Evaluation of dual pathogen recognition receptor agonists as adjuvants for respiratory syncytial virus - virus-like particles for pulmonary delivery by Ahmedali S. Mandviwala, Komal Liman, Anke L. W. Huckriede, Vidya A. Arankalle, Harshad P. Patil

“…This study evaluates the efficacy of two different dual PRR binding chimeric molecules CL413 (TLR2/TLR7 agonist) and CL429 (TLR2/NOD2 agonist) as adjuvants for RSV virus-like particles (VLPs) delivered via the pulmonary route in mice for induction of mucosal and systemic immunity.MethodsBALB/c mice were immunized twice with the RSV-VLPs alone or adjuvanted with CL413, CL429, mixture of single PRR agonists Pam3CSK4+ L18-MDP or Pam3CSK4+ imiquimod via the pulmonary route. …”
Get full text

A Mobile Ecological Momentary Intervention for Reducing Experiential Avoidance in the Context of Rumination: Protocol for a Randomized Controlled Trial by Steven Barnes, Marta Szastok, Małgorzata Para, Fabian Morawiec, Maciej Grzeszczuk, Szymon Wójcik, Barbara Karpowicz, Pavlo Zinevych, Anna Jaskulska, Wiesław Kopeć, Monika Kornacka

“…The app was developed by a multidisciplinary team, incorporating feedback from potential end users. MethodsConsenting individuals (target N=60) who meet the inclusion criteria (self-reporting problems with repetitive negative thinking) will be randomly assigned to 1 of 4 conditions: (1) intervention with therapist support and daily sampling, (2) intervention without support and with daily sampling, (3) partial intervention (emotion validation EMI only) with daily sampling, or (4) control (daily sampling only). …”
Get full text

The Association of Serum Irisin with Bone Mineral Density and Turnover Markers in New-Onset Type 2 Diabetic Patients by Xiujing Wang, Tianxiao Hu, Yun Ruan, Jiaqi Yao, Huiling Shen, Yao Xu, Bojing Zheng, Zhengying Zhang, Jing Wang, Qingying Tan

“…Multiple stepwise regression analysis was conducted to identify the independent factors of irisin. …”
Get full text

The predictive value of the TG/HDL index for metabolic syndrome and its components: A cross-sectional study in the PERSIAN Guilan Cohort Population by Amirali Ebrahimi, Farahnaz Joukar, Kourosh Mojtahedi, Saman Maroufizadeh, Soheil Hassanipour, Mohammad Reza Naghipour, Mehrnaz Asgharnezhad, Fariborz Mansour-Ghanaei

“…Objectives: This study aims to evaluate the association between the TG/HDL-C ratio and MetS in the Guilan Cohort Study (GCS), a population-based survey in northern Iran, and to identify sex-specific cutoff values for MetS prediction. Methods: This cross-sectional analysis included 10,520 adults aged 35–70 from the GCS. …”
Get full text

Association between organochlorine pesticides and metabolic dysfunction-associated steatotic liver disease: Findings from the Dongfeng-Tongji cohort by Yi Guo, Xin Guan, Yutong You, Chengyong Jia, Yuhui Lin, Zhen Yin, Yu Yin, Guorong Zhong, Yuying Wen, Wenhui Li, Hui Zhao, Shengli Chen, Xi Wang, Xinlian Li, Xuanwen Mu, Pinpin Long, Hao Wang, Xiaomin Zhang, Meian He, Yu Yuan, Tao Jing, Huan Guo, Tangchun Wu

“…Objective: To estimate the association between organochlorine pesticides (OCPs) and incident MASLD among Chinese population. Methods: We conducted a longitudinal study involving 1199 participants based on Dongfeng-Tongji cohort. …”
Get full text

Endoscopic variceal ligation combined with carvedilol versus endoscopic variceal ligation combined with propranolol for the treatment of oesophageal variceal bleeding in cirrhosis:... by Jing Wang, Meng Li, Lei Wang, Li Zhang, Ling Yang, Jian Wang, Duolao Wang, Rong Wang, Ya Peng, Chao Ma, Yiling Li, Yi Chen, Jing Xu, Xiaolong Qi, Hua Ye, Zhendong Jin, Hongyun Zhao, Wei Yan, Liwei Zhang, Chuan Liu, Andres Cardenas, Li Du, Ying Song, Biao Xie, Zhi Wei, Jianzhou Li, Wenhui Zhang, Qinghua Pan, Huiling Xiang, Shaoting Zhang, Shuairan Zhang, Xuan Liang, Shengjuan Hu, Lijun Peng, Xiaojie Zhang, Jingyi Xu, Xiaochao Liu, Huanhai Xu, Zhixu Fan, Lichun Shao, Pengyuan He, Qianlong Li, Yunhai Wu, Liyao Zhang, Dianliang Fang, Quanke Li, Dongli Xia, Yuchen Lv, Zongchao Zhang, Chaoguang Yan, Yuxia Wan, Haiming Fang, Wenlong Yang, Xiangman Zhang, Wei Rao, Xiurong Xia, Qiang Qiao, Ruimiao Yu, Changzhen Ren, Yuejun Yang, Zhenzhen Zhai, Xuejin Liu, Xingjun Lu, Yansheng Jia

“…This study aims to compare the effectiveness and safety of these treatments in preventing variceal rebleeding or death in patients with cirrhosis and EVB.Methods and analysis This multicentre, RCT is scheduled to begin in December 2024, with recruitment and follow-up continuing until December 2026. …”
Get full text

FGFR2 identified as a NETs-associated biomarker and therapeutic target in diabetic foot ulcers by Linrui Dai, Shunli Rui, Mengling Yang, Shiyan Yu, Qingqing Chen, Hongyan Wang, Bo Deng, Liling Deng, Wei Hao, Xiaohua Wu, David G. Armstrong, Zhidong Cao, Xiaodong Duan, Wuquan Deng

“…This study aimed to identify and validate novel NETs-associated biomarkers in DFU using an integrative bioinformatics and machine learning approach. Methods Differentially expressed genes (DEGs) were identified from the GEO dataset GSE134431. …”
Get full text

Obesity and outcomes after elective thoracoabdominal aortic aneurysm repairCentral MessagePerspective by Sanford Zeigler, MD, Kyle W. Blackburn, BS, Ahmad Tabatabaeishoorijeh, BS, Veronica A. Glover, PhD, Susan Y. Green, MPH, Marc R. Moon, MD, Scott A. LeMaire, MD, Joseph S. Coselli, MD

“…Multivariable logistic regression modeling identified predictors of operative mortality in patients with obesity. …”
Get full text

Examining the social distributions in neighbourhood black carbon and ultrafine particles in Montreal and Toronto, Canada by Emmanuelle Batisse, Marshall Lloyd, Alicia Cavanaugh, Arman Ganji, Junshi Xu, Marianne Hatzopoulou, Jill Baumgartner, Scott Weichenthal

“…Final exposure surfaces were generated by integrating predictions from land-use regression models and deep convolutional neural network models. …”
Get full text

Impact of DNA‐Methylation Age Acceleration on Long‐Term Mortality Among US Adults With Cardiovascular‐Kidney‐Metabolic Syndrome by Shuang Wu, Jun Zhu, Siqi Lyu, Juan Wang, Xinghui Shao, Han Zhang, Ziyi Zhong, Hongyu Liu, Lihui Zheng, Yang Chen

“…Background The association between DNA methylation age acceleration (DNAmAA) and cardiovascular‐kidney‐metabolic (CKM) syndrome stages and long‐term mortality in the population with CKM syndrome remains unclear. Methods and Results This cohort study included 1889 participants from the National Health and Nutrition Examination Survey (1999–2002) with CKM stages and DNA methylation age data. …”
Get full text

The Diagnostic and Prognostic Value of the 12-Lead ECG in Arrhythmogenic Left Ventricular Cardiomyopathy by Leonardo Calò, MD, Cinzia Crescenzi, MD, Andrea Di Marco, MD, PhD, Francesca Fanisio, MD, Fabiana Romeo, MD, Alessio Gargaro, MSc, Annamaria Martino, MD, PhD, Chiara Cappelletto, MD, Marco Merlo, MD, Mattia Targetti, MD, Elisabetta Toso, MD, Federica Toto, MD, Maria Beatrice Musumeci, MD, Giacomo Tini, MD, Michele Ciabatti, MD, Matteo Stefanini, MD, Stefano Canestrelli, MD, Elisa Fedele, MD, Chiara Lanzillo, MD, PhD, Armando Fusco, MD, PhD, Federica Carla Sangiuolo, MD, PhD, Cinzia Radesich, MD, Maria Perotto, MD, Maurizio Pieroni, MD, Ruggiero Mango, MD, PhD, Alessio Gasperetti, MD, PhD, Camillo Autore, MD, Michela Casella, MD, PhD, Antonio Dello Russo, MD, PhD, Davide Stolfo, MD, PhD, Mikael Laredo, MD, PhD, Estelle Gandjbakhch, MD, PhD, Maddalena Graziosi, MD, PhD, Elena Biagini, MD, PhD, Costantina Catalano, MD, Ludovica Barile, MD, Fabrizio Drago, MD, Marianna Cicenia, MD, Anwar Baban, MD, PhD, Gemma Pelargonio, MD, PhD, Maria Lucia Narducci, MD, Federica Re, MD, Giovanni Peretto, MD, Elena Paiotti, MD, Carles Diez Lopez, MD, Iacopo Olivotto, MD, Fiorenzo Gaita, MD, Gianfranco Sinagra, MD, Giuseppe Novelli, MD, PhD

“…Objectives: The authors aimed to analyze the electrocardiogram (ECG) characteristics of ALVC, to correlate ECG with cardiac magnetic resonance and genetic data, and to evaluate its prognostic value. Methods: We reviewed data of 125 consecutive patients with ALVC (81.5% desmoplakin pathogenic/likely pathogenic variants). …”
Get full text

Simplified Physical Stability Assessment of Chilean Mine Waste Storage Facilities Using GIS and AI: Application in the Antofagasta Region by Gabriel Hermosilla, Gabriel Villavicencio, Giovanni Cocca-Guardia, Vicente Aprigliano, Manuel Silva, Juan Carlos Quezada, Pierre Breul, Vinicius Minatogawa, Jaime Morales

“…The National Service of Geology and Mining (SERNAGEOMIN) requires assessment of the physical stability (PS) of these facilities, but current methods are hindered by data scarcity and resource constraints. …”
Get full text

Mediating role of systemic immune-inflammation index between heavy metal exposure and hepatic steatosis/hepatic fibrosis: evidence from NHANES 2005–2020 by Ningning Wang, Ningning Wang, Ningning Wang, Xuying Li, Xuying Li, Xuying Li, Rui He, Rui He, Xiujuan Zheng, Xiujuan Zheng, Xiujuan Zheng, Mingqi Li, Mingqi Li, Mingqi Li, Shijing Nian, Shijing Nian, Shijing Nian, Kewei Wang, Kewei Wang, Kewei Wang

“…Partial correlation analysis, weighted linear regression, weighted quantile sum (WQS) regression, and mediation effect models were used in the study.ResultsSII showed significant negative correlations with hepatic fibrosis markers (FIB-4: r = −0.290; NFS: r = −0.382, both P < 0.001) but no association with hepatic steatosis indices. …”
Get full text

Higher levels of oxidative balance score linked to lower risk of gallstones: findings from the 2017–2020 National Health and Nutrition Examination Survey by Ting Xiong, Ting Xiong, Ting Xiong, Zhonghuo Chen, Zhonghuo Chen, Zhonghuo Chen, Jianwei Yi, Jianwei Yi, Jianwei Yi, Taozhi Yu, Taozhi Yu, Taozhi Yu, Kai Wang, Kai Wang, Kai Wang, Kai Wang

“…This study aimed to investigate the relationship between OBS and gallstone risk.MethodsThis cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) conducted from 2017 to March 2020. …”
Get full text

Neuroprotective effects of healthful plant-based diets on retinal structure: insights from a large cohort by Qian Zhu, Xiaoxin Liu, Yuan Qu, Yan Jiang, Xinyi Liu, Yu Xiao, Kangjia Lv, Yupeng Xu, Kun Liu

“…Mediation analysis was applied to explore the potential mediation effect of several blood biochemical indicators in simple mediation models. …”
Get full text

Leukocyte Count in Solid Organ Transplant Recipients After SARS-CoV-2 mRNA Vaccination and Infection by Marita Kern, Sebastian Rask Hamm, Christian Ross Pedersen, Dina Leth Møller, Josefine Amalie Loft, Rasmus Bo Hasselbalch, Line Dam Heftdal, Mia Marie Pries-Heje, Michael Perch, Søren Schwartz Sørensen, Allan Rasmussen, Peter Garred, Kasper Karmark Iversen, Henning Bundgaard, Caroline A. Sabin, Susanne Dam Nielsen

“…We aimed to describe the prevalence and relative incidence of decreased leukocyte counts and changes in leukocyte counts before and after SARS-CoV-2 mRNA vaccination and SARS-CoV-2 infection in SOT recipients. Methods: Changes in leukocyte counts from before to after each vaccine dose were investigated using linear mixed models. …”
Get full text

Nestin Regulates Autophagy‐Dependent Ferroptosis Mediated Skeletal Muscle Atrophy by Ubiquitinating MAP 1LC3B by Shunshun Han, Xiyu Zhao, Chunlin Yu, Can Cui, Yao Zhang, Qing Zhu, Mohan Qiu, Chaowu Yang, Huadong Yin

“…Ferroptosis, an iron‐dependent form of programmed cell death driven by lipid peroxidation, has been implicated in various diseases, but its role in skeletal muscle atrophy remains unclear. Methods Ferroptosis in skeletal muscle atrophy was investigated using two models: dexamethasone (Dex)‐induced atrophy (n = 6 independent cell cultures per group) and simulated microgravity (n = 6 mice per group). …”
Get full text

Harnessing multi-omics and artificial intelligence: revolutionizing prognosis and treatment in hepatocellular carcinoma by Zhen Wang, Zhen Wang, Zhen Wang, Gangchen Zhou, Gangchen Zhou, Rongchuan Cao, Rongchuan Cao, Guolin Zhang, Guolin Zhang, Yongxu Zhang, Yongxu Zhang, Mingyue Xiao, Longbi Liu, Longbi Liu, Xuesong Zhang

“…A multi-omics approach has the potential to offer more profound insights into HCC subtypes and enhance patient stratification for personalized treatments.MethodsA comprehensive data set comprising clinical, transcriptomic, genomic and epigenomic information from HCC patients was retrieved from the TCGA, ICGC, GEO and CPTAC databases. …”
Get full text

Team climate, job satisfaction, burnout and practice performance: results of a national survey of staff in general practices in England by Peter Williams, Heather Gage, Bridget Jones, Carole Aspden, Jessica Smylie, Thomas Bird, Morro M. L. Touray, Phelim Brady, John Campbell, Rupa Chilvers, Catherine Marchand, Stephen Peckham, Suzanne H. Richards, Karen Spilsbury, Mark Joy, Simon de Lusignan

“…Objectives To explore factors associated with more favourable team climates in general practices and investigate associations between team climate and outcomes for staff and practice performance. Methods All 6475 general practices in England were eligible to take part in an online cross-sectional survey. …”
Get full text

Exposure to persistent organic pollutants and sarcopenia: Revealing associations, mediated modifications, and potential mechanisms by Jinlong Tao, Jinchan Zhai, Jiaqi Yang, Qiang Niu, Yunhua Hu, Yizhong Yan

“…Objective: This study assessed the association between mixed POPs exposure and sarcopenia and explored the mediating roles of inflammation and oxidative stress, along with potential molecular targets. Methods: A total of 2106 participants from the National Health and Nutrition Examination Survey (NHANES) were analyzed. …”
Get full text