Identifying Current Practices and Areas for Improvement in Medication Management During Care Transition Through an Interprofessional Collaboration Framework by Solh Dost L, Maillard G, Cardoso E, Schneider MP

“…This study examines the current state and areas for improvement in interprofessional medication management during the hospital discharge transition (from hospital discharge to first medical appointment) for patients self-managing their medications.Methods: A qualitative study was conducted using a serial focus group methodology with patients and healthcare professionals from hospital and community settings. …”
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Methotrexate and Tumor Necrosis Factor Inhibitors Independently Decrease Neutralizing Antibodies after SARS-CoV-2 Vaccination: Updated Results from the SUCCEED Study by Carol A Hitchon, Dawn M. E. Bowdish, Gilles Boire, Paul R. Fortin, Louis Flamand, Vinod Chandran, Roya M. Dayam, Anne-Claude Gingras, Catherine M. Card, Inés Colmegna, Maggie J. Larché, Gilaad G. Kaplan, Luck Lukusa, Jennifer L.F. Lee, Sasha Bernatsky, on behalf of the SUCCEED Investigative Team

“…The meta-analysis adjusted OR for methotrexate was 0.39 (95% CI 0.19, 0.76) for BA1. …”
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Impact of environmental pollution on human health: Investigating the role of Polycyclic Aromatic Hydrocarbons in pediatric osteosarcoma by Mingxian Xu, Yu Xu, Yaping Huang, Jixiang Shi, Lifeng Yin, Jian Tu, Junqiang Yin, Changye Zou

“…Among these, ACTB, EGFR, and JUN were identified as key prognostic genes through survival analysis and machine learning models. These genes were enriched in oncogenic pathways, including the PI3K-Akt signaling pathway. …”
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RNA mis‐splicing in children with congenital myotonic dystrophy is associated with physical function by Julia M. Hartman, Kobe Ikegami, Marina Provenzano, Kameron Bates, Amanda Butler, Aileen S. Jones, Kiera N. Berggren, Jeanne Dekdebrun, Marnee J. McKay, Jennifer N. Baldwin, Kayla M. D. Cornett, Joshua Burns, Michael Kiefer, Nicholas E. Johnson, Melissa A. Hale, the DMCRN Consortium

“…However, the association between RNA mis‐splicing and physical function in children with the most severe form of disease, congenital myotonic dystrophy (CDM), is unknown. Methods Eighty‐two participants (42 adults with DM1 and 40 children with CDM) with muscle biopsies and measures of myotonia, motor function, and strength were combined from five observational studies. …”
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Identifying the (Hot Spots) for traffic accidents in Erbil City A study of the problems of the Urban Environment by Sakar Bahaddin Abdullah Almudaris

“…Based of this, this research aims at monitoring the traffic accident locations in Erbil city and identify the hot spots in which the number and intensity of accidents are high, the pattern of their distribution, and to know the special and temporal characteristics of these accidents, and the reasons of their occurrence, for the purpose of constructing an accurate database and propose sound scientific methodologies to the relevant authorities and decision makers for addressing the issue that are based on the descriptive method and statistical spatial analysis, in order to achieve traffic safety to serve the citizens of the city. …”
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Associations of maternal PM2.5 exposure with preterm birth and miscarriage in women undergoing in vitro fertilization: a retrospective cohort study by Miaoxin Chen, Qiaoyu Chen, Gengze Liao, Chunyan Sun, Cong Liu, Xia Meng, Wentao Li, Andong Qiu, Orhan Bukulmez, Haidong Kan, Feng Wang, Lap Ah Tse, Xiaoming Teng

“…Our study used multinomial logistic regression models to explore the potential associations between PM2.5 exposure and adverse pregnancy outcomes. …”
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Impact evaluation of an interdisciplinary approach to patients with chronic non-cancer pain in Chilean primary care by Paula Zamorano, Teresita Varela, Isidora Salvatierra, Alvaro Tellez, Manuel Espinoza, Gustavo Torres, Victoria Rodríguez, María José Figueroa, Alejandro Rodríguez, Denisse Figueroa, Leonardo Silva, Sheila Salazar, Víctor Lucero, Francisco Suarez

“…The clinical intervention introduced patient-centered care, psychotherapy and physiotherapy from the perspective of the neuroscience of pain. The impact analysis was conducted using negative binomial regression models, generalized linear models, and ordered logistic regressions. …”
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Pyrotinib targeted EGFR/GRP78 mediated cell apoptosis in high EGFR gene copy number gastric cancer by Lingbo Bao, Xudong Wang, Xiuyong Liao, Dong Li, ChunXue Li, Nan Dai, Xiaoyan Dai, Jing Yang, Nana Hu, Xueling Tong, Zhenjie He, Yuancheng Zhao, Zheng Liu, Yue Hu, Jinlu Shan, Dong Wang, Mengxia Li, Qian Chen

“…Pyrotinib, an irreversible dual EGFR/HER2 tyrosine kinase inhibitor, has shown clinical efficacy in HER2-driven malignancies, but its potential role in EGFR-high copy number gastric cancer remains to be investigated. Methods Using EGFR-high copy number gastric cancer cell lines, primary cells and subcutaneous tumor models in nude mice, we systematically evaluated pyrotinib’s anti-tumor activity through viability assays, apoptosis analysis, and transcriptomic profiling. …”
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Post-Anesthesia Care Unit (PACU) readiness predictions using machine learning: a comparative study of algorithms by Shahnam Sedigh Maroufi, Maryam Soleimani Movahed, Azar Ejmalian, Maryam Sarkhosh, Ali Behmanesh

“…Unlike prior studies relying on statistical models or single-algorithm methods, this research assesses multiple ML models to predict discharge readiness, comparing them against staff evaluations and the Aldrete checklist. …”
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Oral health care in older people in long-term care facilities: An updated systematic review and meta-analyses of implementation strategies by Lina F. Weening-Verbree, Anouk Douma, Cees P. van der Schans, Getty J. Huisman-de Waal, Annemarie A. Schuller, Sytse U. Zuidema, Wim P. Krijnen, Johannes S.M. Hobbelen

“…Meta-analyses of oral health outcomes (“plaque” and “denture plaque”) were performed with random-effects models using R language for statistical computing. …”
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A comparison of the costs and patterns of expenditure for care for severe mental illness in five countries with different levels of economic development by A-La Park, Oliver Jez, Reinhold Kilian, Ashleigh Charles, Jasmine Kalha, Palak Korde, Max Lachmann, Candelaria Mahlke, Galia Moran, Juliet Nakku, Fileuka Ngakongwa, Jackline Niwemuhwezi, Rebecca Nixdorf, Grace Ryan, Donat Shamba, Mike Slade, Tamara Waldmann

“…Generalized linear regression models were also used to estimate the impact of psychiatric diagnosis, social disability, age and gender on the total COI. …”
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GP73 reinforces cytotoxic T-cell function by regulating HIF-1α and increasing antitumor efficacy by Xiaoli Yang, Yong Li, Min Min, Nan Jiang, Lijuan Sun, Dandan Zhang, Yuan Cao, Yanhong Zhang, Yufei Wang, Hui Zhong, Xueping Ma, Qi Gao, Jialong Liu, Chao Feng, Ruzhou Zhao, Hongbin Song, Linfei Huang, Xiaopan Yang, Lanlan Liu, Cuijuan Duan, Luming Wan, Xufeng Hou, Muyi Liu, Xuemiao Zhang, Congwen Wei

“…In this study, we investigated the mechanism by which GP73 regulates T-cell-mediated antitumor immunity within the tumor microenvironment.Methods We used T-cell specific GP73 knockout mice to establish MC38 and B16 tumor models to investigate the impact of GP73-deficient T cells on tumor growth. …”
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Association between the Fatty Liver Index (FLI) and incident coronary heart disease: insights from a cohort study on the Chinese population by Ying Miao, Ying Miao, Ying Miao, Ying Miao, Ying Miao, Ying Miao, Ying Miao, Yu Wang, Pijun Yan, Pijun Yan, Pijun Yan, Pijun Yan, Pijun Yan, Pijun Yan, Yi Li, Yi Li, Yi Li, Yi Li, Yi Li, Yi Li, Zhuang Chen, Nanwei Tong, Qin Wan, Qin Wan, Qin Wan, Qin Wan, Qin Wan, Qin Wan

“…BackgroundThe debate persists regarding whether metabolic dysfunction-associated steatotic liver disease (MASLD) actively contributes to coronary heart disease or merely acts as a passive indicator.ObjectiveThis research aims to clarify the relationship between liver fat accumulation, as quantified by FLI, and the risk of developing coronary heart disease.MethodsConducted from April to November 2011, the REACTION project, spearheaded by the Endocrinology Branch of the Chinese Medical Association, focused on Chinese adults aged 40 and above. …”
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Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients by Tzu-Chun Cheng, Mien-Chie Hung, Lu-Hai Wang, Shih-Hsin Tu, Chih-Hsiung Wu, Yun Yen, Chi-Long Chen, Jacqueline Whang-Peng, Wen-Jui Lee, You-Cheng Liao, Yu-Ching Lee, Min-Hsiung Pan, Hui-Kuan Lin, Huey-En Tzeng, Peixuan Guo, Cheng-Ying Chu, Li-Ching Chen, Yuan-Soon Ho

“…Furthermore, modulation of HER2 expression by HNMT may explain why those with low HER2 expression still respond to T-Dxd. Methods We investigated the impact of HNMT protein expression on the efficacy of anti-HER2 therapy in both in vivo and ex vivo models of patient-derived xenografts and cell line-derived xenografts. …”
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Donor-derived cell-free DNA and miRNA monitoring for the early prediction and diagnosis of liver allograft rejection and patient outcomes by Judit Julian, Olga Millán, Olga Millán, Esther Titos, Pablo Ruiz, Yiliam Fundora, Alba Díaz, Alba Díaz, Jordi Colmenero, Jordi Colmenero, Constantino Fondevila, Constantino Fondevila, Joan Anton Puig-Butillé, Mercè Brunet, Mercè Brunet

“…The diagnostic performance of the levels of dd-cfDNA and signature miRNAs was assessed through receiver operating characteristic (ROC) curve analysis and logistic regression models.Resultsdd-cfDNA levels were significantly elevated during acute rejection (AR) episodes, with a median 3.9-fold increase over those in stable patients. …”
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Micronutrients Associated With Anemia in School-age Children and Adolescents 2005–2018: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) Project by Rochelle Werner, Hanqi Luo, Lei Liu, Yuqing Wang, Jiaxi Geng, Yi-An Ko, Parminder S Suchdev, Yaw Addo, Zulfiqar Ahmed Bhutta, Victor Temple, Frank Wieringa, Fabian Rohner, Maria J Ramirez-Luzuriaga, Reina Engle-Stone, Anne Williams, Melissa F Young

“…Methods: Children aged 5–19 y from surveys in the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) Project were included with hemoglobin, ≥1 micronutrient (iron, vitamin A, folate, vitamin B12, or zinc) and inflammation biomarker, and n > 100 per survey. …”
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The <i>Cordyceps</i> Genus as a Potential Source of Bioactive Compounds for Adjuvant Cancer Therapy: A Network Pharmacology Approach by Jose Luis Gonzalez-Llerena, Daniela Treviño-Almaguer, Jesus Alejandro Leal-Mendez, Gael Garcia-Valdez, Arely Guadalupe Balderas-Moreno, Michel Stéphane Heya, Isaias Balderas-Renteria, María del Rayo Camacho-Corona, Bryan Alejandro Espinosa-Rodriguez

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Directed modification of β-mannanase substrate affinity based on rational design by Wei Xihuan, Wang Chunjuan, Zhao Mei, Li Jianfang, Wu Minchen

“…Lastly, binding free energies (ΔG_bind) of various β-mannanases with mannobiose were calculated by using the molecular mechanics Poisson- Boltzmann surface area (MM-PBSA) method, respectively. The ΔG_bind of AuMan5A^Y111F was - 237.7 kJ/mol, lower than those of other enzymes. …”
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Hospitalizations and doctor visits among older adults in Europe: cross-country differences using a multilevel approach by Elisa Amo-Saus, Roberto Martinez-Lacoba, Isabel Pardo-García, Pablo Moya-Martínez

“…The analysis included 27 countries. We fitted multilevel mixed-effects logistic regression models with hospitalization and doctor visits per person per year as dependent variables. …”
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Assessing bone regeneration potential of 3D scaffold-free cell pellets from periodontal ligament and bone marrow stem cells by Xiang Liang, Yuxin Gong, Le Bai, Sina Ahmadi, Ming Yu, Zhou Zhang, Siya Fang, Fangfang Xu, Weiqi Wang, Junbo Tu, Sijia Na

“…Notably, accumulating evidence suggests that scaffold-free three-dimensional cell pellets demonstrate therapeutic potential through direct implantation into bone defects area. Methods Two types of stem cells were isolated from bone and tooth, then cultured separately. …”
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