Baseline kidney function and the effects of dapagliflozin on health status in heart failure in DEFINE‐HF and PRESERVED‐HF by Andrew P. Ambrosy, Andrew J. Sauer, Shachi Patel, Sheryl L. Windsor, Barry A. Borlaug, Mansoor Husain, Silvio E. Inzucchi, Dalane W. Kitzman, Darren K. McGuire, Sanjiv J. Shah, Kavita Sharma, Guillermo Umpierrez, Mikhail N. Kosiborod

“…This study aimed to assess whether the treatment effects of dapagliflozin on health status vary based on estimated glomerular filtration rate (eGFR). Methods and Results We conducted a pooled participant‐level analysis of two double‐blind, randomized trials, DEFINE‐HF (n = 236) and PRESERVED‐HF (n = 324), which evaluated dapagliflozin versus placebo. …”
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Exploiting <i>Wolbachia</i> as a Tool for Mosquito-Borne Disease Control: Pursuing Efficacy, Safety, and Sustainability by Riccardo Moretti, Jue Tao Lim, Alvaro Gil Araujo Ferreira, Luigi Ponti, Marta Giovanetti, Chow Jo Yi, Pranav Tewari, Maria Cholvi, Jacob Crawford, Andrew Paul Gutierrez, Stephen L. Dobson, Perran A. Ross

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Synergistic effects of Bacillus subtilis QST 713 and L-arginine supplementation during late gestation on reproductive performance in Landrace × Yorkshire sows: A randomized control... by Thepsavanh Khoudphaithoune, Do Thi Kim Lanh, Nguyen Van Thanh, Bui Van Dung, Peerapol Sukon, Nguyen Hoai Nam

“…Linear and generalized linear mixed models were used for analysis. Results: Co-supplementation with B. subtilis and L-arginine significantly increased IBW (1434.7 g vs. 1310.0 g, p < 0.001), TBW (19.6 kg vs. 16.9 kg, p < 0.001), NBABW (18.1 kg vs. 15.9 kg, p = 0.006), and the proportion of large piglets (33.7% vs. 19.5%, p = 0.0002), while reducing runt piglet incidence (4.0% vs. 14.4%, p < 0.001). …”
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Federally qualified health center patients’ experiences with remote patient monitoring as part of telehealth services for self-measured blood pressure monitoring by Natalia I. Heredia, Maria E. Fernandez, Ella R. Garza, Jabria Pittman, Fernanda Velasco-Huerta, Tracy L. Judd, Jocelyn Hunyadi, Elvis Longanga Diese, Deevakar Rogith, William B. Perkison, Susan H. Fenton

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Heavy metals, epigenetic aging, and mortality: A cohort study by Hua Wang, Yunyun Liu, Shuxiang Yan, Chenbei Li, Jinxin Tang, Hongkun Hu, Mingyang Wu, Chao Tu

“…The relationships between metal exposure, EAMs and mortality risk were evaluated using multiple-linear regression, Cox regression, and weighted quantile sum (WQS) models, while the mediating role of EAMs in these associations was assessed through mediation analysis. …”
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Clinical Characteristics Associated with the PLP-PLS Index, a New Potential Metric to Phenotype Phantom Limb Pain by Jorge Ortega-Márquez, Justyna Garnier, Lucas Mena, Ana Victoria Palagi Vigano, Eleonora Boschetti Grützmacher, Gabriel Vallejos-Penaloza, Valton Costa, Daniela Martinez-Magallanes, Antonio Vaz de Macedo, Waynice Neiva de Paula-Garcia, Denise Saretta Schwartz, Felipe Fregni, Kevin Pacheco-Barrios

“…This study examines the PLP-PLS index as a novel tool to differentiate PLP from PLS and explores the association of clinical factors with the index. Methods: We conducted a cross-sectional analysis of baseline data from 112 participants in a previous factorial trial in patients with unilateral traumatic lower limb amputation. …”
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Immunopeptidomics identified antigens for mRNA-lipid nanoparticle vaccines with alpha-galactosylceramide in multiple myeloma therapy by Eline Menu, Lorenzo Franceschini, Karin Vanderkerken, Elke De Bruyne, Karine Breckpot, Kim De Veirman, Arne Van der Vreken, Fabien Thery, Chenggong Tu, Kevin Mwangi, Sofie Meulewaeter, Lien De Beck, Edith Janssens, Francis Impens, Rein Verbeke, Ine Lentacker

“…To our knowledge, immunization with messenger RNA (mRNA) and the iNKT agonist, α-galactosylceramide (αGC), has not been studied in MM, as knowledge on clinically relevant antigens in preclinical MM models is lacking.Methods Microarray data and immunopeptidomics (imPep) were used to identify candidate antigens for immunization in 5TMM models. …”
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Biomarker and clinical data–based predictor tool (MAUXI) for ultrafiltration failure and cardiovascular outcome in peritoneal dialysis patients: a retrospective and longitudinal st... by Eva María Arriero-País, María Auxiliadora Bajo-Rubio, Roberto Arrojo-García, Pilar Sandoval, Guadalupe Tirma González-Mateo, Patricia Albar-Vizcaíno, Gloria del Peso-Gilsanz, Marta Ossorio-González, Pedro Majano, Manuel López-Cabrera, Gloria del Peso-Gilsanz

“…Objectives To develop a machine learning-based software as a medical device to predict the endurance and outcomes of peritoneal dialysis (PD) patients in real time using effluent-measured biomarkers of the mesothelial-to-mesenchymal transition (MMT).Methods Retrospective, longitudinal, triple blind study in two independent hospitals (Spain), designed under information-theoretical approaches for feature selection and machine learning-based modelling techniques. …”
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Complete loss of PAX4 causes transient neonatal diabetes in humans by James Russ-Silsby, Yunkyeong Lee, Varsha Rajesh, Mahsa Amoli, Nasser Ali Mirhosseini, Tushar Godbole, Matthew B. Johnson, D. Evelyn Ibarra, Han Sun, Nicole A.J. Krentz, Matthew N. Wakeling, Sarah E. Flanagan, Andrew T. Hattersley, Anna L. Gloyn, Elisa De Franco

“…(Arg126∗) variant causes nonsense mediated decay in CRISPR-edited iPSC-derived pancreatic endoderm cells. Integrated analysis of CUT&RUN-sequencing in EndoC-βH1 cells and RNA-sequencing in PAX4-depleted islet stem cell models identified genes directly regulated by PAX4 involved in both pancreatic islet development and glucose-stimulated insulin secretion. …”
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Early onset neonatal bloodstream infections in South African hospitals by Genevieve Theron, Adrie Bekker, Larisse Bolton, Andrew Whitelaw, Arnoldus Engelbrecht, Louisa Erasmus, Aaqilah Fataar, Chandre Geldenhuys, Marlize Kunneke, Dave Le Roux, Natasha O’Connell, Kessendri Reddy, Natasha Rhoda, Lloyd Tooke, Mark Wates, Thandi Wessels, Angela Dramowski

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Serum and tear autoantibodies from NOD and NOR mice as potential diagnostic indicators of local and systemic inflammation in Sjögren’s disease by Shruti Singh Kakan, Sara Abdelhamid, Sara Abdelhamid, Yaping Ju, Yaping Ju, J. Andrew MacKay, J. Andrew MacKay, J. Andrew MacKay, Maria C. Edman, Indu Raman, Chengsong Zhu, Prithvi Raj, Sarah F. Hamm-Alvarez, Sarah F. Hamm-Alvarez

“…Data were analyzed by R package Limma and Seurat.ResultsAnalysis of immunofluorescence in LG sections from both SjD models showed TLS. …”
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Effect of an Energy-Restricted Mediterranean Diet, Physical Activity and Behavioral Support Lifestyle Intervention on Body Composition in Older Adults with Metabolic Syndrome: Thre... by Dora Romaguera, Miguel Ruiz-Canela, J. Alfredo Martínez, Vicente Martín, Ramón Estruch, Jordi Salas-Salvadó, Jadwiga Konieczna

“…The potential interactions of study arm with time were tested in crude and multivariable linear-mixed effects models with repeated measurements at baseline and at 1 and 3 years. …”
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Plasma lipidomics profile in pregnancy and gestational diabetes risk: a prospective study in a multiracial/ethnic cohort by Yeyi Zhu, Cuilin Zhang, Paul S Albert, Mohammad L Rahman, Fasil Tekola-Ayele, Michael Y Tsai, Xiaobin Wang, Yen-Chen A Feng, Oliver Fiehn, Liming Liang

“…We constructed lipid networks using weighted correlation network analysis technique. We examined prospective associations of lipid networks and individual lipids with GDM risk using linear mixed effect models. …”
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Rescue Antenatal Corticosteroids in Late Preterm Birth after Completion of the Initial Cycle of Antenatal Corticosteroids during the Early Preterm Period by Da Eun Jeong, Jung Yun Lee, Eun Ji Oh, Kyong-No Lee, Hyunsu Kim, Hyeon Ji Kim, Jee Yoon Park, Young Hwa Jung, Kyung Joon Oh, Chang Won Choi

“…This study aimed to assess the effectiveness of rescue ACS in reducing the incidence of RDS and hypoglycemia in late preterm infants. Methods: A retrospective cohort study was conducted on women who delivered singleton late preterm infants (34 + 0 to 36 + 6 weeks of gestation) at a tertiary hospital. …”
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Remnant–to–LDL cholesterol discordance as a predictor of thromboembolic events in anticoagulated patients with atrial fibrillation: a report from the prospective Murcia AF project... by Eva Soler-Espejo, Yang Chen, José Miguel Rivera-Caravaca, María Pilar Ramos-Bratos, Raquel López-Gálvez, Francisco Marín, Vanessa Roldán, Gregory Y.H. Lip

“…As atrial fibrillation (AF) is a common arrhythmia associated with increased thromboembolic risk even despite anticoagulation, we assessed the prognostic value of RC in AF, with a particular focus on its association with LDL-C discordance. Methods In this prospective cohort study, AF outpatients initiating oral anticoagulation between January 2016 and November 2021 were enrolled. …”
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Gut microbiota remodeling exacerbates neuroinflammation and cognitive dysfunction via the microbiota-gut-brain axis in prenatal VPA-exposed C57BL/6 mice offspring by Zhaoming Liu, Zhaoming Liu, Caixia Wu, Caixia Wu, Zhaojian Sun, Zuoxian Lin, Yirong Sun, Nouman Amjad, Muhammad Majid, Rajesh Basnet, Zhiyuan Li, Zhiyuan Li, Zhiyuan Li

“…Emerging evidence implicates the microbiota-gut-brain axis as a critical mediator of neuroinflammation and cognitive deficits, but causal pathways in VPA-induced ASD models require systematic exploration. This study investigates how prenatal VPA exposure reshapes gut microbiota composition, exacerbates neuroinflammatory responses, and drives cognitive dysfunction through the microbiota-gut-brain axis in C57BL/6 mouse offspring.MethodsPrenatal VPA-exposed and control offspring underwent behavioral assessments (open field, three-chamber social interaction, marble-burying, and Morris water maze tests). …”
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Nested case-control study investigating factors affecting initial adoption of HIV self-testing among men who have sex with men in Guangzhou, China: amidst comprehensive service cov... by Yuzhou Gu, JiaLi Yang, Yefei Luo, Lishan Zhan, Fanghua Liu, Wenting Zeng, Huifang Xu, Huifang Xu, Yongheng Lu, Yanshan Cai, Zhigang Han

“…Investigating the factors influencing the initial adoption of HIVST among MSM in this context can help develop tailored HIVST service strategies of and further promote HIVST adoption among MSM communities.MethodsWe selected 230 participants from a prospective cohort on HIV infection among MSM population in Guangzhou, China, who had no prior experience of HIVST. …”
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Prognostic implication of venoarterial extracorporeal membrane oxygenation in acute myocardial infarction-related cardiogenic shock by Jonghu Shin, Eun-Mi Kang, Sang-Hyup Lee, Minju Heo, Yong-Joon Lee, Seung-Jun Lee, Sung-Jin Hong, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Chul-Min Ahn

“…Logistic regression models were used to compare in-hospital mortality and to identify prognostic predictors. …”
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Understanding why at-risk population segments do not seek care for tuberculosis: a precision public health approach in South India by Harkesh Dabas, Beena E Thomas, Sarah Helfinstein, Mokshada Jain, Hannah Kemp, Sema K Sgaier, Elisabeth Engl, Gayathri Natarajan, Prithivi Prakash, Jayabal Lavanya, Murugesan Jagadeesan, Rebekah Chang, Tichakunda Mangono, Shamim Mannan, Grace K Charles

“…Previous work identifies barriers only in people within the health system, often long after initial care-seeking.Methods We conducted a community-based survey of 84 625 households in Chennai, India, to identify 1667 people with TB-indicative symptoms in 2018–2019. …”
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Association between remnant cholesterol and low-density lipoprotein cholesterol discordance and type 2 diabetes or prediabetes: results from NHANES by Yijing Xin, Yimeng Wang, Yuyuan Shu, Hanyang Liang, Yanmin Yang

“…This study aimed to investigate the association between RC and LDL-C discordance and type 2 diabetes or prediabetes in the general US adult population. Methods Data from 19,604 participants in the National Health and Nutrition Examination Surveys (NHANES) (2005–2018) were analyzed. …”
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