SARS-CoV-2 seroprevalence among learners in grades 1–7, their parents and teachers in KwaZulu-Natal, South Africa: a cross-sectional study by Reshmi Dassaye, Terusha Chetty, Terusha Chetty, Brodie Daniels, Trisha Ramraj, Zakir Gaffoor, Elizabeth Spooner, Ncengani Mthethwa, Duduzile Faith Nsibande, Vuyolwethu Magasana, Khanya Mohlabi, Isaac Singini, Nomonde Gwebushe, Kubashni Woeber, Kubashni Woeber, Ameena Goga, Ameena Goga

“…All participants provided informed consent, completed a questionnaire and provided a fingerprick of blood for SARS-CoV-2 antibody testing using the COVID-19 IgG/IgM Rapid Test. Statistical methods included descriptive analysis, jackknife-estimated seroprevalence and incidence (unadjusted and sensitivity-adjusted), and logistic regression using generalized linear models.ResultsA total of 645 participants (i.e., 456 learners, 147 parents and 42 teachers) were enrolled into the survey. …”
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Long-term ambient air pollution and the risk of major mental disorder: A prospective cohort study by Chuyu Pan, Bolun Cheng, Shiqiang Cheng, Li Liu, Xuena Yang, Peilin Meng, Xin Qi, Na Zhang, Xiaoyue Qin, Dan He, Wenming Wei, Jingni Hui, Yan Wen, Yumeng Jia, Huan Liu, Feng Zhang

“…We aim to explore the impact of various air pollutants on the risk of major MD. Methods This prospective study analyzed data from 170 369 participants without depression, anxiety, bipolar disorder, and schizophrenia at baseline. …”
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Interleukin‐11 promotes lung adenocarcinoma tumourigenesis and immune evasion by Cristina Cirauqui, Laura Ojeda, Itziar Otano, Irene Pazos, Alba Santos, Eva M. Garrido‐Martín, Patricia Yagüe, Javier Ramos‐Paradas, Sonia Molina‐Pinelo, Giovanna Roncador, José Luis Solórzano, M. Teresa Muñoz, Patricia Cozar, Patricia Plaza, Rocío Suárez, Marta Jiménez, Roberto Moreno, Arantxa Rosado, Pablo Gámez, Ricardo García‐Luján, Jon Zugazagoitia, E. Alejandro Sweet‐Cordero, Mariano Barbacid, Amancio Carnero, Irene Ferrer, Luis Paz‐Ares

“…LUAD cell lines genetically engineered to overexpress or to silence IL‐11 or its receptor (IL‐11RA) were used for in vitro functional analysis and for in vivo experiments. Additionally, we used three different in vivo models: patient‐derived xenografts (PDXs), tobacco‐exposed mice and genetically engineered mouse models. …”
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Antimicrobial Activity and the Synergy Potential of <i>Cinnamomum aromaticum</i> Nees and <i>Syzygium aromaticum</i> (L.) Merr. et Perry Essential Oils with Antimicrobial Drugs by Soraia El Baz, Bouchra Soulaimani, Imane Abbad, Zineb Azgaou, El Mostapha Lotfi, Mustapha Malha, Noureddine Mezrioui

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Geriatric Rehabilitation in Patients with Frailty: Interim Results of the POSTSCRIPTUM. An Open Prospective Study by Olga N. Tkacheva, Nadezhda K. Runikhina, Irina P. Malaya, Albert R Yusupov, Natalia V. Sharashkina, Valentina S. Ostapenko, Yulia V. Kotovskaya, Elen A. Mkhitaryan, Maria S. Arefieva, Evgenii Е. Popov, Elnura E. Esenbekova

“…MATERIALS AND METHODS. A multicenter prospective study of the effectiveness of individual 21-day geriatric rehabilitation programs based on the results of a comprehensive geriatric assessment for patients aged 60 years and older with frailty syndrome. …”
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From fragmented to integrated: Advancing surface water quality assessment through WQPI in the upper Medjerda River, Northeastern Algeria by Benacherine Mostefa, Lyazid Mohamed Nadjib, Allaoua Noua, Soualah Alila Hana, Satour Abd El Latif, Chouiter Norhane, Debassi Bouchra, Zineb Chetouh, Md Galal Uddin

“…In this study, we evaluated the surface water quality of the upper Medjerda River in northeastern Algeria by integrating traditional indices, the Organic Pollution Index (OPI) and the Weighted Arithmetic Water Quality Index (WA_WQI), with advanced multivariate analyses including Principal Component Analysis (PCA) and Generalized Linear Models (GLMs). …”
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Cognitive Function Is Impaired in Patients with Recently Diagnosed Type 2 Diabetes, but Not Type 1 Diabetes by Theresa van Gemert, Wolfgang Wölwer, Katharina S. Weber, Annika Hoyer, Klaus Strassburger, Nora T. Bohnau, Marie A. Brüggen, Katharina Ovelgönne, Eva-Maria Gössmann, Volker Burkart, Julia Szendroedi, Michael Roden, Karsten Müssig, GDS Group

“…To test whether cognitive function is impaired in early states of diabetes and to identify possible risk factors for cognitive impairment. Methods. A cross-sectional analysis within the German Diabetes Study included patients with type 1 or type 2 diabetes within the first year after diagnosis or five years after study inclusion and metabolically healthy individuals. …”
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EPHX2 overexpression deters the advancement of clear cell renal cell carcinoma via lipid metabolism reprogramming by Bo Guan, Cong Huang, Cong Huang, Cong Huang, Jun He, Jun He, Jun He, Weimin Shan, Di Cui, Xiaowei Li, Chaozhao Liang, Chaozhao Liang, Chaozhao Liang, Zongyao Hao, Zongyao Hao, Zongyao Hao

“…However, the specific mechanistic role of EPHX2 in tumorigenesis remains largely unexplored.ObjectiveTo elucidate the mechanistic role of EPHX2 in the progression of ccRCC. MethodsBulk transcriptome data, single-cell transcriptome data, and gene set data for ccRCC were sourced from the TCGA database and GEO database. …”
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Case Management Activities in Palliative Care for Cancer: A Scoping Review by Viviana Fusetti, Alessandra Pigni, Cinzia Brunelli, Antonino Tallarita, Davide Di Benedetto, Sara Alfieri, Augusto Caraceni, Maura Lusignani

“…Methods. This scoping review was performed and reported according to the PRISMA-ScR checklist. …”
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IN VITRO POPULATION GROWTH OF HUMAN GLIOBLASTOMAS: REAL PATIENTS AND CURVE FITTING by Diego Samuel Rodrigues, Letícia Fernanda Alves, João Frederico da Costa Azevedo Meyer, Moníze Valéria Ramos da Silva, Natália Barreto, Catarina Raposo

“…Introduction/Justification: For more than a century, a variety of ordinary differential equation growth models have been used to describe and predict the proliferation of human malignancies. …”
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The preoperative hemoglobin, albumin, lymphocyte, and platelet score (HALP) as a prognostic indicator in patients with non-small cell lung cancer by Qiteng Liu, Qiteng Liu, Qiteng Liu, Qiteng Liu, Hailun Xie, Hailun Xie, Hailun Xie, Wenjuan Cheng, Tong Liu, Tong Liu, Tong Liu, Chenan Liu, Chenan Liu, Chenan Liu, Heyang Zhang, Heyang Zhang, Heyang Zhang, Shiqi Lin, Shiqi Lin, Shiqi Lin, Xiaoyue Liu, Xiaoyue Liu, Xiaoyue Liu, Haiying Tian, Haiying Tian, Haiying Tian, Xiangrui Li, Xiangrui Li, Xiangrui Li, Xin Zheng, Xin Zheng, Xin Zheng, Yue Chen, Yue Chen, Yue Chen, Jinyu Shi, Jinyu Shi, Jinyu Shi, Hong Zhao, Hong Zhao, Hong Zhao, Hanping Shi, Hanping Shi, Hanping Shi

“…This study aims to investigate the prognostic value of HALP in patients with non-small cell lung cancer (NSCLC).MethodsA total of 2,428 patients with NSCLC were enrolled in the INSCOC study. …”
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“A quality of heart, of presence, and of really caring”: toward affirmative intersex health communication in Canada by Terese Knoppers, Angelica Voutsinas, Nicole Palmour, Kaleb Saulnier, Kaleb Saulnier, Morgan Holmes, Marilou Charron, Hortense Gallois, Hortense Gallois, Narges Jamali, Narges Jamali, Leslie Ordal, Yann Joly

“…Interviews were analyzed via template thematic analysis and filtered through a conceptual lens that brought together agency-based and social-ecological models of health communication.ResultsFindings produced three interlocking axes for change: HCP skills and approaches, structural access to care, and norms and discourses. …”
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Protocol for a prospective cohort study: Prevention of Transmissions by Effective Colonisation Tracking in Neonates (PROTECT-Neo) by Martin Wolkewitz, Roland Hentschel, Philipp Henneke, Daniel Jonas, Tim Götting, Sandra Reuter, Daniel Klotz, Simone Hock, Benjamin Blümel, Georg Häcker, Hajo Grundmann, Nico Mutters

“…It is the dual objective of the Prevention of Transmissions by Effective Colonisation Tracking-Neo study to determine the density of transmission events in a level III neonatal intensive care unit (NICU) and to identify risk factors that may be causally associated with transmission events.Methods and analysis A full cohort of patients treated in a 17-bed level III NICU will be prospectively followed and transmission events between two or more patients will be documented. …”
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Effect of thermocycling on flexural strength of dental CAD/CAM ceramics of variable thicknesses and structures: an in vitro study [version 3; peer review: 1 approved, 2 approved wi... by Shahad T. Alameer, Laila Al Dehailan, Sultan Akhtar, Turki Alshehri, Nourhan M. Aly, Yousif A. Al-Dulaijan, Passent Ellakany

“…Scanning electron microscopy (SEM) was employed for analysis. Two factorial ANOVA models assessed the association of different factors (ceramic type and thickness) with flexural strength and elastic modulus. …”
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Predicting Ventricular Tachyarrhythmias in Patients With Left Ventricular Ejection Fraction Improvement Following Cardiac Resynchronization Therapy by Adam Visca, Saadia Sherazi, Ilan Goldenberg, Scott McNitt, Nikhila Rao, Nilesh Rao, Ahmed Shah, Mehmet Aktas, Valentina Kutyifa, Wojciech Zareba, Krishna Rao

“…This study aimed to identify predictors of ventricular tachyarrhythmias (VTA) in patients with CRT‐D devices and LVEF improvement beyond guideline recommendations for a defibrillator. Methods Patients randomized to the CRT‐D arm of the Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy trial who improved their LVEF to > 35% at 12 months following CRT‐D implant were included in this analysis (N = 651). …”
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Crohn’s disease therapeutic dietary intervention (CD-TDI): study protocol for a randomised controlled trial by Subrata Ghosh, Levinus A Dieleman, Christopher Ma, Ian Lewis, Herman W Barkema, Humberto Jijon, Kathy D McCoy, Georgios V Gkoutos, Maitreyi Raman, Lorian M Taylor, Jeff K Vallance, Derek M McKay, David M Mutch, Deanna Gibson, Marcus Rauch

“…We aim to explore the efficacy of the CD therapeutic dietary intervention (CD-TDI), a novel dietary approach developed from best practices and current evidence, to induce clinical and biomarker remission in adult patients with active CD.Methods and analysis This study is a 13-week, multicentre, randomised controlled trial in patients with mild-to-moderate active CD at baseline. …”
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Alpha-estradiol and (R)-(−)-ibuprofen inhibit gastric cancer progression via GLI1 G-quadruplex by Qiang Li, Pan Pan, Qingqing Xian, Jingtan Li, Jingting Wang, Jiaying Cai, Jing Wang, Yanfei Jia, Haiji Sun, Lulu Zhang, Xiaoli Ma

“…These compounds were evaluated for anti-tumor effects through in vitro assays (proliferation, migration, invasion) and in vivo xenograft models. Mechanistic insights into GLI1/PRKACB signaling were obtained via chromatin immunoprecipitation and pathway analysis.ResultsStable G4 structures were confirmed in the GLI1 promoter. …”
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Effect of thermocycling on flexural strength of dental CAD/CAM ceramics of variable thicknesses and structures: an in vitro study [version 2; peer review: 1 approved, 2 approved wi... by Shahad T. Alameer, Laila Al Dehailan, Sultan Akhtar, Turki Alshehri, Nourhan M. Aly, Yousif A. Al-Dulaijan, Passent Ellakany

“…Scanning electron microscopy (SEM) was employed for analysis. Two factorial ANOVA models assessed the association of different factors (ceramic type and thickness) with flexural strength and elastic modulus. …”
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Do Short-Term Improvements in Activities of Daily Living and Instrumental Activities of Daily Living Have Association With Return to Work in Workers With Occupational Injury? From... by Fa-Chen Lin, Chia-Pin Lin, Hung-Yi Chuang, Tse-Wei Wu, Peng-Ju Huang, Chen-Cheng Yang, Chao-Hung Kuo

“…This prospective cohort study aims to determine if a relationship exists between ADL/IADL and RTW among injured workers in Taiwan. Methods: We recruited 162 workers who reported work-related injuries from January 2023 to May 2024. …”
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Impact of Hemoglobin Glycation Index on Complications Following Orthopedic Surgery: A Retrospective Comparative Propensity Score‐Matched Study by Yuhua Xiao, Bochen Sun, Guoyu Yu, Long Chen, Fenqi Luo, Jie Xu, Jun Luo, Ting Xue, Yiyang Xu

“…We aimed to assess the utility of the hemoglobin glycation index (HGI) in predicting early complications following elective orthopedic surgery. Methods We retrospectively enrolled 1496 patients who underwent elective orthopedic surgery at Fujian Provincial Hospital in China from Jan 2015 to Jan 2023. …”
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