Candida albicans-Derived β-Glucan as a Novel Modulator of Tumor Microenvironment: Targeting Macrophage Polarization and Inducing Ferroptosis in Lung Cancer by He X, Ran Q, Li X, Xiong A, Zhang L, Jiang M, Bai L, Peng D, Wang J, Sun B, Li G

“…This study investigates the inhibitory effects of β-glucan extracted from Candida albicans on lung cancer progression, focusing on its impact on TAM polarization and the induction of ferroptosis, a form of regulated cell death.Methods: Utilizing both in vivo animal models and in vitro cellular assays, we assessed the impact of β-glucan on tumor growth, cellular proliferation, and migration. …”
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Development of the composition and technology of a combined gel for the treatment of osteoarthritis with a pharmacological rationale for the content of components by U. V. Nogaeva, Ju. M. Kotsur, E. V. Flisyuk, D. Yu. Ivkin, E. D. Semivelichenko, I. A. Titovich, I. A. Narkevich, V. G. Antonov

“…Pharmaceutical development of the composition and technology of a gel based on meloxicam, a purine derivative and an immunomodulating component for the treatment of OA with pharmacological substantiation of the content of active substances.Materials and methods. A combination of three active pharmaceutical substances was studied: a non-steroidal anti-inflammatory drug – meloxicam, a purine derivative and an original immunomodulator M. …”
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Risk of Moderate to Severe Ocular Surface Disease Associated with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy: A Multicenter Cohort Study by Yu-Ting Tsao, Eugene Yu-Chuan Kang, Chiao-En Wu, Ning Hung, Hung-Chi Chen, Ching-Hsi Hsiao

“…In this study, we investigated the key risk factors for moderate to severe OSD in patients with lung cancer receiving EGFR-TKI therapy. Methods This multicenter retrospective (November 2004–December 2019) cohort study included 31,491 patients with lung cancer. …”
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Genetic variation in patent foramen ovale: a case-control genome-wide association study by Bosi Dong, Yajiao Li, Fandi Ai, Jia Geng, Ting Tang, Wan Peng, Yusha Tang, Hui Wang, Zixuan Tian, Fengxiao Bu, Lei Chen

“…Expression quantitative trait loci (eQTL) analysis was conducted using the GTEx database. Single-cell sequencing analyses with pseudotime trajectory modeling were employed to evaluate their expression in human fetal hearts.ResultsThe case-control GWAS of discovery cohort ultimately included 517 cases and 517 demographically matched controls. …”
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Evaluating the intended and unintended consequences of opioid-prescribing interventions on primary care in British Columbia, Canada: protocol for a retrospective population-based c... by Tara Gomes, Perry Kendall, M Ruth Lavergne, Dimitra Panagiotoglou, Rita McCracken, Erin C Strumpf, Benedikt Fischer, Austyn Brackett, Cheyenne Johnson

“…Specifically, we aim to understand the effects of these measures on physician prescribing behaviours, identify physician characteristics associated with uptake of the new measures, and measure the effects of the policy changes on patients’ access to quality primary care.Methods and analysis This is a population-level, retrospective cohort study of all BC primary care physicians who prescribed any opioid medication for opioid-use disorder or chronic non-cancer pain during the study period, and their patients. …”
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Academic motivation in association with mental health and quality of life among medical and health science students: a survey in Vietnam by Ngoc Le Mai Duong, Viet Ha Nguyen, Minh Tri Ngo, Dai Minh Le, Tien Dat Nguyen, Thi Thu Trang Nguyen, Huu Tu Nguyen, Bao Giang Kim, Thanh Tung Pham

“…This study aimed to describe students’ academic motivation and investigate the association between it and depression, anxiety, and quality of life at Hanoi Medical University. Methods A cross-sectional study was conducted on first and final year students of doctor and bachelor programs from October to November 2018 via a computer-based questionnaire. …”
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ACE Loss Drives Renal Cell Carcinoma Growth and Invasion by Modulating AKT-FOXO1 by Yin L, Mao L, Yin R, Lv C, Shi X, Yue C, Chen Y, Lu C, Wu Z, Xu K, Cao W

“…The clinical significance of ACE was evaluated through Cox regression analysis. To assess the impact of ACE expression on ccRCC cell growth, metastasis, and glucose activity, CCK-8 assays, transwell assays, Seahorse detection, and xenograft models were utilized. …”
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Association of preclinical blood glucose with hospitalization rate and in‐hospital mortality: A single‐center retrospective cohort study by Simon Kloock, Danilo Skudelny, Peter Kranke, Gülmisal Güder, Dirk Weismann, Martin Fassnacht, Christian G. Ziegler, Ulrich Dischinger

“…Multivariable logistic regression models were used to correct for age, prediagnosed diabetes, and sex. …”
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Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma by Jing Wang, Meng Song, Jinming Tang, Haoran Yue, Xiaoyang Guo, Zhan Chen, Xiaolan Shen, Mingbo Cao, Mingbo Cao

“…However, it’s still unclear how ARPs and HCC are related.MethodsThrough the examination of databases like The Cancer Genome Atlas (TCGA) and The International Cancer Genome Consortium (ICGC), we examined the variations in the expression of ARPs between the transcriptomes of normal tissue and HCC. …”
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Association between the triglyceride glucose-waist circumference index and cardiovascular disease across different glycemic statuses among middle-aged and older Chinese adults by Yuyu Cui, Zhening Xu, Lijuan Ding, Yanju Li, Xiaoyan Zhou, Lingxia Li

“…Kaplan–Meier survival analysis, multivariable Cox proportional hazards models, and restricted cubic spline (RCS) regression were employed to assess the association between baseline TyG-WC and incident CVD risk. …”
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Coix Seed Oil Alleviates DSS-Induced Ulcerative Colitis via Intestinal Barrier Repair and Ferroptosis Regulation by Zeng YX, Li NR, Deng BY, Gu YF, Lu SF, Liu Y

“…Here, the effects and mechanisms of CSO on ulcerative colitis (UC) in vivo are systematically investigated.Methods: Firstly, the UC mice was replicated by 3% DSS, and assessed the efficacy of CSO by observing the fecal occult blood, colon length, DAI score and pathological histomorphological changes of colon tissues. …”
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Epicatechin attenuates the stemness of liver cancer stem cells and tumorigenesis through DNA methylation-mediated inactivation of GINS1/HRAS by Xingbao Fang, Yan Cai, Xiongbing Peng, Zhaojun Li, Meifang Huang, Yuehong Li, Peiwan Liu

“…Additionally, xenograft tumor models based on HCC cells were conducted to investigate the anti-tumor effects of EC in vivo. …”
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ECONOMIC BURDEN OF HYPERCHOLESTEROLEMIA IN THE RUSSIAN FEDERATION by A. V. Kontsevaya, Yu. A. Balanova, A. E. Imaeva, M. B. Khudyakov, O. I. Karpov, O. M. Drapkina

“…Evaluation of economic impact due to HCE in the Russian population, including direct expenditures of the Health Care System as well as nondirect impact in common economy.Material and methods. Prevalence of HCE in the RF was identified based on local published studies. …”
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Comment on ‘Egypt’s water budget deficit and suggested mitigation policies for the Grand Ethiopian Renaissance Dam filling scenarios’ by Kevin Wheeler, Marc Jeuland, Kenneth Strzepek, Jim Hall, Edith Zagona, Gamal Abdo, Thinus Basson, Don Blackmore, Paul Block, Dale Whittington

“…Lett. 16 074022) we draw on high quality peer-reviewed literature and appropriate modeling methods to identify and analyze many flaws in their article, which include (a) not accounting for the current storage level in the High Aswan Dam reservoir (b) inappropriately using a mass-balance approach that does not account for the Nile’s hydrology or how water is managed in Egypt, Sudan and Ethiopia; (c) extreme and unfounded assumptions of reservoir seepage losses from the GERD; and (d) calculations of the economic implications for Egypt during the period of reservoir filling which are based on unfounded assumptions. …”
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The impact of depression and associated anxiety symptoms on clinical outcomes in elderly inpatients with digestive system diseases in Southwest China: a retrospective cohort study by Defang Ren, Xingyue Wang, Hongping Shen, Tao Li, Xingyu Sun

“…Multivariable logistic regression models were used to examine the associations, and subgroup analyses stratified by gender and age were performed. …”
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Risk factors for neural tube defects in the war and siege-affected tigray regional state of ethiopia: a case-control study by Birhane Alem Berihu, Afework Mulugeta, Tony Magana, Tafere Gebreegziabher Belay, Peixin Yang, Hayelom Kebede Mekonen

“…Data were collected using a WHO-adapted birth defect survey and ODK/KOBO software. Statistical analysis was conducted using SPSS version 27, with descriptive statistics used for participant characteristics and logistic regression models applied to identify risk factors for neural tube defects, using a significance threshold of p < 0.05. …”
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Vitamin B6 status, type 2 diabetes mellitus, and periodontitis: evidence from the NHANES database 2009–2010 by Jiang Zhu, Wushuang Xu, Senbin Wu, Donghui Song

“…This study aimed to explore the effect of vitamin B6 [evaluated by serum pyridoxal 5’-phosphate (PLP)] on the association of T2DM and periodontitis in American population. Methods Data of this cross-sectional study were extracted from the National Health and Nutrients Examination Survey (NHANES) 2009–2010. …”
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Acceptability, feasibility, fidelity and quality implementation of the culturally adapted version of the Social Competence Promotion Program among Young Adolescents (“Mi Mejor Plan... by Saray Ramirez, Natalia Ríos, Cristian A. Rojas-Barahona, Marcela Cárcamo, Alejandro Sepulveda-Pañaloza, Ricardo Araya, Jorge Gaete

“…We performed an intention-to-treat analysis using mixed models, taking into account the hierarchical nature of the data. …”
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Birth asphyxia and its association with grand multiparity and referral among hospital births: A prospective cross‐sectional study in Benin, Malawi, Tanzania and Uganda by Greta Handing, Manuela Straneo, Christian Agossou, Phillip Wanduru, Bianca Kandeya, Muzdalifat S. Abeid, Kristi S. Annerstedt, Claudia Hanson

“…We investigated birth asphyxia and its association with GM and referral in Benin, Malawi, Tanzania and Uganda. Material and methods This was a prospective cross‐sectional study. …”
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Effectiveness of progesterone supplementation in women presenting low progesterone levels on the day of frozen embryo transfer: a randomised controlled trial by Quang Thanh Le, Thi Minh Chau Le, Khue Tu Duong, Quoc Anh Nguyen, Phuc Thinh Ong, Thi Hong Nhung Nguyen, Thi Cam Thu Thai, Matheus Roque, Carlo Alviggi

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