Modified Alliance-Focused Training with Doubling as an integrative approach to improve therapists’ competencies in dealing with alliance ruptures and prevent negative outcomes in p... by Anne Daubmann, Antonia Zapf, Antje Gumz, Frank Jacobi, Denise Kästner, Laurence Reuter, Carmen Martinez Moura, Klarissa Ehlers, Catherine F Eubanks, John Christopher Muran, Timothy Anderson, Ramona Stöckl, Georg Schwanitz, Lena Stegemann, Lana Rohr, Ulrike Willutzki

“…The Alliance-Focused Training (AFT) is a promising transtheoretical approach to enhance therapists’ skills in dealing with alliance ruptures.Methods and analysis To evaluate the effectiveness of Modified AFT with doubling (MAFT-D), a randomised, patient and evaluator-blinded, multicentre trial was designed comparing MAFT-D (delivered to trainee therapists and supervisors) and psychotherapy training/treatment as usual (TAU) for therapists (n=120) and their patients with depressive disorders (n=240). …”
Get full text

Policies for type 2 diabetes and non-communicable disease management during the COVID-19 pandemic in Kenya and Tanzania: a desk review and views of decision-makers by Frances Mair, Gershim Asiki, Shukri F Mohamed, Christopher Bunn, Sally M Mtenga, Cindy Gray, Peter Binyaruka, Lyagamula Kisia, Richard E Sanya, Caroline H Karugu, Irene Mashiashi, Jennifer P Wisdom, Peter M Kibe

“…This study aimed to identify policy gaps, if any, in the management of NCDs, particularly diabetes, during COVID-19 in Kenya and Tanzania to inform recommendations for priority actions for NCD management during any future similar crises.Methods We undertook a desk review of pre-existing and newly developed national frameworks, policy models and guidelines for addressing NCDs including type 2 diabetes. …”
Get full text

IFITM3 enhances immunosensitivity via MHC-I regulation and is associated with the efficacy of anti-PD-1/-L1 therapy in SCLC by Yanan Cui, Tianyu Qiu, Jiale Wang, Xinyu Liu, Libo Luo, Jizhong Yin, Xinxin Zhi, Wanying Wang, Gaohua Feng, Chunyan Wu, Zhikai Zhao, Hua Zhang, Fei Li, Fengying Wu, Shengxiang Ren

“…This study aimed to elucidate the regulatory mechanisms underlying MHC-I expression and potential combination strategies. Methods Single-cell and bulk RNA sequencing data from SCLC patients were analyzed. …”
Get full text

Is there an association between superoxide dismutase gene polymorphisms, antioxidants in oxidative stress pathway, and oral health-related quality of life after root canal treatmen... by Ludmila da Silva Guimarães, Erlange Andrade Borges da Silva, Juliana Miranda Bonelli, Heitor Ganier Ribeiro, Alice Corrêa Silva-Sousa, Manoel Damião Sousa-Neto, Erika Calvano Küchler, Lívia Azeredo Alves Antunes, Fernanda Signorelli Calazans, Leonardo Santos Antunes

“…In the Multivariate Poisson Regression analysis, SOD2 (rs5746136) was associated with the psychological disability domain [in codominant (p = 0.049) and recessive (p = 0.040) models] and SOD3 (rs13306703), in the handicap domain [in codominant (p = 0.028) and dominant (p = 0.037) models].  …”
Get full text

Using the R = MC2 heuristic to assess whole-of-school physical activity implementation in elementary schools: a cross-sectional study by Derek W. Craig, Kevin Lanza, Christopher D. Pfledderer, Andjelka Pavlovic, Kempson Onadeko, Natalia I. Heredia, Jizyah Injil, Laura F. DeFina, Timothy J. Walker

“…This study examines associations between constructs from the R = MC2 heuristic and schools’ implementation of a WOS approach. Methods We conducted a secondary analysis of cross-sectional data from U.S. elementary schools participating in the NFL PLAY60 FitnessGram Project during the 2022–23 school year. …”
Get full text

A latent class assessment of healthcare access factors and disparities in breast cancer care timeliness. by Matthew R Dunn, Didong Li, Marc A Emerson, Caroline A Thompson, Hazel B Nichols, Sarah C Van Alsten, Mya L Roberson, Stephanie B Wheeler, Lisa A Carey, Terry Hyslop, Jennifer Elston Lafata, Melissa A Troester

“…Associations were evaluated using adjusted linear-risk regression to estimate relative frequency differences (RFDs) with 95% confidence intervals (CIs). Delayed diagnosis models were adjusted for age; delayed and prolonged treatment models were adjusted for age and tumor size, stage, and grade at diagnosis; and OncotypeDx models were adjusted for age and tumor size and grade. …”
Get full text

Causes of death and infant mortality rates among full-term births in the United States between 2010 and 2012: An observational study. by Neha Bairoliya, Günther Fink

“…Random effects models were used to assess the relative contribution of state-level variation to FTIM. …”
Get full text

Association Between Pain and Frailty in Middle-Aged and Older Patients: The Mediating Roles of Sleep and Mood by Wang HP, Wang T, Ye HT, Dong YY, Zhao SJ, Liu QR, Hu XY, Ji MH, Yang JJ

“…This study aimed to investigate the association between pain and frailty, with a particular focus on the mediating roles of sleep and mood.Patients and Methods: A cross-sectional study was conducted involving 244 middle-aged and older participants in local hospital. …”
Get full text

The predictive factors for resorption of lumbar disc herniation by A.J. Sanginov, I.D. Isakov, V.V. Belozerov, E.A. Mushkachev, A.V. Peleganchuk

“…To determine the timing and to identify predictive factors of resorption of lumbar disc herniation. Material and Methods. This study is retrospective cohort and is devoted to the study of two groups of patients: Group 1 with herniated disc resorption and Group 2 with no resorption. …”
Get full text

Efficacy and safety of Pueraria lobata radix as an adjuvant therapy for type 2 diabetes mellitus: rationale, design and protocol for a randomised controlled trial by Yan Zhang, Chenxi Li, Jiancheng Wang, Xu Zhou, Xiang Ye, Weifeng Zhu, Jianrong Chen, Lixia Yuan, Qiuyun Xue, Jieyi Zhou, Qihui Fan, Ruting Feng, Zhengfeng Li

“…The aim of this study is to investigate the efficacy and safety of using PLR solely as an adjuvant therapy for T2DM.Methods and analysis This study is a multicentre, randomised, double-blind, placebo-controlled trial. 200 patients with T2DM will be randomly allocated to either the PLR group or the placebo group for a consecutive 12-week intervention. …”
Get full text

Quantitative evaluation of electrographic response to electroconvulsive therapy in super-refractory status epilepticus by Raphaël Christin, Harrison Hines, Lauren Hophing, Ankit N. Khambhati, Edilberto Amorim, Edilberto Amorim, Manu Hegde, Manu Hegde, Elan L. Guterman, Elan L. Guterman, Jonathan K. Kleen, Jonathan K. Kleen

“…Here, we use quantitative approaches on electroencephalography (EEG) data to evaluate the neurophysiological influences of ECT and how they may relate to patient survival.MethodsThis was a single center study of adult patients who underwent bi-frontal ECT for treatment of SRSE between 2007 and 2021. …”
Get full text

Bone-Specific Alkaline Phosphatase as a Complementary Diagnostic Marker for the Assessment of Children and Adolescents with Secondary Osteoporosis by Eunha Bae, Soo Yeun Sim, Su Jin Park, Sung Eun Kim, Seulki Kim, Shin-Hee Kim, Won Kyoung Cho, Kyoung Soon Cho, Min Ho Jung, Byung-Kyu Suh, Moon Bae Ahn

“…This study aimed to determine whether bone turnover markers (BTMs), particularly serum bone-specific alkaline phosphatase (BsALP) and serum C-telopeptide of collagen type 1 (CTx), accurately reflect BMD. <b>Methods</b>: In this retrospective study, 280 post-puberty males and females who were previously diagnosed with hemato-oncologic, rheumatic, gastrointestinal, and endocrinologic diseases at a single tertiary care center were reviewed. …”
Get full text

Long-term Outcomes of Lupus Nephritis in Comparison to Other CKD Etiologies by Charikleia Chrysostomou, Francesca Faustini, Iva Gunnarsson, Mårten Segelmark, Juan-Jesús Carrero, Peter Barany, Anne-Laure Faucon, Marie Evans

“…Introduction: Little is known regarding the comparison of cardiovascular and kidney outcomes between lupus nephritis (LN) and other etiologies of chronic kidney disease (CKD). Methods: Using data from the Swedish Renal Registry (2006–2021), we compared long-term outcomes between patients with LN-CKD and patients with CKD due to primary glomerular diseases (PGD) and other CKD causes (Other-CKD, mainly diabetes and nephroangiosclerosis). …”
Get full text

Impact of Time-To-Treatment on Outcomes in Autoimmune Membranous Nephropathy by Patrick Hamilton, Sebastian Bate, Omar Ragy, Mrityunjay Hiremath, Samar Bukhari, Anirudh Rao, Arif Khwaja, Durga Anil K Kanigicherla

“…Immunosuppression is initiated after ''watchful-wait'' to avoid side effects in patients who might achieve spontaneous remission; however, the impact of this approach on kidney function is unclear. Methods: This was a retrospective longitudinal cohort study of patients with new consecutive aMN from 2003 to 2019 from 3 UK centers. …”
Get full text

Arctiin, a lignan compound, enhances adipose tissue browning and energy expenditure by activating the adenosine A2A receptor by Yuanfeng Gu, Wenjun He, Wenxuan Li, Jingshu Cai, Zhuyun Wang, Kemeng Li, Guangcheng Qin, Xiaojie Gu, Xiaojing Lin, Li Ma, Xiaoqiu Xiao, Yi Hou, Ting Luo

“…Arctiin (ARC), a lignan compound known for its anti-inflammatory, anti-tumor, and hypoglycemic properties, has not been fully elucidated regarding its effects and mechanisms on obesity. Methods In the present study, we established both high-fat diet-induced obese mouse models and mature adipocyte cultures to comprehensively investigate the therapeutic effects of ARC on obesity. …”
Get full text

The evolution of sprinting performance: Technological and regulatory influences from 1976 to 2024 by Dariusz Tadeusz SKALSKI, Magdalena PROŃCZUK, Kinga ŁOSIŃSKA, Ewelina LULIŃSKA, Joanna MOTOWIDŁO, Petr STASTNY, Adam MASZCZYK, Grzegorz TRYBEK

“…Understanding these factors is essential for assessing how sprint times have evolved and what future trends might emerge. Materials and methods: Utilizing a comprehensive dataset from international athletics federations, this research applies time series analysis, regression modeling, and variance testing to assess trends, gender disparities, and performance variability. …”
Get full text

Multicentre, longitudinal, observational cohort study to examine the relationship between neutrophil function and sepsis in adults and children with severe thermal injuries: a prot... by Jonathan R B Bishop, Paul Harrison, Janet M Lord, Naiem S Moiemen, Amy Bamford, Yvonne Wilson, David Barnes, Jon Hazeldine, Kirsty C McGee, Khaled Al-Tarrah, Tarek Hassouna, Krupali Patel, Rizwana Imran

“…The Scientific Investigation of the Biological Pathways Following Thermal Injury-2 study aims to prospectively validate neutrophil phagocytic activity, IG count and plasma cfDNA levels as early prognostic biomarkers of sepsis in thermally injured adult and paediatric patients.Methods and analysis This multicentre, longitudinal, observational cohort study will enrol 245 paediatric and adult patients with moderate to severe burns within 24 hours of injury. …”
Get full text

Whole-transcriptome sequencing reveals the global molecular responses and ceRNA regulatory network involved in programmed cell death of rice cultivars zyk639 and zyk-lm by Haipeng Zhang, Han Zheng, Weifang Liang, Junjie Zhang, Hongyu Zhao, Jianzhong Li, Yujie Zhou, Liujie Xie, Chulang Yu, Binfeng Dai, Liequan Zhong, Fan Hou, Chengyu Wang, Jianping Chen, Yong Yang

“…However, the regulatory relationship between lncRNAs and rice PCD occurrence is unclear. Methods In this study, messenger RNAs (mRNAs) and lncRNAs associated with PCD regulation were identified in two rice cultivars: japonica rice (Oryza sativa) cultivar zheyoukang639 (zyk639) and its mutant zyk639-lesion mimic (zyk-lm). …”
Get full text

Impact of Vascular Geometry on Thrombosis in Pediatric Patients With Modified Blalock‐Taussig‐Thomas Shunt: A Pilot Study by Ethan Penn, Yi Qiao, Kimsey Platten, Scott M. Bugenhagen, Ram Rohatgi, Jacob R. Miller, Jiaxiao Fang, Kelsey Mercer, Blaire Kulp, Jinli Wang, Guy M. Genin, David Bark, Edon J. Rabinowitz

“…Methods and Results We retrospectively analyzed 11 infants with hypoplastic left heart syndrome who underwent mBTTS placement. …”
Get full text

Genomic epidemiology and public health implications of zoonotic monophasic Salmonella Typhimurium ST34 by Xiaolei Wu, Jiaxin Du, Xiao Zhou, Xianqi Peng, Chenghao Jia, Baikui Wang, Beibei Wu, Yan Li, Yan Li, Min Yue, Min Yue, Min Yue

“…This study aims to fill this crucial gap by assessing the genomic epidemiology of multidrug resistance (MDR) mSTM ST34, as well as its clinical characteristics and virulence.MethodsTo achieve the objectives of this study, we conducted a comprehensive genomic analysis of mSTM ST34 isolates. …”
Get full text