Childhood maltreatment and depression: mediating role of lifestyle factors, personality traits, adult traumas, and social connections among middle-aged and elderly participants by Xuemei Wang, Zhi Cao, Shaohua Yin, Tingshan Duan, Tao Sun, Chenjie Xu

“…A path analysis using structural equation modeling (SEM) was then performed to assess the mediating effects of lifestyle factors, personality traits, adult traumas, and social connections. …”
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The association between triglyceride-glucose index, atherogenic index of plasma, systemic immune-inflammation index, and mortality in patients with acute coronary syndrome: the dir... by Weichen Luo, Zaixiao Tao, Xinxin Li, Yang Xu, Chun Yang, Rui Sun, Mi Wang, Zhenjun Ji, Genshan Ma

“…Additionally, multivariable logistic regression, RCS models, and mediation analysis were used to assess associations and pathways.ResultsElevated TyG index linearly increased mortality risk in ACS patients (Odds Ratio (OR) = 1.64, 95% Confidence Interval (CI):1.07–2.52) and AMI subgroups (OR = 1.56, 95% CI:1.00–2.42), with minimal SII mediation (ACS:3.97%; AMI: non-significant).The AIP index directly increased mortality risk (ACS: Beta coefficient (β) = 0.076; AMI: β = 0.091, p < 0.001), partially offset by SII's negative mediation (ACS:−6.6%; AMI:−7.8%). …”
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Revolutionizing diabetes treatment: computational insights into 4-hydroxy isoleucine derivatives and advanced molecular screening for antidiabetic compounds by Lakshmi Mounika Kelam, Manjinder Singh Gill, M. Elizabeth Sobhia

“…Aim: This study aimed to computationally identify and optimize 4-hydroxy isoleucine (4HILe) derivatives from fenugreek as multitarget antidiabetic agents against α-glucosidase, α-amylase, and aldose reductase [PDB (protein data bank) IDs: 5NN8, 4GQR, 4QX4]. Methods: A multi-step computational workflow was employed to identify and optimize 4HILe derivatives as antidiabetic agents. …”
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Unplanned pregnancy and perinatal depression: secondary exploratory analyses from a racially and ethnically diverse, low-income sample of birthing people in the United States by Katherine A. Czech, Jaime Hamil, Bayley J. Taple, Jody D. Ciolino, Ann Kan, Allison M. Letkiewicz, Alicia Diebold, S. Darius Tandon

“…Methods Pregnant individuals (n = 808) were enrolled in a larger study evaluating the effectiveness of a preventative intervention for postpartum depression, and self-reported depressive symptoms were collected prenatally and at 12 weeks postpartum using the 16-item Quick Inventory of Depressive Symptomatology. …”
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Health-related quality of life with bemarituzumab plus mFOLFOX6 in patients with FGFR2b-overexpressing, advanced gastric or gastroesophageal junction cancer by Z.A. Wainberg, P.C. Enzinger, S. Qin, K. Yamaguchi, J. Wang, X. Zhou, A. Gnanasakthy, K. Taylor, A. Yusuf, I. Majer, A. Jamotte, Y.-K. Kang

“…Materials and methods: Patients were randomized 1 : 1 to bemarituzumab plus mFOLFOX6 (n = 77) or placebo plus mFOLFOX (n = 78). …”
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Sex differential impact of comorbidities in spondyloarthritis: data from COMOSPA study by Maxime Dougados, Anna Molto, Jordi Gratacós, Clementina López-Medina, Mireia Moreno, Maria Llop, Marta Arevalo Salaet, Joan Calvet, Antoni Berenguer-Llergo

“…Objectives To describe and compare the prevalence of comorbidities in female and male patients with spondyloarthritis (SpA) and to assess whether comorbidities had a different impact on disease outcomes in male and female patients.Methods This is a post hoc analysis of the COMOrbidities in SPondyloArthritis study. …”
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Association of the systemic immune-inflammatory index and systemic inflammatory response index with all-cause and cardiovascular mortality in individuals with metabolic inflammator... by Pin Jiang, Jiexia Chen, Jiehua Li

“…However, their associations with all-cause and cardiovascular mortality remain insufficiently explored. Methods This study utilized data from adult participants in the National Health and Nutrition Examination Survey (NHANES) between 2003 and 2018, all of whom had complete MIS-related data. …”
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Nanopore full length 16S rRNA gene sequencing increases species resolution in bacterial biomarker discovery by Pablo Aja-Macaya, Kelly Conde-Pérez, Noelia Trigo-Tasende, Elena Buetas, Mohammed Nasser-Ali, Paula Nión, Soraya Rumbo-Feal, Susana Ladra, Germán Bou, Álex Mira, Juan A. Vallejo, Margarita Poza

“…This was achieved through the analysis of feces from 123 subjects, comparing both methods (Illumina-V3V4 with DADA2 and QIIME2 vs. …”
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Characteristics, management and factors associated with poor outcomes in COVID-19 patients in Burkina Faso: insights from a 2021 large-scale ambispective study by Ariane Mamguem Kamga, Samiratou Ouédraogo, Firmin Nongodo Kaboré, Isidore Tiandiogo Traoré, Esperance Ouédraogo, Armel Poda, Armel Poda, Arnaud Eric Diendéré, Dramane Kania, Hermann Badolo, Guillaume Sanou, Amariane Koné, Therese Samdapawindé Kagoné, Blahima Konaté, Rachel Médah, Nathalie de Rekeneire, Boukary Ouédraogo, Oumar Billa, Gilles Paradis, Halidou Tinto, Tienhan Sandrine Dabakuyo-yonli

“…ObjectivesTo assess treatment and identify predictive factors of worsening in COVID-19 patients.MethodsThis study was ambispective (both prospective and retrospective) and part of a multidisciplinary, multicenter project designed to generate epidemiological, sociological and anthropological data about the COVID-19 epidemic in Burkina Faso. …”
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El desarrollo sostenible en empresas colombianas: un estudio con base en la promoción y protección de los derechos humanos by Andrés Basillo García Sánchez

“…This research report is structured based on an exhaustive study of the most important business models in Colombia, from which the variables that effectively measure the inclusion of human rights within business are extracted, and the analysis of its impact in sustainable development is performed.   …”
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Laherradurin Inhibits Colorectal Cancer Cell Growth by Induction of Mitochondrial Dysfunction and Autophagy Induction by Izamary Delgado-Waldo, Svetlana Dokudovskaya, Yahir A. Loissell-Baltazar, Eduardo Pérez-Arteaga, Jossimar Coronel-Hernández, Mariano Martínez-Vázquez, Eloy Andrés Pérez-Yépez, Alejandro Lopez-Saavedra, Nadia Jacobo-Herrera, Carlos Pérez Plasencia

“…LAH, an acetogenin from the Annonaceae family, has demonstrated antitumor activity in several cancer cell lines and in vivo models, where it reduced the tumor size and induced programmed cell death. …”
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High-flow nasal cannula therapy versus continuous positive airway pressure for non-invasive respiratory support in paediatric critical care: the FIRST-ABC RCTs by Padmanabhan Ramnarayan, Alvin Richards-Belle, Karen Thomas, Laura Drikite, Zia Sadique, Silvia Moler Zapata, Robert Darnell, Carly Au, Peter J Davis, Izabella Orzechowska, Julie Lester, Kevin Morris, Millie Parke, Mark Peters, Sam Peters, Michelle Saull, Lyvonne Tume, Richard G Feltbower, Richard Grieve, Paul R Mouncey, David Harrison, Kathryn Rowan

“…The CEA used multilevel linear regression models that allowed for clustering of patients at site. …”
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Yiqi Huayu Jiedu Decoction reduces colorectal cancer liver metastasis by promoting N1 neutrophil chemotaxis by Hua-Jian Zhou, Bai-Xiang Mu, Meng-Chao Wen, Qi Zhao, Yuanxiang Li, Wen-Xuan Zhao, Hong-Ye Yin, Shuai Ren, Jin-Yong Zhou, Jin-Yong Zhou, Min Chen

“…ObjectiveTo observe the inhibitory effect and potential mechanism of Yiqi Huayu Jiedu Decoction (YHJD) on liver metastasis of colorectal cancer (CRC).MethodsWe compared the changes of liver weight and liver index before and after YHJD treatment in CRC liver metastasis mouse models. …”
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Workplace-based dietary intervention study: Effects on body mass index and fat mass in metalworking industry workers by Luca DI GIAMPAOLO, Rossella MARTELLI, Daria ZICCARDI, Claudia GIURGOLA, Federica MARINO, Vittorio BARASSI, Paola BORRELLI, Laura FORCELLA, Maria Elisa MAIOLO, Rocco MANGIFESTA, Luca COPPETA, Francesca DI MECO

“…Anthropometric measures, including BMI and fat mass, were recorded at baseline and follow-up using bioimpedance analysis. Statistical analyses included paired t-tests and mixed linear models to assess changes over time. …”
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Impact of Institutional Monthly Volume of Transcatheter Edge-to-Edge Repair Procedures for Significant Mitral Regurgitation: Evidence from the GIOTTO-VAT Study by Nicola Corcione, Paolo Ferraro, Filippo Finizio, Michele Cimmino, Michele Albanese, Alberto Morello, Giuseppe Biondi-Zoccai, Paolo Denti, Antonio Popolo Rubbio, Francesco Bedogni, Antonio L. Bartorelli, Annalisa Mongiardo, Salvatore Giordano, Francesco De Felice, Marianna Adamo, Matteo Montorfano, Francesco Maisano, Giuseppe Tarantini, Francesco Giannini, Federico Ronco, Emmanuel Villa, Maurizio Ferrario, Luigi Fiocca, Fausto Castriota, Angelo Squeri, Martino Pepe, Corrado Tamburino, Arturo Giordano

“…We aimed at evaluating whether the institutional monthly volume of TEER influences short- and long-term clinical results. <i>Materials and Methods</i>: This analysis from the multicenter, prospective GIOTTO trial study evaluated the impact of institutional monthly volume on outcomes of TEER to remedy significant mitral regurgitation. …”
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Evaluación del predominio de variables geométricas en la frecuencia natural del sensor piezoeléctrico CTN-10- 3/92. // Geometric variables evaluation with influence in the natural... by R. Armas Cardona, F. Martínez Luzardo, J. García de la Figal Costales

“…In absence of<br />appropriate conventional equipment and in presence of complex structural geometry, the numeric methods results the main<br />tools for the modelation of dynamic problems. …”
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Impact of first-line chemoimmunotherapy with or without radiotherapy on the prognosis of patients with locally advanced or metastatic esophageal squamous cell carcinoma: a multicen... by Xinyi Liu, Jingyuan Wen, Yaowen Zhang, Chenyu Wang, Yatian Liu, Pudong Qian, Jianzhong Cao, Qing Hou, Yuanji Xu, Zhongmei Lin, Xianghua Ye, Min Hou, Yan Gui, Lulu Wang, Wei Zhou, Zhimin Zeng, Yaqi Song, Honglei Luo, Jiahua Lv, Wenbin Shen

“…The research carried out prognostic analysis by harnessing the univariate and multivariate Cox proportional hazards regression models. …”
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Physiological serum uric acid concentrations correlate with arterial stiffness in a sex-dependent manner by Oliver Thews, Thomas Schmid, Alexander Kluttig, Andreas Wienke, Melanie Zinkhan, Wolfgang Ahrens, Till Bärnighausen, Hermann Brenner, Stefanie Castell, Berit Lange, Wolfgang Lieb, Karin Halina Greiser, Marcus Dörr, Lilian Krist, Stefan N. Willich, Volker Harth, Nadia Obi, Michael Leitzmann, Annette Peters, Börge Schmidt, Matthias B. Schulze, Henry Völzke, Matthias Nauck, Stephanie Zylla, Anke Hannemann, Tobias Pischon, Ilais Moreno Velásquez, Matthias Girndt, Claudia Grossmann, Michael Gekle

“…In addition to effects on arterial vascular tone, associations between serum uric acid concentrations—even in the physiological range—and arterial hypertension and vascular-mediated end-organ damage due to an impact on vascular stiffness have been postulated. Methods Therefore, we aim to investigate a possible cross-sectional association between serum uric acid concentrations in the physiological range and differences in arterial pulse wave velocity (PWV), an indicator of vascular remodeling, with a focus on possible differences between female and male individuals. …”
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The Potential of Hydrogeodesy to Address Water‐Related and Sustainability Challenges by Fernando Jaramillo, Saeid Aminjafari, Pascal Castellazzi, Ayan Fleischmann, Etienne Fluet‐Chouinard, Hossein Hashemi, Clara Hubinger, Hilary R. Martens, Fabrice Papa, Tilo Schöne, Angelica Tarpanelli, Vili Virkki, Lan Wang‐Erlandsson, Rodrigo Abarca‐del‐Rio, Adrian Borsa, Georgia Destouni, Giuliano Di Baldassarre, Michele‐Lee Moore, José Andrés Posada‐Marín, Shimon Wdowinski, Susanna Werth, George H. Allen, Donald Argus, Omid Elmi, Luciana Fenoglio, Frédéric Frappart, Xander Huggins, Zahra Kalantari, Simon Munier, Sebastián Palomino‐Ángel, Abigail Robinson, Kristian Rubiano, Gabriela Siles, Marc Simard, Chunqiao Song, Christopher Spence, Mohammad J. Tourian, Yoshihide Wada, Chao Wang, Jida Wang, Fangfang Yao, Wouter R. Berghuijs, Jean‐François Cretaux, James Famiglietti, Alice Fassoni‐Andrade, Jessica V. Fayne, Félix Girard, Matti Kummu, Kristine M. Larson, Martin Marañon, Daniel M. Moreira, Karina Nielsen, Tamlin Pavelsky, Francisco Pena, J. T. Reager, Maria Cristina Rulli, Juan F. Salazar

“…We find a growing body of literature relating to the advancements in hydrogeodetic methods, their accuracy and precision, and their inclusion in hydrological modeling, with a considerably smaller portion related to understanding hydrological processes, water management, and sustainability sciences. …”
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Transcriptional and post-transcriptional regulation of CARMN and its anti-tumor function in cervical cancer through autophagic flux blockade and MAPK cascade inhibition by Xing Zhang, Wenjing Yan, Hua Jin, Bingjia Yu, Hao Zhang, Bo Ding, Xue Chen, Yan Zhang, Qianqian Xia, Dan Meng, Jing Hu, Haohan Liu, Yamei Nie, Fengying Liu, Yun Zheng, Yiran Lu, Juan Wang, Mulong Du, Meilin Wang, Evan Yi-Wen Yu, Xiuting Li, Shizhi Wang

“…Results CARMN was identified as a hub gene in two modules significantly associated with the NOR-CIN-CC transition. Analysis using ten machine learning models confirmed its critical role in this progression. …”
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