Lung function may recover after coal mine fire smoke exposure: a longitudinal cohort study by David Brown, Tyler Lane, Michael J Abramson, Bruce R Thompson, Caroline X Gao, Jillian Ikin, Brigitte Borg, Nicolette R Holt, Catherine L Smith, Annie Makar, Thomas McCrabb, Mikayla Thomas, Kris Nilsen

“…Background and objective The 2014 Hazelwood coal mine fire exposed residents in nearby Morwell to high concentrations of particulate matter <2.5 µm (PM2.5) for approximately 6 weeks. This analysis aimed to evaluate the long-term impact on respiratory health.Methods Adults from Morwell and the unexposed town of Sale completed validated respiratory questionnaires and performed spirometry, gas transfer and oscillometry 3.5–4 years (round 1) and 7.3–7.8 years (round 2) after the fire. …”
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Associations between self-reported sleep duration and incident cardiovascular diseases in a nationwide prospective cohort study of Chinese middle-aged and older adults by Qing Zhao, Yuan Zhu, Yu Zhang, Huanyuan Luo, Huanyuan Luo, Yantao Ma, Xiaoshan Chen, Jiaming Gu, Lizhi Wang, Lizhi Wang, Lizhi Wang, Lizhi Wang, Lizhi Wang

“…Furthermore, we aim to investigate the association between sleep duration and incident CVD in this population, while assessing potential variations across different age and gender subgroups.MethodsUtilizing data from the nationwide prospective survey of the China Health and Retirement Longitudinal Study (CHARLS) conducted in 2011, 2013, 2015, and 2018, involving 17,596 participants aged 45 years and above, we employed Cox proportional hazards regression models. …”
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Patterns of recurrence after curative D2 resection for gastric cancer: Implications for postoperative radiotherapy by Jing Xu, Li Shen, Yongjie Shui, Wei Yu, Qingqu Guo, Risheng Yu, Yulian Wu, Qichun Wei

“…Independent recurrence‐related risk factors were analyzed by logistic regression analysis. New logistic regression models were further developed to predict the probability of recurrence. …”
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Quantitative sensory testing in dogs with spontaneous osteoarthritis by James Russell Hunt, David Knazovicky, Megan Goff, John Harris, Toby G. Knowles, Masataka Enomoto, Michael Mendl, Becky Whay, B. Duncan X. Lascelles, B. Duncan X. Lascelles, B. Duncan X. Lascelles, B. Duncan X. Lascelles, Joanna C. Murrell

“…The hierarchical structure of the QST testing data was accounted for within the statistical analysis by employing general linear modelling within a multilevel modelling framework using the MLwiN statistics package.ResultsOsteoarthritis category was not a major determinant of QST outcome measures for the majority of modalities evaluated. …”
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INBRX-106: a hexavalent OX40 agonist that drives superior antitumor responses via optimized receptor clustering by William L Redmond, Yoshinobu Koguchi, Melissa J Kasiewicz, Annah S Rolig, Nisha Holay, Bryan Becklund, Anya Polovina, Sae Jeong Ahn, Brendan P Eckelman, Rashi Yadav, Thi Staebler, Noah D Simons, Yaiza Diaz de Durana

“…In murine models, hexavalent OX40 agonism resulted in significant tumor regression, enhanced survival, and increased CD8+ T-cell effector function. …”
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Ovarian Cancer G protein-coupled receptor-1 signaling bias dictates anti-contractile effect of benzodiazepines on airway smooth muscle by Dominic R. Villalba, Arun K. Jannu, Elham Javed, Isha Dandekar, Ruping Wang, Deepak A. Deshpande, Steven S. An, Reynold A. Panettieri, Dale D. Tang, Raymond B. Penn, Ajay P. Nayak

“…The present study sought to determine the effects of sulazepam and lorazepam on contraction of human precision cut lung slices (hPCLS), and detail the biochemical mechanisms mediating these effects. Methods Models of histamine (His) -stimulated contraction included imaging of ex vivo human precision cut lung slices (hPCLS) and Magnetic Twisting Cytometry (MTC) analysis of human ASM cell stiffness. …”
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Supplemental oxygen for pulmonary embolism (SO-PE): study protocol for a mechanistic, randomised, blinded, cross-over study by Nour Al Jalbout, Hamid Shokoohi, Christopher Kabrhel, David M Dudzinski, Mads Dam Lyhne, Andrew S Liteplo, Oana Alina Zeleznik, Asger Andersen, Onyinyechi Franca Eke, Christina C Morone, Calvin K Huang, Thomas F Heyne, Mannudeep K Kalra

“…The overall objective of the supplemental oxygen in pulmonary embolism (SO-PE) study is to investigate the mechanisms of supplemental oxygen in patients with acute PE.Methods and analysis This randomised, double-blind, cross-over trial at Massachusetts General Hospital will include adult patients with acute PE and evidence of RV dysfunction but without hypoxaemia (SaO2 ≥90% on room air). …”
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Investigating the associations between personality functioning, cognitive biases, and (non-)perceptive clinical high-risk symptoms of psychosis in the community by Giulia Rinaldi, Stefan Lerch, Frauke Schultze-Lutter, Stefanie Julia Schmidt, Marialuisa Cavelti, Michael Kaess, Chantal Michel

“…Methods A community sample (N = 444, 17–60 years, 61.8% female) was assessed via clinical telephone interview and online questionnaires. …”
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Efficacy of Erwinia amylovora and Xanthomonas campestris pv campestris phages to control fire blight and black rot in vivo by Gloria Vique, Elena Mendoza-Barberá, Maria Dolores Ramos-Barbero, Pedro Blanco-Picazo, Laura Sala-Comorera, Pablo Quirós, Sergio Atares, Ignasi Salaet, Maite Muniesa, Lorena Rodríguez-Rubio

“…In vivo experiments using pears and kohlrabi as infection models further validated the phage effectiveness. …”
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Targeting NOTCH1-KEAP1 axis retards chronic liver injury and liver cancer progression via regulating stabilization of NRF2 by Chunxiao Chang, Meng Wang, Jia Li, Sihao Qi, Xiaojuan Yu, Jun Xu, Shengbin Shi

“…The NOTCH1 signaling pathway, though not fully understood, is implicated in liver injury and may be a potential therapeutic target. Methods Clinical HCC, HBV, HCV and NASH samples and additional in vitro and in vivo performances were subjected to confirm the role of NOTCH1 and its downstream targets via a series of biochemical assays, molecular analysis approaches and targeted signaling pathway assay, etc. …”
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Association Between Low Triglyceride-Glucose Index and Mortality in Acute Decompensated Heart Failure Patients Without Diabetes by Zhang Q, Xu Y, Sun S, Ding X, Wang G, Jiang S, Zheng J, Gao P, Lin J, Wu Y

“…This study aimed to investigate the association between a low TyG index and 1-year mortality in ADHF patients without diabetes.Methods: A total of 652 hospitalized patients with ADHF without diabetes from January, 2020 to May, 2023 were included in this retrospective study. …”
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Integration of sentinel surveillance and climate factors to accelerate malaria elimination in a changing climate of Senegal by Ibrahima Mamby Keita, Mariama Diouf, Medoune Ndiop, Boly Diop, Khaly Gueye, Marianne Kouawo, Ousmane Ndiaye, Doudou Sene, Elhadji Mamadou Ndiaye, Marie Khemesse Ngom Ndiaye

“…This was followed by predictive modelling of MIR and its climatic factors from 2020 to 2023. …”
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For-profit growth and academic decline: a retrospective nationwide assessment of Brazilian medical schools by Bruno B. Andrade, Bruno B. Andrade, Klauss Villalva-Serra, Klauss Villalva-Serra, Rodrigo C. Menezes, Rodrigo C. Menezes, Luiz F. Quintanilha, Katia de Miranda Avena, Katia de Miranda Avena

“…We compared trends across public, non-profit private, and for-profit private institutions, using descriptive statistics, non-parametric tests, correlation analysis, and Bayesian mixed-effects regression models to assess the impact of institutional category and class size on academic performance.ResultsThe number of for-profit medical schools in Brazil nearly doubled between 2013 and 2023. …”
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Health and economic cost estimates of short-term total and wildfire PM2.5 exposure on work loss: using the consecutive California Health Interview Survey (CHIS) data 2015–2018 by Michael Jerrett, Yu Yu, Ying-Ying Meng, Diane Garcia-Gonzales, Mohammad Z Al-Hamdan, Miriam E Marlier, Joseph L Wilkins, Ninez Ponce

“…Instruction To help determine the health protectiveness of government regulations and policies for air pollutant control for Americans, our study aimed to investigate the health and economic impacts of work loss due to sickness associated with daily all-source and wildfire-specific PM2.5 (particulate matter with an aerodynamic diameter smaller than 2.5 μm) exposures in California.Methods We linked the 2015–2018 California Health Interview Survey respondents’ geocoded home addresses to daily PM2.5 estimated by satellites and atmospheric modelling simulations and wildfire-related PM2.5 from Community Multiscale Air Quality models. …”
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Did smoking behavior change in adolescents and young adults with and without diabetes during the COVID-19 pandemic? A cohort study from the DPV registry by Katharina Warncke, Sabine E. Hofer, Simone von Sengbusch, Uwe Ermer, Mareike Niemeyer, Andreas Lemmer, Dörte Hilgard, Alena Welters, Reinhard W. Holl, Alexander J. Eckert

“…Smoking behavior between T1D and T2D or between Germany and Austria was compared with similar regression models. Results Thirty-four thousand two hundred seventy-five patients from the DPV cohort were included in data analysis. …”
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Association of social contact with dementia and cognition: 28-year follow-up of the Whitehall II cohort study. by Andrew Sommerlad, Séverine Sabia, Archana Singh-Manoux, Glyn Lewis, Gill Livingston

“…We therefore examined the association of social contact with subsequent incident dementia and cognition with 28 years' follow-up.<h4>Methods and findings</h4>We conducted a retrospective analysis of the Whitehall II longitudinal prospective cohort study of employees of London civil service departments, aged 35-55 at baseline assessment in 1985-1988 and followed to 2017. …”
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Course of mental distress among psychotherapists throughout two years of the COVID- 19 pandemic: individual and inter-relational resources make a difference—cross-sectional and lon... by Sabine Mogwitz, Gloria-Beatrice Wintermann, Christian Albus, Andreas M. Baranowski, Petra Beschoner, Yesim Erim, Franziska Geiser, Lucia Jerg-Bretzke, Eva Morawa, Susann Steudte-Schmiedgen, Kerstin Weidner

“…The impact of resources on PHQ-2 scores was examined using cross-sectional linear modelling and longitudinal linear mixed modelling with interactions and lagged predictors. …”
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Polymorphism in Genes Encoding HSP40 Family Proteins is Associated with Ischemic Stroke Risk and Brain Infarct Size: A Pilot Study by Ksenia A. Kobzeva, Denis E. Gurtovoy, Alexey V. Polonikov, Vladimir M. Pokrovsky, Evgeny A. Patrakhanov, Olga Y. Bushueva

“…Aim: We sought to determine whether nine single nucleotide polymorphisms (SNPs) in genes encoding HSP40 family proteins (DNAJB1, DNAJB2, DNAJA1, DNAJA2, DNAJA3 and DNAJC7) are associated with the risk and clinical features of IS. Methods: Using TaqMan-based polymerase chain reaction (PCR) and the MassArray-4 system, DNA samples of 2551 Russians — 1306 IS patients and 1245 healthy individuals — were genotyped. …”
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Microarthropods communities as indicators of soil quality in a Mediterranean periurban forest using the QBS-ar index by Cristina Rodríguez-Pajares, E. Jordán Muñoz-Adalia, Mercedes Fernández-Fernández

“…The main variables that caused variations in these indicators by biotope were identified through a Principal Component Analysis (PCA) and analysed using generalized linear models (GLMs). …”
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Sex-specific hemoglobin thresholds and longitudinal trajectories in intracerebral hemorrhage outcomes: a multicenter cohort study by Yu-jia Jin, Guo-shen Yu, Li-li Tang, Jia-wen Li, Qing Lin, Jian Wu, Zai-jun Song, Hong-na An, Xiang-hua Ye, Cheng-jia Liu, Feng Gao, Lu-sha Tong

“…Abstract Background We aim to investigate the association between admission hemoglobin and outcomes after primary intracerebral hemorrhage (ICH), including 3-month outcome and long-term survival and recurrence. Methods Utilizing a multicenter stroke registry database, we retrospectively analyzed patients with spontaneous ICH confirmed within 48 h of symptom onset who had admission hemoglobin measurements and baseline neuroimaging. …”
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