Gestational weight gain adequacy and intrapartum oxytocin and cesarean section use: Observational population‐based study in France by Melissa Amyx, Jennifer Zeitlin, Béatrice Blondel, Camille Le Ray

“…Our objective was to evaluate associations between GWG adequacy and intrapartum obstetric interventions (oxytocin administration; cesarean section) necessitated by labor dysfunction. Material and methods Using national, population‐based French National Perinatal Survey 2016 data, we included term cephalic singleton pregnancies involving trial of labor (n = 9724). …”
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Advancements in Herpes Zoster Diagnosis, Treatment, and Management: Systematic Review of Artificial Intelligence Applications by Dasheng Wu, Na Liu, Rui Ma, Peilong Wu

“…ObjectiveThis study aims to investigate the current research status in the use of AI for herpes zoster, offering a comprehensive synthesis of existing advancements. MethodsA systematic literature review was conducted following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. …”
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Trends of respiratory viruses and factors associated with severe acute respiratory infection in patients presenting at a university hospital: a 6-year retrospective study across th... by Judith Carolina De Arcos-Jiménez, Judith Carolina De Arcos-Jiménez, Pedro Martinez-Ayala, Pedro Martinez-Ayala, Ernestina Quintero-Salgado, Rosendo Lopez-Romo, Jaime Briseno-Ramirez, Jaime Briseno-Ramirez

“…Viral trends were analyzed through interrupted time series (ITS) modeling, incorporating locally estimated scatterplot smoothing (LOESS) and raw positivity rates. …”
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Lonafarnib Protects Against Muscle Atrophy Induced by Dexamethasone by Sanghoon Bae, Van‐Hieu Mai, Seyoung Mun, Dalong Dong, Kyudong Han, Sunghyouk Park, Jung Keun Hyun

“…This study investigates the potential of lonafarnib, a farnesyltransferase inhibitor, to counteract DEX‐induced muscle atrophy by targeting key signalling pathways. Methods We utilized in vitro models with C2C12 myotubes treated with DEX and in vivo models with Caenorhabditis elegans and DEX‐treated Sprague–Dawley rats. …”
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Construction and characterization of chimeric FcγR T cells for universal T cell therapy by Juanjuan Zhao, Manling Chen, Xudong Li, Zhaoqi Chen, Wei Li, Rongqun Guo, Min Wang, Zhongxing Jiang, Yongping Song, Jianxiang Wang, Delong Liu

“…The functionality of CFR T cells was evaluated through degranulation assays, specific target lysis experiments, in vitro cytokine production analysis, and assessment of tumor xenograft destruction specificity in mouse models using different monoclonal antibodies (MoAbs). …”
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The mechanism of plasma exosome miR-15a-5p targeting the CF-modified protein IGF1R to regulate alveolar epithelial autophagy and influence pulmonary interstitial fibrosis by Yina Li, Nan Wang, Jinying Hu, Minlan Luo, Na Zhang, Lili Gao

“…Aims: This study investigates how plasma exosomal miRNAs regulate core fucosylation (CF)-modified targets to influence autophagy and fibrosis in idiopathic pulmonary fibrosis (IPF), aiming to identify novel therapeutic strategies targeting dysregulated alveolar epithelial cell (AEC) autophagy. Materials and methods: Plasma exosomes from IPF patients and healthy controls were isolated via ultracentrifugation, validated by TEM, nanoparticle tracking analysis (NTA), and Western blot (CD9/CD81). …”
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Preclinical Development and Phase I Study of ZSYY001, a Polymeric Micellar Paclitaxel for Advanced Solid Tumor by Ge Gao, Pei Shu, Youzhen Tan, Tongsen Zheng, Wenmao Fan, Luding Lu, Huan Zhou, Zishu Wang, Ling Liu, Zhiqiang Liu, Yongsheng Wang

“…Here, we report the results of a preclinical and phase I clinical study investigating ZSYY001, a nanoparticle formulation of polymeric micellar paclitaxel (PM‐paclitaxel). Methods In preclinical studies, A549, MDA‐MB‐231, and SKOV3 xenograft tumor models were developed. …”
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Radiation induced dermatitis by increasing triglyceride levels to induce autophagy and inhibit the PI3K/Akt/mTOR signaling pathway by Yafang Hong, Hongdan Guan, Yunhao Chen, Yao Wang, Junjian Lin, Ying Wang, Yang Zhang, Rong Zheng, Xingchen Ding, Zihan Zhou, Benhua Xu

“…A binary logistic regression analysis was used to determine risk factors. Mouse models of RD were established by administering radiating at a dose of 9 Gy over two consecutive days. …”
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Real-Time Landform Feature Detection and Segmentation Based on Heterogeneous MPSoCs for Lunar Robotic Exploration by Q. Fan, R. Duan, B. Wu, H. Zhou, S. Zhang, Y. Ma

“…Traditional ground control methods face challenges in meeting the demands of real-time navigation and exploration for lunar rovers and robots due to issues such as latency and communication inefficiencies. …”
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Association of daily step counts and step intensity with mortality among US adults: a cross–sectional study of NHANES 2005–2006 by Tianzhou Peng, Changhao Liu, Ti Yang, Leyi Liao, Qingping Li, Hanbiao Liang, Jiapeng Zhang, Chen Xie, Kai Wang, Chuanjiang Li

“…Abstract Background & aims We aimed to describe the dose–response relationship between daily step counts and intensity with respect to all–cause mortality among US adults diagnosed with metabolic dysfunction–associated steatotic liver disease (MASLD). Methods Using data from the National Health and Nutrition Examination Survey (NHANES) database spanning from 2005 to 2006, a cross–sectional study included 1,108 participants was performed to assess the relationship between daily step counts and step intensity with mortality. …”
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Gut-Microbiome Signatures Predicting Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer: A Systematic Review by Ielmina Domilescu, Bogdan Miutescu, Florin George Horhat, Alina Popescu, Camelia Nica, Ana Maria Ghiuchici, Eyad Gadour, Ioan Sîrbu, Delia Hutanu

“…We systematically reviewed primary studies that correlated baseline or on-treatment gut-microbiome features with nCRT response in locally advanced rectal cancer (LARC). Methods: MEDLINE, Embase and PubMed were searched from inception to 30 April 2025. …”
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Procedure‐specific simulation for vaginal surgery training: A randomized controlled trial by Roxana Geoffrion, Nicole A. Koenig, Geoffrey W. Cundiff, Catherine Flood, Momoe T. Hyakutake, Jane Schulz, Erin A. Brennand, Terry Lee, Joel Singer, Nicole J. Todd

“…The objective of the present study was to investigate whether procedure‐specific simulation skills, vs usual training, result in improved operative competence. Material and methods We completed a randomized controlled trial of didactic and procedural training via low fidelity vaginal surgery models for anterior repair, posterior repair (PR), vaginal hysterectomy (VH), recruiting novice gynecology residents at three academic centers. …”
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Simulated kangaroo care in very preterm infants does not reduce physiological instability: the COSYBABY randomised controlled cross-over trial by Caroline Hartley, Tricia Adjei, Mohammad Chehrazi, Joan Baticula, Izabela Andrzejewska, Matthew Hyde, Neena Modi, Suzan Jeffries

“…Generalised estimating equations models were used to compare physiological instability when the BABYBE mattress was switched on vs. off.ResultsA total of 23 infants born before 32 weeks' gestation were included in the main analysis. …”
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Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis by Meng Wang, Xing Huang, Tingbo Liang, Tianyu Tang, Gang Zhang, Minghao Lu, Zhengtao Hong, Junming Huang, Xiao Zhi

“…This study aimed to demonstrate the potential effect and mechanism of LTX-315 in PD-L1 inhibition-induced anti-pancreatic cancer immunity.Methods Both immunodeficient and immunocompetent mouse models were used to evaluate the therapeutic efficacy of monotherapy and combination therapy. …”
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Artificial intelligence (AI) for paediatric fracture detection: a multireader multicase (MRMC) study protocol by Susan C Shelmerdine, Owen J Arthurs, Dean Langan, Alex Novak, Kanthan Theivendran, Nick Woznitza, Emma Allan, David Rosewarne, Saira Haque, Sarim Ather, Cato Pauling, Emily Ashworth, Ka-Wai Yung, Joy Barber

“…This study aims to evaluate whether a commercially available AI tool (certified for paediatric use) improves healthcare professionals (HCPs) detection of fractures, and how this may impact patient care in a retrospective simulated study design.Methods and analysis Using a multicentric dataset of 500 paediatric radiographs across four body parts, the diagnostic performance of HCPs will be evaluated across two stages—first without, followed by with the assistance of an AI tool (BoneView, Gleamer) after an interval 4-week washout period. …”
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Determining the long-term health burden and risk of sequelae for 14 foodborne infections in British Columbia, Canada: protocol for a retrospective population-based cohort study by Gilaad G Kaplan, Richard J Cook, Dimitra Panagiotoglou, David M Patrick, Ashok Chaurasia, Shannon E Majowicz, Marsha Taylor, Mahmood R Gohari, Steen Ethelberg, Eleni Galanis

“…We aim to estimate the health burden and direct costs of 14 infections commonly transmitted by food, considering the acute illness and subsequent sequelae and mortality, for the population of British Columbia, Canada (~4.7 million).Methods and analysis We will conduct a population-based retrospective cohort study of the British Columbia provincial population, over a 10-year study period (1 January 2005 to 31 December 2014). …”
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The German national cohort study on the development of motor performance, physical activity and health in children and adolescents: the MoMo 2.0-Study protocol by Alexander Burchartz, Claudia Niessner, Klaus Bös, Sarah Heinisch, Alexander Woll, Leon Klos, Annette Worth, Anke Hanssen-Doose, Thomas Hinz, Manuel Völkle, Birte von Haaren-Mack, Larissa Heißler, Darko Jekauc, Simon Kolb, Claudia Lazarides, Carina Nigg, Elke Opper, Elena Brehm, Steffen Schmidt, Lara Tschuschke, Carmen Volk, Susanne Weyland, Hagen Wäsche, Hannah Zimmermann, Clara Zöller

“…The Motorik Monitoring 2.0-Study aims to analyse the developmental, historical and periodic trends in motor performance and PA, as well as the underlying determinants, in children and adolescents in Germany.Methods and analysis A representative sample of children and adolescents aged 4–17 years is drawn across 195 sample points in Germany. …”
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Health care system factors associated with receipt of treatment and treatment intent in stage III non-small cell lung cancer: A population-based study in Ontario by Stephane Thibodeau, Paul Nguyen, Andrew Robinson, Fabio Ynoe de Moraes, Jason Pantarotto, Timothy P. Hanna

“…We investigated the degree that modifiable health system factors are associated with receipt of treatment and treatment intent in stage III NSCLC in a large, universal health system. Methods: This was a population-based, retrospective cohort study with health administrative data from Ontario, Canada, 2010–2018 for those aged ≥ 20 years, with AJCC 7 or 8 stage III NSCLC. …”
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From pandemic to endemic: assessing the impact of COVID-19 history and socio-demographic factors on quality of life in tuberculosis patients by Denisa Maria Mitroi, Mara Amalia Balteanu, Ovidiu Mircea Zlatian, Claudia Lucia Toma, Oana Maria Catana, Adina Andreea Mirea, Georgiana Camen, Viorel Biciusca, Viorel Biciusca, Ramona Cioboata, Ramona Cioboata

“…This study assessed the impact of prior confirmed COVID-19, alongside age, education, smoking, gender, and marital status, on TB relapse risk and quality of life (QOL) among TB patients in South-Western Romania.MethodsA cross-sectional analysis was performed on 763 bacteriologically confirmed TB patients enrolled between October 2022 and January 2025. …”
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Association between dietary consumption of multiple vitamins and age-related macular degeneration: a cross-sectional observational study in the National Health and Nutrition Examin... by Zhao Liu, Zhao Liu, Qiuyuan Wang, Qiuyuan Wang, Lu Li, Lu Li, ShanJun Cai, ShanJun Cai, ShanJun Cai

“…This study aims to examine the association between vitamin intake and AMD prevalence.MethodsData from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2008 were used for cross-sectional analysis. …”
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