Amivantamab versus standard therapies among patients with advanced non-small cell lung cancer and epidermal growth factor receptor exon 20 insertion mutations after platinum-based... by Lan Shen, Guangyuan Hu, Yan Wang, Jing Zhao, Xin Li, Jianmin Zhuo, Grace Kah Mun Low, Shun Lu

“…We aimed to leverage real-world data to describe the unmet needs of these patients and explore the clinical benefits of amivantamab monotherapy through indirect comparison to an external control (EC) from China. Materials and methods Eligible patients with any systemic anti-cancer therapy (SACT) after the aNSCLC diagnosis were identified from the electronic medical records of three tertiary medical institutions. …”
Get full text

Correlations Between TyG-Related Indices and Bone Health: A Cross-Sectional Study of Osteoporosis in a Rural Chinese Population by Jia F, Lu Y, Wen H, Tu J, Ning X, Wang J, Li P

“…Multivariate regression models and restricted cubic spline (RCS) curves were used to assess the relationships between TyG indices and OP.Results: A total of 437 individuals were included in the final analysis, with 38 diagnosed with osteoporosis (prevalence of 8.7%). …”
Get full text

From gaps to compliance: a 12-year retrospective cohort study of trends in mismatch repair protein testing and Lynch syndrome identification in colorectal cancer in Central Switzer... by Bettina Marturet Fendt, Celina Geiss, Muriel Elhai, Joachim Diebold, Alexander Vogetseder

“…METHODS: This retrospective study enrolled 2602 patients with 2673 histologically confirmed colorectal cancers. …”
Get full text

Uptake of DU145 and LNCaP prostate cancer cell line derived extracellular vesicles is inversely correlated with blood–brain barrier integrity in vitro by Ana Špilak, Adrián Klepe, Sophia Theresa Kriwanek, Heinz-Peter Friedl, Andreas Brachner, Christa Nöhammer, Winfried Neuhaus

“…Methods Systematic optimization of the cell culture membrane insert set-up for sEV transport studies was accomplished with inserts with different pore sizes, varied coating procedures and medium compositions. …”
Get full text

Comparing survival outcomes of anti-fibrotic therapy for idiopathic pulmonary fibrosis with and without emphysema: a multi-center real-world study from Taiwan by Yu-Hung Fang, Yi-An Hsieh, Yen-Fu Chen, Yu-Chi Chiu, Yu-Ching Lin, Kuo-Tung Huang, Yung-Chia Huang, Yu-Feng Wei, Chien-Wen Huang, Pin-Kuei Fu, Taiwan Multi-Centre Interstitial Lung Disease Research Consortium

“…Cox proportional hazards models were used for multivariable analysis to identify factors associated with overall mortality during the follow-up period. …”
Get full text

Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma by Bin Liao, Bin Liao, Pan Wang, Sheng Gong, Lu Zhao, Lu Zhao, Jie Liu, Jie Liu, Nan Wu, Nan Wu

“…Immunohistochemistry (IHC) was performed to detect the expression of HIF1α, HIF2α, and IGF1R in GBM tissues and cells, as well as oxygen tension. Cell cycle analysis, apoptosis assays, lactate dehydrogenase (LDH) release measurements, Western blotting, and xenograft tumor models were employed to explore the synergistic regulation of IGF1R by HIF1α and HIF2α, focusing on activation of the PI3K/AKT signaling pathway and its contribution to GBM drug resistance. …”
Get full text

Predicting right ventricular failure after left ventricular assist device implant: A novel approach by Carissa E. Livingston, Dale Kim, Lacey Serletti, Andrea Jin, Sriram Rao, Michael V. Genuardi, Eliot G. Peyster

“…Modern, data‐driven approaches for defining and predicting RVF have been under‐utilized. Methods Two hundred thirty‐two patients were identified with a mean age of 55 years; 40 (17%) were women, 132 were (59%) Caucasian and 74 (32%) were Black. …”
Get full text

Risks of All‐Cause Mortality in Adults With Chronic Kidney Disease With Sarcopenia or Obesity: A Population‐Based Study by Jin'e Li, Hua Tu, Yuying Zhang, Shiqi Yang, Peng Yu, Jianping Liu

“…This study aims to investigate the role of low muscle mass and fat mass in the risk of all‐cause mortality in CKD patients in the United States. Methods This study utilized data from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999–2006 and 2011–2018, including 1553 adults with CKD. …”
Get full text

Potential role of Amyloid-β on the association between Orexin-A and blood-brain barrier leakage of globus pallidus in Alzheimer’s disease and dementia with lewy bodies by Jinghuan Gan, Ziming Xu, Chen Wen, Hao Wu, Zhichao Chen, Zhihong Shi, Hao Lu, Yajie Wang, Shuai Liu, Yong Ji

“…Demographic, clinical, and neuropsychological data were collected. The mediation analysis models were used to calculate the mediating effect of Aβ on the associations between orexin-A and BBB permeability in GP (reflected by K trans or Vp values). …”
Get full text

Dietary inflammatory index and mortality in middle-aged and elderly patients with metabolic syndrome by Xiangmei Li, Lei Liu, Xing Li, Long Yang, Li Men

“…This study aimed to investigate the association between DII and all-cause and cardiovascular mortality among middle-aged and elderly MetS patients. Methods This retrospective cohort study was based on publicly available data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2016. …”
Get full text

Sex differences in chronic kidney disease awareness among US adults, 1999 to 2018. by Sebastian Hödlmoser, Wolfgang C Winkelmayer, Jarcy Zee, Roberto Pecoits-Filho, Ronald L Pisoni, Friedrich K Port, Bruce M Robinson, Robin Ristl, Simon Krenn, Amelie Kurnikowski, Michał Lewandowski, Allison Ton, Juan Jesus Carrero, Eva S Schernhammer, Manfred Hecking

“…We aimed to investigate trends in CKD awareness and the association between individual characteristics and CKD awareness among US men versus women.<h4>Methods and findings</h4>We conducted a serial, cross-sectional analysis of 10 cycles (1999-2018) from the National Health and Nutrition Examination Survey (NHANES). …”
Get full text

Combined effects of nutrition, inflammatory status, and sleep quality on mortality in cancer survivors by Tingyu Zhao, Hui Zhao, Xiao Zhang, Xingyu Jiang, Qi Liang, Siqi Ni, Yi Jiao, Jiamei Yu, Jianghong Dai, Mulong Du, Lingxiang Liu

“…Abstract Background Cancer survivors face many challenges in long-term health management, including malnutrition, systemic inflammation, and sleep issues, which significantly affect their survival and quality of life. Methods A prospective cohort study was derived from the National Health and Nutrition Examination Survey from 2005–2018 harboring 1,908 cancer survivors (weighted population, 11,453,293), of whom 688 deaths (220 from cancer mortality, 468 from non-cancer mortality). …”
Get full text

Uncovering the mechanistic basis of Rheum palmatum L. (rhubarb) in the treatment of chronic kidney disease: an integrative approach using network pharmacology, molecular docking, a... by Wenjing He, Zhen Wei, Siwei Li, Songji Han, Jing Ma, Lei Wu, Dan Lu, Guang Ta

“…(Rhubarb) has shown potential in managing Chronic Kidney Disease (CKD) but its protective mechanisms remain unclear.Objective This study investigates rhubarb’s therapeutic effects and underlying mechanisms in CKD.Materials and methods High-performance liquid chromatography (HPLC) established a rhubarb fingerprint to ensure quality control. …”
Get full text

Mitral valve transcatheter edge‐to‐edge repair in the elderly—A safe and effective therapy by Dominik Felbel, Michael Paukovitsch, Matthias Gröger, Sinisa Markovic, Leonhard Schneider, Wolfgang Rottbauer, Mirjam Keßler

“…Group differences regarding 1 and 3 year mortality and heart failure hospitalization rates were assessed using Kaplan–Meier survival analysis and Cox proportional hazard models. Results A total of 1118 patients [median age 79 (inter‐quartile range 74–83) years; 42% female] were included and divided into 513 elderly (≥80 years) and 605 younger (<80 years) patients. …”
Get full text

Pre-exposure Prophylaxis Awareness and Endorsement among Adolescents and Young Adults in Tanzania: Insights from the 2022 Demographic and Health Survey by Alpha Johnson Kapola, Rahma Musoke, Glenda Marie Manayon, Hassan Fredrick Fussi, Hafidha Mhando Bakari, Haji Mbwana Ally, Swalehe Mustafa Salim, Zuhura Mbwana Ally, Lynn Moshi, Mariam Salim Mbwana, Habib Omari Ramadhani

“…Objectives: This study evaluates the prevalence of PrEP awareness and endorsement, as well as the factors associated with these outcomes, using data from the 2022 Tanzania Demographic and Health Survey. Methods: The analysis included participants aged 15–24 years. …”
Get full text

Inverse association of obesity with bout periodicity in episodic cluster headache: a multicenter cross-sectional study by Byung-Su Kim, Mi Ji Lee, Byung-Kun Kim, Jong-Hee Sohn, Tae-Jin Song, Min Kyung Chu, Soo-Kyoung Kim, Jeong Wook Park, Heui-Soo Moon, Pil-Wook Chung, Soo-Jin Cho

“…We aimed to determine whether body mass index (BMI) and obesity are associated with lifetime bout occurrence and annual bout frequency in patients with episodic cluster headache (ECH). Methods The Korean Cluster Headache Registry (KCHR) is a prospective, multicenter registry of consecutive patients with CH over 4 years. …”
Get full text

Platelet inhibition strategies in rescue stenting after failed thrombectomy: a large retrospective multicenter registry by Aikaterini Anastasiou, Alex Brehm, Johannes Kaesmacher, Adnan Mujanovic, Marta de Dios Lascuevas, Tomás Carmona Fuentes, Alfonso López-Frías, Blanca Hidalgo Valverde, Ansgar Berlis, Christoph J. Maurer, Thanh N. Nguyen, Mohamad Abdalkader, Piers Klein, Guillaume Thevoz, Patrik Michel, Bruno Bartolini, Marius Kaschner, Daniel Weiss, Andrea M. Alexandre, Alessandro Pedicelli, Paolo Machi, Gianmarco Bernava, Shuntaro Kuwahara, Kazutaka Uchida, Jason Wenderoth, Anirudh Joshi, Grzegorz Karwacki, Manuel Bolognese, Agostino Tessitore, Sergio Lucio Vinci, Amedeo Cervo, Claudia Rollo, Ferdinand Hui, Aaisha Siddiqua Mozumder, Daniele Giuseppe Romano, Giulia Frauenfelder, Nitin Goyal, Vivek Batra, Violiza Inoa, Christophe Cognard, Matúš Hoferica, Riitta Rautio, Daniel P. O. Kaiser, Johannes C. Gerber, Julian Clarke, Michael R. Levitt, Marcel N. Wolf, Ahmed E. Othman, Luca Scarcia, Erwah Kalsoum, Diana Melancia, Diana Aguiar de Sousa, Maria Porzia Ganimede, Vittorio Semeraro, Flavio Giordano, Massimo Muto, Aristeidis Katsanos, Umesh Bonala, Anil M. Tuladhar, Sjoerd F. M. Jenniskens, Victoria Hellstern, Ilka Kleffner, Paolo Remida, Susanna Diamanti, Leonardo Renieri, Elena Ballabio, Luca Valvassori, Nikki Rommers, Mira Katan, Victor Schulze-Zachau, Marios-Nikos Psychogios

“…We assessed the effects of platelet inhibition strategy and potentially covariates on the primary outcome of 90-day modified Rankin Scale (mRS) using ordinal shift analysis with proportional odds models. Results: RS was performed in 589 patients (mean age 67.9 years, 60.8% male). …”
Get full text

Measurement invariance of HIV-related stigma scales among men who have sex with men (MSM) and non-MSM populations: implications for comparative studies in China by Tianyue Mi, Xueying Yang, Guanghua Lan, Shan Qiao, Zhiyong Shen, Yuejiao Zhou, Xiaoming Li

“…Confirmatory factor analysis was used to test measurement invariance by progressively adding equality constraints to the models for each stigma dimension.ResultsPartial scalar measurement invariance was achieved for the internalized stigma scale, allowing the intercepts of items 2, 3, and 6 to vary (χ2 = 89.32, df = 43; CFI = 0.986; TLI = 0.981; RMSEA = 0.043, 95%CI [0.030, 0.056]; SRMR = 0.033), indicating that the zero points of item 2 (“I feel ashamed of having HIV”), item 3 (“Having HIV makes me feel unclean”), and item 6 (“I feel guilty because I have HIV”) were different between MSM and non-MSM. …”
Get full text

MORPHOLOGICAL CHANGES OF RAT PERIODONTIUM IN SUPRAOCCLUSAL RELATIONS OF INDIVIDUAL TEETH IN THE AGE ASPECT by S.M. Zviahin, Y.V. Lakhtin

“…Aim: to determine the morphological changes of periodontium in rats of different age groups in the supraocclusal relationship of individual teeth in the age aspect. Materials and methods of the study. The study was conducted on 60 white laboratory rats aged 4 to 22 months and weighing 90 to 330 g. …”
Get full text

Effect of integrating paediatric tuberculosis services into child healthcare services on case detection in Africa: the INPUT stepped-wedge cluster-randomised trial by Lise Denoeud-Ndam, Rhoderick Machekano, Anne Cecile Bissek, Rose Masaba, Millicent Ouma, Saint Just Petnga, Martina Casenghi, Appolinaire Tiam, Stephen Siamba, Nicole Herrera, Patrice Tchendjou, Leonie Simo, Boris Kevin Tchounga, Gordon Odhiambo Okomo

“…Generalised linear mixed Poisson models estimated the intervention’s effect as adjusted rate ratios (aRR) and associated 95% CIs. …”
Get full text