Comparison of the long-term prognostic value of different frailty instruments in older inpatients: a 5-year prospective cohort study by Min Zeng, Yu-Hao Wan, Yao-Dan Liang, Jing Shi, Zhi-Kai Yang, Ting Wang, Chen Ji, Wei He, Ning Sun, Di Guo, Ling-Ling Cui, Lin Yang, Jie-Fu Yang, Hua Wang

“…The predictive value of different frailty scales was compared using Kaplan–Meier (K–M) survival analysis, COX regression models, and the receiver operating characteristic (ROC) curves. …”
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Arterial stiffness and shortened QTc interval are associated with androgen and ACTH levels in classic congenital adrenal hyperplasia by Lorenzo Campioni, Lorenzo Campioni, Maria Chiara Di Carlo, Maria Chiara Di Carlo, Chiara Sola, Chiara Sola, Beatrice Bergoglio, Beatrice Bergoglio, Martina Bollati, Martina Bollati, Giulia Montesano, Federico Ponzetto, Federico Ponzetto, Chiara Lopez, Chiara Lopez, Giovanna Motta, Giovanna Motta, Mirko Parasiliti-Caprino, Mirko Parasiliti-Caprino, Roberta Giordano, Roberta Giordano

“…Propensity score-matched analysis with 1:2 matching ratio, based on the same regression models, confirmed that CAH diagnosis was associated with AASI (p<0.001) and QTc (p=0.004).ConclusionsAdults with classic CAH show increased arterial stiffness and altered cardiac repolarization, likely linked to chronic hormonal imbalance. …”
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Polarization Characteristics of the Hyperactive FRB 20240114A by Jin-Tao Xie, Yi Feng, Di Li, Yong-Kun Zhang, Deng-Ke Zhou, Yuanhong Qu, Xiang-han Cui, Jian-Hua Fang, Jia-Ying Xu, Chen-Chen Miao, Mao Yuan, Chao-Wei Tsai, Pei Wang, Chen-Hui Niu, Xianglei Chen, Mengyao Xue, Junshuo Zhang

“…Additionally, we present a novel method to determine the frequency range of bursts based on their spectral characteristics. …”
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Factors Affecting the Counterproductive Behaviors of Employees in the Organization; Emphasizing the Role of Organizational Embeddedness, Emotional Intelligence and Psychological Ow... by Marziyeh Dehghanizadeh, Mehdi Kheirandish, Hojjat Kheirandish

“…The validity of the questionnaires was confirmed a panel of experts in the field, and Cronbach's alpha coefficient and composite reliability were used to estimate the reliability of the instruments. The analysis method used in this research was the structural equation modeling technique.…”
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SH3GL1‐activated FTH1 inhibits ferroptosis and confers doxorubicin resistance in diffuse large B‐cell lymphoma by Zi‐Wen Duan, Wei‐Ting Wang, Yan Wang, Rong Wang, Wei Hua, Chun‐Yu Shang, Rui Gao, Hao‐Rui Shen, Yue Li, Jia‐Zhu Wu, Hua Yin, Li Wang, Jian‐Yong Li, Wei Xu, Jin‐Hua Liang

“…Nevertheless, a subset of patients experiences refractory or relapsed disease, highlighting the need for new therapeutic strategies. Methods Depmap database based on CRISPR/Cas9 knock out analysis was employed to identify the essential gene SH3GL1, which encodes endophilin A2, as crucial for the proliferation and survival of DLBCL cells. …”
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Association between estimated glucose disposal rate and prediabetes reversion and progression: a nationwide cohort study of middle-aged and elderly people in China by Xin Huang, Xin Huang, Shiming He, Shiming He, Chao Wang, Chao Wang, Guoan Jian, Kun Jiang, Zihao Lu, Wei Wang, Guotai Sheng, Yang Zou

“…This study aims to investigate the association between a novel marker of insulin resistance-the estimated glucose disposal rate (eGDR)-and the reversion of prediabetes to normoglycaemia or progression to diabetes in a Chinese population.MethodsThis prospective cohort study utilized baseline data from the 2011 China Health and Retirement Longitudinal Study involving 2,600 prediabetic participants aged 45 years and older, along with follow-up data from 2015. …”
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Branch Duct IPMN-Associated Acute Pancreatitis in a Large Single-Center Cohort Study by Nicolò de Pretis, Luigi Martinelli, Antonio Amodio, Federico Caldart, Salvatore Crucillà, Maria Sole Battan, Alberto Zorzi, Stefano Francesco Crinò, Maria Cristina Conti Bellocchi, Laura Bernardoni, Giulia De Marchi, Pietro Campagnola, Roberto Salvia, Armando Gabbrielli, Alessandro Marcon, Luca Frulloni

“…Cox proportional hazard models were used to analyze the time to recurrence after the first occurrence of AP. …”
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Impact of hospital-based early detection on management in chronic kidney disease: the CKD Stewardship study (CKD-S) – protocol for a prospective, multicentre, observational cohort... by John Saunders, Brendan Smyth, Amy Kang, Steven Chadban, Shaundeep Sen, George Mangos, Lisa Tienstra, Sarah Norris, Lilijana Gorringe, Lucinda Alix Wynter, Carmen Moroney, Kylie Turner, Sreeram Venugopal, Rowena Monteverde, Leyla Aouad

“…CKD Stewardship (CKD-S) aims to identify hospital inpatients with undiagnosed mid-stage to late-stage CKD with the goal of facilitating diagnosis and initiating guideline-based therapies.Methods and analysis This prospective, multicentre, cohort study compares two models of care, CKD-S and standard care, for identification and management of CKD, across six public hospitals in metropolitan Sydney, Australia. …”
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Cancer, genetic susceptibility and risk of coronary artery disease: A prospective study by Yidan Wang, Shan Zhong, Na Sun, Yunfei Wu, Jun Lyu, Minghui Piao, Wenbo Qu, Xueyu Wang, Wenjun Ni, Xia Gu, Tianshu Han, Jinwei Tian

“…We introduce CAD polygenic risk scores (PRS) and examine associations with cancer status on CAD outcomes. Methods: From the UK Biobank, we identified cancer survivors and CAD outcomes among 464,193 CAD-free participants using linked cancer registries, hospitalizations, and death records. …”
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Curcumin-like Compound Inhibits Proliferation of Adenocarcinoma Cells by Inducing Cell Cycle Arrest and Senescence by Rafael Fonseca, Yasmin dos Santos Louzano, Cindy Juliet Cristancho Ortiz, Matheus de Freitas Silva, Maria Luiza Vieira Felix, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Bruno Zavan, Claudio Viegas, Marisa Ionta

“…<b>Objectives:</b> We investigated the pharmacological potential of a series of curcumin-like compounds using two lung adenocarcinoma cell lines as models. <b>Methods and Results:</b> Cell viability assay led to the identification of PQM-214 as the hit compound, and other methodologies were employed to investigate the mechanisms underlying its antitumor potential, including cell cycle analysis, mitotic index determination, assessment of clonogenic capacity, senescence-associated β-galactosidase and annexin V assays, quantitative PCR, and Western blot analyses. …”
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Identifying inflammatory phenotypes associated with lung involvement in systemic sclerosis: k-means clustering approach by Laura Cano-García, Laura Cano-García, Aimara García-Studer, Aimara García-Studer, Aimara García-Studer, Sara Manrique-Arija, Sara Manrique-Arija, Sara Manrique-Arija, Fernando Ortiz-Marquez, Fernando Ortiz-Marquez, Fernando Ortiz-Marquez, Rocío Redondo-Rodríguez, Rocío Redondo-Rodríguez, Paula Borregón-Garrido, Paula Borregón-Garrido, Natalia Mena-Vázquez, Natalia Mena-Vázquez, Antonio Fernández-Nebro, Antonio Fernández-Nebro, Antonio Fernández-Nebro

“…Objectiveto assess the prognostic impact of clusters of hematologic and biochemical indices on interstitial lung disease (ILD) and respiratory damage associated with systemic sclerosis (SSc)MethodsDesign: We conducted a cross-sectional, uncontrolled study. …”
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Association between physical activity and executive function of Chinese adolescents aged 13–18 by Yuan Liu, Xiaojian Yin, Yi Sun, Feng Zhang, Feng Zhang, Cunjian Bi, Yaru Guo, Yaru Guo, Pengwei Sun, Pengwei Sun, Hong Jun, Hong Jun, Yanyan Hu, Yanyan Hu, He Liu, He Liu

“…Data were analyzed using one-way ANOVA, Pearson correlation analysis, and 30-minute isotemporal substitution models (ISM) to assess the association between PA and EF.ResultsDaily moderate-to-vigorous physical activity (MVPA) time in both boys and girls was negatively correlated with inhibitory control RTs (r = −0.279, −0.173, P &lt; 0.01), 2back-RTs (r = −0.367, −0.268, P &lt; 0.01), and cognitive flexibility RTs (r = −0.283, −0.305, P &lt; 0.01). …”
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Incorporation of Metabolic Dysfunction‐Associated Steatotic Liver Disease in the Health Stage of Cardiovascular‐Kidney‐Metabolic Syndrome Improves Predictive Ability for Coronary A... by Wataru Kawaharata, Marenao Tanaka, Tatsuya Sato, Yukinori Akiyama, Itaru Hosaka, Hiroki Aida, Rie Matsumori, Kei Nakata, Keitaro Nishizawa, Toru Suzuki, Hidemichi Kouzu, Nagisa Hanawa, Masato Furuhashi

“…Although concomitant metabolic dysfunction‐associated steatotic liver disease (MASLD) exacerbates CKM syndrome, MASLD is not included in the original stratification (stages 0–3) for predicting cardiovascular disease (stage 4). Methods We investigated whether the addition of MASLD in the original health stage of CKM syndrome improves the risk stratification of CAD in Japanese participants who underwent annual health checkups. …”
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Ferrostatin-1 improves acute sepsis-induced cardiomyopathy via inhibiting neutrophil infiltration through impaired chemokine axis by Jialin Li, Jialin Li, Fang Xiao, Fang Xiao, Bingsen Lin, Bingsen Lin, Zhilei Huang, Mingyue Wu, Huan Ma, Ruoxu Dou, Xiaodong Song, Zhongxing Wang, Changjie Cai, Xiangdong Guan, Jie Xu, Jie Xu, Fu-Li Xiang, Fu-Li Xiang

“…Our study aims to elucidate the role of Fer-1 in the acute phase of peritonitis sepsis induced cardiac injury.Methods and ResultsCLP was used to induce peritonitis sepsis in mice. …”
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Early intranasal medication administration in out‐of‐hospital cardiac arrest: Two randomized simulation trials by Stephen R. Dowker, Madison L. Downey, Noor K. Majhail, Isabella G. Scott, Jonah Mathisson, Daniel Rizk, Brad Trumpower, Debra Yake, Michelle Williams, Emilee I. Coulter‐Thompson, Christine M. Brent, Graham C. Smith, Robert Swor, David A. Berger, Deborah M. Rooney, Robert W. Neumar, Charles P. Friedman, James M. Cooke, Amanda L. Missel

“…We sought to quantify the effects of intranasal medication administration (INMA) in OHCA workflows. Methods We conducted separate randomized OHCA simulation trials with lay rescuers (LRs) and first responders (FRs). …”
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Improvement of alexithymia in patients treated in mental health services for personality disorders: a longitudinal, observational study by Hanna Sayar, Theresa Wilberg, Theresa Wilberg, Ingeborg Ulltveit-Moe Eikenæs, Andreas Ekberg, Andreas Ekberg, Kai Leitemo, Katharina Teresa Enehaug Morken, Katharina Teresa Enehaug Morken, Eileen Oftedal, Eileen Oftedal, Siri Omvik, Dag Anders Ulvestad, Dag Anders Ulvestad, Geir Pedersen, Elfrida Hartveit Kvarstein, Elfrida Hartveit Kvarstein

“…Supplementary outcomes included global psychosocial function and health-related life quality. Linear mixed models were applied for data analysis.ResultsAlexithymia was highly prevalent in the sample: 53% of subjects reported high levels and 20% moderate levels. …”
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Nanostructured Lipoxin A4: Understanding Its Biological Behavior and Impact on Alzheimer’s Disease (Proof of Concept) by Natália Cristina Gomes-da-Silva, Isabelle Xavier-de-Britto, Marilia Amável Gomes Soares, Natalia Mayumi Andrade Yoshihara, Derya Ilem Özdemir, Eduardo Ricci-Junior, Pierre Basílio Almeida Fechine, Luciana Magalhães Rebelo Alencar, Maria das Graças Muller de Oliveira Henriques, Thereza Christina Barja-Fidalgo, Cristian Follmer, Ralph Santos-Oliveira

“…This study aimed to develop and characterize nanomicelles encapsulating LXA4 (nano-lipoxin A4) to improve its pharmacological efficacy against Alzheimer’s disease (AD), a neurodegenerative condition marked by chronic inflammation and beta-amyloid (Aβ) accumulation. <b>Methods</b>: Nano-lipoxin A4 was synthesized using Pluronic F-127 as a carrier and characterized in terms of morphology, physicochemical stability, and in vitro activity against Aβ fibrils. …”
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Peer support enhanced behavioural crisis response teams in the emergency department: protocol for a stepped-wedge cluster-randomised controlled trial by Ambrose H Wong, James D Dziura, Mark Sevilla, Yue Hu, Megan Evans, Bidisha Nath, Rebekah Heckmann, Riddhi Desai, Anusha Kumar, Isaac V Faustino, Anthony J Pavlo, Joan M Cook, Kendra Davis-Plourde, Richard Youins, Kimberly Guy, Pastor Evelyn Smith, Pastor Dana Smith, Karen Kangas, Lou Hart, Seth Powsner, Chyrell Bellamy

“…The goal of this study is to evaluate if the implementation of a Peer support enhanced Agitation Crisis response Team (PACT) for behavioural crisis management in the ED is more effective than usual care to reduce restraint use and improve outcomes among patients presenting to the ED with behavioural crises.Methods and analysis We will first conduct a stakeholder-informed needs assessment to codesign the protocol and then train staff and peers in PACT intervention readiness. …”
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Screen time exposure and academic performance, anxiety, and behavioral problems among school children by Mohammad Sidiq, Balamurugan Janakiraman, Faizan Kashoo, Rayan Jastania, Abdullah Ibrahim Alhusayni, Abdullah Alzahrani, Aksh Chahal, Alagappan Thiyagarajan, Imran Khan, Chandan Kumar, Rajkumar Krishnan Vasanthi, Fahad Alanazi, Mehrunnisha Ahmad, Chhavi Arora Sehgal, Shabnam Khan, Mshari Alghadier

“…Therefore, we aimed to investigate the relationships between screen time and academic performance, anxiety, and outdoor playing among school children in India. Methods A total of 537 parents responded to this online survey and reported approximately 537 Indian school children (mean age 10.9 years) from five schools. …”
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Early cardiac events after haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide. subanalysis exploring cardiac toxicity conducted on behalf of GE... by Filipe R. Pinto, Enric Cascos, Estefanía Pérez-López, Mónica Baile-González, Carlos Martín Rodríguez, María Jesús Pascual Cascón, Marta Luque, Albert Esquirol, Carmen Martín Calvo, Felipe Peña-Muñóz, Inmaculada Heras Fernando, Itziar Oiartzabal Ormtegi, Adolfo Jesús Sáez Marín, Sara Fernández-Luis, Juan José Domínguez-García, Sara Villar Fernández, José Luis López Lorenzo, Miguel Fernández de Sanmamed Girón, Leslie González Pinedo, Lucía García, Ana Pilar González-Rodriguez, Tamara Torrado, Silvia Filaferro, Pascual Basalobre, Alberto López-García, Guillermo Ortí, Guillermo Ortí, Manuel Jurado Chacón, Manuel Jurado Chacón, María Queralt Salas, María Queralt Salas

“…This study investigates the incidence, predictors, and impact of early cardiac events (ECE) in haplo-HCT recipients.MethodsWe conducted a retrospective, multicenter analysis of 268 patients with acute myeloid leukemia (AML) treated with anthracycline-based induction regimens and undergoing their first haplo-HCT with PTCY (50 mg/kg/day on days +3 and +4) between 2011 and 2022. …”
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