The ATLAS/NOA-29 study protocol: a phase III randomized controlled trial of anterior temporal lobectomy versus gross-total resection in newly-diagnosed temporal lobe glioblastoma by Matthias Schneider, Anna-Laura Potthoff, Yahya Ahmadipour, Valeri Borger, Hans Clusmann, Stephanie E. Combs, Marcus Czabanka, Lasse Dührsen, Nima Etminan, Thomas M. Freiman, Ruediger Gerlach, Florian Gessler, Frank A. Giordano, Eleni Gkika, Roland Goldbrunner, Erdem Güresir, Hussam Hamou, Peter Hau, Sebastian Ille, Max Jägersberg, Naureen Keric, Maryam Khaleghi-Ghadiri, Ralph König, Jürgen Konczalla, Harald Krenzlin, Sandro Krieg, Aaron Lawson McLean, Julian P. Layer, Jens Lehmberg, Vesna Malinova, Bernhard Meyer, Hanno S. Meyer, Dorothea Miller, Oliver Müller, Christian Musahl, Barbara E. F. Pregler, Ali Rashidi, Florian Ringel, Constantin Roder, Karl Rössler, Veit Rohde, I. Erol Sandalcioglu, Niklas Schäfer, Christina Schaub, Nils Ole Schmidt, Gerrit A. Schubert, Clemens Seidel, Corinna Seliger, Christian Senft, Julia Shawarba, Joachim Steinbach, Veit Stöcklein, Walter Stummer, Ulrich Sure, Ghazaleh Tabatabai, Marcos Tatagiba, Niklas Thon, Marco Timmer, Johannes Wach, Arthur Wagner, Christian Rainer Wirtz, Katharina Zeiler, Thomas Zeyen, Patrick Schuss, Rainer Surges, Christine Fuhrmann, Daniel Paech, Matthias Schmid, Yvonne Borck, Torsten Pietsch, Rafael Struck, Alexander Radbruch, Christoph Helmstaedter, Robert Németh, Ulrich Herrlinger, Hartmut Vatter

“…Methods The ATLAS/NOA-29 trial is a prospective, multicenter, multinational, phase III randomized controlled trial designed to compare ATL with standard gross-total resection (GTR) in patients with newly-diagnosed anterior temporal lobe glioblastoma. …”
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Effective and ineffective psychological adjustment in breast cancer patients before receiving neoadjuvant chemotherapy: insights from a cohort study by Majid Omari, Salima Kriya, Sara Nadi, Ghita Zerhouni, Chaymae El Abbas, Achraf El Asri, Zineb Benbrahim, Nawfel Mellas, Karima El Rhazi, Mohammed El Amine Ragala, Jaouad El Hilaly, Karima Halim, Lamiae Amaadour, Btissame Zarrouq

“…Univariate and multivariate linear regression modelling was carried out using a forward “enter” regression procedure. …”
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Immunosuppressive JAG2+ tumor‐associated neutrophils hamper PD‐1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells by Chenyang Wang, Moran Yang, Yujing Zhong, Kankan Cao, Xueling Wang, Chen Zhang, Yiying Wang, Mengdi He, Jiaqi Lu, Guodong Zhang, Yan Huang, Haiou Liu

“…We investigated the biological functions of JAG2 in immune evasion using in vitro co‐culture systems, flow cytometry, tumor‐bearing mouse models, and PDTOs. Results JAG2+ TANs expressed elevated levels of immunosuppressive molecules, including programmed cell death ligand 1 and CD14, and had independent prognostic value for the overall survival of patients with HGSOC. scRNA‐seq analysis revealed that JAG2+ TANs exhibited a terminally mature phenotype. …”
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Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10 by Bernard A Fox, Cristina Bergamaschi, George N Pavlakis, Antonio Valentin, Jenifer Bear, Barbara K Felber, Shawn M Jensen, Hrishikesh Pandit, Bethany A Nagy, Dimitris Stellas, Maggie Cam

“…Bioactive IL-15 is produced in the body as a heterodimeric cytokine, comprising the IL-15 and IL-15 receptor alpha chains (hetIL-15). Several preclinical models support the antitumor activity of hetIL-15 promoting its application in clinical trials.Methods The antitumor activity of hetIL-15 produced from mammalian cells was tested in mouse tumor models (MC38 colon carcinoma and TC-1 epithelial carcinoma). …”
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Socio‐economic status and adherence to HIV preventive and therapeutic interventions: exploring the mediating role of food insecurity among men who have sex with men and transgender... by Paula M. Luz, Thiago S. Torres, Victor C. Matos, Giovanna G. Costa, Brenda Hoagland, Cristina Pimenta, Marcos Benedetti, Beatriz Grinsztejn, Valdilea G. Veloso

“…We explored whether food insecurity mediated the association of socio‐economic status on adherence to ART/PrEP. Methods Adult men who have sex with men (MSM) and transgender and non‐binary persons (TGNB) living in Brazil (May−September/2021) voluntarily participated in a cross‐sectional online study advertised on dating apps and social media. …”
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Therapeutic potential of T-cell receptor targeting the HLA-A*11:01-restricted KRASG12V neoantigen without cross-recognition of the self-antigen RAB7B in solid tumors by Wang Wang, Jingjing Huang, Yanan Hao, Lin Zou, Xiaxia Han, Tong Chen, Meiying Shen, Bozhi Wang, Luo Li, Siyin Chen, Shengchun Liu, Xiaojian Han, Aishun Jin

“…In vivo antitumor efficacy of TCR-T cells was tested in xenograft mouse models of solid tumors.Results The analysis of HLA binding properties for public neoantigens revealed that HLA-A*11:01-presented KRASG12V epitopes exhibited the strongest HLA binding stability. …”
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Mechanisms of Cefiderocol Resistance in Carbapenemase-Producing Enterobacterales: Insights from Comparative Genomics by Alexander Tristancho-Baró, Ana Isabel López-Calleja, Ana Milagro, Mónica Ariza, Víctor Viñeta, Blanca Fortuño, Concepción López, Miriam Latorre-Millán, Laura Clusa, David Badenas-Alzugaray, Rosa Martínez, Carmen Torres, Antonio Rezusta

“…Whole-genome sequencing, variant annotation, structural modelling, and pangenome analysis were performed to characterize resistance mechanisms. …”
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Dose–response study of a fenugreek-based antibiotic alternative in Bábolna Tetra-SL chicks (1–42 days old) with mixed bacterial infections by Ádám Kerek, Ádám Kerek, Ábel Szabó, Péter Ferenc Dobra, Krisztina Bárdos, Krisztina Bárdos, Bettina Paszerbovics, Zsófia Bata, Viviána Molnár-Nagy, Ákos Jerzsele, Ákos Jerzsele, László Ózsvári, László Ózsvári

“…Because of this, there is an urgent need for safe and effective alternatives in animal husbandry.MethodsThis study aimed to perform an in vivo the dose–response analysis of fenugreek (Trigonella foenum-graecum), as a plant-based antibiotic alternative feed supplement in Bábolna Tetra-SL chicks (1–42 days old) with a 1:1 sex ratio. …”
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Historical overview, advancements, and future prospects of coalfield structure research in China by Daiyong CAO, Yiwen JU, Yucheng XIA, Bo JIANG, Shuzheng NING, Yingchun WEI, Anmin WANG, Xiaoming LI, Wenfeng ZHAN, Huantong LI, Lu WANG, Zhuocheng CAI

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The Impact of Digital Technology–Based Exercise Combined With Dietary Intervention on Body Composition in College Students With Obesity: Prospective Study by Chengyuan Hu, Zixin Lv, Jieping Zhu, Chunyuan Lai, Dongjuan Guo, Maolin Chen, Xiaoyan Cheng, Mingxin Rao, Xinyou Zhou, Liqiang Su

“…Linear mixed effects models showed that the sex and diet interaction significantly affected subcutaneous fat mass (P=.02). …”
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Progression of the first stage of spontaneous labour: A prospective cohort study in two sub-Saharan African countries. by Olufemi T Oladapo, Joao Paulo Souza, Bukola Fawole, Kidza Mugerwa, Gleici Perdoná, Domingos Alves, Hayala Souza, Rodrigo Reis, Livia Oliveira-Ciabati, Alexandre Maiorano, Adesina Akintan, Francis E Alu, Lawal Oyeneyin, Amos Adebayo, Josaphat Byamugisha, Miriam Nakalembe, Hadiza A Idris, Ola Okike, Fernando Althabe, Vanora Hundley, France Donnay, Robert Pattinson, Harshadkumar C Sanghvi, Jen E Jardine, Özge Tunçalp, Joshua P Vogel, Mary Ellen Stanton, Meghan Bohren, Jun Zhang, Tina Lavender, Jerker Liljestrand, Petra Ten Hoope-Bender, Matthews Mathai, Rajiv Bahl, A Metin Gülmezoglu

“…We independently applied survival analysis and multistate Markov models to estimate the duration of labour centimetre by centimetre until 10 cm and the cumulative duration of labour from the cervical dilatation at admission through 10 cm. …”
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The Effect of Randomized Beta-Carotene Supplementation on CKD in Men by Api Chewcharat, Pol Chewcharat, Kathryn M. Rexrode, Robert J. Glynn, Julie E. Buring, John Michael Gaziano, Howard D. Sesso

“…Previous studies in animal models have demonstrated a potential protective effect of 30 mg/kg BC supplementation on renal ischemia or reperfusion injury and subsequently improved kidney function. …”
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Cardiovascular risk in childhood and young adulthood is associated with the hemodynamic response function in midlife: The Bogalusa Heart Study by Kai-Cheng Chuang, Maryam Naseri, Sreekrishna Ramakrishnapillai, Kaitlyn Madden, Julia St Amant, Kevin McKlveen, Kathryn Gwizdala, Ramasudhakar Dhullipudi, Lydia Bazzano, Owen Carmichael

“…The HRF has the potential to quantify neurovascular mechanisms by which cardiovascular risks modify brain health, but relationships among HRF characteristics, brain health, and cardiovascular modifiers of brain health have not been well studied to date. Methods: One hundred and thirty-seven middle-aged participants (mean age: 53.6 ± 4.7, female (62 %), 78 % White American participants and 22 % African American participants) in the exploratory analysis from Bogalusa Heart Study completed clinical evaluations from childhood to midlife and an adaptive Stroop task during fMRI in midlife. …”
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Associations between smartphone GPS data and changes in psychological health and burden outcomes among family caregivers and patients with advanced cancer: an exploratory longitudi... by J. Nicholas Odom, Kyungmi Lee, Erin R. Harrell, Kristen Allen Watts, Avery C. Bechthold, Sally Engler, Frank Puga, Natashia Bibriescas, Arif H. Kamal, Christine S. Ritchie, George Demiris, Alexi A. Wright, Marie A. Bakitas, Andres Azuero

“…After pre-processing raw GPS data into daily GPS features (e.g., time spent at home, distance traveled/day), computing biweekly moving averages and standard deviations, and conducting a principal components analysis (PCA) of the resulting variables, within-person regression models were used to assess associations between changes in PRO measures and changes in PCA scores, with adjusted-R2 as the measure of effect size (small = 0.02, medium = 0.13, large = 0.26). …”
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Insights into structure and activity of a UDP-GlcNAc 2-epimerase involved in secondary cell wall polymer biosynthesis in Paenibacillus alvei by Cordula Stefanović, Max S. G. Legg, Nick Mateyko, Jakob J. Ender, Tea Kuvek, Chris Oostenbrink, Christina Schäffer, Stephen V. Evans, Fiona F. Hager-Mair

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Seasonal Variation of Length-Weight Relationship and Some Biological Parameters in the Fish Cyprinion watsoni (Day, 1872) of Sarbaz River by Mohammad Borhani, Mohammadreza Rahmani, Mohammad Purki, Bagher Nezami Balochi

“…Therefore, obtaining information about the relationship length-weight, along with fecundity and gonadal indices, especially during one year, is effective not only in estimating models for the evaluation of aquatic resources but also in understanding their biological aspects, which are a sign of the sustainable dynamics of their population and the health of aquatic ecosystems.Materials and Methods: According to the little available data about Sheydaar fish (Cyprinion watsoni), to understand the annual fluctuations of the length-weight relationship and some other parameters, 100 Cyprinion watsoni fish were collected between May 2015 and July 2016 using fishing nets from the Sarbaz River. …”
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Preoperative level of sex hormones as a predictor (prognostic factor) of the morphological characteristics of testicular malignancies by R. F. Kholbobozoda, A. A. Kostin, N. V. Vorobyev, A. O. Tolkachev, A. A. Krasheninnikov, I. A. Taraki, A. D. Kaprin

“…Aim of the study: to analyze the relationship between hormone levels and the clinical stage and histological characteristics of the tumor in patients with testicular cancer and to develop prognostic models. Material and Methods. This prospective single-center study included 66 patients with testicular cancer. …”
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The extracellular matrix protein type I collagen and fibronectin are regulated by β-arrestin-1/endothelin axis in human ovarian fibroblasts by Ilenia Masi, Flavia Ottavi, Valentina Caprara, Danila Del Rio, Martina Kunkl, Francesca Spadaro, Valerio Licursi, Loretta Tuosto, Anna Bagnato, Laura Rosano’

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Modulating TNFα activity allows transgenic IL15-Expressing CLL-1 CAR T cells to safely eliminate acute myeloid leukemia by Maksim Mamonkin, Malcolm K Brenner, Norihiro Watanabe, Pinar Ataca Atilla, Mary K McKenna, Haruko Tashiro, Madhuwanti Srinivasan, Feiyan Mo, Brian Wesley Simons, Alexandra McLean Stevens, Michele S Redell, Helen E Heslop, Erden Atilla

“…Here, we optimized our CLL-1 CAR for anti-leukemic activity in mouse xenograft models of aggressive AML.Methods First, we optimized the CLL-1 CAR using different spacer, transmembrane and costimulatory sequences. …”
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Video game-based application for fall risk assessment: a proof-of-concept cohort studyResearch in context by Antao Ming, Tanja Schubert, Vanessa Marr, Jaqueline Hötzsch, Sebastian Stober, Peter R. Mertens

“…By data analyses using binary machine learning models a classification of participants was achieved and compared with actual fall events reported for the past 24 months. …”
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