Evaluation of the efficiency and safety of tocilizumab therapy in patients with systemic-onset juvenile idiopathic arthritis: results of a retrospective follow-up by M. M. Kostik, E. A. Isupova, I. A. Chikova, M. F. Dubko, V. V. Masalova, L. S. Snegireva, O. V. Kalashnikova, V. G. Chasnyk

“…The main predictors for achieving remission, which were estimated using the analysis of sensitivity and specificity, as well as Cox regression models, were CRP ≤82.0 mg/l (OR – 7.9; HR – 1.17); ESR ≤32 mm/h (OR – 17.0; HR – 0.85), ferritin ≤273 ng/ml (OR – 56.5; HR – 2.6), hemoglobin >113 g/l (OR – 17.0; HR – 1.33), LDH ≤676 U/l (OR – 113.6; HR – 3.2), platelets >335⋅109 /l (OR – 5.0; HR – 2.5), and a decline in white blood cells two weeks after the first infusion by more than 11% (OR – 13.0; HR – 6.0) and in granulocytes by more than 12% (OR – 14.0; HR – 4.7). …”
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The association between monocyte-to-high-density lipoprotein cholesterol ratio and type 2 diabetes mellitus: a cross-sectional study by Honghai Yu, Cunqing Yang, Cunqing Yang, Jiao Lv, Yunyun Zhao, Guoqiang Wang, Xiuge Wang

“…This study aims to investigate the association between the MHR and the prevalence of T2DM in a general population, using data from the National Health and Nutrition Examination Survey (NHANES).MethodsWe conducted a cross-sectional study analyzing data from five NHANES cycles spanning 2007–2016. …”
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Hypoxic BMSC-derived exosomal miR-210-3p promotes progression of triple-negative breast cancer cells via NFIX-Wnt/β-catenin signaling axis by Meng Wang, Yi Zheng, Qian Hao, Guochao Mao, Zhijun Dai, Zhen Zhai, Shuai Lin, Baobao Liang, Huafeng Kang, Xiaobin Ma

“…This study aims to elucidate the communication between BMSC-derived exosomal miRNA and triple-negative breast cancer (TNBC) in a hypoxic environment. Methods Exosomes were isolated via ultracentrifugation and identified using scanning electron microscopy (SEM), nanoparticle tracking analysis (NTA) and western blot. …”
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Epidemiology of neonatal disorders attributable to low birthweight-global burden of disease research, 1990–2021 by Qi Zhang, Lan Luo, Lai-lai Yan, Lai-lai Yan, Jing Guo, Hui-jun Wu, Zi-wei Zhang, Yu-hua Zhu, Rui Qiao, Rui Qiao

“…Trends and influencing factors were investigated through Joinpoint regression, health inequality analysis, and frontier modeling.ResultsIn 2021, the global age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life year (DALY) rate (ASDR) for neonatal diseases associated with low birth weight (LBW) were 22.76 [95% uncertainty interval (UI): 19.63–26.40] and 2,227.54 (95% UI: 1,939.96–2,563.52) per 100,000, respectively. …”
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Association Between Triglyceride–Glucose Index and Carotid Plaque Stability in Different Glycemic Status: A Single‐Center Retrospective Study by Guijun Huo, Jin Zheng, Junjie Cao, Lili Zhang, Zhichao Yao, Yuqi Zeng, Yao Tang, Zhanao Liu, Ziyi Tan, Dayong Zhou

“…This study investigated the association between the TyG index and unstable carotid plaque. Methods A total of 12 068 participants were enrolled. …”
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Association of triglyceride-glucose related indices with colorectal cancer risk among the US population: a cross-sectional study by Sen Niu, Chenshan Jiang, Xiaofei Miao, Ye Zhang, Zengyao Li, Tong Wang

“…Weighted multivariate logistic regression and generalized additive models assessed the independent associations between these indices and CRC risk. …”
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Psychological health as a mediator in the association between diet and upper gastrointestinal cancer: insights from a large-scale population-based screening project by Yueying Zhang, Shanrui Ma, Xinqing Li, Shaoming Wang, Wenqiang Wei

“…Our study aims to investigate the association between dietary quality and UGI cancer, with a test of the linking role of depression and anxiety symptoms. Methods: Data were drawn from the baseline survey of the National Cohort of Esophageal Cancer study, conducted between 2017 and 2019 in five high-risk regions of China (Linzhou, Cixian, Feicheng, Yangzhong, Yanting) among residents aged 40–69. …”
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Whole exome-seq and RNA-seq data reveal unique neoantigen profiles in Kenyan breast cancer patients by Godfrey Wagutu, John Gitau, John Gitau, John Gitau, Kennedy Mwangi, Mary Murithi, Elias Melly, Alexandra R. Harris, Shahin Sayed, Stefan Ambs, Francis Makokha

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The mediating effect of maternal blood lipids on the association between maternal exposure to PM2.5 and birth weight: a retrospective birth cohort study in Zhejiang, China by Huiqi Chen, Qinqing Chen, Danxiao Wang, Min Lv, Liyun Wang, Yuan Chen, Fangfang Xi, Hefeng Huang, Qiong Luo

“…Linear mixed-effects models were employed to examine associations between PM2.5 and birth weight. …”
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Changes in physical activity and sedentary behaviours of children living in Italy due to the COVID-19 pandemic: the EPaS-ISS study by Paola Nardone, Serena Broccoli, Angela Spinelli, Marta Buoncristiano, Silvia Andreozzi, Mauro Bucciarelli, Marco Giustini, Silvia Ciardullo, on behalf of the EPaS-ISS Group

“…Therefore, the aim of the EPaSS-ISS study was to study the changes in physical activity and sedentary behaviours among 8–9 years old Italian students during the pandemic of COVID-19 compared with before the pandemic. Methods Data were collected using a web questionnaire. …”
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Spatial Correlates of Dementia and Disability After Intracerebral Hemorrhage by Yutong Chen, Cyprien A. Rivier, Samantha A. Mora, Victor Torres Lopez, Sam Payabvash, Kevin Sheth, Andreas Harloff, Guido J. Falcone, Jonathan Rosand, Ernst Mayerhofer, Christopher D. Anderson

“…These insights have the potential to enhance clinical prognostic models for patients with ICH, facilitating more precise predictions of outcomes based on hemorrhage location.…”
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Community health assessment of needs and continuous empowerment (CHANCE): a quantitative cross-sectional survey targeting primary health care nurses in Lebanon by Gladys Honein-AbouHaidar, Reem Hoteit, Sarah Chehayeb, Nuhad Dumit, Tamar Avedissian, Bahia Abdallah, Randa Hamadeh

“…This study aimed to assess the current use of core competencies among community-based nurses, identify their learning needs, and assess factors associated with training needs within PHC centers. Methods A quantitative cross-sectional survey design was used, targeting community health nurses working within primary healthcare centers. …”
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Online Group–Based Dual-Task Training to Improve Cognitive Function of Community-Dwelling Older Adults: Randomized Controlled Feasibility Study by Pui Hing Chau, Denise Shuk Ting Cheung, Jojo Yan Yan Kwok, Wai Chi Chan, Doris Sau Fung Yu

“…Descriptive statistics and linear mixed effects models were used. Effect size was described with Cohen d. …”
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Bone bruising severity after anterior cruciate ligament rupture predicts elevation of chemokine MCP‐1 associated with osteoarthritis by Lukas G. Keil, Douglas S. Onuscheck, Lincoln F. Pratson II, Ganesh V. Kamath, Robert A. Creighton, Daniel B. Nissman, Brian G. Pietrosimone, Jeffrey T. Spang

“…We sought to characterize the severity of bone bruising following acute anterior cruciate ligament injury and determine if it correlates with synovial fluid and serum levels of the proinflammatory chemokine monocyte chemoattractant protein‐1 associated with posttraumatic osteoarthritis. Methods This was a retrospective analysis of data collected prospectively from January 2014 through December 2016. …”
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Skills Development and Graduate Employability in the Tourism and Hospitality Sector of Southwestern Uganda: A Case of Kabale District by Tushabe, Sylivia Byarugaba

“…This study investigated the relationship between skills development and graduate employability, with a focus on alumni from higher education institutions (HEIs) in Kabale District, southwestern Uganda. A mixed-methods approach, integrating correlational and case study designs, was employed to capture both statistical relationships and contextual insights. …”
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Magnetic Fields in Massive Star-forming Regions (MagMaR). V. The Magnetic Field at the Onset of High-mass Star Formation by Patricio Sanhueza, Junhao Liu, Kaho Morii, Josep Miquel Girart, Qizhou Zhang, Ian W. Stephens, James M. Jackson, Paulo C. Cortés, Patrick M. Koch, Claudia J. Cyganowski, Piyali Saha, Henrik Beuther, Suinan Zhang, Maria T. Beltrán, Yu Cheng, Fernando A. Olguin, Xing Lu, Spandan Choudhury, Kate Pattle, Manuel Fernández-López, Jihye Hwang, Ji-hyun Kang, Janik Karoly, Adam Ginsburg, A.-Ran Lyo, Kotomi Taniguchi, Wenyu Jiao, Chakali Eswaraiah, Qiu-yi Luo, Jia-Wei Wang, Benoît Commerçon, Shanghuo Li, Fengwei Xu, Huei-Ru Vivien Chen, Luis A. Zapata, Eun Jung Chung, Fumitaka Nakamura, Sandhyarani Panigrahy, Takeshi Sakai

“…Using the Davis–Chandrasekhar–Fermi method with an angle dispersion function analysis, we estimate in this core a magnetic field strength of 6.2 mG and a mass-to-magnetic-flux ratio of 18. …”
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Hepatopulmonary syndrome in patients with porto-sinusoidal vascular disorder: Characteristics and outcome by Sabrina Sidali, Ylang Spaes, Kinan El Husseini, Odile Goria, Vincent Mallet, Armelle Poujol-Robert, Anne Gervais, Adrien Lannes, Dominique Thabut, Jean-Baptiste Nousbaum, Isabelle Hourmand-Ollivier, Charlotte Costentin, Alexandra Heurgué, Pauline Houssel-Debry, Sophie Hillaire, Nathalie Ganne-Carrié, Nicolas Drilhon, Shanta Ram Valainathan, Lucile Moga, Marion Tanguy, Estelle Marcault, Aurélie Plessier, François Durand, Sarah Raevens, Valérie Paradis, Agnès Cachier, Laure Elkrief, Pierre-Emmanuel Rautou

“…This study aimed to determine the associated factors, plasma mediators, and evolution of HPS in patients with PSVD. Methods: Multicenter observational study of patients with PSVD with signs of portal hypertension in whom contrast-enhanced transthoracic echocardiography (CE-TTE) was performed. …”
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Huqi formula suppresses hepatocellular carcinoma growth by modulating the PI3K/AKT/mTOR pathway and promoting T cell infiltration by Donghao Yin, Xiang Li, Xuemeng Yang, Xiaofei Shang, Zhen Li, Jiahao Geng, Yanyu Xu, Zijing Xu, Zixuan Wang, Zimeng Shang, Zhiyun Yang, Linlan Hu, Quanwei Li, Jiabo Wang, Xinhua Song, Xiuhui Li, Xiaojun Wang

“…Purpose This study aimed to investigate the anti-HCC effects of HQF and its underlying mechanisms. Methods Chemical profiling and quantification of HQF were conducted by LC–MS and HPLC. …”
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Peer-Assisted Lifestyle (PAL) intervention: a protocol of a cluster-randomised controlled trial of a health-coaching intervention delivered by veteran peers to improve obesity trea... by Stephanie L Orstad, Melanie Jay, Victoria Sweat, Sandra Wittleder, Scott E Sherman, Jeannette M Beasley, Shea Smith, Binhuan Wang, Allison Squires, Laura Wong, Yixin Fang, Paula Doebrich, Damara Gutnick, Craig Tenner

“…We describe the rationale and design of a cluster-randomised controlled trial to test the efficacy of the Peer-Assisted Lifestyle (PAL) intervention compared with enhanced usual care (EUC) to improve BM loss, clinical and behavioural outcomes (aim 1); identify BM-loss predictors (aim 2); and increase PCP counselling (aim 3).Methods and analysis We are recruiting 461 veterans aged 18–69 years with obesity or overweight with an obesity-associated condition under the care of a PCP at the Brooklyn campus of the Veterans Affairs NY Harbor Healthcare System. …”
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Berberine in the treatment of radiation-induced skin injury: insights from proteomics and network pharmacology by Jie Zou, Jie Zou, Xia-Juan Xiao, Ping Zhang, Xing-Zi Huang, Jing Wang, Chun-Qin Tao, Xiao-Lan Ou, Gong Chen, Ting-Hao He, Long Yang, Biao Huang, Dao-Jiang Yu, Dao-Jiang Yu, Yu Zhao

“…Berberine (BBR), a bioactive compound recognized for its anti-inflammatory, antioxidant, and anti-fibrotic characteristics, presents a compelling option for treating RISI.MethodsThe molecular targets of BBR and RISI were identified using Swiss Target Prediction and GeneCards databases. …”
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