Call volume, triage outcomes, and protocols during the first wave of the COVID‐19 pandemic in the United Kingdom: Results of a national survey by Helen Snooks, Alan John Watkins, Fiona Bell, Mike Brady, Andy Carson‐Stevens, Edward Duncan, Bridie Angela Evans, Louise England, Theresa Foster, John Gallanders, Imogen Gunson, Robert Harris‐Mayes, Mark Kingston, Ronan Lyons, Elisha Miller, Andy Newton, Alison Porter, Tom Quinn, Andy Rosser, Aloysius Niroshan Siriwardena, Robert Spaight, Victoria Williams

“…Abstract Objectives During the first wave of the COVID‐19 pandemic in the United Kingdom (UK), to describe volume and pattern of calls to emergency ambulance services, proportion of calls where an ambulance was dispatched, proportion conveyed to hospital, and features of triage used. Methods Semistructured electronic survey of all UK ambulance services (n = 13) and a request for routine service data on weekly call volumes for 22 weeks (February 1–July 3, 2020). …”
Get full text

SLNP-based CDK4- targeted nanotherapy against glioblastoma by Uzma Ghani, Fareeha Khalid Ghori, Muhammad Usman Qamar, Muhammad Usman Qamar, Hina Khan, Basit Azad, Sabahat Habib, Saira Justin, Ishaq N. Khan, Ishaq N. Khan, Tawaf Ali Shah, Gamal A. Shazly, Mohammed Bourhia, Fouzia Perveen, Aneela Javed

“…Innovative treatments targeting the pRB pathway with efficient delivery vehicles are required to treat glioblastoma.MethodsFor this purpose, a library of 691 plant extracts previously tested in vitro for anti-cancerous, anti inflammatory, and anti-proliferative characteristics was created after thorough literature investigations. …”
Get full text

Retinal biomarkers for the risk of Alzheimer’s disease and frontotemporal dementia by Ruihan Wang, Jiajie Cai, Yuzhu Gao, Yingying Tang, Hui Gao, Linyuan Qin, Hanlin Cai, Feng Yang, Yimeng Ren, Caimei Luo, Shiyu Feng, Hongbo Yin, Ming Zhang, Chunyan Luo, Qiyong Gong, Xiong Xiao, Qin Chen

“…Cox proportional hazards models were used to estimate the associations between macular OCT parameters and the risk of AD and FTD. …”
Get full text

Enhancing pancreatic cancer treatment: the role of H101 oncolytic virus in irreversible electroporation by Pu Xi, Dejun Zeng, Miao Chen, Lingmin Jiang, Yu Zhang, Dailei Qin, Zehui Yao, Chaobin He

“…Experiments using mouse subcutaneous tumor models confirmed that the combination therapy significantly reduced tumor growth. …”
Get full text

Temporal association of antimicrobial use in livestock with antimicrobial resistance in non-typhoid Salmonella human infections in the Netherlands, 2008–2019 by Linda E. Chanamé Pinedo, Anouk P. Meijs, Huifang Deng, Sabine C. de Greeff, Engeline van Duijkeren, Cindy M. Dierikx, Kees T. Veldman, Pim Sanders, Maaike J.C. van den Beld, Bart Wullings, Eelco Franz, Roan Pijnacker, Lapo Mughini-Gras

“…The focus was on Salmonella Enteritidis (SE) and Salmonella Typhimurium including its monophasic variant (ST/STM). Methods: A national population registry-based study was conducted in the Netherlands from 2008 to 2019. …”
Get full text

Association Between Size of Left Ventricle and Long‐Term Cardiovascular Events by Yun‐Jiu Cheng, Zi‐Li Liao, Li‐Juan Liu, Yue‐Dong Ma, Xu‐Miao Chen, Ze‐Xuan Wu, Hui‐Qiang Wei, Wei‐Dong Lin, Yi‐Jian Liao, Su‐Hua Wu, Yu‐Mei Xue, Li‐Chun Wang, Yang Wu

“…Background The prognostic significance of small left ventricle (LV) in the general population and its association with cardiovascular disease remain elusive. Methods Using data from the UK Biobank, 39 363 participants underwent baseline cardiovascular magnetic resonance imaging and were categorized into 3 groups based on left ventricular end‐diastolic volume index: small, normal, and large LV. …”
Get full text

Regional variations in the impacts of high temperature on hospital admissions in Brazil by Huiqi Chen, Ivan Augusto Cecilio e Silva, Shakoor Hajat, Letícia Xander Russo, Kai Wan, Cherie Part, Zhifu Mi, Josephine Borghi, Dorothea Nitsch, Everton Nunes da Silva, Anna M. Foss

Get full text

Seroprevalence of SARS-CoV-2 antibodies in children of United Kingdom healthcare workers: a prospective multicentre cohort study protocol by Shamez N Ladhani, Mark David Lyttle, Derek Fairley, James McKenna, Claire Mcginn, Kathryn Ferris, Chris Watson, Hannah Mitchell, Jennifer Evans, Michael Corr, Rebecca Moore, Gala Rowe-Setz, Steven Foster, Lisa McFetridge, Sharon Christie, Julieann Maney, Michael David Shields, Tom Waterfield

“…Determining the changing seroprevalence is of vital public health importance and can help inform decisions around the lifting of paediatric specific social distancing measures such as school closures and the cancellation of routine paediatric hospital services.Methods and analysis 1000 healthy children of healthcare workers aged between 2 and 15 years will be recruited from five UK sites (Belfast, Cardiff, Glasgow, London and Manchester). …”
Get full text

Pathways From Socioeconomic Factors to Major Cardiovascular Events Among Postmenopausal Veteran and Nonveteran Women: Findings From the Women's Health Initiative by Hind A. Beydoun, May A. Beydoun, Rebecca L. Kinney, Simin Liu, Rona Yu, Matthew Allison, Robert B. Wallace, Qian Xiao, Longjian Liu, Philippe Gradidge, Su Yon Jung, Hilary A. Tindle, Shawna Follis, Robert Brunner, Jack Tsai

“…Using generalized structural equations modeling coupled with survival analysis techniques, we estimated the effects of SES on major CVD events through smoking, body mass index, comorbidities, cardiometabolic risk factors, and self‐rated health, controlling for WHI component, region, age, race, ethnicity, marital status, and health care provider access. …”
Get full text

Recommendations for a Communication Strategy to Support Informed Decision‐Making About Self or Clinician Sampling for Cervical Screening in the UK: Qualitative Study by Denitza Williams, Eleanor Clarke, Kate J. Lifford, Lindsay Haywood, Fiona Wood, Jo Waller, Adrian Edwards, Natalie Joseph‐Williams, Caroline Evans, Gareth Powell, Rhiannon Phillips, Andrew Carson‐Stevens, Katie Walbeoff, Ardiana Gjini, Kate Brain

“…They advised on recruitment, participant facing documents and were involved in analysis.…”
Get full text

Lupus nephritis and U1-RNP-antibodies are associated with low bone mineral density and osteoporosis in patients with systemic lupus erythematosus: baseline findings in a sub-cohort... by Edgar Wiebe, Elisa Celine Schilling, Dörte Huscher, Andriko Palmowski, Zhivana Boyadzhieva, Sandra Hermann, Burkhard Muche, Mirella Lopez Picazo, Gerhard Krönke, Falk Hiepe, Tobias Alexander, Frank Buttgereit

“…We used multivariable linear and logistic regression models to identify BMD- and osteoporosis-related factors. …”
Get full text

Trends and inequalities in the nutritional status of adolescent girls and adult women in sub-Saharan Africa since 2000: a cross-sectional series study by Serge M A Somda, Abdoulaye Maïga, Safia S Jiwani, Cheikh Mbacké Faye, Shelley Walton, Tome Ca, Richard Kumapley, Giovanna Gatica-Domínguez, Elizabeth Hazel, Inacio Crochemore-Silva, Barbara Baille, Sujata Bose, William K Bosu, Kofi Busia, Ferima Coulibaly-Zerbo, Vrinda Mehra, Roosmarijn Verstraeten

Get full text

The association of exposure to multiple metals with the risk of idiopathic oligoasthenoteratozoospermia: The mediating role of sperm chromatin by Tao Yin, Sen Liang, XinYu Zhou, Xueting Lai, Xun Su, Jiajing Tao, Shiwei Ren, Danyang Li, Yunxia Cao, Dongmei Ji, Chunmei Liang

“…Moreover, we explored the potential mediating roles of sperm DFI and sperm HDS (both treated as continuous variables) in the association between metal exposure and iOAT risk using mediation analysis. Results: Using sperm DFI and sperm HDS as binary variables, multivariate logistic regression models showed that the second and third tertiles of Cr levels in seminal plasma were positively associated with high sperm DFI risk, with reference to the first tertile. …”
Get full text

Distinctive Effects of Fullerene C₆₀ and Fullerenol C₆₀(OH)₂₄ Nanoparticles on Histological, Molecular and Behavioral Hallmarks of Alzheimer’s Dise... by Sholpan Askarova, Kseniia Sitdikova, Aliya Kassenova, Kirill Chaprov, Evgeniy Svirin, Andrey Tsoy, Johannes de Munter, Anna Gorlova, Aleksandr Litavrin, Aleksei Deikin, Andrey Nedorubov, Nurbol Appazov, Allan Kalueff, Anton Chernopiatko, Tatyana Strekalova

Get full text

New Insights into the Anticancer Effects and Toxicogenomic Safety of Two β-Lapachone Derivatives by José Rivaldo De Lima, Alexandre José Da Silva Góes, Elizabeth Fernanda De Oliveira Borba, Meykson Alexandre da Silva, Rodrigo Ribeiro Alves Caiana, Maria do Desterro Rodrigues, Mariza Severina De Lima Silva, Cristiano Aparecido Chagas, Blandine Baratte, Thomas Robert, Stéphane Bach, Isabelle Ourliac-Garnier, Pascal Marchand, Teresinha Gonçalves Da Silva

Get full text

‘Every Touch Point Is an Opportunity’: Tobacco Control Experts' Views on How to Implement Smoking Cessation Interventions Within an Australian Lung Cancer Screening Program by Nathan J. Harrison, Diane Riddiford‐Harland, Sarah York, Henry M. Marshall, Joel J. Rhee, Emily Stone, Mei Ling Yap, Ashleigh R. Sharman, Marianne Weber, Susan A. McCullough, Terri Byrne, Christine L. Paul, Jacqueline A. Bowden, Billie Bonevski, Nicole M. Rankin

“…Individual/pair interviews explored factors that may influence acceptability and feasibility, potential delivery models, and implementation strategies. We interpreted interview data using codebook thematic analysis, then mapped key topics against the Consolidated Framework for Implementation Research and previous LCS expert‐identified determinants. …”
Get full text

To elucidate the effect of Ruanjian Qingmai granules on arteriosclerosis obliterans from the perspective of cholesterol efflux by Chenglin Jia, Biying Hong, Yujie Jiang, Chao Ma, Wei Liu, Wei Liu, Wei Liu, Yicheng Xu, Jian Chen, Yan Xie, Yan Xie, Yan Xie, Guangbo Ge, Guangbo Ge, Guangbo Ge, Ye-min Cao, Tianhua Yan, Yongbing Cao

“…Aim of the studyTo investigate the effect of Ruanjian Qingmai granules (RJQM) on arteriosclerotic obliterans (ASO) and identify its potential bioactive components.Materials and methodsSeparate zebrafish atherosclerosis models and cellular lipid metabolism disorder models were established, and RJQM was administered at different concentrations for intervention. …”
Get full text

Synergistic effects of MK-1775 and gemcitabine on cytotoxicity in non-small cell lung cancer by Chiao-Ping Chen, Tsai-Hsien Hung, Ping-Chih Hsu, Chun-Nan Yeh, Wen-Kuan Huang, Yi-Ru Pan, Yu-Tien Hsiao, Chih-Hong Lo, Chiao-En Wu

“…In xenograft models, the combination significantly inhibited tumor growth without significant toxicity. …”
Get full text

Prognostic significance of severe mitral annular calcification in aortic stenosis: implications for aortic valve replacement outcome by Valeria Pergola, Dan-Alexandru Cozac, Maria Teresa Savo, Saima Mushtaq, Raffaella Motta, Roberto Pedrinelli, Pasquale Perrone-Filardi, Gianfranco Sinagra, Morena De Amicis, Maria Vittoria Chiaruttini, Gabriele Cordoni, Giulia Lorenzoni, Giuseppe Tarantini, Gino Gerosa, Dario Gregori, Giorgio De Conti, Domenico Corrado, Gianluca Pontone

“…This study aims to assess the impact of cardiac CT-derived MAC on cardiovascular outcomes in this population. Methods: Pre-procedural contrast-enhanced CCT was performed, and Guerrero CCT-derived MAC score was used to quantify the MAC severity. …”
Get full text

CPEB4 modulates liver cancer progression by translationally regulating hepcidin expression and sensitivity to ferroptosis by M. Eugenia Delgado, Salvador Naranjo-Suarez, Marta Ramírez-Pedraza, Beatriz I. Cárdenas, Carmen Gallardo-Martínez, Alexandra Balvey, Eulalia Belloc, Judit Martín, Mark Boyle, Raúl Méndez, Mercedes Fernandez

“…While much of the previous research has focused on transcriptional changes, this study examines translational alterations, specifically the role of cytoplasmic polyadenylation element binding protein 4 (CPEB4), a key regulator of translation. Methods: We analyzed publicly available patient databases and conducted studies using human and mouse liver cancer cells, xenograft and allograft models, mouse models of high-fat diet-related liver cancer, and CPEB4 knockout and knockdown mice and cell lines. …”
Get full text