Metabolism disruption induced by high ambient temperature by Ke Zhang, Gongbo Chen, Wan Liu, Jie He, Mengnan Pan, Zhongyang Chen, Jiahui Tong, Feifei Liu, Hao Xiang

“…Objective: To identify acute cardiovascular responses associated with high temperature, and to understand the underlying mechanisms using metabolomics. Methods: We conducted a prospective panel study on young adults, organizing participants to undergo blood collection and temperature monitoring tautologically. …”
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Tobacco policy coverage in California jurisdictions before and after enactment of proposition 56 by Dennis R. Trinidad, Candice D. Donaldson, Brian Dang, Matthew D. Stone, Thet Nwe Myo Khin, Sara B. McMenamin, Yuyan Shi, Tam D. Vuong, Xueying Zhang, Karen Messer, John P. Pierce

“…Discrete-time survival models were fitted to test the effect of Proposition 56 on the rate of population coverage for each policy of interest. …”
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Safety and efficacy of 3D navigation-guided endoscopy for intracranial hemorrhage in patients with early cerebral hernia by Jun Zhang, Sitong Zhou, Taihui Zhang, Yongsheng Chen, Haikang Zhao, Hongyu Cheng, Peng Wang, Zhuhui Li, Jiajing Chen, Wobin Huang, Bocong Liu, Dayu Li, Hanwen Zhao, Xinwei Liu, Wenqiang Gao, Lijin Huang, Yuqian Li

“…This study aimed to assess the effectiveness and feasibility of 3D navigation-guided endoscopy for ICH patients presenting early clinical manifestations of cerebral hernia. Methods: We conducted a retrospective analysis of 11 ICH patients with cerebral hernia who underwent neuroendoscopic hematoma evacuation guided by 3D navigation technology at the Department of Neurosurgery in Dalang Hospital between January 2019 and January 2022. …”
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Interplay of PAK1 and CAMKII in Pancreatic Beta Cell Insulin Secretion by Nely Gisela López-Desiderio, Genaro Patiño-López, Citlaltépetl Salinas-Lara, Carlos Sánchez-Garibay, Olga Villamar-Cruz, Alonso Vilches-Flores, José de Jesús Peralta-Romero, Leonel Armas-López, Jazmín García-Machorro, Luis Enrique Arias-Romero, Héctor Iván Saldívar-Cerón

“…To examine their expression dynamics in a physiological context, we performed immunohistochemistry (IHC) on pancreatic sections from wild-type (WT), prediabetic, and T2DM murine models. Additionally, bioinformatic analysis of publicly available RNA sequencing (RNA-Seq) data from human islets of healthy donors, prediabetic individuals, and T2DM patients provided translational validation. …”
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Ouabain alleviates Mycobacterium abscessus-triggered inflammatory responses through dual regulation of NLRP3 inflammasome activity and M1 macrophage polarization by Nan Li, Nan Li, Nan Li, Songqiang Huang, Songqiang Huang, Xing Shi, Kuo Lu, Kuo Lu, Xiu Yu, Chen Qiu, Rongchang Chen

“…The cardiac glycoside ouabain exhibits broad anti-inflammatory effects in various disease models, but its therapeutic potential against M. abscessus-induced pneumonia remains unexplored.MethodsWe investigated the role of ouabain in M. abscessus-induced inflammation using in vivo and in vitro models. …”
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Mitochondrial metabolism is rapidly re-activated in mature neutrophils to support stimulation-induced response by Jorgo Lika, Jorgo Lika, James A. Votava, Rupsa Datta, Carlos A. Mellado Fritz, Carlos A. Mellado Fritz, Aleksandr M. Kralovec, Aleksandr M. Kralovec, Frances M. Smith, Anna Huttenlocher, Anna Huttenlocher, Melissa C. Skala, Melissa C. Skala, Jing Fan, Jing Fan, Jing Fan

“…This study aims to quantitatively understand neutrophil mitochondrial metabolism throughout differentiation and activation, and to elucidate the impact of mitochondrial metabolism on neutrophil functions.MethodsTo study metabolic remodeling throughout neutrophil differentiation, murine ER-Hoxb8 myeloid progenitor-derived neutrophils and human induced pluripotent stem cell-derived neutrophils were assessed as models. …”
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TSPAN18 facilitates bone metastasis of prostate cancer by protecting STIM1 from TRIM32-mediated ubiquitination by Qianghua Zhou, Xu Chen, Kai Yao, Yangjie Zhang, Haixia He, Hao Huang, Hao Chen, Shengmeng Peng, Ming Huang, Liang Cheng, Qiang Zhang, Ruihui Xie, Kaiwen Li, Tianxin Lin, Hai Huang

“…However, the regulatory mechanism and target therapy of STIM1 is poorly defined. Methods Liquid chromatography-mass spectrometry analysis was performed to identify tetraspanin 18 (TSPAN18) as a binding protein of STIM1. …”
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Protocol for a qualitative study exploring the perception of need, importance and acceptability of a digital diabetes prevention intervention for women with gestational diabetes me... by Siew Mooi Ching, Kimberley Goldsmith, Nicola Guess, Iliatha Papachristou Nadal, Helen Murphy, Barakatun Nisak Mohd Yusof, Irmi Zarina Ismail, Hanifatiyah Ali, Angus Forbes, Nur Hafizah Mahamad Sobri, Faezah Hassan, Nurul Iftida Basri, Mazatulfazura Sf Salim, Choiriyatul Azmiyaty

“…Thus, this study will explore the factors affecting the uptake of healthy behaviour changes and the use of digital technology among women and their healthcare providers (HCPs) to support healthy behaviour changes in women with GDM.Methods and analysis The study will be modelled according to the Capability, Opportunity, Motivation and Behaviour and Behaviour Change Wheel techniques, and use the DoTTI framework to identify needs, solutions and testing of a preliminary mobile app, respectively. …”
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Impact of Left Ventricular Diastolic Pressure Changes on Clinical Outcomes After Transcatheter Aortic Valve Replacement by Jiwon Seo, Ah‐Ram Kim, Iksung Cho, Chi Young Shim, Geu‐Ru Hong, Eui‐Young Choi, Se‐Joong Rim, Young‐Guk Ko, Myeong‐Ki Hong, Jae‐Kwan Song, Jong‐Won Ha

“…In multivariable Cox hazard models, Group 1 was independently associated with a favorable primary outcome (hazard ratio, 0.52 [95% CI, 0.34–0.80]; P=0.003). …”
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The Impact of Automatic Exposure Control Technology on the In Vivo Radiation Dose in Digital Mammography: A Comparison Between Different Systems and Target/Filter Combinations by Ahmad A. Alhulail, Salman M. Albeshan, Mohammed S. Alshuhri, Essam M. Alkhybari, Mansour A. Almanaa, Haitham Alahmad, Khaled Alenazi, Abdulaziz S. Alshabibi, Mohammed Alsufayan, Saleh A. Alsulaiman, Maha M. Almuqbil, Mahmoud M. Elsharkawi, Sultan Alghamdi

“…In this study, we aimed to determine the effect of various mammographic technologies on the in vivo mean glandular doses (MGDs) that are received in clinical settings. <b>Methods</b>: The MGDs and applied acquisition parameters from 194,608 mammograms, acquired employing AEC using different digital mammography systems (GE, Siemens, and two different models of Hologic), were retrospectively collected. …”
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Local adaptation and validation of a transdiagnostic risk calculator for first episode psychosis using mental health patient records by Elizabeth Ford, James Stone, James Stone, James Stone, Dominic Oliver, Dominic Oliver, Dominic Oliver, Benjamin Fell, Gloria Roque, Sam Robertson, Paolo Fusar-Poli, Paolo Fusar-Poli, Paolo Fusar-Poli, Paolo Fusar-Poli, Kathryn Greenwood, Kathryn Greenwood

“…We report the adaptation and internal validation of this risk calculator in a Southeast England region.MethodsIn a retrospective cohort study using EHR patient notes we identified individuals accessing mental healthcare in Southeast England (Nov-1992 to Jan-2023) who received a primary diagnosis of a non-psychotic or non-organic mental disorder. …”
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Barriers to effective communication in UAE community pharmacies: general public perspectives on enhancing patient-pharmacist interaction and policy development by Zelal Kharaba, Ahmad Al-Azayzih, Sayer Al-Azzam, Anan Jarab, Hisham E. Hasan, Dania Rahhal, Feras Jirjees, Khalid A. Al-Kubaisi, Monia H. Aljumah, Faris El-Dahiyat, Sara Meer, Mohammad A. Y. Alqudah, Mamoon A. Aldeyab, Karem H. Alzoubi

“…This study aims to identify and evaluate the factors that obstruct general public-pharmacist interactions, providing insights to enhance pharmacy environments.Methods A total of 406 general publics were surveyed using a validated questionnaire. …”
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Predictive nomograms of repeat intrahepatic recurrence and overall survival after radiofrequency ablation of recurrent colorectal liver metastases by Ji-Chen Wang, Bin-Bin Jiang, Zhong-Yi Zhang, Yu-Hui Liu, Li-Jin Shao, Song Wang, Wei Yang, Wei Wu, Kun Yan

“…Objectives This study was conducted to develop nomograms for predicting repeat intrahepatic recurrence (rIHR) and overall survival (OS), after radiofrequency ablation (RFA), treatment in patients with recurrent colorectal liver metastases (CLMs) after hepatectomy based on clinicopathologic features.Methods A total of 160 consecutive patients with recurrent CLMs after hepatectomy who were treated with ultrasound-guided percutaneous RFA from 2012 to 2022 were retrospectively included. …”
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Long‐Term or Recurrent Antibiotic Use in Early Life and the Risk of Type 2 Diabetes: A Population‐Based Prospective Cohort and a Case–Control Study by Zijun Li, Qiangsheng He, Xin He, Xin Xing, Songbo Fu, Xiaoping Sun, Mina Ma, Danni Wang, Ningning Mi, Jinyu Zhao, Jinqiu Yuan, Kehu Yang

“…We performed this study to investigate this association in two population‐based studies. Methods We undertook a prospective analysis encompassing 147 010 participants from the UK Biobank. …”
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Advances and trends of non-marine shale sedimentology: A case study from Gulong Shale of Daqing Oilfield, Songliao Basin, NE China by Longde SUN, Rukai ZHU, Tianshu ZHANG, Yi CAI, Zihui FENG, Bin BAI, Hang JIANG, Bo WANG

“…Such research will focus on eight aspects: lithofacies and organic matter distribution prediction under a sequence stratigraphic framework for non-marine shale strata; lithofacies paleogeography of shale strata based on the forward modeling of sedimentation; origins of non-marine shale lamina and log-based identification of lamina combinations; source of organic matter in shale and its enrichment process; non-marine shale lithofacies classification by rigid particles + plastic components + pore-fracture system; multi-field coupling organic-inorganic interaction mechanism in shale diagenesis; new methods and intelligent core technology for shale reservoir multi-scale characterization; and quantitative evaluation and intelligent analysis system of shale reservoir heterogeneity.…”
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Effects of ambient air pollution mixtures and household fuel use on progression to advanced cardiovascular-kidney-metabolic syndrome among middle-aged and older adults by Shunchang Fan, Haoyue Hu, Yucheng Li, Ying Deng, Shiao Wang, Juxian Xian, Daoqi Zhu, Minyi Zhang

“…This study assesses the associations of ambient air pollution and household fuel usage with the risk of CKM syndrome in advanced stages among middle-aged and older adults. Methods: Data from the China Health and Retirement Longitudinal Study (CHARLS) spanning 2011 and 2015 were used. …”
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Publication of works presented in the 2016 and 2018 editions of the National Student Scientific Event on Internal Medicine -MEDINTÁVILA by Frank Hernández-García, Ibraín Enrique Corrales-Reyes, Enrique Rolando Pérez-García, Juan Antonio Sorí-Peña, Onelis Góngora-Gómez, Christian Richard Mejía

“…Objective: To characterize the research works presented in the 2016 and 2018 editions of the Evento Científico Estudiantil Nacional de Medicina Interna (National Student Scientific Event on Internal Medicine - (MEDINTÁVILA) and those published in scientific journals, as well as to identify factors associated with their publication. Materials and methods: Cross-sectional analytical study. A search strategy was carried out in April 2020 in Google Scholar in order to verify if the works presented in the 2016 y 2018 editions of the event had been published, in English or Spanish, in scientific journals. …”
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Neutrophil-lymphocyte ratio (NLR); an accurate inflammatory marker to predict diabetic foot ulcer amputation: a matched case-control study by Faeze Afshar, Morteza Daraie, Fatemeh Mohammadi, Kiana Seifouri, Samira Amin Afshari, Soheil Heidari Some’eh, Amirhossein Yadegar, Parnian Naghavi, Alireza Esteghamati, Soghra Rabizadeh, Mahsa Abbaszadeh, Manouchehr Nakhjavani, Sahar Karimpour Reyhan

“…Inflammatory biomarkers, including the neutrophil‒lymphocyte ratio (NLR) and platelet‒lymphocyte ratio (PLR), have shown promise in predicting the development of diabetes complications. Methods This study included 126 individuals with known DFUs who underwent amputation or debridement surgery during hospitalization between January 2017 and December 2022. …”
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Plasma polymeric immunoglobulin receptor exacerbates lung injury in Klebsiella pneumoniae-induced pneumosepsis by Shuaiwei Wang, Hao Fu, Hao Fu, Xiaoqing Li, Xiaoqing Li, Hongrui Xu, Yu Bai, Wenjun Jiang, Xiaozhe Cheng, Na Chen, Na Chen, Yijie Zhang, Yijie Zhang, Wei Li

“…The role and underlying mechanisms of plasma pIgR were investigated in mouse models of sepsis and primary alveolar type 2 epithelial cells (AT2).ResultsQuantitative proteomic and ELISA analysis revealed a significant association between plasma pIgR and the prognosis of patients of pneumonia-induced sepsis. …”
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Direct high-precision radon quantification for interpreting high-frequency greenhouse gas measurements by D. Kikaj, E. Chung, A. D. Griffiths, S. D. Chambers, G. Forster, G. Forster, A. Wenger, P. Pickers, P. Pickers, C. Rennick, S. O'Doherty, J. Pitt, K. Stanley, D. Young, L. S. Fleming, L. S. Fleming, K. Adcock, E. Safi, T. Arnold, T. Arnold

“…Translating spot measurements of atmospheric GHG amount fractions into regional flux estimates (“top-down” analysis) is usually performed with atmospheric transport models (ATMs), which calculate the sensitivity of regional emissions to changes in observed GHGs at a finite number of locations. …”
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