Association of phenotypic aging, lifestyle, and genetic risk with incidence of atrial fibrillation: A large prospective cohort study in the UK Biobank by Tingting Lin, Ximin Fan, Liangtang Zeng, Qiang Li, Feilong Wang, Hao Lu

“…Setting and participants: This study included 327,122 participants from the UK Biobank. Methods: PhenoAge acceleration (PhenoAgeAccel) was calculated by regressing phenotypic age (PhenoAge) on chronological age. …”
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Outcome differences in acute vs. acute on chronic heart failure and cardiogenic shock by Tara L. Jones, Michael C. Tan, Vidang Nguyen, Kathleen E. Kearney, Charles C. Maynard, Emily Anderson, Claudius Mahr, James M. McCabe

“…We sought to compare outcomes between patients with acute CS and patients with acute on chronic decompensated HF presenting with laboratory and haemodynamic features consistent with CS. Methods and results Sequential patients admitted with CS at a single quaternary centre between January 2014 and August 2017 were identified. …”
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Correlation Between Learning and Memory Impairment and Changes in Cerebral White Matter Nerve Fibers and Pericytes in Rats with Chronic Cerebral Ischemia by HUANG Jia, WANG Mengxue, NI Jinglei, LIANG Shengxiang, LIN Bingbing

“…ObjectiveTo analyze the correlation between the changes of learning and memory and the progressive degeneration of white matter nerve fibers and pericytes in the corpus callosum and hippocampus of rats with chronic cerebral ischemia, then to explore the mechanism of learning and memory impairment caused by chronic cerebral ischemia, and provide a possible predictive target for vascular cognitive impairment.MethodsA total of 24 SPF male SD rats were divided randomly into sham operation group, 28 days after operation group and 56 days after operation group, with eight rats in each group. …”
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GOLD(I)-BASED COMPLEX AUDMAP: A PROMISING ANTIPROLIFERATIVE AGENT FOR MELANOMA TREATMENT by Isabela Carvalho Diniz, Fernanda Van Petten de Vasconcelos Azevedo, Camilla Abbehausen, Jennyfer Castro da Silva, Carmen Silvia Passos Lima

“…Objectives: To evaluate the antiproliferative activity and cell death mechanisms induced by the AuDMAP complex in SK-MEL-28 and A-375 melanoma cell lines, as well as determining its toxicity against non-tumoral HaCaT cells. Materials and Methods: Melanoma and non-tumor cells were cultured in DMEM + 10% FBS + 1% penicillin-streptomycin and treated with AuDMAP (0.78–100 µM) for 48h, with cisplatin as a control. …”
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The impact of detention on the health of asylum seekers: An updated systematic review: A systematic review by Trine Filges, Elizabeth Bengtsen, Edith Montgomery, Malene Wallach Kildemoes

“…Data collection and analysis Of 22,226 potential studies, 14 met the inclusion criteria. …”
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RECENT STRONG EARTHQUAKES IN CENTRAL ASIA: REGULAR TECTONOPHYSICAL FEATURES OF LOCATIONS IN THE STRUCTURE AND GEODYNAMICS OF THE LITHOSPHERE. PART 1. MAIN GEODYNAMIC FACTORS PREDET... by S. I. Sherman, Ma Jin, E. A. Gorbunova

“…The slip component corresponds to shearing along the faults revealed by geological methods, i.e. correlates with rock mass displacements in the near-fault medium. (6) GPS geodetic meas-urements show that shearing develops in the NW direction in the Tibet. …”
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A 5-Year Follow-Up of Patient-Reported Outcome Measures Following External Beam Radiotherapy or Radical Prostatectomy in Localised Prostate Cancer by Rowan V. David, Peter L. Stapleton, Arman A. Kahokehr, Jason Lee, David I. Watson, John Leung, Michael E. O’Callaghan

“…We describe PROMs using the Expanded Prostate Cancer Index Composite (EPIC-26) five years post-EBRT compared against radical prostatectomy (RP). <b>Methods</b>: A prospective cohort of patients with localised prostate cancer treated from 2000 to 2020 captured by a state-level cancer registry was analysed. …”
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The association between vision impairment and multi-site pain in middle-aged and older adults in China: results from the China health and retirement longitudinal study by Tianyi Luo, Cunzi Li, Lan Zhou, Lan Zhou, Yingrui Liu, Hongyan Sun, Ming Ming Yang

“…BackgroundPrevious research on the association between vision impairment (VI) and multi-site pain has been sparse, and no studies have specifically examined this relationship in low- and middle-income countries (LMICs).ObjectiveThis study aims to investigate the relationship between VI and the coexistence of pain in 15 different body sites and multi-site pain among middle-aged and older adults in China using nationally representative survey data.MethodsWe conducted a cross-sectional study using data from the 2020 China Health and Retirement Longitudinal Study (CHARLS), which included 10,240 participants. …”
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Study on the characteristics and influencing factors on non-marital non-commercial heterosexual transmission of HIV/AIDS in Anhui Province, China, 2015–2022 by Jin Zhang, Ziwei Wang, Yangguang Wang, Yongsheng Ye, Jinling Song, Liping Gong, Seying Dai, Yinguang Fan

“…In order to provide a reference basis of HIV prevention and control for targeted people. Methods The information of newly reported persons with HIV in Anhui Province from the year 2015 to 2022 was downloaded from the Chinese HIV/AIDS Comprehensive Response Information Management System (CRIMS). …”
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[18F]F-FMISO and [18F]F-FLT PET/CT dual-nuclide imaging for in vivo prediction of drug resistance in pancreatic cancer by SUN Chenwei, HAI Wangxi, QU Qian, XI Yun

“…Subcutaneous xenograft models of pancreatic cancer were established by injecting male BALB/c nude mice with pancreatic cancer cells into the left axillary subcutaneous region. …”
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Minimum and optimal combined variations in sleep, physical activity, and nutrition in relation to all-cause mortality risk by Emmanuel Stamatakis, Nicholas A. Koemel, Raaj K. Biswas, Matthew N. Ahmadi, Margaret Allman-Farinelli, Stewart G. Trost, Elif Inan-Eroglu, Borja del Pozo Cruz, Yu Sun Bin, Svetlana Postnova, Mitch J. Duncan, Dorothea Dumuid, Helen Brown, Carol Maher, Luigi Fontana, Stephen Simpson, Peter A. Cistulli

“…We examined the combined associations of SPAN and the minimum between-individual variations associated with meaningfully lower all-cause mortality risk. Methods This prospective cohort analysis included 59,078 participants from the UK Biobank (median age: 64.0 years; 45.4% male) who wore trackers for 7 days and self-reported dietary data. …”
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Protocol for a multisite randomised controlled trial assessing the effect of the Telehealth for Early Developmental Intervention in babies born very preterm (TEDI-Prem) programme o... by Alicia J Spittle, Peter J Anderson, Angela T Morgan, Rachel Schembri, Li Huang, Kim Dalziel, Rod W Hunt, Katherine Lee, Anne E Holland, Karli Treyvaud, Abbey L Eeles, Stacey Dusing, Shaaron Brown, Susan M Fehring, Gillian Henty, Elizabeth Kozaris

“…Here we present the protocol outlining a multicentre, pragmatic, parallel-group, randomised controlled trial to determine the efficacy of TEDI-Prem plus usual care, compared with usual care alone.Methods and analysis We will recruit 466 VPT infants from the neonatal units of five hospitals in Victoria, Australia. …”
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Neurologists&amp;rsquo; Openness to Evidence-Based Innovation in Multiple Sclerosis Care: Individual and Structural Determinants by Monreal E, Gómez-Ballesteros R, Meca-Lallana V, Caminero AB, Meca-Lallana JE, Martínez-Yélamos S, Landete L, García-Domínguez JM, Agüera E, García-Arcelay E, Medrano N, Villar LM, Maurino J

“…This study assessed neurologists’ openness to adopting healthcare innovations (sNfL testing), focusing on individual characteristics and structural factors like workplace environment and resources.Methods: An observational, cross-sectional study was conducted in partnership with the Spanish Society of Neurology. …”
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Tumor gene expression signatures associated with outcome in large B−cell lymphoma treated with CD19-directed CAR T−cell therapy (axicabtagene ciloleucel) by Yuan Tian, Justin Budka, Frederick L. Locke, Jason R. Westin, Christina To, Gayatri Tiwari, Daqin Mao, Davide Bedognetti, Rhine R. Shen, Jorge Andrade, Simone Filosto

“…Herein, we leveraged the ZUMA-7 phase III randomized trial of relapsed/refractory large B-cell lymphoma (LBCL) patients treated with axicabtagene ciloleucel (axi-cel; CD19-targeting CAR T cells) to discover tumor gene expression signatures (GES) associated with outcome.MethodsWith tumor transcriptomics from 134 axi-cel patients, we employed multivariate penalized Cox models analyzing event-free survival (EFS), progression-free survival (PFS), and duration of response (DOR).Results and DiscussionWe identified two novel GES, a six-gene/transcript signature (6-GES; CD19, CD45RA, CCL22, KLRK1, SOX11, SIGLEC5) correlated with improved outcome after axi-cel (HR: 0.27, 95% CI: 0.16–0.44 for EFS), representing lymphomas with abundant target antigen (CD19) expression, adhesion molecules, and relatively low immune infiltration mostly composed of cytotoxic lymphocytes (T and NK cells) and DCs, and secondly, a 17-gene/transcript signature (17-GES; CD45RO, BCL2, IL-18R1, TNFSF4 [OX40L], KLRB1 [CD161], KIR3DL2, ITGB8, DUSP5, GPC4, PSMB5, RPS6KB1, SERPINA9, NBN,GLUD1, ESR1, ARID1A, and SLC16A1) correlated with disease progression after axi-cel (HR: 6.12, 95% CI: 3.57–10.50 for EFS), consistent with high immune inflammation and escape mechanisms, such as the upregulation of genes involved in repair of damaged DNA or chromatin remodeling, inhibition of apoptosis, and a metabolically restrictive environment. …”
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A study on the relationship between depression, treatment side effects, and marital quality in cervical cancer patients undergoing radiotherapy and chemotherapy (宫颈癌放化疗患者抑郁与治疗副反应和婚... by LI Yuhuan (李玉环), ZENG Ya (曾娅), XING Yuzhen (邢育珍)

“…Results Depression in cervical cancer patients treated with radiotherapy was significantly and positively correlated with treatment side-effects and neurotic personality (P＜0. 01), and significantly and negatively correlated with marital relationship and quality of life (P＜0. 01). Analysis of structural equation modelling indicated that the relationship between treatment side-effects and depression in patients treated with radiotherapy and or chemotherapy for cervical cancer was moderated by the role of neurotic personality and quality of life, and was not mediated by the role of marital relationship. …”
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The Relationship Between Psychosocial Factors and Response to Epidural Steroid Injection for Chronic Lumbosacral Radicular Pain: A Prospective Pilot Study by Stensland M, Sanford E, Houle TT, McGeary C, Cobos BA, Lugosi S, Lehman L, Nabity PS, Covell C, Fitzgerald E, Mojallal M, Reed DE, Pangarkar S, Eapen BC, Nanda U, McCormick ZL, McGeary D

“…Data were analyzed using principal component analysis and generalized linear mixed-effects modeling.Results: A total of 40 patients (age 52 ± 13.05) participated in this study. …”
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Novel multimodal mechanical stimulation is superior to TENS to treat and prevent chronic low back pain: a randomized controlled trial by Amy Lynn Baxter, Amy Lynn Baxter, Jena L. Etnoyer-Slaski, Owen Tucker, Jessica Allia Rice Williams, Kevin Swartout, Lindsey L. Cohen, M. Louise Lawson

“…Over time, Linear Mixed Models (intention-to-treat) showed M-Stim significantly improved pain and disability for both aLBP and cLBP, (p &lt; .001 to p = .024). …”
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Anticancer Activity of Phospholipid-Dexibuprofen Conjugates Loaded in Nanostructured Lipid Carriers by Thiruchenthooran V, Świtalska M, Maciejewska G, Palko-Łabuz A, Bonilla-Vidal L, Espina M, Luisa Garcia M, Wietrzyk J, Souto EB, Sánchez-López E, Gliszczyńska A

“…Vaikunthavasan Thiruchenthooran,1 Marta &amp;Sacute;witalska,2 Gabriela Maciejewska,3,4 Anna Palko-&amp;Lstrok;abuz,5 Lorena Bonilla-Vidal,6,7 Marta Espina,6,7 Maria Luisa Garcia,6,7 Joanna Wietrzyk,2 Eliana B Souto,8 Elena Sánchez-López,6,7 Anna Gliszczy&amp;nacute;ska1 1Department of Food Chemistry and Biocatalysis, Wroc&amp;lstrok;aw University of Environmental and Life Sciences, Wroc&amp;lstrok;aw, Poland; 2Department of Experimental Oncology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroc&amp;lstrok;aw, Poland; 3Central Laboratory of the Instrumental Analysis, Wroc&amp;lstrok;aw University of Technology, Wroc&amp;lstrok;aw, Poland; 4Omics Research Center, Wroc&amp;lstrok;aw Medical University, Wroc&amp;lstrok;aw, Poland; 5Department of Biophysics and Neuroscience, Wroc&amp;lstrok;aw Medical University, Wroc&amp;lstrok;aw, Poland; 6Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, University of Barcelona, Barcelona, Spain; 7Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Barcelona, Spain; 8UCD School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Dublin 4, D04 V1W8, IrelandCorrespondence: Anna Gliszczy&amp;nacute;ska, Email anna.gliszczynska@upwr.edu.pl Elena Sánchez-López, Email esanchezlopez@ub.eduPurpose: In our work, we focused on the development of nanostructured lipid carriers (NLCs) loaded with dexibuprofen (DXI) and their application for cancer therapy by proposing the binding of phospholipids with this non-steroidal anti-inflammatory drug (NSAID) to obtain new delivery systems.Methods: We successfully synthesized seven conjugates with good yields, four of which are new, and have not been previously published in the literature. …”
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Resepsi audiens terhadap “Soft Masculinity” Boygroup Kpop by Raden Roro Nur Himma Sophia Syamwakumala

“…Qualitative descriptive research methods are used to describe the phenomenon in depth and critically. …”
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Association between outdoor light at night exposure and preterm birth and effect modification by pre-pregnancy stress: A national population-based retrospective cohort study by Manman Chen, Qiongjie Zhou, Yuanyuan Li, Qu Lu, Anying Bai, Fangyi Ruan, Yandan Liu, Yu Jiang, Xiaotian Li

“…Stratified analysis was also conducted to explore differences across socioeconomic status. …”
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