Association between Variation of Troponin and Prognosis of Acute Myocardial Infarction before and after Primary Percutaneous Coronary Intervention by Xiaoxiao Zhao, Ying Wang, Chen Liu, Peng Zhou, Zhaoxue Sheng, Jiannan Li, Jinying Zhou, Runzhen Chen, Yi Chen, Hanjun Zhao, Hongbing Yan

“…This study aimed to assess the relationship between △cTnI, the ratio of △cTnI to cTnI on initial admission, and the incidence of MACE during the follow-up period. Methods. A total of 2596 patients with cTnI measured upon admission and one-time measurement of cTnI during hospitalization were enrolled. …”
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In vivo CRISPR screening identifies POU3F3 as a novel regulator of ferroptosis resistance in hepatocellular carcinoma via retinoic acid signaling by Yu Tian, Xin Bao, Shan Lei, Youcai Huang, Xiaoling Wang, Yanyang Tu, Qinglian He, Feixiang Zhang, Haicheng Xu, Milad Ashrafizadeh, Gautam Sethi, Furong Wang, Zhirui Zeng

“…Hence, the present study has been designed to identify critical molecular targets associated with sorafenib resistance and investigate the potential inhibitors in overcoming this therapeutic challenge. Methods In vivo whole-genome CRISPR/Cas9 library screens were conducted to identify resistance factors to ferroptosis agonists, such as RSL3 and sorafenib, in HCC. …”
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SARS‐CoV‐2 Is Linked to Brain Volume Loss in Multiple Sclerosis by Tomas Uher, Dominika Stastna, Ingrid Menkyova, Vaclav Capek, Jiri Lindner, Petra Nytrova, Jan Krasensky, Eliza Varju, Miguel D'haeseleer, Eva Kubala Havrdova, Dana Horakova, Manuela Vaneckova, Niels Bergsland

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Cerebrospinal fluid proteome profiling across the Alzheimer’s disease continuum: a step towards solving the equation for ‘X’ by Sophia Weiner, Mathias Sauer, Laia Montoliu-Gaya, Andrea L. Benedet, Nicholas J. Ashton, Fernando Gonzalez-Ortiz, Joel Simrén, Nesrine Rahmouni, Cecile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Ville Leinonen, Tuomas Rauramaa, Mikko Hiltunen, Pedro Rosa-Neto, Kaj Blennow, Henrik Zetterberg, Johan Gobom

“…Abstract Background While the temporal profile of amyloid (Aβ) and tau cerebrospinal fluid (CSF) biomarkers along the Alzheimer’s disease (AD) continuum is well-studied, chronological changes of CSF proteins reflecting other disease-relevant processes, denoted ‘X’ in the ATX(N) framework, remain poorly understood. Methods Using an untargeted mass spectrometric approach termed tandem mass tag (TMT), we quantified over 1500 CSF proteins across the AD continuum in three independent cohorts, finely staged by Aβ/tau positron emission tomography (PET), fluid biomarkers, or brain biopsy. …”
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DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1 by Yepeng Hu, Shu Ye, Jing Kong, Qiao Zhou, Zhe Wang, Yikai Zhang, Han Yan, Yaqiong Wang, Tiekun Li, Yi Xie, Bingbing Chen, Yiming Zhao, Tianyue Zhang, Xianan Zheng, Junjia Niu, Bibi Hu, Shengyao Wang, Zhida Chen, Chao Zheng

“…Methods The expression of DOT1L was confirmed by Western blotting in MPC-5 cells and cortex of kidney from db/db mice, as well as immunofluorescence staining in human renal biopsy samples. …”
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Lifestyle factors and urine levels of organophosphorus flame retardants in endometrial cancer: insights from a case-control study by Yu-Che Ou, Fu-Jen Cheng, Wan-Ting Huang, Wen-Chin Lee, Hung-Chun Fu, Chen-Hsuan Wu, Ying-Yi Chen, Kuo-Chung Lan, Xuan-Ping Liou, Hao Lin, Chia-Te Kung

“…This study aimed to investigate the association between urine levels of OPFRs and endometrial cancer (EC), and to explore the correlation between concentrations of parent OPFR compounds and their metabolites. Methods: Urine samples from 76 EC patients and 76 healthy controls were collected and analyzed for the levels of five common parent OPFRs and their respective metabolites. …”
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Patterns of Factors in the National Institute on Aging Health Disparities Research Framework Domains and Mild Cognitive Impairment Risk by Maria Vassilaki, MD, PhD, Jeremiah A. Aakre, MPH, Timothy G. Lesnick, MS, Walter K. Kremers, PhD, Jonathan Graff-Radford, MD, David S. Knopman, MD, Thomas H. Mosley, PhD, B. Gwen Windham, MD, MHS, Michael E. Griswold, PhD, Yonas E. Geda, MD, MSc, Val J. Lowe, MD, Clifford R. Jack, Jr., MD, Ronald C. Petersen, MD, PhD, Prashanthi Vemuri, PhD

“…Using a cohort study design, the resulting composite scores were considered as covariates for incident mild cognitive impairment analysis using Cox proportional hazards models. Results: Three principal components explained 40.30% of the variance and were differentially associated with mild cognitive impairment risk. …”
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Association of hyperactivity–impulsivity and inattention symptom profiles with suicide attempt: an 18-year population-based cohort study by Samuele Cortese, Cédric Galéra, Marie-Claude Geoffroy, Gustavo Turecki, Richard E Tremblay, Ayla Inja, Sylvana M Côté, Michel Spodenkiewicz, Isabelle Ouellet-Morin, Michel Boivin, Frank Vitaro, Mara Brendgen, Ginette Dionne, Johanne Renaud, Massimilano Orri

“…Suicide attempt in adolescence and young adulthood (by age 23) was self-reported. Multitrajectory modelling was used to identify profiles of ADHD symptoms, and regression analysis was used to test their association with suicide attempt, adjusting for childhood socioeconomic and clinical characteristics.Findings We identified four ADHD symptom profiles with distinct associations with suicide attempt for males and females. …”
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TGFB1/CXCL5 axis regulation by LCN2 overexpression: a promising strategy to inhibit colorectal cancer metastasis and enhance prognosis by Xiaotian Song, Xiaotian Song, Shuai Xu, Shuai Xu, Dan Song, Juan Wang, Bin Bai, Yanxin An, Bin Yang, Shiqi Wang, Qingchuan Zhao, Pengfei Yu

“…We evaluated the migratory and invasive capabilities of CRC cells influenced by LCN2 using in vitro transwell assays and in vivo lung metastatic models. RNA sequencing and proteome analysis were employed to identify potential downstream targets of LCN2. …”
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Defects in the necroptosis machinery are a cancer resistance mechanism to checkpoint inhibitor immunotherapy by Katja Steiger, Peter May, Florian Bassermann, Anna Sax, Stefan Enssle, Nardine Soliman, Tatiana Nedelko, Giada Mandracci, Fabian Stögbauer, Laura Joachim, Christof Winter, Nadia El Khawanky, Hendrik Poeck, Simon Heidegger

“…However, it is unclear to which extent functional necroptosis in tumor cells contributes to ICI immunotherapy.Methods With genetically engineered tumor cell lines that lack specific components of the necroptosis machinery (mixed lineage kinase domain-like pseudokinase (MLKL), receptor interacting protein kinase 3 (RIPK3)), we addressed the importance of necroptotic tumor cell death for the efficacy of ICI immunotherapy in murine models. …”
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Beneficial effects of reduced soft tissue vibrations with compression garments on delayed neuromuscular impairments induced by an exhaustive downhill run by Robin Gassier, Loïc Espeit, Antoine Ravel, Pierre Beaudou, Robin Trama, Pascal Edouard, Pascal Edouard, Arsène Thouze, Léonard Féasson, Léonard Féasson, Frédérique Hintzy, Jérémy Rossi, Christophe Hautier

“…However, an in-depth analysis of changes in STV has never been proposed, and previous protocols did not overcome the repeated bout effect. …”
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Gender and age differences in weekend eating habits: associations with fat mass percentage in a cross-sectional study by Stefania Gorini, Stefania Gorini, Elisabetta Camajani, Elisabetta Camajani, Alessandra Feraco, Alessandra Feraco, Andrea Armani, Andrea Armani, Chiara Quattrini, Maria Grazia Tarsitano, Edda Cava, Laura Di Renzo, Massimiliano Caprio, Massimiliano Caprio, Antonino De Lorenzo, Mauro Lombardo

“…This study investigates gender and age differences in weekend eating behaviors and their association with fat mass percentage (FM%).MethodsA cross-sectional study was conducted on 2,596 participants at an obesity center in Italy. …”
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Primary lymphomas of the genitourinary tract: A population-based study by Carlotta Palumbo, Elio Mazzone, Francesco A. Mistretta, Sophie Knipper, Zhe Tian, Paul Perrotte, Francesco Montorsi, Shahrokh F. Shariat, Fred Saad, Claudio Simeone, Alberto Briganti, Alessandro Antonelli, Pierre I. Karakiewicz

“…Estimated annual proportion change methodology (EAPC), multivariable logistic regression models, cumulative incidence plots and multivariable competing risks regression models were used. …”
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Central Neck Dissection in Papillary Thyroid Carcinoma: Benefits and Doubts in the Era of Thyroid Lobectomy by Jacopo Zocchi, Gioacchino Giugliano, Chiara Mossinelli, Cecilia Mariani, Giacomo Pietrobon, Francesco Bandi, Stefano Malpede, Enrica Grosso, Marco Federico Manzoni, Elvio De Fiori, Giovanni Mauri, Manila Rubino, Marta Tagliabue, Mohssen Ansarin

“…In this study, we aimed to report our long-standing experience in PCND and its potential contemporary role in the treatment of PTC. Methods: A retrospective institutional review was performed on all patients who underwent operation for PTC including PCND between 1998 and 2021. …”
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Outcomes and cost-effectiveness of an integrated holistic care package on persons affected by podoconiosis, lymphatic filariasis and leprosy and community members in north-western... by Oumer Ali, Awoke Mihretu, Natalia Hounsome, Vasso Anagnostopoulou, Stephen A. Bremner, Mersha Kinfe, Asrat Mengiste, Maya Semrau, Abebaw Fekadu, Gail Davey

“…Mixed effects linear regression models were used to estimate change in outcomes between baseline and 6 months after initiation of the care package. …”
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Pancreatic, nutritional and clinical outcomes in children 0–5 years with cystic fibrosis during the first 2 years of CFTR modulator therapy (PaNC): a multicentre prospective observ... by Tamarah Katz, Sophie King, Gillian M Nixon, Caitlin Miles, Jodi Grunert, Kristyn Ford, Carla Hall, Charlotte Hawthorn, Denise Wong See, Mylie McMahon, Hannah Vass, Sarah Watkins, Gemma Zanardo, Isabella Brookes, Siobhan Handley, Talia Woodward, Jasmin Wademan, Bella Cameron, Zoe Davidson

“…There is a lack of robust, real-world longitudinal data on CFTR modulator therapy in infants and young children where extrapulmonary outcomes such as growth, micronutrient status and pancreatic function are the key focus.Methods and analysis Pancreatic, nutritional and clinical outcomes in children 0–5 years with CF during the first 2 years of CFTR modulator therapy (PaNC) is a prospective cohort study involving all eight tertiary paediatric CF centres in Australia. …”
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Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosis by Fan Li, Haiyi Hu, Liyang Li, Lifeng Ding, Zeyi Lu, Xudong Mao, Ruyue Wang, Wenqin Luo, Yudong Lin, Yang Li, Xianjiong Chen, Ziwei Zhu, Yi Lu, Chenghao Zhou, Mingchao Wang, Liqun Xia, Gonghui Li, Lei Gao

“…Methods The influence of tryptophan metabolism on tumor cells was explored using single-cell RNA sequencing data. …”
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Typology of out-of-home eaters: a description of sociodemographic, lifestyle, nutritional and environmental characteristics in the NutriNet-Santé cohort by Emma Meyer, Benjamin Allès, Justine Berlivet, Sandrine Péneau, Alice Bellicha, Mathilde Touvier, Brigitte Langevin, Philippe Pointereau, Denis Lairon, Serge Hercberg, Emmanuelle Kesse-Guyot, Julia Baudry

“…This study aimed to identify a typology of OOH consumers by frequency and type of meal consumed OOH and their associated sociodemographic, lifestyle, nutritional, and environmental characteristics. Methods Based on a sub-sample of adults of the French NutriNet-Santé cohort who completed a food frequency questionnaire and a questionnaire on OOH consumption habits in 2014 (n = 29,140, mean age: 53.6 (SD = 14.0) years, 74.3% women), we conducted a Multiple Factor Analysis followed by a clustering procedure. …”
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Association between sleep quality and mild cognitive impairment in Chinese patients with type 2 diabetes mellitus: a cross-sectional study by Rehanguli Maimaitituerxun, Hengxue Wang, Wenhang Chen, Jingsha Xiang, Yu Xie, Fang Xiao, Xin Yin Wu, Letao Chen, Jianzhou Yang, Aizhong Liu, Songning Ding, Wenjie Dai

“…Therefore, this study aims to identify the association between sleep quality and MCI among patients with T2DM in China. Methods This cross-sectional study was conducted among patients with T2DM who were referred to the Endocrinology Department of Xiangya Hospital, Central South University. …”
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Knockout of the inhibitory receptor TIGIT enhances the antitumor response of ex vivo expanded NK cells and prevents fratricide with therapeutic Fc-active TIGIT antibodies by Dean A Lee, Jeremiah L Oyer, Md Faqrul Hasan, Tayler J Croom-Perez, Liza D Robles-Carrillo, Sanjana Kumar, Brendan W Andersen, Brian P Tullius, Alicja J Copik, Amanda R Campbell, Thomas A Dieffenthaller, Catherine A Cash, Jonathan E Eloriaga, Meisam Naeimi Kararoudi

“…Since NK cells express TIGIT and Fc-receptor CD16, Fc-active anti-TIGIT may deplete NK cells via fratricide, which has not been studied.Methods CRISPR-Cas9-based TIGIT knockout (KO) was performed in expanded NK cells. …”
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