Passive dehydration alters raw bioimpedance parameters: generic vs. individualized phase angle and estimated characteristic frequency by David H. Fukuda, Modesto A. Lebron, Kworweinski Lafontant, Gavin N. Van Staden, Adam J. Wells, Jeffrey R. Stout

“…Background Bioelectrical impedance analysis (BIA) is commonly used to determine body composition, including estimates of total body water (TBW), intracellular water (ICW), and extracellular water (ECW). …”
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Mediation Effect of Relaxin in Cerebrospinal Fluid on the Association Between Smoking and Sleep by Xu Z, Ma M, Liu Y, Tang J, Luo X, Chen YH, Wang K, Chen X, Kang Y, Zheng K, Hu W, Chen L, Wang F, Wu Y

“…Logistic regression and mediation models analyzed the relationships between nicotine dependence, PSQI scores, and CSF relaxin. …”
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Novel post-translational modification learning signature reveals B4GALT2 as an immune exclusion regulator in lung adenocarcinoma by Ge Zhang, Zhenfa Zhang, Lianmin Zhang, Guangyao Zhou, Pengpeng Zhang, Dingli Wang, Shuai Jiang

“…The spatial distribution patterns between B4GALT2 and immune cell populations, specifically CD8+ T lymphocytes and CD20+ B lymphocytes, were elucidated through multiplexed immunofluorescence analysis. Laboratory investigations subsequently established B4GALT2’s regulatory influence on LUAD cellular expansion in both laboratory cultures and animal models. …”
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Peripartum heart failure in Finland: A population‐based record linkage study by Antti M. Puhakka, Georg Macharey, Volker Ziller, Mika Gissler, Aydin Tekay, Corinna Keil, Denise Hilfiker‐Kleiner

“…This study aims to comprehensively investigate the prevalence of HFPP in the Finnish population and identify the underlying risk factors associated with its occurrence. Methods We conducted a retrospective analysis using data from the Finnish Medical Birth Register and the Finnish Care Register for Health Care, covering 1996 to 2021. …”
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ChatGPT and Google Gemini are Clinically Inadequate in Providing Recommendations on Management of Developmental Dysplasia of the Hip Compared to American Academy of Orthopaedic Sur... by Patrick P. Nian, BA, Amith Umesh, BA, Ruth H. Jones, BS, Akshitha Adhiyaman, BS, Christopher J. Williams, BS, Christine M. Goodbody, MD, Jessica H. Heyer, MD, Shevaun M. Doyle, MD

“…Background: Large language models, including Chat Generative Pre-trained Transformer (ChatGPT) and Google Gemini have accelerated public accessibility to information, but their accuracy to medical questions remains unknown. …”
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iCogCA to Promote Cognitive Health Through Digital Group Interventions for Individuals Living With a Schizophrenia Spectrum Disorder: Protocol for a Nonrandomized Concurrent Contro... by Christy Au-Yeung, Helen Thai, Michael Best, Christopher R Bowie, Synthia Guimond, Katie M Lavigne, Mahesh Menon, Steffen Moritz, Myra Piat, Geneviève Sauvé, Ana Elisa Sousa, Elisabeth Thibaudeau, Todd S Woodward, Martin Lepage, Delphine Raucher-Chéné

“…A nonrandomized concurrent controlled design will assess effectiveness design, in which one intervention (eg, ABCR) acts as the active control for the other (eg, MCT) and vice versa, comparing cognitive and clinical outcomes between the interventions using generalized linear mixed effect modeling. Implementation strategy evaluation will consider the digital platform’s efficacy for mental health care practitioners’ training, contextual factors influencing implementation, and sustainability, using descriptive statistics for quantitative data and thematic analysis for qualitative data. …”
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Prognostic Value of Non-Traditional Lipid Indices for In-Hospital Mortality in Patients with Acute Coronary Syndromes by Rustem Yilmaz, Kenan Toprak, Ahmet Karagoz, Osman Can Yontar, Melisa Ucar, Halil Ibrahim Kokcu, Berkant Ozturk, Enes Kaya, Mustafa Yilmaz, Ersoy Öz

“…This study aimed to assess the prognostic value of these non-traditional lipid indices, along with traditional lipid and biochemical markers, for in-hospital mortality in ACS patients. <i>Materials and Methods</i>: This retrospective observational study analyzed data from ACS patients admitted to the coronary care unit (CCU) between January 2019 and September 2024. …”
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Modulating verticality representation and uprightness by virtual reality: rationale and protocol for a within-person randomised intervention associating a basic study in healthy in... by Dominic Perennou, Eugénie Lhommée, Aurélien Hugues, Stéphanie Dehem, Celine Piscicelli, Remi Gimat, Shenhao Dai, Adélaïde Marquer

“…The cumulative effect of the VTR on the post-stroke lateropulsion will also be analysed.Methods and analysis This pilot study is a single-centre, within-person randomised trial conducted in the department of Physical and Rehabilitation Medicine of the University Hospital of Grenoble-Alpes (France). …”
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Associations of device-measured physical activity across adolescence with metabolic traits: Prospective cohort study. by Joshua A Bell, Mark Hamer, Rebecca C Richmond, Nicholas J Timpson, David Carslake, George Davey Smith

“…We described associations of total activity, moderate-to-vigorous physical activity (MVPA), and sedentary time from three accelerometry measures taken across adolescence with detailed traits related to systemic metabolism.<h4>Methods and findings</h4>There were 1,826 male and female participants recruited at birth in 1991-1992 via mothers into the Avon Longitudinal Study of Parents and Children offspring cohort who attended clinics in 2003-2005, 2005-2006, and 2006-2008 who were included in ≥1 analysis. …”
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Persistent opioid use among patients who underwent intermediate-to-major elective surgery at a Swiss cantonal hospital: a prospective cohort study by Flavia Breitenmoser, Aaron Rixecker, Rahel Naef, Pascal Probst, Nils Horn, Markus K. Müller, Alexander Dullenkopf, JoEllen Welter

“… STUDY AIM: To investigate the extent of persistent opioid use among patients undergoing intermediate-to-major elective surgery at a Swiss cantonal hospital and as a secondary aim to identify factors potentially predictive of persistent opioid use (6 to 12 weeks after surgery). METHODS: For this single-centre prospective cohort study, all consecutive patients undergoing elective primary hip arthroplasty, partial or complete prostatectomy, caesarean delivery, spinal surgery, intermediate-to-major visceral surgery or major hand surgery were screened for enrolment from June 2022 to May 2023. …”
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Risk factors for early and late unplanned readmissions to the intensive care unit – results of a survey among intensivist by I. A. Ruslyakova, V. S. Afonchikov, E. A. Morozov, V. V. Gomonova, A. S. Zhernokleev, K. M. Magomedisaev, S. A. Nechayev, E. Z. Shamsutdinova, M. V. Bezrodny, A. E. Tanchuk, K. I. Shirokov, D. A. Chernyshev, M. Yu. Kabanov

“…Materials and methods. The survey of intensivists was conducted in 9 hospitals in Saint Petersburg and the Leningrad Region from July 2023 to July 2024. …”
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Diabetes distress among immigrants of south Asian descent living in New York City: baseline results from the DREAM randomized control trial by Farhan Mohsin, Laura Wyatt, Hayley Belli, Shahmir Ali, Deborah Onakomaiya, Supriya Misra, Yousra Yusuf, Shinu Mammen, Jennifer Zanowiak, Sarah Hussain, Haroon Zafar, Sahnah Lim, Nadia Islam, Naheed Ahmed

“…This study examines the prevalence of DD among foreign-born individuals of South Asian descent in New York City (NYC) and its association with sociodemographic and clinical factors. Methods Baseline data was collected from the Diabetes Research, Education, and Action for Minorities (DREAM) Initiative, an intervention designed to reduce hemoglobin A1c (HbA1c) among South Asian individuals with uncontrolled T2D at primary care practices in NYC. …”
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Carbon monoxide polyhemoglobin improves the therapeutic effect and relieves inflammation in the colon tissue of haemorrhagic shock/resuscitation rats by Shasha Hao, Huan Wang, Shen Li, Honghui Zhang, Xintong Xie, Jiaxin Liu, Chengmin Yang, Wentao Zhou, Hong Wang

“…Objective The objective of this study was to test the therapeutic effect of carbon monoxide polyhemoglobin (polyCOHb) in haemorrhagic shock/resuscitation and its underlying mechanisms.Methods 48 rats were divided into two experimental parts, and 36 rats in the first experiment and 12 rats in the second experiment. …”
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Antipsychotic and pharmacogenomic effects on cross-sectional symptom severity and cognitive ability in schizophreniaResearch in context by Siobhan K. Lock, Djenifer B. Kappel, Michael J. Owen, James T.R. Walters, Michael C. O'Donovan, Antonio F. Pardiñas, Sophie E. Legge

“…Here, we sought to investigate the relationships between phenotypic severity and both medication and pharmacogenomic variables in a cross-sectional sample of people with schizophrenia or schizoaffective disorder depressed type. Methods: Confirmatory factor analysis derived five dimensions relating to current symptom severity (positive symptoms, negative symptoms of diminished expressivity, negative symptoms of reduced motivation and pleasure, depression and suicide) and cognitive ability in participants prescribed with antipsychotic medication. …”
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Human dental follicle stem cell-derived exosomes reduce root resorption by inhibiting periodontal ligament cell pyroptosis by Xinyi Li, Xinyang Liu, Jianing Zhou, Ping Zhang, Song Chen, Ding Bai

“…Abstract Background To explore the therapeutic effects and mechanisms of the exosomes derived from dental follicle stem cells (DFSC-Exos) in reducing osteoclastogenesis and root resorption (RR) by inhibiting periodontal ligament cell (PDLC) pyroptosis. Methods DFSC-Exos, with force stimulation (Force-Exos) or without (Ctrl-Exos), were co-cultured with human PDLCs in vitro and injected into the periodontal ligament (PDL) of rats following the establishment of RR models in vivo. …”
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VEGF-A cis-located SNPs on human chromosome 6 associated with VEGF-A plasma levels and survival in a coronary disease cohort by J. C. Meza-Alvarado, A. P. Pilbrow, C. M. Frampton, V. A. Cameron, A. M. Richards, R. W. Troughton, R. N. Doughty, R. A. Page, B. Mallard, C. Bromhead, B. R. Palmer

“…Association with clinical endpoints was assessed using Kaplan-Meier analysis and multivariate regression models. To validate the findings from imputed data, DNA samples of 2027 CDCS patients and 227 HVOL participants were manually genotyped for variants rs6921438 and rs7767396. …”
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A Novel Research Paradigm for Sarcopenia of Limb Muscles: Lessons From the Perpetually Working Diaphragm's Anti‐Aging Mechanisms by Enhui Li, Rui Wang, Yanli Li, Xiang Zan, Shufen Wu, Yiru Yin, Xiaorong Yang, Litian Yin, Yu Zhang, Jianguo Li, Xin Zhao, Ce Zhang

“…Critically, the potential endogenous anti‐aging mechanisms of DIA that may provide new insights into the mechanisms of sarcopenia in limb muscles remain scarce. Methods Treadmill and grip tests assessed limb muscle function, while a lung function system evaluated respiratory function in both adult (6‐month‐old) and old (22‐month‐old) mice. …”
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Amino acid intake, plasma metabolites, and incident type 2 diabetes risk: a systematic approach in prospective cohort studies by Siyue Wang, Yanping Li, Molin Wang, Jeffrey Yuan, Oana A. Zeleznik, A. Heather Eliassen, Andrew T. Chan, Frank B. Hu, Yang Hu, Qi Sun

“…Finally, Cox regression models were used to determine and confirm the prospective associations of AA intake, plasma metabolite signatures, with T2D incidence. …”
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Schema-Informed Digital Mental Health Intervention for Maladaptive Cognitive-Emotional Patterns: Randomized Controlled Trial by Seohyun Jeong, Hyeonseong Kim, Silvia Kyungjin Lho, Inae Hwang, Seongjun Mun, Soohyun Kim, Hyejin Lim, Hyeonhee Kim, Min-Sup Shin, Woori Moon

“…ObjectiveThis study evaluated the effectiveness of a schema-informed digital intervention (Mindling) aimed at reducing distress and enhancing coping in adults experiencing schema-linked difficulties such as perfectionism (unrelenting standards schema), low self-worth (self-sacrifice schema), social withdrawal (social isolation and alienation schema), and anxiety (negativity and dependence schemas). MethodsA total of 300 adults (aged 18-60 years) with elevated perceived stress and one dominant distress pattern were recruited on the web and randomized to an intervention group (n=201) or waitlist control (n=99). …”
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Adenoviral-vectored neoantigen vaccine augments hyperexpanded CD8+ T cell control of tumor challenge in mice by David Li, Gabriel Dagotto, Alessandro Colarusso, Robert C Patio, Tochi Anioke, Victoria Giffin, Ruoran Guan, Trisha Anand, Esther Mbiwan, Malika Aid, Dan Barouch

“…In this study, we examine how an Ad-vectored neoantigen vaccine would impact tumor immunity compared with a peptide neoantigen vaccine.Methods We generated Ad serotype 26 (Ad26) vaccine candidates encoding B16-F10-ovalbumin (OVA) and MC38-specific neoantigens. …”
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