Characteristics of Australian and New Zealand osteopaths who treat patients presenting with non-musculoskeletal complaints: outcomes from two practice-based research networks by Brett Vaughan, Francesco Cerritelli, Jerry Draper-Rodi, Jack Feehan, Ana Paula A. Ferreira, Michael Fleischmann, Gopi McLeod, Cindy McIntyre, Chantal Morin, Lee Muddle, Oliver P. Thomson, Loïc Treffel, Nicholas Tripodi, Kesava Kovanur Sampath, Niklas Sinderholm Sposato, Amie Steel, Jon Adams

“…The aim of this study was to describe the practice of Australian and New Zealand osteopaths who report often treating patients with non-musculoskeletal complaints. Methods This study is a secondary analysis of data from the Australian and New Zealand osteopathy practice-based research networks (PBRNs) collected in Australia from July to December 2016 and in New Zealand from August to December 2018. …”
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Hyperammonemia heightens anesthetic sensitivity in male rats with acute hepatic encephalopathy via affecting brain areas represented by the cerebellum by Sa Wang, Xin-Xin Zhao, Dan Tang, Shi-An Li, Tian-Qi Li, Bing-Xue Peng, Yi-Hao Wang, Sai-Hong Xu, Po Gao, Xue Xue, Ying-Fu Jiao, Yan Zhou, Wei-Feng Yu

“…However, anesthetic sensitivity in HE and the role of hyperammonemia, in the context of anesthetic sensitivity of HE both remain uncertain. Methods We injected male Sprague Dawley rats with thioacetamide (TAA) to induce acute HE. …”
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The influence of socioeconomic status on the association between residential greenness and gestational diabetes mellitus in an urban setting: a multicenter study by Tian Zhang, Wen Jiang, Yun Huang, Cuiping Wang, Jun Cao, Wei Qiu, Rong Huang, Jun Zhang, Weiping Ye, Qingli Zhang

“…This multicenter study conducted in a dense megacity aims to clarify these associations and explore the modification effects of demographic and socioeconomic factors. Methods The study included 19,618 pregnant women in 20 hospitals throughout Shanghai, China, between 2015 and 2017. …”
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Targeting HK3 in tumor-associated macrophages enhances antitumor immunity through augmenting antigen cross-presentation in cervical cancer by Hui Wang, Ying Chen, Min Wu, Jian Liu, Jingyu Wang, Yifan Yang, Chaoyang Sun, Shan He, Shen Qu, Xun Tian, Jinglan Chen, Han Jiang, Liting Liu, Yafei Huang

“…Although TAMs frequently exhibit an immunosuppressive phenotype, their plasticity enables them as an intriguing reprogrammable target for immunotherapy of CC.Methods Consensus clustering was employed to delineate immune infiltration patterns in a cohort of 119 patients with CC. …”
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A cross-sectional study on the correlation between fasting blood glucose and bone turnover markers in Chinese patients with osteoporotic fractures by Meng-cheng Zhu, Meng-cheng Zhu, Min-zhe Xu, Min-zhe Xu, Chang-xuan Li, Chang-xuan Li, Jia-hao Wang, Jia-hao Wang, Chong Li, Chong Li, Ya-qin Gong, Ya-qin Gong, Jian Jin, Ke Lu, Ke Lu, Yan-ming Hao, Yan-ming Hao

“…This study examined the association between FBG levels and bone turnover markers (BTMs) in patients hospitalized for OPFs requiring surgical intervention.MethodsA retrospective cross-sectional analysis was conducted on 888 patients treated for OPFs at Kunshan Hospital affiliated with Jiangsu University from November 2018 to August 2023. …”
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The rising burden of diabetes and state-wise variations in India: insights from the Global Burden of Disease Study 1990–2021 and projections to 2031 by Shubham Chauhan, Mahalaqua Nazli Khatib, Suhas Ballal, Pooja Bansal, Kiran Bhopte, Abhay M. Gaidhane, Balvir S. Tomar, Ayash Ashraf, M. Ravi Kumar, Ashish Singh Chauhan, Muhammed Shabil, Diptismita Jena, Ganesh Bushi, Prakasini Satapathy, Lara Jain, Vaibhav Jaiswal, Manvi Pant

“…With variations in disease burden across states, a detailed understanding of trends in incidence, prevalence, and Disability Adjusted Life Years (DALYs) is essential for targeted interventions.MethodsThis study utilized Global Burden of Disease (GBD) data from 1990 to 2021 to examine trends in diabetes across Indian states. …”
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Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome by Nagui Gendi, Costantino Pitzalis, Paul Emery, Kate L Hackett, Kristen Davies, Jessica Tarn, Rebecca Bragg, Ben Hargreaves, Samira Miyamoto, Peter McMeekin, Sheryl Mitchell, Simon Bowman, Elizabeth J Price, Colin Pease, Jacqueline Andrews, Peter Lanyon, John Hunter, Monica Gupta, Michele Bombardieri, Nurhan Sutcliffe, John McLaren, Annie Cooper, Marian Regan, Ian Giles, David Isenberg, Saravan Vadivelu, David Coady, Bhaskar Dasgupta, Neil McHugh, Steven Young-Min, Robert Moots, Mohammed Akil, Bridget Griffiths, Dennis W Lendrem, Wan-Fai Ng

“…Using multiple regression analysis, we modelled the relationship between Profile of Fatigue and Discomfort physical and mental fatigue scores and potentially related variables.Results Pain, depression and daytime sleepiness scores were closely associated with both physical and mental fatigue (all p ≤ 0.0001). …”
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Implementation of C-reactive protein point of care testing to improve antibiotic targeting in respiratory illness in Vietnamese primary care (ICAT): a study protocol for a cluster... by H Rogier van Doorn, Behzad Nadjm, Yoel Lubell, Rachel Claire Greer, Sabine Dittrich, Sonia Lewycka, Nga Thi Thuy Do, Maida Vandendorpe, Van Anh Nguyen, Pham Ngoc Thach, Ta Thi Dieu Ngan, Nguyen Van Kinh, Cao Hung Thai, Le Thi Kim Dung, Tu Nguyen Thi Cam, Thanh Ha Nguyen

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Condomless sexual encounters among female sex workers included in a longitudinal coital diary study in Zimbabwe by Galven Maringwa, Tatenda Kujeke, Memory Makamba, Gracious Madimutsa, Sungai T. Chabata, Harriet Jones, Fortunate Machingura, Elizabeth Fearon, Frances M. Cowan, James R. Hargreaves

“…We aimed to estimate the prevalence and patterns of condomless sex by partner type at the sexual encounter level, as well as identify factors associated with condomless sex among FSWs recruited into a diary study in Zimbabwe. Methods We conducted a longitudinal coital diary study in site A and site B between 25 November 2020 and 30 December 2021. …”
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Efficacy of a Blended Low-Intensity Internet-Delivered Psychological Program in Patients With Multimorbidity in Primary Care: Randomized Controlled Trial by Alicia Monreal-Bartolomé, Adoración Castro, M Ángeles Pérez-Ara, Margalida Gili, Fermín Mayoral, María Magdalena Hurtado, Esperanza Varela Moreno, Cristina Botella, Azucena García-Palacios, Rosa M Baños, Yolanda López-Del-Hoyo, Javier García-Campayo, Jesus Montero-Marin

“…ObjectiveThis study aimed to assess the effectiveness of improved treatment as usual (iTAU) combined with a blended low-intensity psychological intervention delivered using information and communication technologies for the treatment of multimorbidity (depression and type 2 diabetes or low back pain) in primary care settings. MethodsA 2-armed, parallel-group, superiority randomized controlled trial was designed for this study. …”
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The role of the control of “life’s essential 8” for prevention on heart failure and all-cause mortality in patients with hypertension: the Kailuan cohort study by Jing Wang, Shuilin Wu, Liuxin Li, Jing Wu, Shiqiu Meng, Xueying Qin, Xin Chen, Shoulin Wu, Jie Shi, Yanping Bao, Feng Wang

“…However, evidence on the beneficial effects and necessity of LE8 control is still lacking, especially for hypertension. Methods The study population was drawn from the Kailuan cohort, hypertensive population at baseline with the non-hypertensive population matched 1:1 according to age and sex were involved in this analysis. …”
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Effect of Mediterranean Diet Adherence and Its Interaction with Genetic Susceptibility to Obesity on Adiposity in European Children: The IDEFICS/I.Family Study by Miguel Seral-Cortes, Gabin Drouard, Guiomar Masip, Leonie Bogl, Michael Tornaritis, Ronja Foraita, Luis A. Moreno

“…Then, the same models were used to estimate gene x diet effects, based on the PRS x MD adherence. …”
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Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor by Junying Wang, Mengping Chen, Jinxing Jiang, Yike Wan, Xin Li, Minyue Zhang, Fei Xiao, Lu Zhong, Hua Zhong, Zhaoyu Qin, Jian Hou

“…Nevertheless, in myeloma, the precise mechanisms underlying SEL-induced XPO1 degradation and its impact on drug responsiveness remain largely undefined. Methods We assessed XPO1 protein and mRNA levels using western blotting and RT-qPCR. …”
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Transmission of community- and hospital-acquired SARS-CoV-2 in hospital settings in the UK: A cohort study. by Yin Mo, David W Eyre, Sheila F Lumley, Timothy M Walker, Robert H Shaw, Denise O'Donnell, Lisa Butcher, Katie Jeffery, Christl A Donnelly, Oxford COVID infection review team, Ben S Cooper

“…The main aim of our study was to quantify the relative importance of different transmission pathways of SARS-CoV-2 in the hospital setting.<h4>Methods and findings</h4>This is an observational cohort study using data from 4 teaching hospitals in Oxfordshire, United Kingdom, from January to October 2020. …”
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GALNT14 Genetic Variants Harbor Differential Prognostic Values Linking to Distinct Macrophage Cell Types in Hepatocellular Carcinoma by Chu YD, Ho PH, Chen WT, Shih YL, Lai MW, Hsu CW, Yeh CT

“…Prognostic evaluation was performed using Kaplan-Meier survival analysis and Cox proportional hazards models, with statistical significance set at P &lt; 0.05.Results: GWAS identified 39 SNP loci linked to rs9679162 and associated with postoperative prognosis. …”
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Targeted inhibition of gastric cancer progression via a chitosan-RNU11 siRNA nanoparticle delivery system: mechanistic insights and therapeutic potential by Peng Cheng, Zhengrong Zhong, Yanling Wang, Caituan Feng, Jitong Zheng, SuogaoWang, Xiangjun Meng, Dong Wang

“…GC cell lines (AGS and HGC27) were treated with various formulations, and functional assays, including EdU proliferation, Transwell invasion/migration, and cell cycle/apoptosis analysis, were conducted. The in vivo efficacy of Si-RNU11 + CH-NP was evaluated in GC xenograft mouse models. …”
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The triglyceride-glucose index and acute kidney injury risk in critically ill patients with coronary artery disease by Yi Zhang, Gang Li, Junjie Li, Bohao Jian, Keke Wang, Jiantao Chen, Jian Hou, Jianbo Liao, Zhuoming Zhou, Zhongkai Wu, Mengya Liang

“…This research delved into the utility of the TyG index in predicting the risk of acute kidney injury (AKI) in patients with coronary artery disease (CAD), an area not extensively covered in existing literature.Methods A cohort of patients with CAD was recruited from the Medical Information Mart for Intensive Care-IV database, and categorized into quartiles based on their TyG index. …”
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Intraocular pressure correlation to progressive retinal nerve fiber layer loss in primary open angle glaucoma as measured by standard and modified goldmann applanation tonometers by Sean McCafferty, Manjool Shah, Anupam Laul, Khin Kilgore

“…From the database, 148 eyes, 75 patients met the inclusion criteria of a diagnosis of primary open angle glaucoma (POAG) with at least 5 sequential quality optical coherence tomographer (OCT) measurements. Methods Sequential OCT images were obtained with the spectral domain Zeiss OCT5000. …”
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Comparison of Smile Parameters, Maxillary Arch Changes and Perceived Smile Attractiveness in Patients Treated with Conventional and Self-ligating Bracket Systems: An Observational... by Rieshy Vasudevan, Selvapriya Selvam, Shweta Nagesh

“…Pre- and post-treatment digital models were used to assess changes in intermolar and intercanine widths. …”
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Association between sleep disorder and delirium in adult patients undergoing cardiac surgery: a retrospective cohort study by Beibei Wang, Qiao Liu, Dou Dou, Dongyun Bie, Ran An, Yuan Jia, Su Yuan, Fuxia Yan

“…This study investigates the association between sleep disorders and the risk of delirium in patients after cardiac surgery, aiming to raise public awareness of the relationship. Methods This retrospective cohort study utilized data from the MIMIC-IV database. …”
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