Curcumin supplementation accelerates high-altitude acclimatization, prevents polycythemia and modulates gut microbiota in male Han population: a randomized controlled trial by Jilei Hu, Hongmei Lang, Die Fan, Ting Wen, Jiaojiao Shi, Chunxiu Xiao, Yunming Li, Chao Kang, Peijie Shi, Peijie Shi, Lirong Shen, Ning Lin, Ning Lin, Ning Lin

“…BackgroundPrevious evidence showed that curcumin enhanced the oxygen supply efficiency of hemoglobin and alleviated acute plateau hypoxia injury in animal models. However, its efficacy on human beings is not yet verified. …”
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Study of the Characteristics of a Co-Seismic Displacement Field Based on High-Resolution Stereo Imagery: A Case Study of the 2024 MS7.1 Wushi Earthquake, Xinjiang by Chenyu Ma, Zhanyu Wei, Li Qian, Tao Li, Chenglong Li, Xi Xi, Yating Deng, Shuang Geng

“…The successful extraction of this high-resolution vertical displacement field validates the efficacy of satellite-based high-resolution stereo-imaging methods for overcoming the limitations of GNSS and InSAR techniques in characterizing near-field surface displacements associated with earthquake ruptures. …”
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Thiamine dose response in human milk with supplementation among lactating women in Cambodia: study protocol for a double-blind, four-parallel arm randomised controlled trial by Kyly C Whitfield, Hou Kroeun, Tim Green, Frank T Wieringa, Mam Borath, Prak Sophonneary, Jeffrey R Measelle, Dare Baldwin, Lisa N Yelland, Shalem Leemaqz, Kathleen Chan, Jelisa Gallant

“…Thiamine fortification of salt is a potentially low-cost, passive means of combating thiamine deficiency; however, both the dose of thiamine required to optimise milk thiamine concentrations as well as usual salt intake of lactating women are unknown.Methods and analysis In this community-based randomised controlled trial, 320 lactating women from Kampong Thom, Cambodia will be randomised to one of four groups to consume one capsule daily containing 0, 1.2, 2.4 or 10 mg thiamine as thiamine hydrochloride, between 2 and 24 weeks postnatal. …”
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Genetic polymorphism of msp2 in Plasmodium falciparum isolates among asymptomatic malaria infections from two ecological settings in Cameroon by Aline G. Bouopda-Tuedom, Luc Abate, Brice L. Feufack-Donfack, Christelle M. Ngou, Albert N. Bayibeki, Carole E. Eboumbou Moukoko, Lawrence S. Ayong, Antoine Berry, Thierry Lefèvre, Isabelle Morlais, Sandrine E. Nsango

“…General linear mixed models were fitted to evaluate the impact of study site, participant age, gender and bed net ownership on genetic diversity. …”
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Novel Cerium- and Terbium-Doped Gadolinium Fluoride Nanoparticles as Radiosensitizers with Pronounced Radiocatalytic Activity by Nikita A. Pivovarov, Danil D. Kolmanovich, Nikita N. Chukavin, Irina V. Savintseva, Nelli R. Popova, Alexander E. Shemyakov, Arina D. Filippova, Maria A. Teplonogova, Alexandra V. Yurkovskaya, Ivan. V. Zhukov, Azamat Y. Akkizov, Anton L. Popov

“…<b>Background:</b> The use of nanoradiosensitizers is a promising strategy for the precision enhancement of tumor tissue damage during radiotherapy. <b>Methods:</b> Here, we propose a novel biocompatible theranostic agent based on gadolinium fluoride doped with cerium and terbium (Gd_0.7Ce_0.2Tb_0.1F₃ NPs), which showed pronounced radiocatalytic activity when exposed to photon or proton beam irradiation, as well as remarkable MRI contrast ability. …”
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The Effect of Percutaneous Coronary Intervention on Patients with Acute Myocardial Infarction and Cardiogenic Shock Supported by Extracorporeal Membrane Oxygenation by Yan Wang, Hongfu Fu, Jin Li, Haixiu Xie, Chenglong Li, Zhongtao Du, Xing Hao, Hong Wang, Liangshan Wang, Xiaotong Hou

“…This study aims to investigate whether PCI can mitigate mortality among patients with AMICS supported by ECMO. Methods: Data from patients ≥18 years, who underwent VA-ECMO assistance in China between January 1, 2017, and June 30, 2022, were retrieved by searching the Chinese Society of Extracorporeal Life Support (CSECLS) Registry. …”
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Longer Drug Retention of Interleukin-12/23 or Interleukin-17 Inhibitors Compared With TNF Inhibitors in Female Patients With TNF Inhibitor-Experienced Psoriatic Arthritis by Godehard A. Scholz, MD, PhD, Eleftherios Papagiannoulis, MSc, Christoph Blapp, MSc, Raphael Micheroli, MD, Adrian Ciurea, MD, Michael J. Nissen, MD, Nikhil Yawalkar, MD, Diana Dan, MD, Jennifer Amsler, MD, Almut Scherer, PhD, Burkhard Möller, MD

“…Objective: To compare the effectiveness of Interleukin (IL)-12/23 or IL-17A inhibitors (summarized to inhibitors of the Th17 cell generation or function, Th17i) with tumor necrosis factor inhibitors (TNFi) in patients with TNFi-experienced psoriatic arthritis (PsA). Patients and Methods: We conducted a comparative effectiveness study by taking advantage of prospectively collected patients with PsA data from the Swiss Clinical Quality Management in Rheumatic Diseases register, encompassing the interval from January 1, 2015 to August 1, 2021. …”
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Study protocol for a phase II, double-blind, randomised controlled trial of cannabidiol (CBD) compared with placebo for reduction of brain neuroinflammation in adults with chronic... by Yi Zhang, Robert Edwards, A Eden Evins, Jodi M Gilman, Chelsea K Pike, Minhae Kim, Kristina Schnitzer, Nathaniel Mercaldo, Vitaly Napadow, Erin Janas Morrissey, Zeynab Alshelh, Marco L Loggia

“…The principal aim of this trial is to evaluate whether CBD, compared with placebo, affects neuroinflammation, as measured by TSPO levels.Methods and analysis This is a double-blind, randomised, placebo-controlled, phase II clinical trial. …”
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Mitigating air pollution’s impact on lung cancer in a large-scale longitudinal study: The unexplored potential of dietary interventions by Yong-sheng Yang, Xu-wei Tang, Ji-fu Wu, Zhi-ying Zhan, Zhi-jian Hu, Fei He

“…Cox proportional hazard models were used to calculate the hazard ratios (HRs) and 95 % confidence intervals (CIs). …”
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Combined 25-hydroxyvitamin D concentrations and physical activity on mortality in US stroke survivors: findings from the NHANES by Junqi Liao, Jingyi Chen, Huimin Wu, Qing Zhu, Xiaogang Tang, Li Li, Aimei Zhang, Peiyi Mo, Yan Liu, Xinyi Yang, Yang Han, Zhaoyao Chen, Wenlei Li, Yuan Zhu, Minghua Wu

“…We examined the association of 25(OH)D and PA with all-cause or cause-specific mortality risk in stroke survivors. Methods The analysis included 677 stroke survivors from National Health and Nutrition Examination Survey (NHANES) 2007–2008 to 2017–2018. …”
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Prognostic value of metabolic tumor volume on [18F]FDG PET/CT in addition to the TNM classification system of locally advanced non-small cell lung cancer by Alexander Brose, Isabelle Miederer, Jochem König, Eleni Gkika, Jörg Sahlmann, Tanja Schimek-Jasch, Mathias Schreckenberger, Ursula Nestle, Jutta Kappes, Matthias Miederer

“…Kaplan-Meier curves and stratified Cox proportional hazard regression models were used to investigate the prognostic value of PET parameters and TNM along with clinical variables. …”
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The Evolving Global Burden of Young‐Onset Parkinson's Disease (1990–2021): Regional, Gender, and Age Disparities in the Context of Rising Incidence and Declining Mortality by Yanjie Jiang, Hanyu Wang, Xingyi He, Rui Fu, Zhihui Jin, Qinwei Fu, Xinlang Yu, Wenshan Li, Xiaoyu Zhu, Shipeng Zhang, Yan Lu

“…ABSTRACT Background Young‐onset Parkinson's disease (YOPD) has emerged as a significant global public health challenge characterized by its early onset among individuals in their prime working years, complex disruptions to social roles, and a substantial socioeconomic burden encompassing diminished productivity, escalating healthcare costs, and markedly reduced quality of life. Methods Using Global Burden of Disease (GBD) 2021 data, this study analyzed YOPD burden (ages 20–49) from 1990 to 2021, assessing age‐standardized incidence rate (ASIR), mortality rate (ASMR), disability‐adjusted life years rate (ASDR), and trends via Bayesian Age‐Period Cohort (BAPC) modeling. …”
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Efficacy and Safety of Sotrovimab Versus Oral Antiviral for Early Treatment in High-Risk Patients in Omicron Era: A Multicenter Retrospective Study by Antonio Russo, Mariantonietta Pisaturo, Chiara Cacace, Augusta Troise, Gabriele Granata, Pierantonio Grimaldi, Enrico Allegorico, Francesca Ambrisi, Martina Papillo, Fabio Giuliano Numis, Nicola Coppola

“…Sotrovimab, a monoclonal antibody, and oral antivirals such as nirmatrelvir/ritonavir and molnupiravir have been used for early intervention, but their comparative efficacy and safety, particularly during the Omicron-dominant phase, require further evaluation. Methods: A multicenter, retrospective study performed in southern Italy including all adult patients who received early antiviral treatment (sotrovimab or nirmatrelvir/r or molnupiravir) between January 2022 and February 2024 (omicron phase). …”
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Determinants of non-adherence to antibiotic treatment guidelines in hospitalized adults with suspected community-acquired pneumonia: a prospective study by Dagfinn Lunde Markussen, Jannicke Slettli Wathne, Christian Ritz, Cornelis H. van Werkhoven, Sondre Serigstad, Rune Oskar Bjørneklett, Elling Ulvestad, Siri Tandberg Knoop, Synne Jenum, Harleen M. S. Grewal

“…This study aims to identify factors contributing to deviations from antibiotic treatment guidelines in hospitalized adults with suspected community-acquired pneumonia (CAP). Methods We conducted a prospective study at Haukeland University Hospital's Emergency Department in Bergen, Norway, from September 2020 to April 2023. …”
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Associations of sleep characteristics with all-cause, cardiovascular and non-cardiovascular mortality among rural Chinese older adults: a cohort study by Jie Lu, Yajun Liang, Rui Liu, Yifeng Du, Chengxuan Qiu, Tong Zhao, Keke Liu, Shi Tang, Jiafeng Wang, Juan Ren, Yifei Ren, Ming Mao

“…Study objectives The longitudinal associations of sleep timing and time in bed (TIB) with all-cause, cardiovascular and non-cardiovascular mortality are unclear in Chinese rural populations.Methods This population-based cohort study included 2468 participants who were aged ≥60 years and residing in rural communities in western Shandong Province. …”
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Avoidance of healthcare service use and correlates among HIV-positive patients in Vietnam: a cross-sectional study by Huong Lan Thi Nguyen, Thu Minh Bui, Carl A Latkin, Cyrus SH Ho, Roger CM Ho, Don Bradley, Toan Van Ngo, Vu Anh Trong Dam, Tham Thi Nguyen, Hien Thu Nguyen, Ga Mei Zeng, Quang N Nguyen

“…This study investigates HIV-positive patients’ avoidance of healthcare services and its correlates.Design A cross-sectional study.Setting The secondary data analysis used cross-sectional data from a randomised controlled intervention, examining the effectiveness of HIV-assisted smartphone applications in the treatment of HIV/AIDS patients in the Bach Mai and Ha Dong clinics in Hanoi.Methods Simple random sampling was used to identify 495 eligible patients. …”
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The Influence of Compensation, Competency and Workload on Employee Performance Surabaya Health Office with Job Satisfaction as an Intervening Variable by Dhian Wulandari, Agus Sukoco

“…The research population was all ASN of the Surabaya Health Office with a sample of 56 respondents taken using a simple random sampling technique. The data analysis method uses Structural Equation Modeling (SEM) based on Partial Least Square (PLS). …”
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Prevalence and Clinical Parameters Associated With Chronic Total Occlusions in Patients With Chronic Coronary Syndromes: Insights From a Nationwide Registry by Armin Attar, Mehrab Sayadi, Alireza Hosseinpour, Emmanouil S. Brilakis, Fereshte Mehdizade, Zahra Namvar, Alireza Khosravi, Maryam Boshtam, Feridoun Noohi, Ahmadreza Assareh, Toba Kazemi, Hossein Farshidi, Arsalan Khaledifar, Maryam Abbaszadeh, Nizal Sarrafzadegan

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Optimising Psychological Well-Being in Chinese-Australian Adolescents: A 24-Hour Movement Guidelines Approach by Wei-Cheng Chao, Asaduzzaman Khan, Jui-Chi Shih, Wen Li, Ching-Lin Wu, Kuan-Chung Chen, Bill Cheng

“…This study used multiple linear regression modelling to examine the associations between meeting or not meeting recommendations. …”
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Cross-sectional study on the association between 24-hour urinary potassium excretion and the risk of H-type hypertension and non-H-type hypertension in Chinese adults by Qingfang He, Xiaofu Du, Xiangyu Chen, Lixin Wang, Yujia Fang, Jieming Zhong

“…We aimed to describe the relationship between 24-hour (h) urinary potassium excretion and the risk of H-type hypertension and non-H-type hypertension, thus to guide personal and public health campaigns including dietary recommendations to lower H-type hypertension and non-H-type hypertension in China.MethodsIn 2020 in Zhejiang, China, a cross-sectional survey on Salt Reduction and Prevention of Hypertension was conducted by using a stratified multistage random sampling strategy, with participants aged 21 to 72 years. …”
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