Late Immune-Related Adverse Events After At Least Two Years of Immune Checkpoint Inhibitor Therapy: Incidence and Association With Survival in Patients With Advanced NSCLC by Omar Elghawy, MD, Adam Barsouk, MD, Jonathan H. Sussman, BS, Benjamin A. Bleiberg, MD, Lauren Reed-Guy, MD, Christopher D’Avella, MD, Aditi Singh, MD, Christine Ciunci, MD, MSCE, Kyle Robinson, MD, John Kosteva, MD, Corey Langer, MD, Roger B. Cohen, MD, Charu Aggarwal, MD, MPH, Melina Marmarelis, MD, MSCE, Lova Sun, MD, MSCE

“…Background: Limited data are available on late immune-related adverse events (IRAEs) in patients with metastatic NSCLC receiving immunotherapy (ICI) beyond 2 years. Methods: A single-institution retrospective analysis including patients who received longer than 2 years of ICI therapy for metastatic NSCLC between 2012 and 2023 was performed. …”
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APOKASC-3: The Third Joint Spectroscopic and Asteroseismic Catalog for Evolved Stars in the Kepler Fields by Marc H. Pinsonneault, Joel C. Zinn, Jamie Tayar, Aldo Serenelli, Rafael A. García, Savita Mathur, Mathieu Vrard, Yvonne P. Elsworth, Benoit Mosser, Dennis Stello, Keaton J. Bell, Lisa Bugnet, Enrico Corsaro, Patrick Gaulme, Saskia Hekker, Marc Hon, Daniel Huber, Thomas Kallinger, Kaili Cao, Jennifer A. Johnson, Bastien Liagre, Rachel A. Patton, Ângela R. G. Santos, Sarbani Basu, Paul G. Beck, Timothy C. Beers, William J. Chaplin, Katia Cunha, Peter M. Frinchaboy, Léo Girardi, Diego Godoy-Rivera, Jon A. Holtzman, Henrik Jönsson, Szabolcs Mészáros, Claudia Reyes, Hans-Walter Rix, Matthew Shetrone, Verne V. Smith, Taylor Spoo, Keivan G. Stassun, Ji Wang

“…We recommend the use of multiple methods, calibration to a fundamental scale, and the use of stellar models to interpret frequency spacings.…”
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A G-quadruplex-binding platinum complex induces cancer mitochondrial dysfunction through dual-targeting mitochondrial and nuclear G4 enriched genome by Keli Kuang, Chunyan Li, Fatlinda Maksut, Deepanjan Ghosh, Robin Vinck, Maolin Wang, Joël Poupon, Run Xiang, Wen Li, Fei Li, Zhu Wang, Junrong Du, Marie-Paule Teulade-Fichou, Gilles Gasser, Sophie Bombard, Tao Jia

“…However, the impact of G4-based targeted therapy on both nuclear and mt genome, affecting mt function and its underlying mechanisms remain largely unexplored. Methods The mechanisms of action and therapeutic effects of a G4-binding platinum(II) complex, Pt-ttpy, on mitochondria were conducted through a comprehensive approaches with in vitro and in vivo models, including ICP-MS for platinum measurement, PCR-based genetic analysis, western blotting (WB), confocal microscope for mt morphology study, extracellular flux analyzer, JC1 and Annexin V apoptosis assay, flow cytometry and high content microscope screening with single-cell quantification of both ROS and mt specific ROS, as well as click-chemistry for IF study of mt translation. …”
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Circadian rhythm dysfunction and psychopathology in the offspring of parents with bipolar disorder: a high-risk study in the Chinese population by Jing Wang, Tao Li, Yun Kwok Wing, Jihui Zhang, Jie Chen, Bin Zhang, Weidong Song, Chao Jiang, Jiyang Pan, Kun Zhang, Yaping Liu, Ngan Yin Chan, Hongliang Feng, Lulu Yang, Binbin Lei, Qunfeng Wang, Jessie Chi Ching Tsang, Joey W.Y. Chan, Kathleen Ries Merikangas

“…Generalised estimating equations and shared frailty proportional hazards models of survival analysis were applied to compare the outcomes in the offspring.Results Adjusting for age, sex and region of recruitment, there was a significantly higher risk of delayed sleep phase symptoms (9.55% vs 2.58%, adjusted OR: 4.04) in O-BD than in O-control. …”
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Using Implementation Science to Evaluate the Implementation of Patient-Reported Outcome Measures (PROMs) in a Clinical Heart Failure Care Setting by Sarah V.C. Lawrason, MSc, PhD, Heather Ross, MSc, MD, Michael McDonald, MD, Juan Duero Posada, MD, Samantha Engbers, BAH, Anne Simard, MHSc

“…The purpose of this study was to use implementation science frameworks to systematically evaluate the uptake and integration of PROMs into clinical HF care. Methods: The Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework guided this mixed-methods, 1-year quality-improvement project. …”
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Enteric-coated microencapsulation improves the therapeutic effect of cinnamon oil on artificially infected chicken with Escherichia coli by Huanling Xing, Fang Zhou, Jianhao Lin, Junfeng Ban, Junyi Huang, Xinghai Li, Hanjun He, Yanqun Li, Mei Bai, Xiangxiu Liang, Hong Wu

“…Different concentrations of enteric CEO microcapsules and CEO were used to treat artificially infected chicken E. coli models, respectively. Cecal content was collected for 16S rRNA gene sequence analysis and metabonomics. …”
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Longitudinal Lipid Trajectories and Progression of CKD in Children by Uwe Querfeld, Marietta Kirchner, Francesca Mencarelli, Karolis Azukaitis, Aysun Bayazit, Ali Duzova, Anke Doyon, Nur Canpolat, Ipek Kaplan Bulut, Lukasz Obrycki, Justine Bacchetta, Rukshana Shroff, Dusan Paripovic, Cengiz Candan, Jerome Harambat, Alev Yilmaz, Harika Alpay, Jun Oh, Hakan Erdogan, Claus P. Schmitt, Anette Melk, Franz Schaefer

“…Kidney survival was significantly different for HDL-C (P = 0.0128), but not for other lipid trajectories in the Kaplan-Meier analysis. There was no significant association of any of the lipid trajectories with CKD progression in Cox proportional hazard models. …”
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Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell lines by Alexandra Razumovskaya, Mariia Silkina, Mariia Silkina, Mariia Silkina, Andrey Poloznikov, Timur Kulagin, Maria Raigorodskaya, Nina Gorban, Anna Kudryavtseva, Maria Fedorova, Boris Alekseev, Alexander Tonevitsky, Alexander Tonevitsky, Alexander Tonevitsky, Sergey Nikulin, Sergey Nikulin, Sergey Nikulin

“…Prognostic performance was evaluated through Kaplan-Meier survival analysis and log-rank tests, while independent prognostic significance was assessed using multivariate Cox proportional hazards modeling.ResultsA small set of genes showed consistent correlation with resistance to chemotherapy across different datasets. …”
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hiPSC-derived cardiac fibroblasts dynamically enhance the mechanical function of hiPSC-derived cardiomyocytes on an engineered substrate by Mitchell Josvai, Mitchell Josvai, Jodi Lawson, Jodi Lawson, Harshal Kanade, Harshal Kanade, Meghana Kalluri, Meghana Kalluri, Corey L. Anderson, Jianhua Zhang, Alana Stempien, Alana Stempien, Lee L. Eckhardt, Timothy J. Kamp, Timothy J. Kamp, Wendy C. Crone, Wendy C. Crone, Wendy C. Crone, Wendy C. Crone

“…Coculture of CFs and human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) enhances CM mechanical output, yet the mechanism remains unclear.MethodsHere, we use an in vitro engineered platform to compare the effects on CM mechanical function of direct CM-CF Coculture and soluble signaling alone through CF Conditioned Medium to a CM Only monoculture. …”
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B4GALT5 inhibits CD8+ T-cell response by downregulating MHC-I level through ERAD pathway in PDAC by Hui Li, Hao Zhang, Xiao-Mei Yang, Xue-Li Zhang, Zhigang Zhang, Yan Yang, Xin Xing, Shi-Qi Yin, Xia-Qing Li, Hong-Tai Ma, Aziguli Tulamaiti, Shu-Yu Xiao, Yu-Tong Liu, Yan-Miao Huo

“…This study aims to investigate the role of beta-1,4-galactosyltransferase-5 (B4GALT5) in immune evasion by pancreatic cancer cells and evaluate its potential as an immunotherapeutic target.Methods We conducted a comprehensive analysis using RNA sequencing data and tissue microarrays from patients with PDAC to investigate the association between B4GALT5 expression and patient prognosis. …”
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DIFFERENCES IN EX-VIVO CHEMOSENSITIVITY TO ANTHRACYCLINES IN FIRST LINE ACUTE MYELOID LEUKEMIA by Juan Eduardo Megias-Vericat, David Martínez-Cuadrón, Joaquin Martínez López, Juan Miguel Bergua, Mar Tormo, Josefina Serrano, Ataulfo González, Jaime Pérez de Oteyza, Susana Vives, Belen Vidriales, Pilar Herrera, Juan Antonio Vera, Aurelio López Martínez, Adolfo De la Fuente, María Lourdes Amador, José Ángel Hernández-Rivas, María Ángeles Fernández, Carlos Javier Cerveró, Daniel Morillo, Pilar Hernández Campo, Julián Gorrochategui, Daniel Primo, José Luis Rojas, Margarita Guenova, Joan Ballesteros, Miguel Ángel Sanz, Pau Montesinos

“…The choice of the anthracycline employed has been widely studied in multiple clinical trials showing similar complete remission rates. MATERIALS AND METHODS: Using an ex vivo test we have analyzed if a subset of AML patients may respond differently to cytarabine combined with idarubicin, daunorubicin or mitoxantrone.  …”
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Pediatric, adult, and late onset multiple sclerosis: Cognitive phenotypes and gray matter atrophy by Ermelinda De Meo, Emilio Portaccio, Rosa Cortese, Luis Ruano, Benedetta Goretti, Claudia Niccolai, Francesco Patti, Clara Chisari, Paolo Gallo, Paola Grossi, Angelo Ghezzi, Marco Roscio, Flavia Mattioli, Chiara Stampatori, Marta Simone, Rosa Gemma Viterbo, Raffaello Bonacchi, Assunta Maria Rocca, Elisa Leveraro, Antonio Giorgio, Nicola De Stefano, Massimo Filippi, Matilde Inglese, Maria Pia Amato

“…A subset of 222 MS patients and 92 controls underwent 3T‐MRI scan for brain atrophy and lesion analysis. Multinomial probabilistic models identified likelihood of belonging to cognitive phenotypes (“preserved‐cognition,” “mild verbal memory/semantic fluency,” “mild multi‐domain,” “severe attention/executive,” and “severe multi‐domain”) and experiencing MRI abnormalities based on disease duration and age at onset. …”
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Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort studyResearch in context by Jack L. Janetzki, Jung Ho Kim, Evan Minty, Jung Ah Lee, Daniel R. Morales, Rohan Khera, Chungsoo Kim, Thamir M. Alshammari, Scott L. DuVall, Michael E. Matheny, Thomas Falconer, Seonji Kim, Thanh-Phuc Phan, Phung-Anh Nguyen, Min-Huei Hsu, Jason C. Hsu, Rae Woong Park, Kenneth K.C. Man, Sarah Seager, Mui Van Zandt, James P. Gilbert, Patrick B. Ryan, Martijn J. Schuemie, Marc A. Suchard, George Hripcsak, Nicole Pratt, Seng Chan You

“…However, no large-scale international study has thoroughly assessed this risk. Methods: A retrospective cohort study was conducted using a large, distributed network analysis across 14 databases from 5 countries (United States, South Korea, Japan, Taiwan, and Australia). …”
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Outcome of different facial nerve managements in petrous bone cholesteatoma patients with facial paralysis by Qin Wang, Ruoya Wang, Jianze Wang, Na Sai, Shuhang Fan, Jianbin Sun, Zhikai Zhao, Junhui Huang, Weidong Shen, Weiju Han

“…The aim of this study is to analyze the long-term FN function outcomes in PBC patients with FN paralysis who have underwent different managements and to explore the prognostic factors. Methods A retrospective analysis of 160 PBC patients with preoperative FN paralysis was conducted, and long-term FN function outcome was evaluated. …”
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PD-L2 act as an independent immune checkpoint in colorectal cancer beyond PD-L1 by Lvyun Zhu, Ying Qu, Junru Yang, Tong Shao, Jingyu Kuang, Chuanyang Liu, Yanhua Qi, Ming Li, Ming Li, Yingying Li, Sujuan Zhang, Jingyang Wang, Yu Liu, Jiali Liu, Yanming Hu, Lingyun Zhu, Tao Hou

“…Nonetheless, many CRC patients exhibit limited responses to such immunotherapy, and the resistance mechanisms remain incompletely understood.MethodsWe conducted experiments with C57BL/6 mice, and used the MC38 cell line for ICB treatment studies in syngeneic mouse models. …”
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Personalized information support for hypertension management: an open-label cluster randomized controlled trial in rural Anhui, ChinaResearch in context by Xingrong Shen, Ruirui Cui, Nana Li, Xin Yang, Tongqing Xu, Shumin Zeng, Xuanhe Liu, Yuning Wang, Ying Li, Dongying Xiao, Xuewu Zhang, Rong Liu, Tingting Zhang, Xiyan Kong, Jing Chai, Dongxiao Gu, Debin Wang

“…Digital intervention has great potential in realizing PHM. Methods: This two-arm cluster randomized controlled trial aimed at assessing the added value of personalized information for leveraging commonly recognized objective behaviors facilitated by pragmatic digital applications. …”
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Impact of tertiary Gleason pattern 5 on prostate cancer aggressiveness: Lessons from a contemporary single institution radical prostatectomy series by Zachary B. Koloff, Daniel A. Hamstra, John T. Wei, Jeffrey S. Montgomery, Scott A. Tomlins, Angela J. Wu, Todd M. Morgan, Javed Siddiqui, Kellie Paich, Arul M. Chinnaiyan, Felix Y. Feng, Alon Z. Weizer, Lakshmi P. Kunju, Brent K. Hollenbeck, David C. Miller, Ganesh S. Palapattu, Rohit Mehra

“…Objective: To better evaluate tertiary Gleason pattern reporting and to evaluate the impact of tertiary Gleason pattern 5 (TP5) on prostate cancer pathological features and biochemical recurrence at our large single institution. Methods: We retrospectively reviewed 1962 patients who underwent radical prostatectomy (RP) for prostate cancer; TP5 was reported in 159 cases (8.1%). …”
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Associating Patient Responses with Drug Sensitivity in Non-Small Cell Lung Carcinoma Using an Immunoassay on Patient-Derived Cell Cultures by Ana Podolski-Renić, Sofija Jovanović Stojanov, Dragana Marić, Jelena Dinić, Miodrag Dragoj, Ana Stepanović, Ema Lupšić, Milica Pajović, Sofija Glumac, Maja Ercegovac, Milica Pešić

“…<b>Methods</b>: We established short-term primary cell cultures from thirteen patients with NSCLC of different subtypes and stages, including both cancer and stromal cells. …”
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Enhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial by Chris Hollis, Kareem Khan, Peter Fonagy, Rohan Borschmann, Cathy Creswell, Kapil Sayal, Nitish Jawahar, A Jess Williams, Ellen Townsend, Dorothee Auer, Praveetha Patalay, Yvonne Kelly, Christopher R Tench, Paul Stallard, Louise Arseneault, Sieun Lee, Sally Merry, Charlotte Hall, Jo Gregory, Rory O’Connor, Emma Nielsen, Edmund Sonuga-Barke, Seonaid Cleare, James Gross, Amelia Chapman-Nisar, Nkem Naeche, Petr Slovak, Emily Lloyd, Josimar De Alcantara Mendes, Carolyn Ten Holter, Marina Jirotka, Zsofia Lazar, Aaron Kandola, Sonia Livingstone, Kasia Kostryka-Allchorne, Jake Bourgaize, Mariya Stoilova, Marianne Etherson, Chris Greenhalgh, Jim Warren, Vajisha Wanniarachchi, Kevin Glover, Mathijs Lucassen, Karolina Stasiak, Camilla Babbage, Adam Parker, Joanna Lockwood, Elvira Perez Vallejos, Rebecca Woodcock, Sarah Doherty, Lucy-Paige Willingham

“…The present study is designed to evaluate the impact of access to Purrble among LGBTQ+ youth who have self-harmful thoughts, when compared with waitlist controls.Methods and analysis The study is a single-blind, randomised control trial comparing access to the Purrble robot with waitlist control. …”
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Interprofessional Differences in Multidimensional Self-Efficacy Associated With Professional Performance in Nephrology During Case-Based Learning by Chia-Ter Chao, Mei-Yi Wu, Kuan-Yu Hung, Mai-Szu Wu, Jyh-Chong Liang

“…We undertook confirmatory factor analysis (CFA), followed by structural equation modeling (SEM) to evaluate associations between 5 dimensions of learning SE (conceptual understanding [CU], higher-order cognitive skills [HC], practical work [PW], everyday application [EA], and medical science communication [MSC]) and their professional SE in nephrology according to participants' medical professions. …”
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