Current status and prospects of mining technology in metal mines by Liancheng WANG, Anlin SHAO, Fuming QU, Xingtong YUE, Huaiyuan WANG, Xingfan ZHANG, Xiaobo LIU

“…This gap is particularly noticeable in ultra-deep mining, where practical experience is especially lacking. (2) Future mining technologies that require urgent attention can be categorized into four types based on their criticality and urgency: bottleneck technologies, foundational technologies, urgent technologies, and forward-looking technologies. (3) The current “bottleneck” technical challenges facing China’s mining sector include the development of intelligent and unmanned technologies for open-pit mining, advanced deep mining technologies for underground operations, and the research and application of specialized mining software. (4) The urgent technologies identified in this study include precise detection and safety management technologies for goaf areas, ultra-large-scale filling mining technologies for metallic mines, and intelligent ore grade detection technologies. (5) Foundational technologies encompass rock mechanics modeling for deep mining, multi-scale fracture simulation processes under geothermal system rock–hydraulic coupling, and dynamic control theories for managing disasters associated with deep mining activities. (6) Forward-looking technologies include a range of innovations, such as new transportation technologies for deep open-pit mines, advanced deep-well lifting techniques, novel efficient rock-breaking technologies, integrated mining and beneficiation technologies, co-extraction methods for both mineral and geothermal resources, and fluidized mining techniques for metallic minerals. …”
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Glioma-Associated Mesenchymal Stromal/Stem Cells Derived Exosomal miR-191 Promotes the Proneural-to-Mesenchymal Transition in Glioblastoma Cells via PTEN/PI3K/AKT Signaling by Lv P, Zhang Y, Zhao Z, Wu W, Zhou Y, Liu Z, Wang H, Jiang X, Li S, Yan P, Huang X, Xiang W, Fu P

“…This study aimed to explore the effects and mechanisms of GaMSCs-derived exosomal miRNA-191-5p on the PMT of glioblastoma.Methods and Results: Conditioned medium from three independently established GaMSCs lines (GaMSCs-CM) significantly enhanced the tumorigenicity of glioma cells. …”
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Phoenix dactylifera seed-derived biochar as a sustainable and environmentally feed supplement in camel: impacts gas production, methane emissions, nutrient degradability and fermen... by Hesham S. Ghazzawy, Nashi K. Alqahtani, Nashi K. Alqahtani, Nashi K. Alqahtani, Abdullah Sheikh, Mohamed Shawky El Sayed, Roshmon Thomas Mathew, Hassan M. Ali-Dinar, Ehab El-Haroun, Mohamed M. A. Abd-Elkarim, Sameh A. Abdelnour, Ali S. A. Saleem

“…This study investigated the potential of date palm seed-derived biochar as a sustainable feed additive for dromedary camels to reduce methane (CH₄) emissions and improve gas production, nutrient degradability, fermentation parameters, and performance predictions using in vitro models.MethodsThe PSB was synthesized and stored at 4°C until use. …”
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Stress and Hypertension Among African American Female Family Caregivers of Persons Living With Alzheimer Disease and Related Dementias: Protocol for a Pilot Internet-Based Randomiz... by Kathy D Wright, Ingrid K Richards Adams, Nathan P Helsabeck, Karen M Rose, Karen O Moss, Donya Nemati, Navia Palmer, Bohyun Kim, Sunita Pokhrel Bhattarai, Christopher Nguyen, Daniel Addison, Maryanna D Klatt

“…Additionally, it explores the mediation of stress reactivity or resilience between interventions and self-care behaviors. MethodsA small randomized controlled trial pilot study will recruit 28 African American or Black female caregivers aged 40 years diagnosed with hypertension and on an antihypertensive medication. …”
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Blood lactate as a predictor of clinical outcomes and health-care resource needs in combat abdominal injuries by І.В. Собко, О.В. Рабощук, А.В. Верба, С.А. Асланян, Г.П. Хитрий, В.М. Мошківський, І.П. Кураченко, Т.С. Бордюг

“…The aim of this study is to determine the predictive efficacy of serum lactate regarding the risk of death and health-care resources needs in patients with CAI. Materials and methods. We examined 86 injured servicemen with CAI who were randomized into two groups — survivors and nonsurvivors. …”
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Step up to triple therapy versus switch to dual bronchodilator therapy in patients with COPD on an inhaled corticosteroid/long-acting β2-agonist: post-hoc analyses of KRONOS by Dave Singh, Mona Bafadhel, Niki Arya, Jonathan Marshall, Himanshu Parikh, Dobrawa Kisielewicz, Charlotta Movitz, Karin Bowen, Mehul Patel

“…Methods In KRONOS (NCT02497001), symptomatic participants with moderate-to-very severe COPD (exacerbations in the prior year were not required for inclusion) were randomized to budesonide/glycopyrronium/formoterol fumarate dihydrate 320/14.4/10 μg (BGF), glycopyrronium/formoterol fumarate dihydrate 14.4/10 μg (GFF), budesonide/formoterol fumarate dihydrate 320/10 μg (BFF) via metered-dose inhaler, or budesonide/formoterol fumarate dihydrate 400/12 μg via dry-powder inhaler (BUD/FORM) for 24 weeks. …”
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Abstract 224: Morphological characteristics of carotid webs associated with stroke risk and clot burden by Pedro N. Martins, Mateus D. Monteiro, Mohamed A. Tarek, Fadi Nahab, Jaydevsinh Dolia, Jason Allen, Michael Frankel, Raul Nogueira, Diogo Haussen

“…We aim to evaluate the associations between CaW morphological features evaluated via computed tomography angiography (CTA) with clinical and radiological variables. Methods This is a retrospective analysis of a prospectively collected mechanical thrombectomy database. …”
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Correlation Between the Online Visiting Time and Frequency Increase in Telemedicine Services Offered by Health Care Providers Before, During, and After the COVID-19 Pandemic in Chi... by Weiyi Wang, Yuntian Chu, Fangfang Cui, Xiaobing Shi, Xu Zhang, Dongxu Sun, Jinming Shi, Jie Zhao

“…ObjectiveWe aimed to determine the frequency change in health care providers offering telemedicine services before, during, and after COVID-19, as well as the correlation between the frequency change and telemedicine visit time. MethodsThe Telemedicine Informationization Professional Committee of China (TIPC) carried out a nationwide questionnaire survey. …”
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Comparison of dried blood spot (DBS) and plasma HIV-1 viral load measurements using Roche COBAS AmpliPrep/COBAS TaqMan assay, Northwest Ethiopia by Firehiwot Kebede, Getu Girmay, Gezahegn Bewket, Muluneh Assefa, Tadelo Wondmagegn, Mulualem Lemma, Nega Berhane

“…Thus, in this study, we aimed to compare the quantitative determination of HIV-1 RNA levels using plasma and DBS samples among people living with HIV in Northwest Ethiopia. Methods An institutional-based analytical cross-sectional study was conducted from March to July 2020 using 48 paired plasma and DBS samples among people living with HIV at the HIV Treatment Center, Northwest Ethiopia. …”
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The association between stress hyperglycemia ratio and 1-year outcomes in patients with acute myocardial infarction: a retrospective large sample cohort study by Ning Yan, Peng Wu, Peng Wu, Zhengjun Zhang, Mohan Wang, Juan Ma, Ali Ma, Dapeng Chen, Xueping Ma, Xiaocheng Li

“…This study explores the relationship between SHR and 1-year outcomes after AMI using a large cohort analysis.MethodsThis retrospective study enrolled 4012 AMI patients from General Hospital of Ningxia Medical University(2016-2019). …”
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Vaccine effectiveness against SARS-CoV-2 infection or COVID-19 hospitalization with the Alpha, Delta, or Omicron SARS-CoV-2 variant: A nationwide Danish cohort study. by Mie Agermose Gram, Hanne-Dorthe Emborg, Astrid Blicher Schelde, Nikolaj Ulrik Friis, Katrine Finderup Nielsen, Ida Rask Moustsen-Helms, Rebecca Legarth, Janni Uyen Hoa Lam, Manon Chaine, Aisha Zahoor Malik, Morten Rasmussen, Jannik Fonager, Raphael Niklaus Sieber, Marc Stegger, Steen Ethelberg, Palle Valentiner-Branth, Christian Holm Hansen

“…This study aimed to estimate the effectiveness in 2 age groups (12 to 59 and 60 years or above) of 2 or 3 vaccine doses (BNT162b2 mRNA or mRNA-1273) by time since vaccination against SARS-CoV-2 infection and Coronavirus Disease 2019 (COVID-19) hospitalization in an Alpha-, Delta-, or Omicron-dominated period.<h4>Methods and findings</h4>A Danish nationwide cohort study design was used to estimate VE against SARS-CoV-2 infection and COVID-19 hospitalization with the Alpha, Delta, or Omicron variant. …”
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Culturally Adapted Guided Internet-Based Cognitive Behavioral Therapy for Hong Kong People With Depressive Symptoms: Randomized Controlled Trial by Jia-Yan Pan, Jonas Rafi

“…These scales were administered at preintervention, postintervention, and at 3-month and 6-month follow-up assessments. Data analysis was conducted using linear mixed effects modeling, adhering to the intent-to-treat principle. …”
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Protection afforded by post-infection SARS-CoV-2 vaccine doses: A cohort study in Shanghai by Bo Zheng, Bronner P Gonçalves, Pengfei Deng, Weibing Wang, Jie Tian, Xueyao Liang, Ye Yao, Caoyi Xue

“…We aimed to estimate the protective effect against SARS-CoV-2 reinfection of an additional vaccine dose after an initial Omicron variant infection. Methods: We report a retrospective, population-based cohort study performed in Shanghai, China, using electronic databases with information on SARS-CoV-2 infections and vaccination history. …”
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Characterisation of pregnancy-induced alterations in apolipoproteins and their associations with maternal metabolic risk factors and offspring birth outcomes: a preconception and l... by Li Chen, Karen Mei-Ling Tan, Melvin Khee-Shing Leow, Kok Hian Tan, Jerry Kok Yen Chan, Shiao-Yng Chan, Yap Seng Chong, Peter D. Gluckman, Johan G. Eriksson, Markus R. Wenk, Sartaj Ahmad Mir

“…Linear regression models and network analysis were implemented to investigate the association of apolipoproteins with maternal genetic variants, biochemical measures, metabolic risk factors, and offspring birth outcomes. …”
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Prenatal exposure to polyfluoroalkyl substances and visual acuity in preschool children: Findings from the Guangxi Zhuang birth cohort in China by Lidi Lei, Fangfang Lv, Peini Lu, Caimei Mo, Jinxiu Li, Xuemei Xu, Gangjie Wei, Xuanqian Huang, Xiaoqiang Qiu, Dongping Huang, Xiaomei Zhou, Hui Wei, Xiaoyun Zeng, Shun Liu

“…Multiple linear regression models and logistic regression models were performed to study the single effects of individual PFAS on VA and visual impairment (VI), respectively. …”
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ADRB2 inhibition suppresses cancer immune evasion by regulating tumor SOX10-PD-L1 axis and T cell function by Yang Wang, Wei Zhang, Yu Zhang, Ling Chen, Shiyu Wang, Kun Song, Feng Yu, Jing Ouyang, Shan Cao, Cong Peng, Dongbo Liu, Yingying Dai, Wenwu Pei, Ziyang Hong, Weihua Huang, Yijing He, Panpan Liu, Hanying Yi, Gan Zhou, Howard McLeod

“…Inhibiting ADRB2 with β-blockers has demonstrated potential in boosting the effectiveness of immune checkpoint inhibitors across a spectrum of cancers, yet the precise mechanisms remain to be fully elucidated.Methods In vivo and in vitro experiments were performed to evaluate the role of ADRB2 in melanoma models, including its effects on T cells. …”
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Understanding the link between ALDH2 genotypes and diabetes by Miaomiao Peng, Miaomiao Peng, Ruikang Liu, Ruikang Liu, Ruikang Liu, Jiaoyue Zhang, Jiaoyue Zhang, Wen Kong, Wen Kong, Juan Zheng, Juan Zheng, Xiang Hu, Xiang Hu, Limin Wan, Shengqing Hu, Shenghua Tian, Shenghua Tian, Ying Wang, Ying Wang, Geng Liu, Geng Liu, Kangli Qiu, Kangli Qiu, Tianshu Zeng, Tianshu Zeng, Lulu Chen, Lulu Chen

“…This study aimed to examine the ALDH2–diabetes association using standardized clinical criteria while systematically investigating potential confounding, mediating, and interacting factors in a community-based cohort.MethodWe analyzed baseline data from 4,535 participants in the China Cardiometabolic Disease and Cancer Cohort Study (4C study). …”
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Using Nebular Near-infrared Spectroscopy to Measure Asymmetric Chemical Distributions in 2003fg-like Thermonuclear Supernovae by J. O’Hora, C. Ashall, M. Shahbandeh, E. Hsiao, P. Hoeflich, M. D. Stritzinger, L. Galbany, E. Baron, J. DerKacy, S. Kumar, J. Lu, K. Medler, B. Shappee

“…We quantify the asymmetry of these features using five methods: velocity at peak flux, profile tilts, residual testing, velocity fitting, and comparison to deflagration–detonation transition models. …”
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JWST COMPASS: NIRSpec/G395H Transmission Observations of the Super-Earth TOI-776 b by Lili Alderson, Sarah E. Moran, Nicole L. Wallack, Natasha E. Batalha, Nicholas F. Wogan, Anne Dattilo, Hannah R. Wakeford, Jea Adams Redai, Munazza K. Alam, Artyom Aguichine, Natalie M. Batalha, Anna Gagnebin, Peter Gao, James Kirk, Mercedes López-Morales, Annabella Meech, Johanna Teske, Angie Wolfgang

“…For both reductions, a flat line is preferred for Visit 1 while a flat line with an offset between the NRS1 and NRS2 detectors is preferred for Visit 2; however, we are able to correct for this offset during our modeling analysis following methods outlined in previous works. …”
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Machine learning approaches to identify neonates and young children at risk for postdischarge mortality in Dar es Salaam, Tanzania and Monrovia, Liberia by Rodrick Kisenge, Todd A. Florin, Cynthia G. Whitney, Michelle Niescierenko, Julia Kamara, Abraham Samma, Evance Godfrey, Chris A. Rees, Readon C. Ideh, Ye-Jeung G. Coleman-Nekar, Hussein K. Manji, Christopher R. Sudfeld, Adrianna L. Westbrook, Claudia R. Morris, Karim P. Manji, Christopher P. Duggan, Rishikesan Kamaleswaran

“…Our objective was to determine if machine learning models would have greater discriminatory value to identify neonates and young children at risk for postdischarge mortality.Methods We conducted a planned secondary analysis of a prospective observational cohort at Muhimbili National Hospital in Dar es Salaam, Tanzania and John F. …”
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