Sex-Specific Physical Activity and Weight Status in German Schoolchildren: Interim Results from the Hand on Heart Study by Meike Schrader, Jennifer Wieprecht, Federico Morassutti Vitale, Simone Katrin Manai, Samar Shamas, Marcel Müller, Maren Baethmann, Anja Tengler, Roxana Riley, Guido Mandilaras, Nikolaus Alexander Haas, Delphina Gomes

“…Sex-specific differences in sport participation, sport types, and weight status were analyzed using descriptive statistics and logistic regression models. Results: based on the eligibility criteria for analysis (ages 8–18 years), 883 pupils were included (mean age 13.1 ± 2.4 years), 406 (46%) were females. …”
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Trends in knee cartilage repair procedures in the United States, 2010 to 2020 by Akshar P. Thakkar, Ting Zhang, Michael Bodine, Aaron A. Bare, Michael B. Ellman, Sanjeev Bhatia, Andreas H. Gomoll, Brian J. Chilelli

“…Student t and χ2 tests were used for statistical comparisons and analysis of data trends. Regression models and compound annual growth rates further assessed the trends of each procedure. …”
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Post-treatment changes in bowel and urinary function in prostate cancer patients treated with moderate or ultra-hypofractionation: A prospective cohort study by W.D. Heemsbergen, F. Sinzabakira, K.C. de Vries, M. Franckena, M.E.M.C. Christianen, F.E. Froklage, H. Westerveld, L. Incrocci

“…We evaluated post-treatment changes in health-related quality of life (HRQoL) outcomes after moderate (MHF) or ultra-hypofractionated (UHF) radiotherapy in a real-world PCa patient population. Methods: In this prospective cohort study, T1-4N0M0 PCa patients receiving MHF (20x3/3.1 Gy, n = 140) or UHF (7x6.1 Gy, n = 138) were assessed. …”
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In vitro impact of Streptococcus mitis on the inhibition of oral cancer cell proliferation via mitotic modulation by Inori Inui, Inori Inui, Shinichi Mochizuki, Fumika Hirabayashi-Nishimuta, Yoshie Yoshioka, Osamu Takahashi, Masaaki Sasaguri, Manabu Habu, Wataru Ariyoshi, Ryota Yamasaki, Ryota Yamasaki

“…In this study, we aimed to elucidate the effects of Streptococcus spp. on oral squamous cell carcinoma (OSCC) cells in vitro.MethodsHSC-3 (tongue carcinoma) and Ca9-22 (gingival carcinoma) cells were used as models of OSCC cells, and their responses were examined after adding major oral Streptococcus species—S. mitis, S. sanguinis, S. anginosus, S. salivarius, and S. mutans—to the culture medium. …”
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Nano-coolants for thermal enhancement in heat exchangers: A review of prospects, challenges and applications by E.T. Bello, A. Nasir, A.S. Abdulkareem, M.M. Muhammadu, N.A. Musa, J.O. Tijani, Samson Oluwaseyi Bada

“…This review provides a comprehensive analysis of the prospects, challenges and applications of nano-coolants in various heat exchanger systems. …”
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Primary liver cancer burden and its association with health development in the Western Pacific, 1990–2021 by Teng-Chao Zhou, Teng-Chao Zhou, Dan Qin, Peng Yan, Peng Yan, Bin Lan, Bin Lan, Qing Wang, Qing Wang, Jie Tan, Jie Tan

“…This study aimed to assess the burden of primary LC and its association with health system development indicators across the WPR from 1990 to 2021.MethodsWe conducted a secondary analysis using data from the Global Burden of Disease (GBD) Study 2021, covering 31 countries and territories in the WPR. …”
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Fractionated stereotactic radiotherapy of brainstem metastases – Clinical outcome and prognostic factors by Anna Krämer, Laura Hahnemann, Fabian Schunn, Christoph A. Grott, Michael Thomas, Petros Christopoulos, Jonathan W. Lischalk, Juliane Hörner-Rieber, Philipp Hoegen-Saßmannshausen, Tanja Eichkorn, Maximilian Y. Deng, Eva Meixner, Kristin Lang, Angela Paul, Fabian Weykamp, Jürgen Debus, Laila König

“…Overall survival (OS), local control (LC) and total intracranial brain control (TIBC) were analyzed via Kaplan-Meier method. Cox proportional hazards models were used to identify prognostic factors. …”
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Hydrogen gas (H2) delivered by intraperitoneal injection alleviated methionine- and choline-deficient diet-induced metabolic dysfunction–associated steatotic liver disease in mice... by Yun Chen, Yun Chen, Kangrong Wang, Kangrong Wang, Wenhai Guo, Chengqin Lu, Chengqin Lu, Wenting Suo, Wenting Suo, Qiuling Li, Qiuling Li, Yao Deng, Yao Deng, Xinling Chen, Xinling Chen, Min Dai, Min Dai, Min Dai, Xiaodong Zhang, Jiean Xu, Jiean Xu, Wen Su, Shuangling Yang, Hongzhi Yang, Fuman Yan, Haimei Liu, Haimei Liu, Yaxing Zhang, Yaxing Zhang

“…However, the effect of intraperitoneal injection of H2 on metabolic dysfunction–associated steatotic liver disease (MASLD) is unclear.ObjectiveThe aim of this study is to investigate whether intraperitoneal injection of H2 can improve MASLD, and if so, what are the key innate immune mechanisms involved?MethodsThe MASLD mouse model was established by feeding a methionine- and choline-deficient (MCD) diet for 3 weeks. …”
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Mapping grey matter and cortical thickness alterations associated with subjective cognitive decline and mild cognitive impairment among rural-dwelling older adults in China: A popu... by Ziwei Chen, Qianqian Xie, Jiafeng Wang, Yan Wang, Huisi Zhang, Chunyan Li, Yongxiang Wang, Lin Cong, Shi Tang, Tingting Hou, Lin Song, Yifeng Du, Chengxuan Qiu

“…Data were analyzed using voxel-based morphometry (VBM), surface-based morphometry analysis (SBM), and logistic regression models. Results: SCD was defined in 243 persons and MCI in 246 individuals. …”
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Polygenic risk score prediction accuracy convergence by Léo Henches, Jihye Kim, Zhiyu Yang, Simone Rubinacci, Gabriel Pires, Clara Albiñana, Christophe Boetto, Hanna Julienne, Arthur Frouin, Antoine Auvergne, Yuka Suzuki, Sarah Djebali, Olivier Delaneau, Andrea Ganna, Bjarni Vilhjálmsson, Florian Privé, Hugues Aschard

“…Summary: Polygenic risk scores (PRSs) models trained from genome-wide association study (GWAS) results are set to play a pivotal role in biomedical research addressing multifactorial human diseases. …”
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Pembrolizumab-axitinib versus nivolumab-cabozantinib as first-line therapy in patients with metastatic renal cell carcinoma: a retrospective real-world comparison (ARON-1) by Matteo Santoni, Giandomenico Roviello, Enrique Grande, Ugo De Giorgi, Ondrej Fiala, Emmanuel Seront, Javier Molina-Cerrillo, Renate Pichler, Zin W. Myint, Jakub Kucharz, Ravindran Kanesvaran, Thomas Büttner, Martin Pichler, Umberto Basso, Jindrich Kopecky, Maria T. Bourlon, Linda Cerbone, Tomas Buchler, Alvaro Pinto, Alfonso Gómez de Liaño, Caterina Gianni, Anca Zgura, Pasquale Rescigno, Jawaher Ansari, Orazio Caffo, Zsófia Küronya, Maria Giuseppa Vitale, Dipen Bhuva, Martina Catalano, Nuno Vau, Ray Manneh Kopp, Sebastiano Buti, Aristotelis Bamias, Camillo Porta, Kaisa Sunela, Francesco Massari

“…This retrospective study compares the effectiveness of pembrolizumab plus axitinib (PA) and nivolumab plus cabozantinib (NC) as first-line treatments for mRCC in a real-world setting. Methods Patient data were collected from 55 centers across 16 countries, encompassing individuals diagnosed with mRCC receiving first-line treatment with PA or NC between January 2016 and October 2023. …”
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The Association Between an Individual’s Local Food Environment and Diet Quality among Postpartum Women Living in Rural Bangladesh by Alexandra L Bellows, Andrew Thorne-Lyman, Saijuddin Shaikh, Md Tanvir Islam, Shahnaj Parvin, Rezwanul Haque, Monica M Pasqualino, Frank Curriero, Hasmot Ali, Alain B Labrique, Md Iqbal Hossain, Amanda C Palmer

“…To assess the association between food environment indicators and diet quality indicators, we fit linear regression models for the FVS outcome, Poisson regression models for the dietary diversity outcome, and logistic regression models for individual food group outcomes. …”
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T cell receptor-like antibody specifically targets and eliminates cells infected with cytomegalovirus by Dabing Chen, Caidong Hu, Yunda Hong, Jingjing Xu, Jiaqi Sun, Jinhua Ren, Yangtao Wu, Ningshao Xia, Quan Yuan, Jianda Hu, Ting Yang

“…The affinity of the antibody for the pCMV-pp65495 − 503/HLA-A2 complex was validated using ELISA, surface plasmon resonance analysis, and flow cytometry. Additionally, its anti-CMV activity was further confirmed in both in vitro assays and animal models. …”
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Development of Powerly, unguided mobile app intervention preventing postpartum depression and anxiety & study protocol of randomized clinical trial by Marta A. Marciniak, Judith Rohde, Kenneth S.L. Yuen, Harald Binder, Henrik Walter, Matthias J. Wieser, Raffael Kalisch, Karin Roelofs, Birgit Kleim

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Kidney Transplantation Improves Survival in Lupus Nephritis With End-Stage Kidney Disease by Benoît Brilland, Jean-François Augusto, Pierre-Antoine Michel, Noémie Jourde-Chiche, Cécile Couchoud

“…The primary outcome was all-cause mortality, which was assessed using Kaplan-Meier analysis and adjusted Cox proportional hazards models. …”
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The prognostic value of HFA-PEFF score in connective tissue disease-associated PAH: evidence from a cohort study by Jiayi Dai, Li Ma, Yixin Zhang, Linwei Shan, Dongyu Li, Lin Li, Qi Hu, Zhangdi Zhou, Xiaoxuan Sun, Qiang Wang, Lei Zhou

“…Survival was analyzed using Kaplan–Meier analysis and Cox proportional hazards models. Results Compared to the HFA-PEFF score < 5 group, the ≥ 5 group exhibited significantly higher levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), a greater proportion of WHO functional class III-IV, shorter 6-min walk distance (6MWD), larger right ventricular (RV) volume, worse RV function, smaller left ventricular (LV) volume, and higher native T1 values. …”
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Role of individual and combined impact of simvastatin and α-TCP in rat calvarial bone defect: An experimental study by Surendar Sugumaran, Deepak Selvam, M.S. Nivedhitha, Karthik Ganesh Mohanraj, Bader O. Almutairi, Selvaraj Arokiyaraj, Ajay Guru, Jesu Arockiaraj

“…Materials and Methods: In this investigation, 24 Wistar Albino rats weighing 200–250 g were utilized. …”
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Ten‐Year Cardiovascular Disease Risk Score and Cognitive Function Among Older Adults: The National Health and Nutrition Examination Survey 2011 to 2014 by Jingkai Wei, Hanzhang Xu, Angela D. Liese, Anwar T. Merchant, Liang Wang, Chih‐Hsiang Yang, Matthew C. Lohman, Monique J. Brown, Tiansheng Wang, Daniela B. Friedman

“…We aimed to examine the associations of Framingham risk score with cognitive function among older adults in a nationally representative sample, as well as by race or ethnicity, education, and family income. Methods and Results A total of 2254 older adults ≥60 years (57% female, 79% non‐Hispanic White) in the National Health and Nutrition Examination Survey 2011 to 2014 were included in the final sample for analysis. …”
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Effectiveness of AZD7442 (Tixagevimab/Cilgavimab) for Pre-Exposure Prophylaxis Against COVID-19 Hospitalization in Israel During the Omicron Sub-Variant Time Period by Samah Hayek, Joseph Levy, Galit Shaham, Noa Dagan, Danielle Serby, Hadar Duskin-Bitan, Sabada Dube, Cátia Ferreira, Idit Livnat, Carla Talarico, Sylvia Taylor, Sudhir Venkatesan, Adva Yarden, Ran D. Balicer, Doron Netzer, Alon Peretz

“…Abstract Introduction The effectiveness of AZD7442 (tixagevimab/cilgavimab) against COVID-19 hospitalizations was determined at 3 and 6 months among immunocompromised individuals in Israel during different variant circulations. Methods This was a retrospective cohort study using data from Clalit Health Services in Israel. …”
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3D cone-beam C.T. imaging used to determine the effect of disinfection protocols on the dimensional stability of full arch impressions by Kuei-ling Hsu, Abdulrahman A. Balhaddad, Isadora Martini Garcia, Fabrício Mezzomo Collares, Vineet Dhar, Louis DePaola, Mary Anne Melo

“…Aim: This study aimed to investigate the dimensional stability of irreversible hydrocolloid and polyvinylsiloxane (P.V.S.) impressions after exposure to four commercial disinfectants using cone-beam computed tomography (CBCT). Materials and Methods: Two different impression materials were tested: irreversible hydrocolloid and P.V.S. …”
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