Acute bacterial meningitis without cerebrospinal fluid pleocytosis in children: results from a nationwide prospective surveillance system between 2001 and 2022 by Lama Jaber, Corinne Levy, Naïm Ouldali, Emmanuelle Varon, Muhamed-Kheir Taha, Stéphane Bonacorsi, Stéphane Béchet, François Angoulvant, Robert Cohen, Alexis Rybak

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Real-world effectiveness of COVID-19 vaccine in people with HIV compared with a matched HIV-negative cohort: A test-negative design by Xueying Yang, Jiajia Zhang, Ziang Liu, Shujie Chen, Sharon Weissman, Gregory A. Poland, Refilwe Nancy Phaswana-Mafuya, Bankole Olatosi, Xiaoming Li

“…Objectives: We estimated vaccine effectiveness (VE) against SARS-CoV-2 infection among a statewide cohort of people with HIV (PWH) and compared the estimates with a matched cohort of people without HIV (PWoH) in South Carolina (SC), USA. Methods: A population-based cohort was retrieved from statewide electronic health records between January 2, 2021, and April 14, 2022, during which several variants were circulating in SC (i.e., Alpha, Delta, Omicron). …”
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Stroke risk associated with cold spells occurring during the warm season by Cheng He, Susanne Breitner, Siqi Zhang, Markus Naumann, Claudia Traidl-Hoffmann, Gertrud Hammel, Annette Peters, Michael Ertl, Alexandra Schneider

“…Here, we aimed to investigate the potential relationship between exposure to relatively low temperature exposure during the warm season and stroke risk. Methods: We conducted a time-stratified case-crossover study using a validated, complete, and detailed registration of all stroke cases in the city of Augsburg, Germany, from 2006 to 2020 to assess the association between the occurrence of stroke and exposure to cold spell events during the warm season (May–October). …”
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Association of cumulative exposure to Chinese visceral adiposity index and gastrointestinal cancer: a prospective cohort study by Jiaxing Li, Jiaxing Li, Chao Ma, Chao Ma, Kuan Liu, Kuan Liu, Wanchao Wang, Shuqing Cui, Shuqing Cui, Yuan Tian, Zhigang Dong, Wenqiang Wei, Shouling Wu, Siqing Liu

“…The dose-response relationship between CVAI and the risk of developing GI cancers was examined using restricted cubic spline (RCS) in multivariable adjusted models. Multivariate Cox proportional hazards regression analysis was performed to assess the association between cumCVAI quartiles and the incidence of GI cancers. …”
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Disability, childhood experiences of violence and associated health outcomes in refugee settlements in Uganda by George Odwe, Stella Muthuri, Francis Obare, Peter Kisaakye, Gloria Seruwagi, Yohannes Dibaba Wado, Caroline W. Kabiru, Chi-Chi Undie

“…Analysis entailed cross-tabulation with a chi-square test and estimation of bivariate and multivariate logistic regression models. …”
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Acetylcholine from tuft cells promotes M2 macrophages polarization in Hirschsprung-associated enterocolitis by Ziyi Zheng, Lin Lin, Huifang Lin, Jie Zhou, Zhe Wang, Yang Wang, Jianxin Chen, Caimin Lai, Renfu Li, Zhiyong Shen, Ming Zhong, Cheng Xie, Yinjian Chen, Xuechao Zhang, Zhongjie Guo, Rui Dong, Rui Dong, Shiwei He, Feng Chen

“…Organoid and cell culture techniques were used to verify the anti-inflammatory mechanism of ACH in vitro models.ResultsscRNA-seq analysis revealed that tuft cells expressed the CHAT protein. …”
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Associations of lung function impairment and biological aging with mortality and cardiovascular disease incidence: findings from UK biobank participants by Jiali Chen, Cheng Wang, Pengyu Duan, Yonghong Bi, Yao Meng, Weiyu Feng, Zhehao Jin, Hangbing Li, Huihui Wang, Xiaoyan Li, Kun Zuo, Xiangcheng Zhao, Longfei Li, Yuling Xing, Lan Luo, Yang Yu, Miao Yu, Muyan Cui, Bing Zhang

“…This study aimed to investigate the mediating role of biological aging, as well as the interactions and joint effects of lung function impairment and biological aging on adverse health outcomes.MethodsA total of 349,456 UK Biobank participants (aged 40–69 years) were categorized into normal, PRISm, and AL groups based on baseline spirometric measurements. …”
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Persistence of Long COVID Symptoms Two Years After SARS-CoV-2 Infection: A Prospective Longitudinal Cohort Study by Gili Joseph, Ili Margalit, Yael Weiss-Ottolenghi, Carmit Rubin, Havi Murad, Raquel C. Gardner, Noam Barda, Elena Ben-Shachar, Victoria Indenbaum, Mayan Gilboa, Sharon Alroy-Preis, Yitshak Kreiss, Yaniv Lustig, Gili Regev-Yochay

“…Additionally, the study aimed to identify clinical features and blood biomarkers associated with persistent Long COVID symptoms. Methods: We sent a detailed long COVID symptoms questionnaire to an existing cohort of 1258 vaccinated adults (age 18–79 years) who had mild infection (e.g., non-hospitalized) SARS-CoV-2 Delta variant 2 years earlier. …”
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Subclinical Myocardial Injury and Global Cognitive Performance by Shubham Tomar, MBBS, MPH, Karita C.F. Lidani, MD, MSc, PhD, Aline A.I. Moraes, MD, PhD, Shi Huang, PhD, Christian Oakley, BS, Khurram Nasir, MD, MPH, Michael J. Blaha, MD, MPH, Susan R. Heckbert, MD, PhD, Timothy M. Hughes, PhD, Christopher R. deFilippi, MD, Yader Sandoval, MD, Allan S. Jaffe, MD, Andrew P. DeFilippis, MD, MSc

“…Objectives: The purpose of this study was to evaluate the relationship of myocardial injury, measured by high-sensitivity cardiac troponin T (hs-cTnT), with global cognitive performance and its decline over time. Methods: Hs-cTnT assessed at baseline (2000-2002) and exam 5 (2010-2012) in 4,445 participants. …”
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The Role of Atrial Fibrillation and Oral Anticoagulation Status in Health‐Related Quality of Life 12 Months After Ischemic Stroke or TIA by Manuel C. Olma, Lena Steindorf‐Sabath, Serdar Tütüncü, Claudia Kunze, Cornelia Fiessler, Paulus Kirchhof, Joanna Dietzel, Johannes Schurig, Patrick Oschmann, Ludwig Niehaus, Christian Urbanek, Götz Thomalla, Darius G. Nabavi, Joachim Röther, Ulrich Laufs, Roland Veltkamp, Peter U. Heuschmann, Karl Georg Haeusler, Matthias Endres, for the MonDAFIS Investigators

“…It is known that AF impairs health‐related quality of life (HRQOL) in the general population, but data on HRQOL in stroke patients with newly diagnosed AF are sparse. Methods Post hoc analysis of the prospective, investigator‐initiated, multicenter MonDAFIS study (NCT02204267) to analyze whether AF‐related oral anticoagulation (OAC), and/or AF‐symptom severity are associated with HRQOL after ischemic stroke or transient ischemic attack (TIA). …”
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Population impact and effectiveness of sequential 13-valent pneumococcal conjugate and monovalent rotavirus vaccine introduction on infant mortality: prospective birth cohort studi... by Anthony Costello, Neil French, Charles Mwansambo, Ellen Heinsbroek, Naor Bar-Zeev, Amelia Crampin, Nigel Cunliffe, Sonia Lewycka, Carina King, James Beard, Tambosi Phiri, Hazzie Mvula, Dan Hungerford, Jennifer Verani, Cynthia Whitney, Rob Heyderman, Osamu Nakagomi, Jacqueline E Tate, Umesh D Parashar

“…We evaluated mortality impact and vaccine effectiveness (VE) of PCV13 introduced in November 2011, with subsequent RV1 roll-out in October 2012, in Malawi.Methods We conducted two independent community-based birth cohort studies. …”
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Impact of Different Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blocker Resumption Timing on Post Acute Kidney Injury Outcomes by Jia-Jin Chen, Cheng-Chia Lee, Chieh-Li Yen, Pei-Chun Fan, Ming-Jen Chan, Tsung-Yu Tsai, Yung-Chang Chen, Chih-Wei Yang, Chih-Hsiang Chang

“…Cox proportional models estimated hazard ratios (HRs) for outcomes across different resumption timings, following a target trial design. …”
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<i>Commiphora leptophloeos</i> Bark Decoction: Phytochemical Composition, Antioxidant Capacity, and Non-Genotoxic Safety Profile by José Rafael da Silva Araujo, Rafael de Felício, Camila Marinho da Silva, Palloma Lima de Oliveira, Silvany de Sousa Araújo, Laís Roberta Deroldo Sommaggio, Adriana Fabiana Corrêa da Silva, Paulo Henrique Valença Nunes, Bruno Oliveira de Veras, Erwelly Barros de Oliveira, Jaciana dos Santos Aguiar, Maria Aparecida Marin-Morales, Daniela Barretto Barbosa Trivella, Ana Maria Benko-Iseppon, Márcia Vanusa da Silva, Ana Christina Brasileiro-Vidal

“…This study aimed to evaluate the aqueous bark extract of <i>C. leptophloeos</i>, focusing on its chemical composition and its antioxidant, cytotoxic, and genotoxic properties. <b>Methods</b>: The aqueous extract was obtained by decoction of dried bark samples. …”
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Pathologic upstaging and survival outcomes for patients undergoing segmentectomy versus lobectomy in clinical stage T1cN0M0 non–small cell lung cancerCentral MessagePerspective by Ryan C. Jacobs, MD, MS, Erik E. Rabin, MD, Charles D. Logan, MD, Sandeep N. Bharadwaj, MD, Hee Chul Yang, MD, Raheem D. Bell, MD, Emily J. Cerier, MD, Chitaru Kurihara, MD, Kalvin C. Lung, MD, Diego M. Avella Patino, MD, Samuel S. Kim, MD, Ankit Bharat, MBBS

“…Objectives: To assess the impact of the extent of surgical resection on overall survival in patients with clinical T1cN0M0 (cT1cN0M0) non–small cell lung cancer (NSCLC), with and without pathologic nodal upstaging (pN1+). Methods: The National Cancer Database (NCDB) was queried to identify patients with cT1cN0M0 NSCLC who underwent lobectomy or segmentectomy without receiving neoadjuvant therapy between 2010 and 2021. …”
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High genetic relatedness between multidrug resistant bacteria before and after the 2022 invasion of Ukraine by Francois Lebreton, Viacheslav Kondratiuk, Valentyn Kovalchuk, Niels Pfennigwerth, Ting L. Luo, Brendan T. Jones, Nadiia Fomina, Frieder Fuchs, Jörg B. Hans, Jessica Eisfeld, Ana Ong, Sören Gatermann, Jason W. Bennett, Patrick Mc Gann

“…Here, we analyzed a collection of Acinetobacter baumannii and Pseudomonas aeruginosa collected from Ukraine before and after the invasion to glean a greater understanding of their relationship and origins. Methods Genomic analysis was conducted on 167 A. baumannii and 93 P. aeruginosa cultured from 223 Ukrainian patients hospitalized in Ukraine or other European countries. …”
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Mean Arteriolar Diameter Measured from Wide-Field Swept-Source OCT Angiography: A Highly Sensitive Indicator for Mean Arterial Pressure by Yuchen Li, Yuyao Qu, Hanze Zhang, Yue Bian, Langxuan Yuan, Jingbo Hu, Shengrui Xu, Xiayu Xu, PhD, Jianqin Lei, MD

“…Generalized linear mixed models were used to test correlations between systemic parameters and these metrics. …”
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Regional aortic wall shear stress increases over time in patients with a bicuspid aortic valve by Savine C.S. Minderhoud, Aïmane Arrouby, Allard T. van den Hoven, Lidia R. Bons, Raluca G. Chelu, Isabella Kardys, Dimitris Rizopoulos, Suze-Anne Korteland, Annemien E. van den Bosch, Ricardo P.J. Budde, Jolien W. Roos-Hesselink, Jolanda J. Wentzel, Alexander Hirsch

“…The aim of this study was to study regional WSS and changes over time in BAV patients. Methods: BAV patients and age-matched healthy controls underwent four-dimensional (4D) flow cardiovascular magnetic resonance (CMR). …”
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Neutrophil–Lymphocyte Ratio and KELIM Score as Prognostic Markers in High-Grade Serous Advanced Ovarian Cancer Patients Treated with Neoadjuvant Chemotherapy by Vasilis Theodoulidis, Kalliopi Kissoudi, Kimon Chatzistamatiou, Panagiotis Tzitzis, Dimitris Zouzoulas, Iakovos Theodoulidis, Christos Anthoulakis, Theodoros Moysiadis, Maria Topalidou, Eleni Timotheadou, Grigoris Grimpizis, Dimitris Tsolakidis

“…This study evaluated the prognostic value of two biomarkers—the neutrophil–lymphocyte ratio (NLR) and the cancer antigen-125 (CA-125) ELIMination rate constant K (KELIM)—in predicting survival outcomes and recurrence rates in patients with AOC undergoing NACT. <b>Methods</b>: A retrospective, single-center analysis was conducted on 78 patients with high-grade serous AOC (stages III–IV) treated with platinum-based NACT followed by IDS between January 2013 and December 2023. …”
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Leveraging data science to understand and address multimorbidity in sub-Saharan Africa: the MADIVA protocol by Kobus Herbst, Stephen Tollman, Kathleen Kahn, Francesc Xavier Gómez-Olivé, Jaya George, Catherine Kyobutungi, Karen Hofman, Gershim Asiki, Michèle Ramsay, Daniel Ohene-Kwofie, Chodziwadziwa W Kabudula, Helen Robertson, Isaac Kisiangani, Palwende Boua, Eric Maimela, Damazo T Kadengye, Michelle Kamp, Daniel Maina Nderitu, Phelelani Thokozani Mpangase, Kayode Adetunji, Samuel Iddi, Skyler Speakman, Scott Hazelhurst, Kerry Glover, Tabitha Osler, Tanya Akumu, Diana Awuor, Victoria Bronstein, Joan Byamugisha, Jacques D Du Toit, Barry Dwolatzky, Paul A Harris, Celeste Holden, Nhlamulo Khoza, Faith Kimongo, Dekuwin E Kogda, Michael Klipin, Stephen P Levitt, Dylan Maghini, Karabo Maila, Ndivhuwo Makondo, Molulaqhooa Linda Maoyi, Reineilwe Given Mashaba, Nkosinathi Gabriel Masilela, Theophilous Mathema, Daphine T Nyachowe, Evelyn Thsehla, Siphiwe A Thwala, Roy Zent, Patrick Opiyo Owili

“…These datasets will be harmonised, linked and curated, and then used to develop MM risk prediction models, novel data science methods and interactive dashboards for research and clinical use. …”
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Novel sponge formulation of mesenchymal stem cell secretome and hyaluronic acid: a safe and effective topical therapy for Psoriasis vulgaris by Estefanía Elgueta, Catalina P. Prieto, Dan Hartmann, Daniela Carrillo, Natalie Edwards, Constanza Martínez, Dan Pérez, Bárbara Casas, Luis Vergara, Fernando Valenzuela, Verónica Catalán, José Lattus, Felipe Oyarzun-Ampuero, Verónica Palma

“…This formulation had previously demonstrated efficacy in vitro and in experimental psoriasis mouse models. Methods In vitro characterization studies included dynamic light scattering, nanoparticle tracking analysis, optical/electronic microscopy, microbiological experiments, and angiogenic capacity (HUVEC cells). …”
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