-Jing Li, Zi-Ru Li, Jia-Hui Chen, Hua Zhang, Xiao-Fang Li, Yue-Hui Zhou, Hui-Li Liao, Shu-Ning Sun, Zhong-Qi Yang, Shi-Hao Ni, Lu Lu

“…This study investigates associations between lifestyle factors, EAA biomarkers, and mortality risk. Method: The 2532 adults of 50 years or older that registered in NHANES between 1999–2002.This study evaluated compares first- to third-generation epigenetic clocks (HannumAge, HorvathAge, PhenoAge, GrimAge2, DunedinPoAm) in predicting mortality risk associations between five lifestyle domains (diet, abdominal adiposity, physical activity, smoking, alcohol) and EAA were analyzed via multivariable regression, with mediation models testing EAA’s role in lifestyle-mortality relationships. …”
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Radiomics feature similarity: A novel approach for characterizing brain network changes in patients with behavioral variant frontotemporal dementia by Salvatore Nigro, Marco Filardi, Benedetta Tafuri, Roberto De Blasi, Maria Teresa Dell’Abate, Alessia Giugno, Valentina Gnoni, Giammarco Milella, Daniele Urso, Chiara Zecca, Stefano Zoccolella, Giancarlo Logroscino

“…Introduction: Network modeling is increasingly used to study brain alterations in neurological disorders. …”
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Comparative pharmacokinetic study of dosage forms with morpholinium 2-[5-(pyridin-4-yl)-1,2,4-triazol-3-ylthio] acetate by I. V. Bushueva, V. V. Gladyshev, О. I. Panasenko, E. G. Knish

“…Using mathematical models of income distribution and excretion of drugs greatly enhances the interpretation of the results of biopharmaceutical research. …”
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Performance of Artificial Intelligence in Addressing Questions Regarding the Management of Pediatric Supracondylar Humerus Fractures by John D. Milner, MD, Matthew S. Quinn, MD, Phillip Schmitt, BS, Ashley Knebel, BA, Jeffrey Henstenburg, MD, Adam Nasreddine, MD, Alexandre R. Boulos, MD, MPH, Jonathan R. Schiller, MD, Craig P. Eberson, MD, Aristides I. Cruz, Jr., MD, MBA

“…We hypothesized that both ChatGPT and Gemini would demonstrate high-quality, evidence-based responses with no significant difference between the models across evaluation criteria. Methods: The responses from ChatGPT and Gemini to responses based on the 14 AAOS guidelines were evaluated by seven fellowship-trained pediatric orthopaedic surgeons using a questionnaire to assess five key characteristics on a scale from 1 to 5. …”
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Prediction for cardiac and pulmonary toxicity in a multicentric cohort of advanced stage NSCLC patients using sub-regions of the heart by Albrecht Weiß, Steffen Löck, Ting Xu, Zhongxing Liao, Miguel Garrett Fernandes, René Monshouwer, Johan Bussink, Esther G.C. Troost

“…Results: In univariate modeling, the Mean Lung Dose (MLD) significantly predicted CAE grade ≥ 3 in the training-set (pMLD = 0.02, AUCtrain = 0.69), which was confirmed in validation (AUCval, = 0.77). …”
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Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease by Slaven Crnkovic, Helene Thekkekara Puthenparampil, Shirin Mulch, Valentina Biasin, Nemanja Radic, Jochen Wilhelm, Marek Bartkuhn, Ehsan Bonyadi Rad, Alicja Wawrzen, Ingrid Matzer, Ankita Mitra, Ryan D Leib, Bence Miklos Nagy, Anita Sahu-Osen, Francesco Valzano, Natalie Bordag, Matthias Evermann, Konrad Hoetzenecker, Andrea Olschewski, Senka Ljubojevic-Holzer, Malgorzata Wygrecka, Kurt Stenmark, Leigh M Marsh, Vinicio de Jesus Perez, Grazyna Kwapiszewska

“…Bidirectional cellular crosstalk was examined using direct and indirect co-culture models, and phenotypic responses were assessed via transcriptome analysis. …”
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Prognostic impact of gait speed, muscle strength and muscle mass in chronic heart failure—A prospective cohort study by Vladimir Cejka, Hermann Riepl, Nora Schwegel, Ewald Kolesnik, David Zach, Viktoria Santner, Viktoria Höller, Natascha Schweighofer, Barbara Obermayer‐Pietsch, Thomas Pieber, Caroline Morbach, Stefan Frantz, Andreas Zirlik, Dirk vonLewinski, Stefan Störk, Florian Posch, Klemens Ablasser, Nicolas Verheyen

“…Fine and Gray regression models were calculated, treating non‐cardiovascular death as the competing event. …”
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Identification and preclinical efficacy evaluation of two lytic bacteriophages targeting highly virulent and multidrug-resistant Klebsiella pneumoniae by Ai Guo, Dianbao Zuo, Li Shi, Ming Guo, Jinquan Li, Caili Li, Puqing Wang, Xiaodong Sun, Ming Sang

“…More importantly, we established the murine pneumonia infection models through nasal instillation, assessed the therapeutic potential of the phage in vivo by observing pathological morphology via HE staining, detecting pro-inflammatory cytokine levels via qPCR and ELISA, and monitoring bacterial load changes in lung tissue through PCR analysis. …”
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Renewable Energy Sources and the New Paradigm in Energy Engineering by Eden Mamut

“…But, in a document of the European Commission [1] developed based on a comprehensive analysis of a large volume of scientific publications, it is mentioned that <em>“Mostly due to current methods of capture and data malpractice, approximately 50% of all research data and experiments is considered not reproducible, and the vast majority (likely over 80%) of data never makes it to a trusted and sustainable repository.”…”
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Indicators of Global Climate Change 2024: annual update of key indicators of the state of the climate system and human influence by P. M. Forster, C. Smith, C. Smith, T. Walsh, W. F. Lamb, W. F. Lamb, R. Lamboll, C. Cassou, C. Cassou, M. Hauser, Z. Hausfather, Z. Hausfather, J.-Y. Lee, J.-Y. Lee, M. D. Palmer, M. D. Palmer, K. von Schuckmann, A. B. A. Slangen, S. Szopa, B. Trewin, J. Yun, N. P. Gillett, S. Jenkins, H. D. Matthews, K. Raghavan, A. Ribes, J. Rogelj, J. Rogelj, J. Rogelj, D. Rosen, X. Zhang, M. Allen, M. Allen, L. Aleluia Reis, L. Aleluia Reis, R. M. Andrew, R. A. Betts, R. A. Betts, A. Borger, J. A. Broersma, S. N. Burgess, L. Cheng, P. Friedlingstein, P. Friedlingstein, C. M. Domingues, C. M. Domingues, M. Gambarini, M. Gambarini, T. Gasser, J. Gütschow, M. Ishii, C. Kadow, J. Kennedy, R. E. Killick, P. B. Krummel, A. Liné, A. Liné, A. Liné, D. P. Monselesan, C. Morice, J. Mühle, V. Naik, G. P. Peters, A. Pirani, J. Pongratz, J. Pongratz, J. C. Minx, J. C. Minx, M. Rigby, R. Rohde, A. Savita, A. Savita, S. I. Seneviratne, P. Thorne, C. Wells, L. M. Western, G. R. van der Werf, S. E. Wijffels, S. E. Wijffels, V. Masson-Delmotte, P. Zhai

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Starfield’s 4Cs of NCD management in primary healthcare: a conceptual framework development from a case study of 19 countries by Helena Legido-Quigley, Eva Turk, Juan Carlos Rivillas, Tiara Marthias, Darius Erlangga, Jasper Tromp, Pami Shrestha, Chuan De Foo, Kim Bao Giang, Maria Eugenia Esandi, Laura Antonietti, Shangzhi Xiong, Likke Prawidya Putri, Aungsumalee Pholpark, Natchaya Ritthisirikul, Piya Hanvoravongchai, Krishaa Logan, Elliot Eu, Ewa Kosycarz, Marcela Schenck, Wilson Benia, Doan Thi Thuy Duong, Supri Shrestha

“…Therefore, this study aims to explore and elucidate the key themes and subthemes related to and extending beyond Starfield’s 4Cs of PHC by integrating findings from a comprehensive literature review and a qualitative study.Methods In this case study analysis, case studies of PHC systems from 19 countries were purposefully selected to represent a range of income levels and diversity in health systems and PHC landscapes. …”
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Growth-promoting hormonal alterations in pregnant women living with HIV receiving dolutegravir-based antiretroviral treatment are associated with lower infant 1-year weight z-score... by Kathleen M. Powis, Kathleen M. Powis, Kathleen M. Powis, Jennifer Jao, Jennifer Jao, Jennifer Jao, Justine Legbedze, Caroline Dunk, Keolebogile N. Mmasa, Samuel W. Kgole, Gosego Masasa, Terence Mohammed, Joseph Makhema, Sikhulile Moyo, Mitchell E. Geffner, Elaine J. Abrams, Lena Serghides, Lena Serghides

“…BackgroundSeveral maternal hormones regulate fetal growth, but concentrations of these hormones in pregnancy among women living with HIV and associations between hormone levels and infant anthropometrics is limited.MethodsPregnant women with HIV receiving dolutegravir/tenofovir/emtricitabine and HIV-seronegative women and their infants prospectively enrolled in the Botswana-based Tshilo Dikotla study were included in this analysis. …”
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Variations of Lipoprotein(a) Levels in the Metabolic Syndrome: A Report from the Maracaibo City Metabolic Syndrome Prevalence Study by Valmore Bermúdez, Joselyn Rojas, Juan Salazar, Luis Bello, Roberto Áñez, Alexandra Toledo, Maricarmen Chacín, Miguel Aguirre, Marjorie Villalobos, Mervin Chávez, María Sofía Martínez, Wheeler Torres, Yaquelin Torres, José Mejías, Edgardo Mengual, Liliana Rojas, Milagro Sánchez de Rosales, Ana Quevedo, Raquel Cano, Mayela Cabrera, Rafael París, Adonías Lubo, María Montiel, Climaco Cano

“…The purpose of this study was to assess the impact generated by this diagnosis in serum Lp(a) concentrations. Materials and Methods. A total of 1807 subjects of both genders (55.3% women and 44.7% men) belonging to the Maracaibo City Metabolic Syndrome Prevalence Study were evaluated. …”
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Natural immunity and protection against variants in South African children through five COVID-19 waves: A prospective study by Heather J. Zar, Lesley Workman, Rae MacGinty, Maresa Botha, Marina Johnson, Adam Hunt, Tiffany Burd, Mark P. Nicol, Stefan Flasche, Billy J. Quilty, David Goldblatt

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ACSL4 knockdown inhibits colorectal cancer progression through stimulating anti-tumor immunity by Yiming Liu, Xingyu Jiang, Dongquan Jing, Yanting Lin, Rui Gao, Qixiang Zhao, Huijuan Da, Yiming Ren, Qiuhua Cao, Ning Liu, Xiaoyun Han, Juan Du, Xinghua Gao

“…Background: Long-chain acyl-CoA synthetase 4 (ACSL4), a crucial modulator of ferroptosis, is associated with tumor progression, though its impact on colorectal cancer (CRC) immune dynamics is not fully understood.Methods: ACSL4 expression was analyzed in CRC tissues and correlated with patient prognosis. …”
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