Physical Activity Elements and Adverse Outcomes in Patients with Chronic Kidney Disease in Guangdong (PEAKING) project: protocol for a prospective cohort study by Hui Liu, Qian Wang, La Zhang, Xindong Qin, Xusheng Liu, Jianfeng Wu, Yifan Wu, Changyuan Yang, Ruolan Duan, Zhenhua Yang, Jiamei Qiu, Minhui Pi, Xitao Ling, Cuixia Xiao, Jiahao Zeng, Jiawei He, Jiasheng Huang, Lizhe Fu, Haijing Hou, Bengt Lindholm, Fuhua Lu, Guobin Su, Shujuan Chen, Yenan Mo, Fangyu Chen, Xina Jie, Yongling Huang, Qingxia Lin

“…Therefore, the Physical Activity Elements and Adverse Outcomes in Patients with Chronic Kidney Disease in Guangdong study aims to investigate the levels and types of PA elements and their association with adverse outcomes in Chinese non-dialysis CKD (ND-CKD) patients.Methods and analysis In this prospective cohort study, 374 patients with ND-CKD will be recruited from Guangdong province, South of China. …”
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Scope of practice of primary care nurses: a protocol for an umbrella review of international literature by Kris Aubrey-Bassler, Marie-Ève Poitras, Shabnam Asghari, Michelle Swab, Lindsay Hedden, Maria Mathews, Ruth Martin-Misener, Elizabeth J Halcomb, Julia Lukewich, Leslie Meredith, Dana Ryan, Suzanne Braithwaite, Danielle Macdonald, Kathleen Leslie, Anaelle Morin, Monica McGraw, Patrick Chiu, Émilie Dufour, Sophia Myles, Annie Rioux-Dubois, Deanne Curnew, Jen Calver, Jill Bruneau

“…We will conduct an umbrella review to synthesise and compare international knowledge syntheses focused on scope of practice enactment (ie., roles and activities) of PCNs in primary care.Methods and analysis We will conduct the umbrella review according to the Joanna Briggs Institute methodology, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol (PRISMA-P) guidelines, and using the Nursing Care Organization Framework as guidance. …”
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Time in target range for systolic blood pressure and stroke in people with and without diabetes: the Kailuan prospective cohort study by Yuxin Yang, Shouling Wu, Jingdi Zhang, Yang Liu, Mingjie Yin, Zhenyu Huo, Shuohua Chen, Guodong Wang, Yao Xiao, Yue Wang, Yuanyuan Li, Jiawen Deng, Tingting Geng, Hong Zhang

“…We aimed to investigate the associations of SBP-TTR with stroke among participants with or without diabetes using data from the Kailuan study.MethodsWe included 28,591 participants [mean age, 57.5 years; 83.8% men; 23.2% with diabetes] from the Kailuan Study. …”
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Spatiotemporal patterns of influenza in Western Australia by Kefyalew Addis Alene, Hannah C. Moore, Archie C.A. Clements, Beth Gilmour, Dylan D. Barth, Rebecca Pavlos, Ben Scalley, Christopher C. Blyth

“…Methods: Data for confirmed influenza cases were obtained from the WA Notifiable Infectious Diseases Database for the period 2017–2020. …”
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COL10A1+ fibroblasts promote colorectal cancer metastasis and M2 macrophage polarization with pan-cancer relevance by Shangshang Hu, Muzi Ding, Jinwei Lou, Jian Qin, Yuhan Chen, Zixuan Liu, Yue Li, Junjie Nie, Mu Xu, Huiling Sun, Xinliang Gu, Tao Xu, Shukui Wang, Shukui Wang, Yuqin Pan

“…Cancer-associated fibroblasts (CAFs) support tumor progression, but their functional heterogeneity remains poorly understood. Methods We integrated multi-omics data from 10,164 samples, including single-cell, bulk, spatial transcriptomics, and proteomics, to identify and characterize CAF subpopulations. …”
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The mediating role of depression in the association between health-related quality of life and suicidal ideation in adolescents: findings from a longitudinal study by Martina Preisig, Isabelle Häberling, Lukasz Smigielski, Sophie Emery, Noemi Baumgartner, Mona Albermann, Michael Strumberger, Klaus Schmeck, Lars Wöckel, Suzanne Erb, Bruno Rhiner, Brigitte Contin-Waldvogel, Susanne Walitza, Susanne Walitza, Susanne Walitza, Gregor Berger

“…A series of t-tests, Chi-squared-tests, Fisher’s exact tests and a mediation analysis including three robust linear mixed-effects models were conducted.ResultsDepressed adolescents with suicidal ideation reported lower health-related quality of life across physical, psychological, peer, and school domains compared to those without suicidal ideation, while no significant difference was observed in the family-related domain. …”
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Association between health communication on integrated healthcare and primary healthcare visits among rehabilitation outpatients: A multicenter cross-sectional study in China by Ruixue Ye, Yucong Zou, Jie Yan, Jianjun Long, Yawei Li, Guo Dan, Yongjun Jiang, Yulong Wang

“…Objective: This study examines the relationship between health communication on integrated healthcare and primary healthcare visits among rehabilitation outpatients in China. Methods: A multi-stage sampling scheme was used to select the rehabilitation outpatients as study participants. …”
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Piezo1/ITGB1 Synergizes With Ca2+/YAP Signaling to Propel Bladder Carcinoma Progression via a Stiffness‐Dependent Positive Feedback Loop by Minghai Ma, Jianpeng Li, Xing Li, Minxuan Jing, Lu Wang, Yunzhong Jiang, Zezhong Yang, Jiale He, Min Wang, Hang Liu, Yutong Chen, Kaibo Mi, Lei Wang, Jinhai Fan, Hongxia Du

“…This study systematically investigates the functional synergy of Piezo1/ITGB1 in orchestrating ECM biomechanical remodeling to fuel BLCA progression. Methods Utilizing an integrative framework combining clinical histopathology, in vivo tumor models, multiomics profiling, molecular biology experiments, matrix stiffness quantification, calcium flux analysis, and YAP signaling interrogation, we dissected the mechanochemical interplay between Piezo1/ITGB1 activation and ECM dynamics. …”
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Long-term outcomes of bilateral salpingo-oophorectomy in women with personal history of breast cancer by Diana M Eccles, Antonis C Antoniou, Marc Tischkowitz, Clare Turnbull, Eva Morris, Paul Pharoah, Craig Knott, Bethany Torr, Andrew Bacon, Lucy Loong, Catherine Huntley, Tameera Rahman, Steven Hardy, Hend Hassan, Isaac Allen, Yvonne Walburga

“…Objectives To investigate the association between bilateral salpingo-oophorectomy (BSO) and long-term health outcomes in women with a personal history of breast cancer.Methods and analysis We used data on women diagnosed with invasive breast cancer between 1995 and 2019 from the National Cancer Registration Dataset (NCRD) in England. …”
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Associations Between Atherosclerosis and Subsequent Cognitive Decline: A Prospective Cohort Study by Jie Liang, Yang Pan, Wenya Zhang, Darui Gao, Jingya Ma, Yanyu Zhang, Mengmeng Ji, Yiwen Dai, Yuling Liu, Yongqian Wang, Yidan Zhu, Bin Lu, Wuxiang Xie, Fanfan Zheng

“…Cognitive function was reassessed in wave 2 (2022–2023) using linear mixed models for analysis. A total of 932 participants (63.7% women; mean age, 60.0±6.9 years) were included. …”
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A multi-omics study of magnesium sulfate to improve prognosis in sepsis-related encephalopathy: integrating clinical data-driven network pharmacology by Yingming Kong, Yanghao Tai, Bin Chen, Meng Zhang, Haoyu Ji, Rongke Feng, Liang Shi, Hao Chen, Hao Chen

“…This study integrated MIMIC-IV database and network pharmacology to explore magnesium sulfate’s neuroprotective mechanisms and clinical impact on SAE outcomes.MethodsRetrospective data from 4,650 SAE patients in MIMIC-IV 3.0 were analyzed. …”
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Dissecting Trichoderma antagonism: Role of strain identity, volatiles, biomass, and morphology in suppressing cacao pathogens by Insuck Baek, Jishnu Bhatt, Jae Hee Jang, Seunghyun Lim, Amelia Lovelace, Minhyeok Cha, Dilip Lakshman, Moon S. Kim, Lyndel W. Meinhardt, Sunchung Park, Ezekiel Ahn

“…Dual culture assays, detailed morphological analysis of both antagonist and pathogen, volatile organic compound (VOC) assays (comparing standard plug vs. pre-grown biomass methods), and the effect of UVC pretreatment were investigated. …”
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Family-focused intervention programme to foster adolescent mental health and well-being: protocol for a multicountry cluster randomised factorial trial (FLOURISH Phase 2) by Heather M Foran, Marija Raleva, Nina Heinrichs, Graham Moore, Yulia Shenderovich, Xiang Zhao, Judith Simon, Antonio Piolanti, Viorel Babii, Janina Mueller, Franziska Waller, Dennis Wienand, Swetha Sampathkumar, Ivo Kunovski

“…Effective and scalable interventions are urgently needed to address these challenges.Methods and analysis This protocol outlines a multicountry cluster randomised factorial trial, implemented according to the multiphase optimisation strategy (Phase 2), which evaluates the effectiveness and costs of three add-on components for the Parenting for Lifelong Health for Parents and Teens programme: adolescent mental health tools based on UNICEFs Helping Adolescents Thrive comics, adolescent peer support based on UNICEFs ‘I Support My Friends’ intervention and engagement booster designed to enhance attendance and programme completion through incentives. …”
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Prognostic value of the lactate dehydrogenase to albumin ratio in cancer patients by Dongqi Chai, Dongqi Chai, Dongqi Chai, Tao Yang, Tao Yang, Tao Yang, Lilong Zhang, Lilong Zhang, Lilong Zhang, Yuanjian Hui, Yuanjian Hui, Jiarui Feng, Jiarui Feng, Weixing Wang, Weixing Wang, Weixing Wang

“…ObjectiveThis study aimed to explore the prognostic relevance of the lactate dehydrogenase-to-albumin ratio (LAR) in cancer patients.MethodsA comprehensive literature search was conducted across PubMed, EMBASE, and the Cochrane Library for studies published before March 15, 2025. …”
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Trajectories of antenatal depression and adverse pregnancy outcomes: A prospective cohort study by Jianfei Chen, Siqi Li, Sai Yang, Yang Chen, Jackson Jr Nforbewing Ndenkeh, Intan Maharani Sulistyawati Batubara, Luyang Zhu, Jun Liu, Xinlong Pan, Zhijie Zou, Cuifang Fan, Xiaoli Chen, Zhao Ni

“…Latent class growth modeling and logistic regression were used for data analysis. …”
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Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial by Amy Y. X. Yu, Shabnam Vatanpour, Aravind Ganesh, Thalia S. Field, Philip A. Barber, Philip M. C. Choi, Brian Buck, Timothy Kleinig, Carlos A. Molina, Bruce C. V. Campbell, Ramana Appireddy, Keith W. Muir, Michael D. Hill, Shelagh B. Coutts

“…Background In this subanalysis of the TEMPO‐2 (Tenecteplase Versus Standard of Care for Minor Ischaemic Stroke With Proven Occlusion) trial, a randomized clinical trial comparing tenecteplase and nonthrombolytic control in patients with minor stroke and symptomatic intracranial occlusion, we investigated sex differences in the efficacy and safety of tenecteplase. Methods We compared outcomes after tenecteplase versus control, stratified by sex. …”
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Evaluating GPT-4o in infectious disease diagnostics and management: A comparative study with residents and specialists on accuracy, completeness, and clinical support potential by Lili Zhan, Xiumin Dang, Zhenghua Xie, Chaoying Zeng, Weixing Wu, Xiaoyu Zhang, Li Zhang, Xinjian Cai

“…Background Artificial intelligence (AI), particularly GPT models like GPT-4o (omnimodal), is increasingly being integrated into healthcare for providing diagnostic and treatment recommendations. …”
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Enlarged choroid plexus is linked with poorer physical function in rural older adults: a population-based study by Qianqian Xie, Ziwei Chen, Jiafeng Wang, Huisi Zhang, Yan Wang, Xiaoyu Wang, Chunyan Li, Yongxiang Wang, Lin Cong, Daniel Ferreira, Anna-Karin Welmer, Lin Song, Yifeng Du, Chengxuan Qiu

“…However, no population-based studies have thus far examined the association of ChP with physical function in older people. Methods This population-based cross-sectional study included 1217 participants (age ≥ 60 years; 57.35% women) in the MRI substudy of the Multimodal Interventions to delay Dementia and disability in rural China. …”
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Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis by Wenwen Zhu, Jiali Fang, Chenbo Ji, Hong Zhong, Tianying Zhong, Xianwei Cui

“…We here aimed to investigate the association between NEOs exposure and GDM occurrence. Methods: 100 pregnant women who completed a 75 g oral glucose tolerance test (OGTT) at 24–28 weeks of gestation were enrolled. …”
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The efficacy and peripheral blood predictors in recurrent platinum-resistant ovarian cancer patients treated with immune checkpoint inhibitors by Baoyue Pan, Xiaojing Zheng, Yongwen Huang, Wei Wei, Shije Xu, Siyu Chen, Jiaxin Yin, Yu Zhang, Jundong Li, Min Zheng

“…Abstract Introduction The prognostic factors associated with recurrent platinum-resistant ovarian cancer treated with immune checkpoint inhibitor (ICI) therapy need to be identified. Methods We retrospectively analyzed the efficacy of ICI therapy in patients with recurrent platinum-resistant ovarian cancer at our center. …”
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