Disrupting EDEM3‐induced M2‐like macrophage trafficking by glucose restriction overcomes resistance to PD‐1/PD‐L1 blockade by Shaoyong Peng, Minshan Wu, Qian Yan, Gaopo Xu, Yumo Xie, Guannan Tang, Jinxin Lin, Zixu Yuan, Xiaoxia Liang, Ze Yuan, Jingrong Weng, Liangliang Bai, Xiaolin Wang, Huichuan Yu, Meijin Huang, Yanxin Luo, Xiaoxia Liu

“…Cancer‐associatedfibroblasts (CAFs) are significant in immune escape and resistance toimmunotherapy, emphasizing the urgent need for new treatment strategies. Methods Flow cytometric, Western blotting, proteomics analysis, analysis of public database data, genetically modified cell line models, T cell coculture, crystal violetstaining, ELISA, metabonomic and clinical tumour samples were conducted to assess the role of EDEM3 in immune escape and itsmolecular mechanisms. …”
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Recognition mechanism and sequence optimization of organophosphorus pesticides aptamers for better monitoring contaminations in food by Pengfei Chen, Chaoqiong Hu, Xuan Tao, Zheng Zhou, Lijun Wang, Xiao Yang, Zhenming Che, Xianggui Chen, Yukun Huang

“…The aim of the research was to develop a new strategy to design oligonucleotide sequences for binding OPPs by combination of experimental and molecular modeling methods. 3D models of aptamers binding OPPs were constructed, and binding energy and the most probable binding site for the OPPs were then determined by molecular docking, and the binding sites were further confirmed by the results of 2-AP replaced experiments. …”
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Evolving Landscape of Melanoma in Portugal, Spain, Italy, and Greece: Trends and Insights by L. Cayuela, J.J. Pereyra-Rodríguez, J.C. Hernández-Rodríguez, R.C. Bueno-Molina, A. Cayuela

“…Objective: To study melanoma incidence trends from 1990 to 2021 in Southern European countries—Portugal, Spain, Italy, Greece—and explore regional and age-period-cohort (A-P-C) patterns. Methods: Data from the Global Burden of Disease Study 2021 were used to calculate age-standardized incidence rates (ASIRs). …”
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Functionally important respiratory symptoms and continued cigarette use versus e-cigarette switching: population assessment of tobacco and health study waves 2-6Research in context by James D. Sargent, Kristin Lauten, Kathryn C. Edwards, Susanne E. Tanski, Todd A. MacKenzie, Laura M. Paulin, Mary F. Brunette, Maciej L. Goniewicz, Amanda Malasky, Debra Stark, Fernando B. de Moura, Holly Griffin, Kimberly H. Nguyen, Eric Backlund, Heather L. Kimmel, John H. Kingsbury, Jenny E. Ozga, K Michael Cummings, Andrew Hyland

“…We hypothesized that complete cigarette-to-e-cigarette switching would improve respiratory symptoms compared to continued smoking. Methods: Longitudinal analysis of data from waves 2–6 (W2–W6; 2014–2021) of the Population Assessment of Tobacco and Health (PATH) Study, an observational cohort study that surveyed 5653 US adults ≥18 years without COPD/chronic bronchitis/emphysema. …”
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Steps towards overcoming challenges in clinical practice at 1.5T MR-Linac for lung cancer adaptive radiotherapy by Min Liu, Feng Yang, Bin Tang, Xin Xin, Xiongfei Liao, Mingzhe Liu, Yanhua Liu, Jie Li, Xianliang Wang, Lucia Clara Orlandini

“…This study investigates clinical cases to determine whether these challenges affect all lung targets or if, for a subset partially located in high-density dose regions, the sCT calculations performed in the Unity clinical workflow are sufficiently accurate, supporting their routine clinical application. Methods Forty-eight lung cancer patients undergoing stereotactic body radiotherapy at Unity MR-Linac, were included in this study. …”
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Deficiency of myeloid NPC1 exacerbates liver injury and fibrosis by impairing macrophage efferocytosis by Dongwei Guan, Pengju Huang, Xinlei Liu, Qing Li, Xiaoxun Zhang, Nan Liu, Yong Wang, Ying Wan, Jin Chai, Shiying Cai, Rui Chen, Zhijia Ye

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Outcomes of Ixazomib Treatment in Relapsed and Refractory Multiple Myeloma: Insights from Croatian Cooperative Group for Hematologic Diseases (KROHEM) by Josip Batinić, Barbara Dreta, Goran Rinčić, Antonia Mrdeža, Karla Mišura Jakobac, Delfa Radić Krišto, Milan Vujčić, Mario Piršić, Željko Jonjić, Vlatka Periša, Jasminka Sinčić Petričević, Božena Coha, Hrvoje Holik, Toni Valković, Marija Stanić, Ivan Krečak, Ante Stojanović, Domagoj Sajfert, Sandra Bašić-Kinda

“…<i>Background and Objectives</i>: Ixazomib, used in combination with lenalidomide and dexamethasone (IRd), has shown efficacy in clinical trials for relapsed/refractory multiple myeloma (RRMM). <i>Materials and Methods</i>: This study evaluates the real-world effectiveness and safety of IRd in Croatian RRMM patients. …”
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Estimating the prevalence of persistent symptoms after SARS-CoV-2 infection (post-COVID-19 syndrome): a regional cross-sectional study protocol by Vivienne C Bachelet, Karena Espinoza, Lindybeth Sarmiento Varón, Hermy Alvarez, Leyla Carolina Huirimilla Casanova, Maria Paz Díaz Mora, Luis Alfredo Muñoz Cuevas, Jorge Gonzalez-Puelma, Lidia Amarales, Jonathan Lühr Henriquez, Felipe Retamal-Matus, Roberto Uribe-Paredes, Cristian Andrés Núñez-Espinosa, Claudia Estrada-Goic, Mercedes N López Nitsche, Marcelo A Navarrete

“…This study aims to estimate the prevalence of post-COVID-19 syndrome in Punta Arenas, Chile, and to explore the associated symptoms, mainly focusing on psychological, physical and molecular impacts on the affected population.Methods and analysis This cross-sectional study will use stratified random sampling to select a representative sample of 282 adults from Punta Arenas. …”
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Radiological score, asthma and NSAID‐exacerbated respiratory disease predict relapsing chronic rhinosinusitis by Markus Lilja, Anni Koskinen, Sari Hammarèn‐Malmi, Anu Laulajainen‐Hongisto, Jura Numminen, Jyri Myller, Seija Vento, Elina Penttila, Maija Hytönen, Paula Virkkula, Peter W. Hellings, Sven F. Seys, John Lee, Heini Huhtala, Johanna Sahlman, Sanna Toppila‐Salmi

“…Abstract Objectives The aim was to evaluate the predictive potential of Sinonasal Radiological (SR) and the Lund‐Mackay (LM) score of sinus computed tomography (CT) scans on postoperative relapses of chronic rhinosinusitis (CRS). Materials and Methods CRS patients (n = 483, 12–80 years) underwent routine sinus CT scans. …”
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Early nasal microbiota and subsequent respiratory tract infections in infants with cystic fibrosis by Ruth Steinberg, Nadja Mostacci, Elisabeth Kieninger, Bettina Frauchiger, Carmen Casaulta, Jakob Usemann, Alexander Moeller, Daniel Trachsel, Isabelle Rochat, Sylvain Blanchon, Dominik Mueller-Suter, Barbara Kern, Maura Zanolari, Urs Frey, Kathryn A. Ramsey, Markus Hilty, Philipp Latzin, Insa Korten, SCILD study group, BILD study group

“…We calculated generalized additive mixed models and permutational analysis of variance. Results Here, we show that the nasal microbiota is already altered before the first RTI or antibiotic treatment in infants with CF. …”
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Genome-wide association study on salt tolerance of core germplasm resources in watermelon by YUAN Gaopeng, ZHAO Yanlong, SUN Dexi, GAO Bowen, LI Weihua, SHI Mingkun, ZHANG Jingyu, ZHU Yingchun

“…We employed the FaST-LMM (factored spectrally transformed linear mixed models) method to conduct a genome-wide association study (GWAS) on the phenotypic data, locating and displaying the single nucleotide polymorphisms (SNPs) associated with these phenotypic traits using a Manhattan plot. …”
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Deciphering the effect of exercise timing on glucose metabolism: a randomised controlled trial by Fabienne Bruggisser, Denis Infanger, Henner Hanssen, Raphael Knaier

“…Serum glucose response was quantified over 120 min by calculating the area under the curve (AUC) using the trapezoidal method. To analyse the effect of treatment over time, linear mixed effects models were used, adjusting for sex, age and body mass index. …”
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Therapeutic potential of placenta-derived stem cells cultivated on noggin-loaded nanochitosan/polypyrrole-alginate conductive scaffold to restore spinal cord injury by Asma Manzari-Tavakoli, Amirhesam Babajani, Nasim Vousooghi, Ali Moghimi, Roghayeh Tarasi, Fahimeh Safaeinejad, Samira Norouzi, Soheyl Bahrami, Hassan Niknejad

“…This study aims to investigate the potential of a nanochitosan/polypyrrole-alginate conductive scaffold, loaded with the Noggin growth factor, an inhibitor of BMP-4 signaling, and human amniotic epithelial cells (hAECs), in promoting the regeneration of SCI in animal models. Methods The attachment and distribution of isolated hAECs on a fabricated nanochitosan/polypyrrole-alginate conductive scaffold were assessed using SEM. …”
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Association between thyroid function and thyroid homeostasis parameters and the prevalence and all-cause and cardiovascular mortality of chronic kidney disease: a population-based... by Xue Liu, Yuhao Zhang, Yuchen Li, Xiude Fan, Haiqing Zhang

“…Abstract Background To evaluate the relationship between thyroid function and thyroid homeostasis parameters with the prevalence of chronic kidney disease (CKD) and furtherly explore the all-cause and cardiovascular mortality among individuals with CKD using data from the National Health and Nutrition Examination Survey (NHANES) 2007–2012. Methods This study included 8,526 adults, including 1,625 patients with CKD. …”
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Regenerative potential of PRP-based scaffolds in chronic wound healing: Mechanisms, advances, and therapeutic insights by Farag M.A. Altalbawy, Bilal Abdul Majeed Mukhlif, Ahemad Hussen, Jaafaru Sani Mohammed, Renuka Jyothi S, Arshdeep Singh, Shakti Bedanta Mishra, Ashish Singh Chauhan, Mohammad Ebrahim Astaneh, Narges Fereydouni

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Observational study of sudden cardiac arrest risk (OSCAR): Rationale and design of an electronic health records cohort by Kyndaron Reinier, Harpriya S. Chugh, Audrey Uy-Evanado, Elizabeth Heckard, Marco Mathias, Nichole Bosson, Vinicius F. Calsavara, Piotr J. Slomka, David A. Elashoff, Alex A.T. Bui, Sumeet S Chugh

“…We will use conventional approaches (diagnosis code algorithms) and artificial intelligence (natural language processing, deep learning) to define patient phenotypes and biostatistical and machine learning approaches for analysis. Conclusions: The OSCAR cohort will provide a large, diverse dataset and adjudicated SCA outcomes to facilitate the derivation and testing of risk prediction models for incident SCA.…”
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The association of heavy metals/metalloid and stroke—Findings in Shanxi, China and the US NHANES from 2011 to 2020 by Yuese Yuan, Li Zhang, Fuying Liu, Haobo Liu, Ying Wang, Xiujuan Yang, Liangpo Liu, Ben Li, Li Wang, Jin Yang, Hongyan Cao, Yulan Qiu, Jinping Zheng, Jian Guo, Yi Gao

“…Background: Previous studies provided contradictory evidence regarding the relationship between metal concentrations and ischemic stroke (IS). Methods: A total of 100 adults with IS were included in this study, as well as an equal number of controls. …”
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Preclinical Characterization of Efficacy and Pharmacodynamic Properties of Finotonlimab, a Humanized Anti-PD-1 Monoclonal Antibody by Yunqi Yao, Xiaoning Yang, Jing Li, Erhong Guo, Huiyu Wang, Chunyun Sun, Zhangyong Hong, Xiao Zhang, Jilei Jia, Rui Wang, Juan Ma, Yaqi Dai, Mingjing Deng, Chulin Yu, Lingling Sun, Liangzhi Xie

“…<b>Background/Objectives:</b> Finotonlimab (SCTI10A) is a humanized anti-PD-1 antibody tested in Phase III trials for several solid tumor types. <b>Methods</b>: This study characterized the in vitro and in vivo efficacy, Fc-mediated effector function, and non-clinical PK/PD properties of finotonlimab. …”
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Impact of disease location and laterality on hemodynamic response following pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension by Bryan O. Pérez Martínez, MD, Gabriella V. Rubick, MD, Avi Toiv, MD, Sidney Perkins, MD, Jorge Vinales, Victor M. Moles, MD, Vallerie V. McLaughlin, MD, Thomas M. Cascino, MD MSc, Bryan Kelly, DO, Gillian Grafton, DO, Rana Awdish, MD, Jonathan W. Haft, MD, Vikas Aggarwal, MD MPH

“…Objectives: Examine the effect of obstructive disease location and laterality on hemodynamic response following PTE. Methods: This analysis is a retrospective cohort study of 56 consecutive patients diagnosed with CTEPH who underwent PTE at the University of Michigan Hospital between August 2019 and July 2022. …”
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Association between maternal serum essential trace element concentration in early pregnancy and gestational diabetes mellitus by Jinlang Lyu, Peng Tang, Yuanyuan Wang, Na Han, Rong Zhang, Xiangming Yang, Yuelong Ji, Jue Liu, Bin Wang, Lailai Yan, Qin Li, Xu Ma, Hai-Jun Wang

“…Compared to those with the lowest tertile, the pregnant women with the highest tertile of Co concentrations had decreased risk of GDM (OR = 0.56, 95% CI: 0.34–0.93, P = 0.024) in the adjusted models. The association was further confirmed in the multiple-exposure analysis. …”
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