EPHX1 enhances drug resistance to regorafenib by activating the JAK/STAT signaling pathway in hepatocellular carcinoma cell lines by Bin Xu, Xiangnan Liang, Wuguang Liu, BaiTong Wu, Qiuxiang Wang, Gong Kai, Chun Han, Binwen Sun, Bing Dong, Chengyong Dong, Liming Wang

“…Objective To investigate the role and mechanisms of EPHX1 in mediating regorafenib resistance in HCC. Methods We assessed the protein expression levels of EPHX1 in human HCC tissues and adjacent non-tumor tissues. …”
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Maternal exposure to per- and polyfluoroalkyl substances and epitope level antibody response to vaccines against measles and rubella in children from the Boston birth cohort by Xiumei Hong, William R. Morgenlander, Kari Nadeau, Guoying Wang, Pamela A. Frischmeyer-Guerrerio, Colleen Pearson, William G. Adams, Hongkai Ji, H. Benjamin Larman, Xiaobin Wang

“…However, research about the impact of PFAS exposure on antibody responses to the measles, mumps, rubella (MMR) vaccine is limited and inconsistent. Methods: This report includes 748 mother–child pairs from the Boston Birth Cohort, with 8 PFAS compounds measured in maternal plasma shortly after delivery. …”
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Prognostic value of the vasoactive-inotropic score in predicting outcomes following LVAD implantation by Taylor Pickering, DO, Kyle A. McCullough, MD, Cody W. Dorton, DO, David A. Rawitscher, MD, J. Michael DiMaio, MD, Nitin Kabra, MD, Greg Milligan, MD, Akash Rusia, MD, Patrick Ogbue, MD, Aasim Afzal, MD, Timothy J. George, MD

“…The vasoactive-inotropic score (VIS), which quantifies vasoactive support, may predict outcomes in this population. Methods: A retrospective analysis of 146 patients undergoing HeartMate 3 LVAD implantation from 2017 to 2024 at a single institution was performed. …”
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Does Empirical Antibiotic Use Improve Outcomes in Ventilated Patients with Pandemic Viral Infection? A Multicentre Retrospective Study by Elisabeth Papiol, Julen Berrueta, Juan Carlos Ruíz-Rodríguez, Ricard Ferrer, Sara Manrique, Laura Claverias, Alejandro García-Martínez, Pau Orts, Emili Díaz, Rafael Zaragoza, Marco Marotta, María Bodí, Sandra Trefler, Josep Gómez, Ignacio Martín-Loeches, Alejandro Rodríguez

“…<b>Objective:</b> To evaluate whether EAT at ICU admission reduces ventilator-associated pneumonia (VAP) incidence or ICU mortality in critically ill patients with pandemic viral pneumonia, stratified by presence of COI. <b>Methods:</b> This retrospective analysis combined two national multicentre ICU registries in Spain, including 4197 adult patients requiring invasive mechanical ventilation for influenza A(H1N1) or COVID-19 between 2009 and 2021. …”
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Evaluating the Efficacy of Gelatin-Chitosan-Tetraethyl Orthosilicate Calcium Hydroxide Composite as a Dental Pulp Medicament on  COX-2, PGP 9.5, TNF-α Expression and Neutrophil num... by Yulita Kristanti, Mh Busra Fauzi, Bidhari Pidhatika, Iwa Sutardjo Rus Sudarso, Retno Ardhani, Al-qatta Ghadah Abdulrahman, Endytiastuti Endytiastuti, Heni Susilowati, Juni Handajani

“…The objective of this study was to evaluate the effect of composites containing gelatin (G), chitosan (CH), tetraethyl orthosilicate (TEOS), and Ca(OH)2, namely G-CH-TEOS-Ca (OH)2 (Extended data) on inflammation of the dental pulp (expression of COX-2, PGP 9.5, TNF-α, and neutrophil number). Materials and methods A total of 16 Wistar rat models of acute pulp injury were prepared and divided into two groups, treatment and control, 8 with each. …”
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The relationship between vitamin D levels and Alzheimer’s disease risk: insights from a centenarian study of Chinese women by Yupeng Li, Xujie Wang, Mei Yu, Fei Wang, Dong Song, Musong Liu, Xu Liang, Hongzhou Liu, Jiangbo Liu, Shihui Fu, Shihui Fu, Xuhui Liu

“…This study aimed to examine the association between serum 25-hydroxyvitamin D [25(OH)D] levels and AD risk in Chinese female centenarians.MethodsWe included 514 female participants aged ≥100 years from the China Healthy Longevity Multicenter Study (CHLMS). …”
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Statins for extension of disability-free survival and primary prevention of cardiovascular events among older people: protocol for a randomised controlled trial in primary care (ST... by Rory Wolfe, Christopher M Reid, Andrew Tonkin, John J McNeil, Mark Nelson, Sophia Zoungas, Stephanie A Ward, Stephen J Nicholls, Geoffrey Cloud, Ingrid Hopper, Andrea Curtis, Joanne Ryan, Lawrence Beilin, Anthony Wierzbicki, Simone Spark, Trevor T-J Chong, Alissia Kost

“…This paper presents the protocol for the STAtins in Reducing Events in the Elderly (STAREE) trial, a randomised double-blind placebo-controlled trial examining the effects of statins in community dwelling older people without CVD, diabetes or dementia.Methods and analysis We will conduct a double-blind, randomised placebo-controlled trial among people aged 70 years and over, recruited through Australian general practice and with no history of clinical CVD, diabetes or dementia. …”
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Effectiveness of bright light therapy and combination with myopic defocus for controlling myopic eye growth in schoolchildren: study protocol for a randomised controlled trial (pha... by Dennis Yan-yin Tse, Rachel Ka Man Chun, Chi Ho To, Ian G Morgan, Jinxiao Lian, Carly SY Lam, Wai-Ching Lam, Christopher Kai Shun Leung, Lai Ming Ho, Ying Hon, Billy Kin Kwok Cheung, Desmond Man Kit Lam, Andy Chi Wai Kong, Thomas C Lam

“…This study hypothesises that bright light therapy (BLT), delivered via a home-based device mimicking sunlight, could slow myopia progression in schoolchildren.Methods and analysis We propose a 2-year, double-masked, randomised controlled trial to investigate the effectiveness of BLT and its combination with myopia control treatment in schoolchildren. …”
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Contemporary carotid artery stenting practices and peri-procedural outcomes in different European countries: ROADSAVER study multicentric insights by Stefan Müller-Hülsbeck, Zsolt Vajda, Piotr Odrowąż-Pieniążek, Zoltán Ruzsa, Roel Beelen, Aleksandar Gjoreski, Koen Deloose, Sérgio Castro, Benjamin Faurie, Alejandro Tomasello Weitz, Arne Schwindt, Paweł Latacz, Antonio Orgaz Pérez-Grueso, Vladimir Cvetić, Ralf Langhoff, Sasko Kedev, all ROADSAVER study investigators

“…The primary outcome measure was the 30-day rate of major adverse events, defined as any death or stroke occurring within 30 days post-procedure. This sub-analysis compared patient characteristics and procedural techniques across 13 participating countries and investigated differences in outcomes via logistic regression modelling. …”
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A practice and exploration of blended learning in medical morphology during the post-COVID-19 pandemic era by Qinlai Liu, Na Yuan, Yongan Wang, Beibei Sun, Leiying Yang, Zhaopeng Wang, Chen Fang, Wenping Sun, Baihua Luo, Yaling Liu, Xin Liu, Li Ge

“…It also has substantial promotional instructive modeling value. Clinical trial registration Not applicable.…”
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Comparison of robustness, resilience and intrinsic capacity including prediction of long-term adverse health outcomes: The KORA-Age study by Michaela Rippl, Marie-Theres Huemer, Lars Schwettmann, Eva Grill, Annette Peters, Michael Drey, Barbara Thorand

“…We therefore aimed to assess which concept is most useful for determining long-term health of older adults. Methods: Analyses were based on the KORA (Cooperative Health Research in the Region of Augsburg)-Age study (n = 940, 65–93 years). …”
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Effectiveness of Kushal Maa, a group-based mhealth interactive education and social support intervention for maternal and neonatal health outcomes: study protocol for a multisite r... by Praveen Kumar, Lakshmi Gopalakrishnan, Nadia Diamond-Smith, Azaz Khan, Abhishek Singh, Rashmi Bagga, Alison M El Ayadi, Anant Bhan, Alka Ahuja, Pushpendra Singh, Mona Duggal, Jasmeet Kaur, Deepak Tugnawat, Tracy Lin, Sujata Saunik, Garima Singh Verma, Shailendrakumar Gujarathi, Dinesh Chandke, Shashi Kant Dhir, Supriya Dhakne-Palwe, Mrunal Patil, Sonam Kumar, Nitin Vasaikar, Laura Weil

“…The current study seeks to estimate the effectiveness of the Kushal Maa intervention compared with standard care on maternal and neonatal health-related behaviours and health, characterise the mechanisms of intervention impact and evaluate the cost-effectiveness of the Kushal Maa intervention in improving postpartum maternal and neonatal health compared with the standard of care.Methods and analysis We will conduct a prospective, parallel block-randomised controlled trial with a 1:1 allocation ratio among 2100 pregnant women across three geographically diverse Indian states. …”
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Evaluating spatiotemporal variations and exposure risk of ground-level ozone concentrations across China from 2000 to 2020 using high-resolution satellite-derived data by Q. He, Q. He, J. Cao, P. E. Saide, P. E. Saide, T. Ye, W. Wang, M. Zhang, J. Huang

“…To address this gap, we characterized ground-level ozone variations and exposure risks across multiple spatial (pixel, county, region, and national) and temporal (daily, monthly, seasonal, and annual) scales using daily 1 km ozone data from 2000 to 2020, derived from satellite-sourced land surface temperature data via a machine-learning hindcast method. The model provided reliable estimates, validated through rigorous cross-validation and direct comparison with external ground-level ozone measurements. …”
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From colorless to pink: Structural insights into vitamin B12-induced color change in monoclonal antibodies by Kai-feng He, Hao-dong Cui, Wen-hui Deng, Na Xing, Guo-jian Liu, Abdallah Iddy Chaurembo, Li-dan Fu, Yuan Li, Xin-yue Tong, Han-bin Lin, Chun-he Wang

“…This study investigated the mechanism linking this color change to Vitamin B12 (VB12), which converts to hydroxycobalamin (OH-Cbl) under light and binds covalently to cysteine residues in antibodies via cobalt-sulfur bonds. Methods: Three batches of IgG1 antibodies (SP1, SP2, and NL)—were expressed in CHO cells, exposed to light, and purified. …”
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Biomarker combinations from different modalities predict early disability accumulation in multiple sclerosis by Vinzenz Fleischer, Tobias Brummer, Muthuraman Muthuraman, Muthuraman Muthuraman, Falk Steffen, Milena Heldt, Maria Protopapa, Muriel Schraad, Gabriel Gonzalez-Escamilla, Sergiu Groppa, Stefan Bittner, Frauke Zipp

“…Second, we applied structural equation modeling (SEM) to the single biomarkers in order to determine their causal inter-relationships.ResultsBaseline GMV on its own allowed identification of subsequent EDSS progression based on ROC analysis. …”
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Anti-CTGF/PD-1 bispecific antibody Y126S restrains desmoplastic and immunosuppressive microenvironment in pancreatic cancer by Wei Chen, Hai Huang, Wang Peng, Jingwen Liang, Shiru Chen, Yuchong Zhao, Mengdie Cao, Yilei Yang, Shuya Bai, Qiaodan Zhou, Jiamei Jiang, Yilin Gu, Ronghua Wang, Bin Cheng

“…TME remodeling, antibody distribution, and therapeutic efficacy were assessed using flow cytometry, immunohistochemical/Masson staining, atomic force microscopy, positron emission tomography (PET) imaging, distribution analysis, and other experimental techniques.Results Here, Y126S was characterized in vitro and its antitumor efficacy was evaluated and validated in orthotopic PDAC mice and KPC mouse models. …”
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Study the effect of Lactobacillus plantarum ATCC 14917 for caries prevention and anti-obesity by Wei Yang, Wei Yang, Mingxin Jiang, Bairu Chen, Bairu Chen, Kongzhao Jiang, Nan Ma, Nan Ma, Yimin Li, Yimin Li, Meng Wang, Meng Wang, Meihua Bao, Meihua Bao, Chengyue Wang, Chengyue Wang, Xiaopeng Yang, Xiaopeng Yang

“…Lactobacillus plantarum, has gained attention recently due to its probiotic properties, useful traits, and potential medical applications.ObjectiveExamining the anti-obesity and anti-caries effects of L. plantarum ATCC 14917 on dental caries and obese rat models caused by a high-fat and high-sugar diet is the aim of this study.MethodIn vitro, we assessed the L. plantarum strain’s probiotic properties, such as its antibacterial activity and ability to build biofilms, to determine its ability to inhibit Streptococcus mutans. …”
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Tacrolimus IPV Group Membership Does Not Consistently Track With Electronically Monitored or Self-reported Adherence in Adolescent and Young Adult Kidney Transplant Recipients by Cyd K. Eaton, PhD, Cozumel S. Pruette, MD, MHS, Kristin A. Riekert, PhD, Nazanin Yousefzadeh, MS, Ahna L. Pai, PhD, Sandra Amaral, MD, MHS, Vikas R. Dharnidharka, MD, MPH, Bärbel Knäuper, PhD, Jodi M. Smith, MD, MPH, Susan L. Furth, MD, PhD, Bethany J. Foster, MD, MSCE

“…However, the association between tacrolimus IPV and electronically monitored or self-reported adherence is unknown. Methods. This secondary analysis of the TAKE-IT (Teen Adherence in Kidney Transplant Effectiveness of Intervention Trial) compared electronically monitored and self-reported adherence between participants with high and low tacrolimus IPV among 103 adolescent and young adult kidney transplant recipients (mean age = 15.18 y, 59% male, 60% White, 65% >1-y posttransplant). …”
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CRO-INSIGHT: Utilization of Implantable Cardioverter Defibrillators in Non-ischemic and Ischemic Cardiomyopathy in a Single Croatian Tertiary Hospital Centre by Mislav Puljevic, Eugen Ciglenecki, Vedran Pasara, Ivan Prepolec, Mia Dubravcic Dosen, Pero Hrabac, Ana-Marija Brekalo, Martina Lovric Bencic, Miroslav Krpan, Richard Matasic, Borka Pezo-Nikolic, Davor Puljevic, Davor Milicic, Vedran Velagic

“…Statistical analyses included a detailed descriptive analysis, Kaplan–Meier survival estimates, and Cox regression models. …”
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Do preoperative interventions affect patient satisfaction or expectation fulfilment following total hip arthroplasty? A systematic review by April-Rose Matt, Joanne L. Kemp, Andrea B. Mosler, Lucy Salmon, Diogo Almeida Gomes, Alysha De Livera, Erica Hateley, Adam L. Semciw

“…Methods: MEDLINE, EMBASE, Cochrane Register of Clinical Trials, CINAHL and Sports Discus were searched from inception to May 2023. …”
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